Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SLC12A3 6559 HYDROCHLOROTHIAZIDE CHEMBL435 inhibitor, blocker TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 10894798, 11752352, 16172412, 12772080, 9038817, 16078592, 9596079
SLC12A3 6559 DIAZOXIDE CHEMBL181 unknown TdgClinicalTrial, TEND, DrugBank 17139284, 17016423
SLC12A3 6559 POLYTHIAZIDE CHEMBL1587 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11752352, 10894798, 12217863
SLC12A3 6559 CYCLOTHIAZIDE CHEMBL61593 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
SLC12A3 6559 HYDROFLUMETHIAZIDE CHEMBL1763 inhibitor ChemblInteractions
SLC12A3 6559 CHLORTHALIDONE CHEMBL1055 inhibitor ChemblInteractions
SLC12A3 6559 BENDROFLUMETHIAZIDE CHEMBL1684 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 18216144, 11752352, 10894798
SLC12A3 6559 METOLAZONE CHEMBL878 inhibitor, blocker TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank, TTD 11752352
SLC12A3 6559 BENZTHIAZIDE CHEMBL1201039 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 17139284, 17016423
SLC12A3 6559 QUINETHAZONE CHEMBL1532 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 20528637, 19474192, 19636250, 12538756
SLC12A3 6559 CHLOROTHIAZIDE CHEMBL842 inhibitor TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
SLC12A3 6559 CHLOROTHIAZIDE SODIUM CHEMBL1200616 inhibitor ChemblInteractions
SLC12A3 6559 TRICHLORMETHIAZIDE CHEMBL1054 inhibitor ChemblInteractions
SLC12A3 6559 METHYCLOTHIAZIDE CHEMBL1577 inhibitor ChemblInteractions
SLC12A3 6559 INDAPAMIDE CHEMBL406 inhibitor ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SLC12A3 rs1529927 CC bumetanide efficacy yes CC homozygotes had increased urinary excretion of sodium chloride and potassium, as compared to GG homozygotes, during the 24 hours after drug administration. Genotype CC is associated with increased response to bumetanide, furosemide and torasemide in healthy individuals as compared to genotype GG. 20877298 982045433