PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CAND1	2	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
BRCA1	7	MED21	1	biochemical, affinity chromatography technology	Scully R (1997), Scully R (1997)	2
FBXW4	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Lockwood WW (2013), Lockwood WW (2013), Hauri S (2016)	4
BRCA1	7	CAND1	2	affinity chromatography technology	Ertych N (2016)	1
USP37	1	BRCA1	7	bioid	Yeh C (2015)	1
SKP2	2	TRIM21	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006), Sabile A (2006)	5
VCP	6	FAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Song EJ (2005), Song EJ (2005), Shin HY (2010), Haenzelmann P (2011), Haenzelmann P (2011), Kang W (2011), Alexandru G (2012), Lee JJ (2013), Lee JJ (2013), Lee JJ (2013), Yu CC (2013), Baron Y (2014), Franz A (2016), Raman M (2015)	17
YAF2	1	23429	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO44	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
SKP1	0	FBXL6	5	two hybrid, biochemical, affinity chromatography technology	Lievens S (2009), Wan C (2015), Hauri S (2016)	3
RBX1	2	SKP2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim AY (2008), Ohta T (2001), Saiga T (2009), Rodier G (2008), Zhou W (2014), Zhou W (2014)	6
FBXO5	2	BTRC	1	pull down, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Hansen DV (2004), Loveless TB (2015), Coyaud E (2015), Huttlin EL (2017), Margottin-Goguet F (2003)	5
SKP1	0	FBXW5	6	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Busino L (2012), Watanabe N (2004), Jeong YT (2013), Tian X (2015), Hauri S (2016)	6
NUAK1	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014)	2
SLBP	0	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology	Djakbarova U (2016), Djakbarova U (2016), Djakbarova U (2016)	3
FBXW2	0	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Xu J (2017), Xu J (2017), Xu J (2017), Huttlin EL (2017)	4
FBXL2	2	VCP	6	affinity chromatography technology	Kuchay S (2017)	1
COPS6	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
CDC37	0	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
FBXL2	2	UBE2D1	0	pull down	Han S (2015)	1
COPS6	0	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
FBXO7	1	UBE2D1	0	pull down	Teixeira FR (2016)	1
FBXW8	2	CUL7	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Huber C (2005), Huber C (2005), Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Skaar JR (2007), Skaar JR (2007), Tsutsumi T (2008), Kong C (2012), Xu X (2012), Xu X (2008), Xu X (2008)	13
KDM2A	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2004), Busino L (2007), Hauri S (2016)	3
BTRC	1	UBE2D1	0	affinity chromatography technology	Fernandez-Sanchez ME (2010)	1
FBXO34	0	FBXO30	1	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	CUL1	7	affinity chromatography technology	von der Lehr N (2003)	1
COPS6	0	FBXO22	1	affinity chromatography technology	Sowa ME (2009)	1
CDK2	0	CDKN1B	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Youn CK (2005), Porter LA (2003), Law BK (2002), Connor MK (2003), Naderi S (2005), Varshochi R (2005), Hsu SP (2008), McAndrew CW (2007), Peiretti A (2003), Peiretti A (2003), Haddad MM (1999), Xu X (1999), Xu X (1999), Radu M (2008), Mori S (1999), Schulman BA (1998), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Sheaff RJ (1997), Vlach J (1996), Vlach J (1996), Vlach J (1997), Liu S (2009), Rosner M (2004), Ciarallo S (2002), Ciarallo S (2002), Wang Y (2008), Bockstaele L (2006), Chu I (2007), Chu I (2007), Levkau B (1998), Levkau B (1998), Lacy ER (2005), Zhao J (1998), Seo DW (2006), Kossatz U (2006), Grimmler M (2007), Grimmler M (2007), Varjosalo M (2013), Varjosalo M (2013), Montagnoli A (1999), So J (2015), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Lovisa S (2016), Qiu H (2016), Carrasco-Garcia E (2011), Huttlin EL (2017), Hu B (2017)	52
BRCA1	7	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu Y (2012), Lu Y (2012), Parameswaran B (2015)	3
VCP	6	CUL7	4	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Hanson D (2014)	2
FBXO25	1	CDK9	3	enzymatic study	Teixeira FR (2013)	1
