PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HSP90AB1	2	PTGES3	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Wang J (2011), Taipale M (2014), Taipale M (2014), Weikl T (1999), Picard D (2006), Chadli A (2008), Karagoez GE (2011)	7
SLC6A4	3	CALR	1	pull down	Tate CG (1999)	1
SNCA	0	HSPA8	4	pull down, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	Redeker V (2012), Pemberton S (2011), Choi HS (2012), Choi HS (2012), Woods WS (2007), Choi HS (2012)	6
HSPA1A	0	HSPA8	4	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
STUB1	4	SNCA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Kalia LV (2011), Kalia LV (2011), Tetzlaff JE (2008)	3
SNCG	0	SLC6A4	3	affinity chromatography technology, imaging technique	Wersinger C (2009), Wersinger C (2009)	2
STX1A	2	SLC6A4	3	affinity chromatography technology	Quick MW (2002)	1
HSP90AB1	2	HSPA8	4	biochemical, affinity chromatography technology	Wan C (2015), Reidy M (2018)	2
PTGES3	0	STUB1	4	affinity chromatography technology	Schuelke JP (2010)	1
HSPA1A	0	SNCA	0	fluorescent resonance energy transfe, pull down	Roodveldt C (2009), Roodveldt C (2009)	2
SLC6A4	3	PTGES3	0	affinity chromatography technology	El-Kasaby A (2014)	1
SNCA	0	SLC6A4	3	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Wersinger C (2009), Wersinger C (2009), Wersinger C (2006), Wersinger C (2006), Wersinger C (2006)	5
SLC6A4	3	HSPA8	4	affinity chromatography technology	El-Kasaby A (2014)	1
STUB1	4	HSPA8	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, unspecified method, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study	Ballinger CA (1999), Ballinger CA (1999), Ballinger CA (1999), Tateishi Y (2004), Tateishi Y (2004), Jiang J (2001), Wang L (2011), Wang L (2011), Wang L (2011), Stankiewicz M (2010), Yang M (2011), Yang M (2011), Urushitani M (2004), Grelle G (2006), Kim SA (2005), Arndt V (2005), Alberti S (2004), Meacham GC (2001), Smith MC (2013), Smith MC (2013), Matsumura Y (2013), Spooner RA (2008), Taipale M (2014), Taipale M (2014), Heimdal K (2014), Grelle G (2006), Grelle G (2006), Kamynina E (2007), Zhang H (2015), Zhang H (2015), Zhang H (2015), Li P (2015), Guo Y (2016), Zhang H (2017), Pakdaman Y (2017)	35
SLC6A4	3	STUB1	4	affinity chromatography technology	El-Kasaby A (2014)	1
PTGES3	0	CALR	1	biochemical	Wan C (2015)	1
SLC6A4	3	HSPA1A	0	pull down, fluorescent resonance energy transfe, affinity chromatography technology	El-Kasaby A (2014), El-Kasaby A (2014), El-Kasaby A (2014)	3
SLC6A4	3	CANX	4	pull down	Tate CG (1999)	1
HSP90AB1	2	CALR	1	biochemical	Wan C (2015)	1
SLC6A4	3	HSP90AB1	2	affinity chromatography technology	El-Kasaby A (2014)	1
PTGES3	0	STIP1	1	biochemical	Wan C (2015)	1
HSPA1A	0	STIP1	1	biochemical, affinity chromatography technology	Wan C (2015), Scholz GM (2001)	2
CALR	1	CANX	4	affinity chromatography technology	Oliver JD (1999)	1
STUB1	4	HSPA1A	0	pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ballinger CA (1999), Ballinger CA (1999), Imai Y (2002), Havugimana PC (2012), Jinwal UK (2012), Yang SW (2013), Choi JR (2016), Schoenbuehler B (2016)	8
HSP90AB1	2	STIP1	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology	Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Chadli A (2008), Huttlin EL (2017)	8
HSPA8	4	STIP1	1	biochemical, far western blotting, pull down, pull down, pull down, biochemical	Havugimana PC (2012), Gebauer M (1998), Gebauer M (1998), Liu FH (1999), Tsukahara F (2000), Wan C (2015)	6
HSP90AB1	2	STUB1	4	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	HSPA1A	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Falsone SF (2005)	2
SLC6A4	3	STIP1	1	affinity chromatography technology	El-Kasaby A (2014)	1