PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPN11	20	SLN	0	two hybrid	Daakour S (2016)	1
PLN	1	TMEM79	1	two hybrid	Corominas R (2014)	1
SLN	0	TMEM79	1	two hybrid	Rolland T (2014)	1
SLN	0	PLN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Asahi M (2003), Asahi M (2002), Asahi M (2002)	3
SLN	0	CCDC155	2	two hybrid	Rolland T (2014)	1
LMNA	2	CCDC155	2	two hybrid	Dittmer TA (2014)	1
PLN	1	ATP2A2	7	affinity chromatography technology, pull down, affinity chromatography technology	Asahi M (2002), Kimura Y (2002), Asahi M (2000)	3
LMNA	2	SLN	0	two hybrid	Dittmer TA (2014)	1
SLN	0	ATP2A2	7	affinity chromatography technology	Asahi M (2002)	1
SLN	0	ATP2A1	3	affinity chromatography technology, affinity chromatography technology	Asahi M (2003), Asahi M (2002)	2
PLN	1	ATP2A1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Asahi M (2002), Asahi M (1999), Asahi M (2001)	3
SLN	0	SYNE4	1	two hybrid	Rolland T (2014)	1