BRCA1	7	MYC	2	affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Li H (2002), Xiong J (2003), Xiong J (2003), Wang Q (1998), Wang Q (1998), Wang Q (1998), Harte MT (2010), Harte MT (2010), Xiong J (2003), Xiong J (2003), Zhou C (2003)	11
SKP1	0	FBXL5	3	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Winston JT (1999), Vashisht AA (2009), Salahudeen AA (2009), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Rolland T (2014), Yu H (2011), Wu WD (2016), Huttlin EL (2017)	10
CENPE	1	SKP1	0	two hybrid, far western blotting, pull down, imaging technique	Liu D (2006), Liu D (2006), Liu D (2006), Liu D (2006)	4
MYC	2	FBXO5	2	genetic interference	Toyoshima M (2012)	1
FBXO18	0	SKP1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim J (2002), Kim J (2002), Kim J (2002), Kim JH (2004), Jeong YT (2013), Hauri S (2016)	6
FAF1	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang L (2011), Zhang L (2012), Kim H (2015)	3
CAND1	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Zheng J (2002), Bennett EJ (2010)	2
FBXO21	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang C (2015), Zhang C (2015), Hauri S (2016)	3
VCP	6	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li JM (2013), Riemer A (2014), Zhang Z (2015)	3
FBXO27	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
CDC37	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CUL4A	2	SUGT1	1	biochemical	Havugimana PC (2012)	1
FBXW7	2	MCL1	1	enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Min SH (2012), Tong J (2017), Tong J (2017), Ye M (2017), Tong J (2017)	5
CUL1	7	FBXL19	5	affinity chromatography technology	Reitsma JM (2017)	1
FBXW4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2003), Lockwood WW (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	5
FBXO6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017), Reitsma JM (2017)	10
CENPE	1	CUL1	7	two hybrid	Du J (2009)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
CRY1	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Busino L (2007), Papp SJ (2015)	2
MYC	2	TRRAP	31	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, pull down	Liu X (2003), McMahon SB (2000), McMahon SB (1998), Park J (2002), Bres V (2009), Cowling VH (2006), Frank SR (2001), Kim J (2010), Kim J (2010), Koch HB (2007), Toyoshima M (2012), Liu X (2003)	12
CUL4A	2	BTRC	1	affinity chromatography technology	He YJ (2006)	1
FBXW7	2	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Thompson BJ (2007), Welcker M (2004), Welcker M (2004), Yada M (2004), Yada M (2004), Yada M (2004), Koch HB (2007), Kim BY (2010), Cho HJ (2010), Popov N (2007), Fujii M (2006), Yumimoto K (2012), Diefenbacher ME (2015), Kourtis N (2015), Kourtis N (2015), Li J (2017), Wang Y (2017), Reiterer V (2017), Chandra S (2013), Chandra S (2013), Chandra S (2013), Chandra S (2013)	22
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
VCP	6	CDKN1B	1	affinity chromatography technology	Yu CC (2013)	1
PCGF1	1	23429	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Huttlin EL (2015), Oliviero G (2015), Oliviero G (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	11
CUL1	7	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Cenciarelli C (1999), Sowa ME (2009), Megumi Y (2005), Davis M (2002), Kawakami T (2001), Read MA (2000), Suzuki H (1999), Kumar KG (2007), Schweitzer K (2007), Chua YS (2011), Winston JT (1999), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Latres E (1999), Yoshida Y (2007), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), Chung FZ (2014), Chen ZW (2015), Kim TY (2014), Read MA (2000), Coyaud E (2015), Low TY (2014), Coyaud E (2015), He N (2005), Huttlin EL (2017), Kuang P (2016), Reitsma JM (2017), Reitsma JM (2017)	34
COPS6	0	CDK2	0	affinity chromatography technology	Bennett EJ (2010)	1
USP37	1	CUL1	7	affinity chromatography technology	Burrows AC (2012)	1
FBXW7	2	RBX1	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2012), Matsumoto A (2011), Strohmaier H (2001), Ye M (2017)	4
VCP	6	RNF2	1	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Cao Q (2014)	2
23429	0	RNF2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Cao Q (2014), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	11
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
