PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STXBP1	38	STX1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Bhaskar K (2004), Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Barclay JW (2003), Ciufo LF (2005)	6
DGUOK	1	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX12	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SCAMP1	3	ITSN1	5	two hybrid, pull down	Fernandez-Chacon R (2000), Fernandez-Chacon R (2000)	2
NAPA	2	VAMP2	3	pull down, biochemical	Hanson PI (1995), Havugimana PC (2012)	2
KCNB1	11	SNAP25	8	pull down	MacDonald PE (2002)	1
STX4	2	SYT1	4	pull down	Thomas DM (1999)	1
DGUOK	1	APP	1	pull down	Olah J (2011)	1
STX4	2	STX12	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	3
DNAAF2	2	APP	1	pull down	Olah J (2011)	1
SRCIN1	3	SNAP25	8	pull down, two hybrid	Chin LS (2000), Chin LS (2000)	2
UNC13B	8	STX1A	2	two hybrid, biochemical	Betz A (1997), Betz A (1997)	2
DGUOK	1	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP25	8	STX5	0	pull down	Subramaniam VN (1997)	1
STX4	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid	Paumet F (2000), Mollinedo F (2003), Jagadish MN (1996), Reed GL (1999), Rolland T (2014)	5
STX12	2	VAMP7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP25	8	APP	1	pull down	Olah J (2011)	1
NAPA	2	SNAP25	8	pull down	Hanson PI (1995)	1
SNAP25	8	TRIM9	3	pull down, affinity chromatography technology, affinity chromatography technology	Li Y (2001), Li Y (2001), Winkle CC (2014)	3
STX3	3	SYT1	4	pull down	Thomas DM (1999)	1
HGS	5	APP	1	pull down, pull down, pull down	Pridgeon JW (2009), Olah J (2011), Virok DP (2011)	3
SNAPIN	1	SNAP25	8	pull down, affinity chromatography technology, pull down	Ilardi JM (1999), Ilardi JM (1999), Zhang Q (2012)	3
VAMP7	0	STX4	2	affinity chromatography technology	Martinez-Arca S (2003)	1
VAMP7	0	SNAP25	8	pull down	Martinez-Arca S (2003)	1
STX11	1	APP	1	pull down	Olah J (2011)	1
NUFIP1	0	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX5	0	GOSR1	1	biochemical, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Hay JC (1997), Hay JC (1998), Shorter J (2002), Shorter J (2002), Shorter J (2002), Subramaniam VN (1997), Subramaniam VN (1997)	7
STX5	0	NAPA	2	two hybrid, pull down	Rual JF (2005), Rabouille C (1998)	2
STX3	3	SNAP25	8	pull down, pull down	Ravichandran V (1996), Steegmaier M (1998)	2
STX2	1	SYT1	4	pull down	Thomas DM (1999)	1
STX3	3	GOSR1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HGS	5	VAMP2	3	affinity chromatography technology	Sun W (2003)	1
GOSR1	1	STX12	2	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	3
STX3	3	STX4	2	two hybrid	Rolland T (2014)	1
DGUOK	1	VAMP2	3	affinity chromatography technology	Huttlin EL (2015)	1
SNAP25	8	PRRT2	0	two hybrid	Stelzl U (2005)	1
STXBP1	38	STX2	1	affinity chromatography technology, affinity chromatography technology	Schraw TD (2003), van Breevoort D (2014)	2
DGUOK	1	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUFIP1	0	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX2	1	VAMP2	3	two hybrid	Imai A (2003)	1
NUFIP1	0	SRCIN1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAPA	2	STX12	2	pull down, affinity chromatography technology, affinity chromatography technology	Tang BL (1998), Huttlin EL (2015), Huttlin EL (2017)	3
CDH1	4	SRCIN1	3	bioid	Guo Z (2014)	1
NUFIP1	0	VAMP2	3	affinity chromatography technology	Huttlin EL (2015)	1
HGS	5	SNAP25	8	affinity chromatography technology	Sun W (2003)	1
SYT1	4	STX1A	2	pull down, pull down, pull down	Shao X (1997), Thomas DM (1999), Thomas DM (1999)	3
NSF	3	STX5	0	affinity chromatography technology	Behrends C (2010)	1
NUFIP1	0	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP7	0	STX1A	2	pull down	Martinez-Arca S (2003)	1
HGS	5	STXBP1	38	pull down	Pridgeon JW (2009)	1
VAMP2	3	SYT1	4	affinity chromatography technology	Zhang Q (2012)	1
STXBP1	38	STX11	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
NSF	3	SNAP25	8	biochemical	Wan C (2015)	1
STXBP1	38	STX3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	van Breevoort D (2014), van Breevoort D (2014), Huttlin EL (2015), Huttlin EL (2017)	4
