Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SLC1A4 6509 L-ALANINE CHEMBL279597 DrugBank 17475673, 17510490, 17311416, 17195090, 17237199

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SLC1A4 rs10211524 AA antipsychotics efficacy yes Only in patients who were in the "high severity group" based on baseline severity score, using clinical global impressions (CGI) score. Within a cohort of 1) all patients, 2) patients receiving atypical monotherapy and 3) patients receiving risperidone. Response assessed using CGI scale, patients were either complete responders (CR) or incomplete responders (IR) based on this scale. Those with the AA genotype were more prevalent in the IR group in all three cohorts. Note that this association did not withstand correction for multiple testing. Genotype AA is associated with decreased response to antipsychotics in people with Schizophrenia as compared to genotypes AG + GG. 25209194 1446895589