MYC	2	MCL1	1	genetic interference	Toyoshima M (2012)	1
RING1	2	23429	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Garcia E (1999), Garcia E (1999), Garcia E (1999), Garcia E (1999), Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	13
SKP1	0	RING1	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
FBXO42	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2009), Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	4
CCND1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006), Wei S (2008), Yu ZK (1998)	4
SKP1	0	FBXO46	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Lievens S (2009), Lockwood WW (2013), Hauri S (2016)	4
CUL1	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Shima Y (2008), Reitsma JM (2017)	3
SKP1	0	FBXO44	0	pull down, two hybrid, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Kumanomidou T (2010), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Glenn KA (2008), Yoshida Y (2011), Rolland T (2014), Huttlin EL (2015), Sjoegren B (2015), Kumanomidou T (2015), Huttlin EL (2017), Hauri S (2016)	14
SKP2	2	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang W (2003), Sitry D (2002), Fujita N (2002), Ji P (2006), Zancai P (2005), Ji P (2004), Iovine B (2011), Calvisi DF (2009), Spruck C (2001), Bashir T (2010), Bashir T (2010), Li P (2004), Boutonnet C (2010), Rosner M (2004), Rosner M (2004), Carrano AC (1999), Carrano AC (1999), Carrano AC (1999), Wu J (2012), Strohmaier H (2001), Rodier G (2008), Rodier G (2008), Ooi LC (2013), Yumimoto K (2013), Ooi LC (2013), Cen B (2010), Enchev RI (2012), Yumimoto K (2012), Shi P (2011), Lovisa S (2016), Cen B (2009), Chan CH (2013), Ma X (2017)	33
FBXO9	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Busino L (2007), Hauri S (2016)	2
KDM2B	11	RBX1	2	affinity chromatography technology	Han XR (2016)	1
FBXW7	2	COPS6	0	genetic interference	Bailey ML (2015)	1
MYC	2	TRIM21	0	affinity chromatography technology	Agrawal P (2010)	1
CDC37	0	FBXW4	0	two hybrid	Soler-Lopez M (2011)	1
BCOR	2	23429	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Huttlin EL (2015), Oliviero G (2015), Huttlin EL (2017), Hauri S (2016)	6
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
RNF2	1	YAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
FBXO45	1	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Chung FZ (2014), Chung FZ (2014)	2
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
FBXO6	0	TRIM21	0	affinity chromatography technology	Liu B (2012)	1
FBXW11	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Fuchs SY (1999), Tan P (1999), Bennett EJ (2010), Cui W (2012), Dehan E (2009), Busino L (2003), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Chen TC (2014), Reitsma JM (2017)	14
PCGF1	1	RNF2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Gao Z (2012), Gao Z (2012), Woodsmith J (2012), Woodsmith J (2012), Cao Q (2014), Hein MY (2015), Taherbhoy AM (2015), Taherbhoy AM (2015), Oliviero G (2015), Oliviero G (2015), Hauri S (2016), Hauri S (2016)	16
VCP	6	FBXW11	2	affinity chromatography technology	Li JM (2013)	1
COPS6	0	CKS1B	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
RNF2	1	KDM2B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Wu X (2013), Cao Q (2014), Inagaki T (2015), Inagaki T (2015), Hein MY (2015), Hauri S (2016)	7
MCL1	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Ding Q (2007), Ding Q (2007), Ding Q (2007)	3
CUL4A	2	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Angers S (2006), Hu J (2004), Chua YS (2011), Tron AE (2012), Zheng J (2002), He YJ (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Olma MH (2009), Olma MH (2009), Yang Y (2016), Yang Y (2016)	18
ZC3HC1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005)	3
FBXO25	1	RBX1	2	affinity chromatography technology	Maragno AL (2006)	1
BTRC	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Suzuki H (2000), Strack P (2000), Margottin F (1998), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Watanabe N (2004), Wu G (2003), Kawakami T (2001), Hattori K (1999), Hattori K (1999), Hattori K (1999), Kitagawa M (1999), Hart M (1999), Su Y (2008), Banerjee S (2010), Winston JT (1999), Winston JT (1999), Estrabaud E (2007), Latres E (1999), Latres E (1999), Liu J (2004), Lievens S (2009), Yoshida Y (2007), Yoshida Y (2007), Busino L (2012), Li T (2005), da Silva Almeida AC (2013), Sahasrabuddhe AA (2014), Choi BH (2014), Chong RA (2014), Kim TY (2014), Coyaud E (2015), Deng W (2015), Coyaud E (2015), Liu YQ (2015), He N (2005), Kuchay S (2017), Hauri S (2016)	40
