Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
SLC22A3	6581	SarCNU	CHEMBL166937		NCI	10632359, 11783015

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
SLC22A3	rs8187725	T	catecholamines	"other","metabolism/PK"	yes	In cells expressing the T variant, the uptake of these drugs was significantly reduced(about 80%).	Allele T is associated with decreased metabolism of catecholamines and metformin as compared to allele C.	20859243	769180270
SLC22A3	rs2076828	G	metformin	efficacy	yes	A healthy human cohort that was used to determine the effects of functional variants, including rs2076828, on metformin disposition and response. Carriers of the G allele had significantly smaller changes in their glucose AUC (mean ± S.D.; CC, -88 ± 40 mg/dl per hour; CG, -34 ± 51 mg/dl per hour; GG, -41 ± 72 mg/dl per hour) and significantly lower glucose AUC even before metformin dosing (mean ± S.D.; CC, 376 ± 62 mg/dl per hour; CG, 348 ± 55 mg/dl per hour; GG, 330 ± 41 mg/dl per hour; P < 0.05). Even after adjusting for the differences in glucose AUC before metformin dosing the variant remained significantly associated with metformin response (P < 0.05).	Allele G is associated with decreased response to metformin in healthy individuals as compared to allele C.	25920679	1444932172