PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNTA1	1	SCN4A	3	unspecified method	Boisguerin P (2004)	1
SNTA1	1	GOLGA2	2	unspecified method	Boisguerin P (2004)	1
SNTA1	1	HTR2C	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	ADRA1D	1	unspecified method	Boisguerin P (2004)	1
GRB2	2	FABP1	0	two hybrid	Wang J (2008)	1
GRB2	2	SNTA1	1	affinity chromatography technology	Xu H (2001)	1
MLC1	0	DTNA	4	affinity chromatography technology	Lanciotti A (2010)	1
KCNJ4	5	DMD	6	affinity chromatography technology	Leonoudakis D (2004)	1
GOLGA2	2	NDEL1	2	two hybrid	Rolland T (2014)	1
DMD	6	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	100289290	0	unspecified method	Boisguerin P (2004)	1
GOLGA2	2	LMO1	0	two hybrid	Rolland T (2014)	1
SCN5A	9	SNTA1	1	affinity chromatography technology, unspecified method	Gee SH (1998), Gee SH (1998)	2
ADRA1D	1	DTNA	4	affinity chromatography technology	Lyssand JS (2008)	1
SNTA1	1	RYR2	26	affinity chromatography technology	Lyssand JS (2008)	1
SNTG2	2	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
UTRN	6	DTNA	4	affinity chromatography technology, far western blotting, far western blotting	Nawrotzki R (1998), Tommasi di Vignano A (2000), Tommasi di Vignano A (2000)	3
SNTA1	1	GDA	1	unspecified method	Boisguerin P (2004)	1
SPZ1	0	DTNA	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNTA1	1	SSTR1	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	XRCC6	3	two hybrid	Stelzl U (2005)	1
COPB1	0	XRCC6	3	two hybrid	Wang J (2011)	1
SNTA1	1	FAM189B	2	unspecified method	Boisguerin P (2004)	1
KCNJ12	0	DMD	6	affinity chromatography technology	Leonoudakis D (2004)	1
SNTA1	1	MAS1	2	unspecified method	Boisguerin P (2004)	1
SNTA1	1	6955	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	DMD	6	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn AH (1996), Yang B (1995), Gee SH (1998), Lyssand JS (2008), Huttlin EL (2017)	5
SNTA1	1	NMU	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	RGS11	0	affinity chromatography technology	Lyssand JS (2008)	1
SNTA1	1	ATP6V0B	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	PSKH1	0	unspecified method	Boisguerin P (2004)	1
COPB1	0	GRB2	2	two hybrid	Wang J (2011)	1
MLC1	0	SNTA1	1	affinity chromatography technology	Lanciotti A (2010)	1
SNTA1	1	SLC34A3	3	affinity chromatography technology	Lyssand JS (2008)	1
NDEL1	2	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	ADRA2A	0	unspecified method	Boisguerin P (2004)	1
KCNJ12	0	DTNA	4	affinity chromatography technology	Leonoudakis D (2004)	1
SNTA1	1	GUCY1A2	2	unspecified method	Boisguerin P (2004)	1
ATP2B2	10	ABCC4	3	affinity chromatography technology	Huttlin EL (2017)	1
ADGRB1	10	SNTG2	2	unspecified method	Stephenson JR (2013)	1
KCNJ4	5	SNTA1	1	affinity chromatography technology, unspecified method	Leonoudakis D (2004), Boisguerin P (2004)	2
SNTA1	1	ATP2B2	10	unspecified method	Boisguerin P (2004)	1
SNTA1	1	TLX3	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	IL2RA	0	unspecified method	Boisguerin P (2004)	1
TNS2	3	UTRN	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	St-Denis N (2016), Li X (2016), Yadav L (2017), Yadav L (2017)	4
SNTA1	1	MAPK12	1	two hybrid, enzymatic study, affinity chromatography technology	Hasegawa M (1999), Hasegawa M (1999), Hasegawa M (1999)	3
SNTA1	1	GLS2	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	CD3E	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	MTMR2	2	unspecified method	Boisguerin P (2004)	1
SNTA1	1	PFN2	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	GLS	3	pull down, two hybrid	Olalla L (2001), Olalla L (2001)	2
SNTA1	1	KCNA4	5	unspecified method	Boisguerin P (2004)	1
TNS2	3	NMU	1	two hybrid	Grossmann A (2015)	1
SNTA1	1	MAP4	8	unspecified method	Boisguerin P (2004)	1
SNTA1	1	COPB1	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	KCNJ15	2	unspecified method	Boisguerin P (2004)	1