COPS6	0	FBXL12	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXO32	2	SKP1	0	pull down, affinity chromatography technology	Gomes MD (2001), Al-Yacoub N (2016)	2
FBXO42	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun L (2009), Huttlin EL (2017), Hauri S (2016)	3
SKP1	0	FBXL15	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Cui Y (2011), Huttlin EL (2015), Busino L (2007), Huttlin EL (2017), Hauri S (2016)	6
NEDD8	0	GHR	1	unspecified method	Bulatov E (2015)	1
COPS6	0	FBXO21	2	affinity chromatography technology	Bennett EJ (2010)	1
FBXO17	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
COPS6	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Reitsma JM (2017)	7
FBXO7	1	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
NEDD8	0	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim TY (2014), Coyaud E (2015)	3
TRIM21	0	UBC	7	enzymatic study	McEwan WA (2013)	1
FBXW8	2	FBXO4	0	affinity chromatography technology	Ponyeam W (2012)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
FAF1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Zhang L (2012), Zhang L (2012)	4
CDK2	0	TRIM21	0	affinity chromatography technology	Neganova I (2011)	1
CUL1	7	FBXO30	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
FBXO11	14	RBX1	2	affinity chromatography technology	Abida WM (2007)	1
CCNF	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2011), Jeong YT (2013), Choudhury R (2017), Reitsma JM (2017)	4
YAF2	1	RING1	2	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Rolland T (2014), Yu H (2011), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
FBXL2	2	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Ilyin GP (1999), Kuchay S (2013), Winston JT (1999), Li LQ (2016), Kuchay S (2017), Hauri S (2016)	7
RBX1	2	CCND1	1	affinity chromatography technology	Maeda I (2001)	1
FBXO6	0	NEDD8	0	affinity chromatography technology	Liu B (2012)	1
USP37	1	UBC	7	unspecified method, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Ernst A (2013), Tanno H (2014), Tanno H (2014), Tanno H (2014), Kawaguchi K (2017), Kwasna D (2018)	6
CUL1	7	FBXL6	5	affinity chromatography technology	Reitsma JM (2017)	1
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
MCL1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Ye M (2017), Feng C (2017)	2
FBXO11	14	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Abida WM (2007), Duan S (2011), Rossi M (2013), Rolland T (2014), Kuchay S (2017), Hauri S (2016)	6
USP37	1	SKP1	0	affinity chromatography technology, bioid	Burrows AC (2012), Yeh C (2015)	2
NEDD8	0	PSMA2	1	affinity chromatography technology	Norman JA (2006)	1
CUL4A	2	SKP2	2	affinity chromatography technology	Bondar T (2006)	1
FBXO44	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Glenn KA (2008), Yoshida Y (2011), Bennett EJ (2010), Huttlin EL (2015), Sjoegren B (2015), Huttlin EL (2017), Reitsma JM (2017)	8
FBXL5	3	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
FBXW4	0	PSMA2	1	affinity chromatography technology	Lockwood WW (2013)	1
FBXL7	0	CUL1	7	affinity chromatography technology	Liu Y (2015)	1
MYC	2	FBXW8	2	affinity chromatography technology, affinity chromatography technology, two hybrid	Koch HB (2007), Koch HB (2007), Koch HB (2007)	3
FBXO32	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Yacoub N (2016), Al-Yacoub N (2016), Reitsma JM (2017)	3
FBXO25	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
CDC37	0	TTC9C	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FBXL15	0	RBX1	2	affinity chromatography technology	Cui Y (2011)	1
CTNNB1	30	CACYBP	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Matsuzawa SI (2001), Wang D (2011), Chen TC (2014)	3
NFKBIA	0	FBXW8	2	affinity chromatography technology	Keutgens A (2010)	1
TRIM21	0	CDKN1B	1	affinity chromatography technology	Sabile A (2006)	1