CDH1	4	KIF5B	1	bioid	Guo Z (2014)	1
STX12	2	STX5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP25	8	STX1A	2	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Dulubova I (1999), McMahon HT (1995), Gonelle-Gispert C (2000), Gonelle-Gispert C (2000), Ilardi JM (1999), Li Y (2001), Ravichandran V (1996), Chapman ER (1994), Chapman ER (1994), Chen X (2002), Steegmaier M (1998), Darios F (2010)	14
NAPA	2	NSF	3	pull down, pull down, affinity chromatography technology	Barnard RJ (1997), Hanson PI (1995), Behrends C (2010)	3
STX1A	2	NAPA	2	affinity chromatography technology, pull down	McMahon HT (1995), Hanson PI (1995)	2
SYT1	4	SNAP25	8	pull down, pull down, affinity chromatography technology	Gerona RR (2000), Zhang X (2002), Zhang Q (2012)	3
STXBP1	38	STX4	2	affinity chromatography technology	Schraw TD (2003)	1
HGS	5	STX12	2	affinity chromatography technology	Sun W (2003)	1
FBXO7	1	SRCIN1	3	enzymatic study	Teixeira FR (2016)	1
NSF	3	STX12	2	affinity chromatography technology	Behrends C (2010)	1
SNAP25	8	STX12	2	affinity chromatography technology	Hirling H (2000)	1
UNC13B	8	VAMP2	3	biochemical	Betz A (1997)	1
KIF5B	1	SNAP25	8	two hybrid, pull down	Diefenbach RJ (2002), Diefenbach RJ (2002)	2
SNAP25	8	WASHC3	2	two hybrid	Venkatesan K (2009)	1
CPLX1	0	SNAP25	8	x-ray crystallography, pull down	Chen X (2002), Hu K (2002)	2
STXBP1	38	APP	1	pull down	Olah J (2011)	1
SCAMP1	3	SNAP25	8	pull down	Fernandez-Chacon R (2000)	1
NUFIP1	0	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX4	2	STX5	0	two hybrid	Rolland T (2014)	1
UNC13B	8	SNAP25	8	biochemical	Betz A (1997)	1
SYT3	3	SNAP25	8	pull down	Gerona RR (2000)	1
SNAP25	8	VAMP2	3	affinity chromatography technology, pull down, two hybrid, far western blotting, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Li Y (2001), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002), Zhang Q (2012), Zhang Q (2012)	7
ITSN1	5	SNAP25	8	pull down, two hybrid	Okamoto M (1999), Okamoto M (1999)	2
NAPA	2	APP	1	pull down	Olah J (2011)	1
GOSR1	1	NSF	3	affinity chromatography technology	Behrends C (2010)	1
STX3	3	VAMP2	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Imai A (2003), Huttlin EL (2015), Huttlin EL (2017)	3
SNAP25	8	STXBP1	38	biochemical	Wan C (2015)	1
STX2	1	SNAP25	8	pull down	Ravichandran V (1996)	1
STX3	3	VAMP7	0	affinity chromatography technology	Vogel GF (2015)	1
STX4	2	NAPA	2	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
STX4	2	SNAP25	8	pull down, pull down, affinity chromatography technology, pull down	Ravichandran V (1996), Reed GL (1999), Reed GL (1999), Steegmaier M (1998)	4
SNAP25	8	STX11	1	two hybrid, two hybrid	Rual JF (2005), Stelzl U (2005)	2
CDH1	4	STX5	0	bioid	Guo Z (2014)	1
CPLX1	0	VAMP2	3	x-ray crystallography	Chen X (2002)	1
STX3	3	STX5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAMP2	3	STX11	1	pull down, affinity chromatography technology	Valdez AC (1999), Huttlin EL (2017)	2
DGUOK	1	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX11	1	GOSR1	1	affinity chromatography technology	Huttlin EL (2017)	1
DNAAF2	2	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DNAAF2	2	SNAP25	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX1A	2	VAMP2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid, far western blotting, x-ray crystallography	Dulubova I (1999), McMahon HT (1995), Perez-Branguli F (2002), Margittai M (1999), Hao JC (1997), Hao JC (1997), Hao JC (1997), Chen X (2002)	8
DNAAF2	2	SYT1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SNAP25	8	GOSR1	1	pull down	Subramaniam VN (1997)	1
CDH1	4	SNAP25	8	bioid	Guo Z (2014)	1
GOSR1	1	APP	1	pull down	Olah J (2011)	1
FBXO7	1	SNAP25	8	enzymatic study	Teixeira FR (2016)	1
STX1A	2	CPLX1	0	affinity chromatography technology, x-ray crystallography, pull down	Dulubova I (1999), Chen X (2002), Hu K (2002)	3
CDH1	4	STX4	2	bioid	Guo Z (2014)	1
STX1A	2	KCNB1	11	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Dai XQ (2012), Dai XQ (2012), Leung YM (2005), Leung YM (2005)	4
DNAAF2	2	STX1A	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2