TNS2	3	DMD	6	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
SNTA1	1	ADGRB2	8	unspecified method	Boisguerin P (2004)	1
ADRA1D	1	UTRN	6	affinity chromatography technology, affinity chromatography technology	Lyssand JS (2008), Lyssand JS (2008)	2
SNTA1	1	SCN1A	54	affinity chromatography technology, unspecified method	Gee SH (1998), Gee SH (1998)	2
SNTA1	1	HTR2B	4	unspecified method	Boisguerin P (2004)	1
SNTA1	1	AGTR2	2	unspecified method	Boisguerin P (2004)	1
SNTA1	1	PRLHR	0	unspecified method	Boisguerin P (2004)	1
DMD	6	NOS1	4	imaging technique	Brenman JE (1995)	1
SNTA1	1	SCTR	1	unspecified method	Boisguerin P (2004)	1
DGKZ	6	SNTA1	1	pull down	Hogan A (2001)	1
SPZ1	0	SNTA1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNTA1	1	TGFA	1	unspecified method	Boisguerin P (2004)	1
GDA	1	GLS	3	biochemical	Kristensen AR (2012)	1
SNTA1	1	NAT1	2	unspecified method	Boisguerin P (2004)	1
SNTA1	1	PLCB3	1	affinity chromatography technology	Lyssand JS (2008)	1
SNTA1	1	ADAMTS6	5	unspecified method	Boisguerin P (2004)	1
SNTA1	1	ADGRB3	4	unspecified method	Boisguerin P (2004)	1
SNTA1	1	SLC2A3	0	unspecified method	Boisguerin P (2004)	1
FAM189B	2	UTRN	6	affinity chromatography technology	Huttlin EL (2017)	1
KCNJ12	0	SNTA1	1	affinity chromatography technology	Leonoudakis D (2004)	1
ADGRB1	10	SNTA1	1	unspecified method	Stephenson JR (2013)	1
SNTA1	1	SLC6A3	6	unspecified method	Boisguerin P (2004)	1
SNTA1	1	IL9	0	unspecified method	Boisguerin P (2004)	1
MLC1	0	KCNJ10	0	affinity chromatography technology	Lanciotti A (2010)	1
HTR2C	1	ATP2B2	10	affinity chromatography technology	Huttlin EL (2017)	1
SNTG2	2	DTNA	4	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	MCM7	5	unspecified method	Boisguerin P (2004)	1
SNTA1	1	SLC1A7	1	unspecified method	Boisguerin P (2004)	1
NDEL1	2	SNTA1	1	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	28577	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	F8A1	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	KCNJ10	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	ITGB5	3	unspecified method	Boisguerin P (2004)	1
SNTA1	1	GNAT3	1	affinity chromatography technology	Lyssand JS (2008)	1
TNS2	3	SNTA1	1	affinity chromatography technology	Li X (2016)	1
SNTA1	1	FABP1	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	UTRN	6	unspecified method, affinity chromatography technology	Ahn AH (1996), Lyssand JS (2008)	2
GOLGA2	2	MCM7	5	two hybrid	Rolland T (2014)	1
SNTA1	1	KCNA5	2	unspecified method	Boisguerin P (2004)	1
SNTA1	1	ADH5	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	ABCC4	3	pull down	Li C (2007)	1
HMG20A	0	SNTA1	1	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	LMO1	0	unspecified method	Boisguerin P (2004)	1
SNTA1	1	MAGEE1	3	affinity chromatography technology	Albrecht DE (2004)	1
SNTG2	2	SNTA1	1	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	NEB	21	affinity chromatography technology	Lyssand JS (2008)	1
SNTA1	1	ADRB1	3	unspecified method	Boisguerin P (2004)	1
TNS2	3	DTNA	4	affinity chromatography technology	Li X (2016)	1
DTNA	4	DMD	6	two hybrid, pull down, far western blotting, affinity chromatography technology	Sadoulet-Puccio HM (1997), Sadoulet-Puccio HM (1997), Tommasi di Vignano A (2000), Huttlin EL (2017)	4
SNTG2	2	DMD	6	affinity chromatography technology	Huttlin EL (2017)	1
SNTA1	1	SLC16A7	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	STAM	3	affinity chromatography technology	Lyssand JS (2008)	1
SNTA1	1	C3AR1	1	unspecified method	Boisguerin P (2004)	1
SNTA1	1	NOS1	4	pull down	Gee SH (1998)	1
DTNA	4	SNTA1	1	pull down, affinity chromatography technology	Sadoulet-Puccio HM (1997), Lyssand JS (2008)	2
HMG20A	0	DTNA	4	affinity chromatography technology, two hybrid	Huttlin EL (2017), Ceballos-Chavez M (2012)	2
KCNA5	2	KCNA4	5	affinity chromatography technology	Nitabach MN (2001)	1