FBXO7	1	PSMA2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Vingill S (2016), Vingill S (2016), Vingill S (2016), Vingill S (2016), Vingill S (2016), Vingill S (2016), Teixeira FR (2016)	7
CUL1	7	FBXO45	1	affinity chromatography technology	Reitsma JM (2017)	1
RING1	2	RNF2	1	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cao R (2005), Gearhart MD (2006), Wang H (2004), Trojer P (2011), Gao Z (2012), Gao Z (2012), Cao Q (2014), Hein MY (2015)	8
CUL1	7	FBXL17	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Tan MK (2013), Raducu M (2016), Reitsma JM (2017)	4
COPS6	0	FBXO44	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
FBXL2	2	FBXO3	0	affinity chromatography technology	Krzysiak TC (2016)	1
FBXW11	2	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Suzuki H (2000), Tan P (1999), Suzuki H (1999), Suzuki H (1999), Herter JR (2002), Chong RA (2014), Herter JR (2002), Huttlin EL (2015), Huttlin EL (2017), Gazdoiu S (2007)	10
FBXO31	4	GHR	1	unspecified method	Bulatov E (2015)	1
STYX	1	FBXO31	4	affinity chromatography technology	Reiterer V (2017)	1
TRIM21	0	CUL1	7	affinity chromatography technology, biochemical, pull down	Sabile A (2006), Sabile A (2006), Sabile A (2006)	3
UBC	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
FBXO25	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010), Hagens O (2006), Maragno AL (2006)	4
TRIM21	0	UBE2D1	0	pull down, pull down	Mallery DL (2010), Kong HJ (2007)	2
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
SKP1	0	FBXO5	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Busino L (2007), Hauri S (2016)	4
FBXW11	2	TRIM21	0	pull down, affinity chromatography technology	Sabile A (2006), Sabile A (2006)	2
CDK9	3	CUL1	7	affinity chromatography technology, affinity chromatography technology	Kiernan RE (2001), Garriga J (2003)	2
FBXW4	0	COPS6	0	affinity chromatography technology	Lockwood WW (2013)	1
PSMA2	1	VCP	6	affinity chromatography technology, biochemical	Bousquet-Dubouch MP (2009), Havugimana PC (2012)	2
BRCA1	7	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology	Zhang H (2000), Zhang H (2000), Ertych N (2016)	3
COPS6	0	FBXL14	2	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017)	2
CKS1B	0	CDC37	0	pull down	Radulovic M (2010)	1
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
YAF2	1	BCOR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hein MY (2015), Oliviero G (2015), Huttlin EL (2017), Hauri S (2016)	5
PTCH1	8	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yamaki Y (2016), Yamaki Y (2016)	2
FBXW7	2	FBXW2	0	affinity chromatography technology	Huttlin EL (2017)	1
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
NFKBIA	0	UBE2D1	0	two hybrid, enzymatic study	Desterro JM (1997), Kroll M (1997)	2
TRRAP	31	CUL1	7	affinity chromatography technology	Finkbeiner MG (2008)	1
FBXW5	6	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu J (2008), He YJ (2006), Kanei-Ishii C (2012)	3
FBXO42	0	RBX1	2	affinity chromatography technology	Sun L (2009)	1
FBXW8	2	BTRC	1	affinity chromatography technology	Ponyeam W (2012)	1
FBXW11	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Suzuki H (2000), Sowa ME (2009), Sowa ME (2009), Coyaud E (2015), Coyaud E (2015), Coyaud E (2015), Huttlin EL (2017), Liu X (2017)	9
BTRC	1	COPS6	0	affinity chromatography technology	Fang L (2015)	1
FBXO18	0	UBC	7	enzymatic study	Kim JH (2015)	1
CDK2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Fogeron ML (2013)	2
FBXW2	0	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Busino L (2012), Saiga T (2009), Watanabe N (2004), Winston JT (1999), Tian X (2015), Hauri S (2016)	9
FBXO11	14	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Abida WM (2007), Duan S (2011), Bennett EJ (2010), Jeong YT (2013), Reitsma JM (2017), Reitsma JM (2017)	6
BTRC	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, bioid	Schweitzer K (2007), Schweitzer K (2007), Coyaud E (2015)	3
NFKBIA	0	PSMA2	1	pull down	Alvarez-Castelao B (2005)	1
FBXO31	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Kumar R (2005), Vadhvani M (2013), Jeffery JM (2017)	4
FBXL19	5	CDK9	3	affinity chromatography technology	Lee BK (2017)	1
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
