PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNAPC2	0	SNAPC1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoon JB (1996), Huttlin EL (2015), Huttlin EL (2017)	3
SNAPC1	0	SNAPC5	4	pull down, affinity chromatography technology, affinity chromatography technology	Ma B (2001), Huttlin EL (2015), Huttlin EL (2017)	3
TBP	0	POU2F1	5	pull down, affinity chromatography technology	Zwilling S (1994), Zwilling S (1994)	2
MAPK6	1	HNRNPD	3	two hybrid	Vinayagam A (2011)	1
NCAPH2	4	SNAPC4	6	affinity chromatography technology	Huttlin EL (2017)	1
SNAPC4	6	SNAPC1	0	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Ma B (2001), Ma B (2001), Huttlin EL (2015), Huttlin EL (2017)	4
TBP	0	SNAPC4	6	pull down	Hinkley CS (2003)	1
SNAPC4	6	SNAPC2	0	pull down, pull down, pull down, affinity chromatography technology	Wong MW (1998), Wong MW (1998), Ma B (2001), Yoon JB (1996)	4
MAPK6	1	PSME3	0	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPD	3	SNAPC4	6	two hybrid	Lehner B (2004)	1
MAPK6	1	SNAPC4	6	two hybrid	Vinayagam A (2011)	1
PSME3	0	SNAPC1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBP	0	TAF10	0	biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Bellorini M (1997), Ruppert S (1993), Knuesel MT (2009), Kouskouti A (2004), Liu X (2008), Demeny MA (2007), Wieczorek E (1998), Wieczorek E (1998), Kamileri I (2012), Havugimana PC (2012), Le Douarin B (1995)	11
PSME3	0	SNAPC4	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TBP	0	SNAPC1	0	pull down	Yoon JB (1996)	1
ATG16L1	1	SNAPC4	6	affinity chromatography technology	Behrends C (2010)	1
TAF10	0	SNAPC4	6	affinity chromatography technology	Jeronimo C (2007)	1
SNAPC2	0	TBP	0	pull down, affinity chromatography technology, pull down	Sadowski CL (1996), Yoon JB (1996), Yoon JB (1996)	3
POU2F1	5	SNAPC4	6	x-ray crystallography, two hybrid	Hovde S (2002), Wong MW (1998)	2
SNAPC4	6	SNAPC5	4	pull down	Ma B (2001)	1