Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
SLC22A2	rs316019	A	tipiracil hydrochloride	efficacy	no	The SNP was tested for association alone and with three other SNPs after univariate and multivariate analysis in a training (N= 52, Japan) and testing cohorts (N = 127, Italy). It was not significantly associated with progression-free or overall survival in either cohort.	Allele A is not associated with response to tipiracil hydrochloride and trifluridine in people with Colorectal Neoplasms as compared to allele C.	28992563	1449146823
SLC22A2	rs316019	C	metformin	metabolism/PK	no		Allele C is not associated with exposure to metformin as compared to allele A.	29352482	1449165153
SLC22A2	rs145450955	GG	lamivudine	metabolism/PK	no	No significant differences in various pharmacokinetic parameters were seen between the genotypes. These included apparent oral clearance (p = 0.328), maximum plasma concentration (p = 0.314), time to reach max plasma concentration (p = 0.701), half-life (p = 0.734), area under the concentration-time curve from 0 to 24h (p = 0.693), area under the concentration-time curve from 0 to infinity (p = 0.701), renal clearance (p = 0.851), creatinine clearance (p = 0.588) and apparent tubular secretion clearance (p = 0.859). Please note alleles have been complemented to the plus chromosomal strand.	Genotype GG is not associated with clearance of lamivudine in healthy individuals as compared to genotype AG.	23252721	1184168575
SLC22A2	rs316019	CC	l-tryptophan	metabolism/PK	yes	A gene dose effect was observed in that clearance of tryptophan decreased in the following manner: CC>AC>AA.	Genotype CC is associated with increased clearance of l-tryptophan as compared to genotypes AA + AC.	22590580	982046569
SLC22A2	rs316019	CC	metformin	metabolism/PK	yes	Healthy individuals with the CC genotype had decreased area under the serum concentration-time curve from zero to infinity (AUCinf), decreased peak concentration (Cmax), and increased clearance (CL/F) of metformin, as compared to those with the AC genotype. Please note alleles have been complemented to the plus chromosomal strand.	Genotype CC is associated with increased clearance of metformin in healthy individuals as compared to genotype AC.	23417334	1183682332
SLC22A2	rs316019	A	metformin	metabolism/PK	no		Allele A is not associated with steady-state concentration of metformin in healthy individuals as compared to allele C.	25939711	1446898150
SLC22A2	rs316009	TT	metformin	efficacy	yes	using computational model-based approaches and genetic, demographic, and long-term HbA1c data from 1,056 patients.	Genotype TT is associated with increased response to metformin in people with Diabetes Mellitus as compared to genotypes CC + CT.	27415606	1448267827
SLC22A2	rs316019	A	metformin	efficacy	no	This variant is not associated with metformin glycemic response assessed as HbA1c reduction in patients on metformin monotherapy.	Allele A is not associated with response to metformin in people with Diabetes Mellitus, Type 2 as compared to allele C.	27859023	1448631760
SLC22A2	rs316019	A	sulfonamides, urea derivatives	efficacy	no		Allele A is not associated with response to sulfonamides, urea derivatives in people with Diabetes Mellitus as compared to allele C.	29681852	1449310690