FBXW11	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe N (2005), Fuchs SY (1999), Gao D (2011), DAnnibale S (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Low TY (2014)	8
FBXO25	1	NUAK1	2	enzymatic study	Teixeira FR (2013)	1
FBXO27	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FBXO8	1	SKP1	0	affinity chromatography technology, pull down	Yano H (2008), Winston JT (1999)	2
BCOR	2	PCGF1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gearhart MD (2006), Gearhart MD (2006), Gearhart MD (2006), Gao Z (2012), Junco SE (2013), Junco SE (2013), Hein MY (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Hauri S (2016)	13
PCGF1	1	YAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Gao Z (2012), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	5
FBXO6	0	CDC37	0	affinity chromatography technology	Liu B (2012)	1
MYC	2	USP37	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Pan J (2014), Pan J (2014), Pan J (2014), Pan J (2014)	4
CCND1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, pull down	Wei S (2008), Wei S (2008), Wei S (2008)	3
PTCH1	8	BTRC	1	affinity chromatography technology	Yamaki Y (2016)	1
BRCA1	7	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li H (2010), Li H (2010), Li H (2010), Ertych N (2016)	4
FBXO17	1	FBXW2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKP2	2	MYC	2	affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), von der Lehr N (2003), Zhang Q (2013), Kim TA (2013), Jamal A (2015), Fujii M (2006)	9
BCOR	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Oliviero G (2015), Hauri S (2016)	3
CACYBP	0	SKP1	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Matsuzawa SI (2001), Matsuzawa SI (2001), Matsuzawa SI (2001), Ning X (2012), Chen TC (2014), Niu YL (2016), Zhai H (2017)	7
FBXO6	0	FBXW2	0	affinity chromatography technology	Liu B (2012)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
VCP	6	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dai RM (1998), Dai RM (1998), Gao Y (2000), Hotta K (2013), Yu CC (2013), Li JM (2013), Li JM (2013), Schweitzer K (2016)	8
COPS6	0	CDKN1B	1	affinity chromatography technology	Choi HH (2015)	1
FBXL3	1	CRY1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Busino L (2007), Busino L (2007), Yumimoto K (2013), Huttlin EL (2015), Papp SJ (2015), Papp SJ (2015), Huttlin EL (2017)	8
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
CCND1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006)	2
RBX1	2	FBXO18	0	affinity chromatography technology, pull down	Kim J (2002), Kim JH (2004)	2
FBXO7	1	NEDD8	0	affinity chromatography technology	Teixeira FR (2016)	1
FBXL4	1	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
MYC	2	FBXO8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cho HJ (2010), Cho HJ (2010), Cho HJ (2010), Cho HJ (2010)	4
FBXO2	0	UBE2D1	0	pull down	Nelson RF (2006)	1
BCOR	2	RNF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Cao Q (2014), Hein MY (2015), Hein MY (2015), Oliviero G (2015), Hauri S (2016)	7
RBX1	2	FBXO22	1	affinity chromatography technology	Dias DC (2002)	1
FBXO3	0	SKP1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Yu H (2011), Cloutier P (2017), Hauri S (2016)	4
COPS6	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
YAF2	1	KDM2B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017), Hauri S (2016)	3
CUL7	4	UBC	7	affinity chromatography technology	Hanson D (2014)	1
SKP1	0	FBXW9	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Lievens S (2009), Hauri S (2016)	3
FBXW8	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Litterman N (2011), Busino L (2012), Watanabe N (2004), Ponyeam W (2012), Tian X (2015), Xu X (2008), Hauri S (2016)	9
STYX	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
FAF1	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Zhang L (2012)	2
BCOR	2	KDM2B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gearhart MD (2006), Inagaki T (2015), Inagaki T (2015), Hein MY (2015), Oliviero G (2015)	6
SKP1	0	CCNF	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), DAngiolella V (2012), Yoshida Y (2011), Kuchay S (2017), Choudhury R (2017)	5
CTNNB1	30	CDK2	0	pull down, affinity chromatography technology	Park CS (2004), Park CS (2004)	2
SKP1	0	MED21	1	pull down, pull down, protein complementation assay	Ang K (2012), Ang K (2012), Ang K (2012)	3
RBX1	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Li Y (2010), Shaik S (2012), Costessi A (2011), Bashir T (2010), Lan L (2012), Welcker M (2011), Wilkins A (2004), Yada M (2004), Li C (2011), Lee DF (2009), Santra MK (2009), Chen BB (2012), Liu J (2002), Duan S (2011), Barbash O (2011), Kamura T (2003), Abbas T (2008), Peschiaroli A (2009), Popov N (2010), Uchida S (2011), Dimitrova YN (2010), Maerki S (2009), Malatesta M (2012), Davis MA (2013), Chen H (2013), Mallampalli RK (2013), Rossi M (2013), Mori Y (2013), Lu A (2013), Fischer ES (2014), Andresen CA (2014), Herrero-Ruiz J (2014), Johansson P (2014), Uchiki T (2009), Min SH (2012), Gao D (2010), Canettieri G (2010), Lin MY (2011), Read MA (2000), Zhang DD (2004), Zhang DD (2005), Fukushima H (2013), Matsumoto S (2015), Ibeawuchi SR (2015), Malonia SK (2015), Liu Y (2015), Liu Y (2015), Gao J (2015), Zhang C (2015), Chu WK (2015), Barbash O (2009), Kershaw NJ (2014), Nam S (2009), Wu HC (2014), Kim JH (2015), Kung YA (2017), Nguyen TV (2016), Shimizu K (2017), Gschweitl M (2016), Terai K (2013), Chandra S (2013), Dai X (2017), Qie S (2017), Chen BB (2013), Kroenke J (2014)	65
PCGF1	1	RING1	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Woodsmith J (2012), Oliviero G (2015), Oliviero G (2015), Hauri S (2016), Hauri S (2016)	9
CUL1	7	FBXL8	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
CRY1	0	BTRC	1	affinity chromatography technology	Busino L (2007)	1
CUL1	7	FBXL14	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Huttlin EL (2017), Reitsma JM (2017)	3
COPS6	0	FBXL15	0	affinity chromatography technology	Bennett EJ (2010)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
CUL1	7	FBXO5	2	affinity chromatography technology	Reitsma JM (2017)	1
SKP1	0	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down	Hattori K (1999), Tan P (1999), Suzuki H (1999), Winston JT (1999), Surjit M (2012), Chong RA (2014)	6
CDK2	0	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
CDKN1B	1	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Guidoboni M (2005), Vlach J (1996), Vlach J (1997), Tsai CH (2009), Ciarallo S (2002), Bindra RS (2002), Kossatz U (2006), Grimmler M (2007), Rolland T (2014), Hein MY (2015), Barbash O (2009), Huttlin EL (2017)	13
CUL7	4	FBXW7	2	affinity chromatography technology, affinity chromatography technology	Arai T (2003), Arai T (2003)	2
COPS6	0	FBXW9	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
TRRAP	31	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Finkbeiner MG (2008), Finkbeiner MG (2008), Finkbeiner MG (2008)	3
MYC	2	CDK9	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kanazawa S (2003), Bres V (2009), Eberhardy SR (2001), Gargano B (2007), Jaenicke LA (2016)	5
SLBP	0	CDK2	0	affinity chromatography technology	Dankert JF (2016)	1
PSMA2	1	FBXW7	2	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
FBXL5	3	RBX1	2	affinity chromatography technology, biochemical	Salahudeen AA (2009), Vinas-Castells R (2013)	2
FBXW7	2	CDK2	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2012), Zhang W (2012)	2
CUL4A	2	FBXW8	2	affinity chromatography technology	He YJ (2006)	1
MYC	2	CUL4A	2	affinity chromatography technology	Choi SH (2010)	1
NEDD8	0	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
CRY1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Papp SJ (2015), Huttlin EL (2017)	3
FBXW7	2	MED21	1	affinity chromatography technology, affinity chromatography technology	Davis MA (2013), Kourtis N (2015)	2
MCL1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Ye M (2017), Feng C (2017)	2
BCOR	2	RING1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Hein MY (2015), Oliviero G (2015), Hauri S (2016)	4
FBXO25	1	CAND1	2	affinity chromatography technology, affinity chromatography technology	Teixeira FR (2010), Teixeira FR (2010)	2
FBXO4	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Li Y (2010), Li Y (2010), Hagens O (2006), Lee EK (2013), Tian X (2015), Huttlin EL (2017), Qie S (2017), Hauri S (2016)	12
SUGT1	1	SKP1	0	pull down, pull down, pull down, affinity chromatography technology, biochemical	Nowotny M (2003), Zhang M (2008), Zhang M (2008), Niikura Y (2006), Wan C (2015)	5
CUL4A	2	CTNNB1	30	affinity chromatography technology	Tripathi R (2007)	1
SKP2	2	CKS1B	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe, pull down, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang W (2003), Wang W (2003), Sitry D (2002), Sitry D (2002), Ganoth D (2001), Calvisi DF (2008), Xu S (2007), Ungermannova D (2005), Spruck C (2001), Yao ZP (2006), Seeliger MA (2005), Huang KS (2005), Rodier G (2008), Ungermannova D (2013), Radulovic M (2010), Huttlin EL (2017)	16
CKS1B	0	SKP1	0	pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology	Yao ZP (2006), Seeliger MA (2005), Radulovic M (2010), Ungermannova D (2013), Hauri S (2016)	5
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
SKP1	0	FBXL8	0	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lievens S (2009), Rolland T (2014), Hein MY (2015), Hauri S (2016)	4
RBX1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, bioid	Tan M (2010), Oshikawa K (2003), Coyaud E (2015)	3
CDC25A	2	CDK2	0	pull down, enzymatic study, affinity chromatography technology	Xu X (1996), Cheng A (2005), Li X (2016)	3
CAND1	2	YAF2	1	affinity chromatography technology	Bennett EJ (2010)	1
FBXW11	2	BCOR	2	affinity chromatography technology	Low TY (2014)	1
FBXW2	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Xu J (2017)	2
FBXO2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wen H (2010), Glenn KA (2008), Jeong YT (2013), Reitsma JM (2017)	4
CUL1	7	CKS1B	0	affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Radulovic M (2010), Huttlin EL (2017)	3
CDK9	3	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Varjosalo M (2013), Huttlin EL (2015), Li J (2013), Huttlin EL (2017)	5
FAF1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Zhang L (2012), Zhang L (2012)	3
COPS6	0	FBXO17	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	4
CUL1	7	FBXL12	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Kim M (2008), Postow L (2013), Nishiyama M (2015), Reitsma JM (2017)	5
USP37	1	BTRC	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, bioid, affinity chromatography technology	Burrows AC (2012), Burrows AC (2012), Burrows AC (2012), Saxena N (2014), Yeh C (2015), Huttlin EL (2017)	6
BRCA1	7	CDC37	0	affinity chromatography technology	Ertych N (2016)	1
SKP2	2	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
CTNNB1	30	TRRAP	31	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sustmann C (2008), Sierra J (2006), Sierra J (2006), Gomes NP (2006)	4
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
CDKN1B	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miranda-Carboni GA (2008), Bondar T (2006), Li B (2006), Li B (2006), Gao J (2015)	5
FBXW11	2	RBX1	2	affinity chromatography technology	Tan P (1999)	1
FBXW8	2	CCND1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Okabe H (2007), Wei S (2008)	3
RNF2	1	UBE2D1	0	enzymatic study, two hybrid	Lee SJ (2001), Markson G (2009)	2
CTNNB1	30	UBE2D1	0	pull down	Saha A (2008)	1
FBXW11	2	FBXO5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao D (2011), Kim TY (2014), Margottin-Goguet F (2003)	3
FBXL12	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim M (2008), Postow L (2013), Postow L (2013), Nishiyama M (2015), Hauri S (2016)	5
CDK2	0	CAND1	2	affinity chromatography technology	Neganova I (2011)	1
CTNNB1	30	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, enzymatic study, protein complementation assay, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang J (2006), Yang J (2006), Cong F (2003), Kitagawa M (1999), Kitagawa M (1999), Kitagawa M (1999), Hart M (1999), Hart M (1999), Hart M (1999), Su Y (2008), Winston JT (1999), Peschiaroli A (2010), Latres E (1999), Liu J (2004), Dorrello NV (2006), Godin JD (2010), Guardavaccaro D (2008), Evrard-Todeschi N (2008), Saha A (2008), Saha A (2008), Chen CH (2012), Wei S (2008), Dehan E (2009), Wang D (2011), Gao D (2011), Li VS (2012), Sahasrabuddhe AA (2014), Mbom BC (2014), Mbom BC (2014), Kovacev J (2014), Gao C (2014), Kluge SF (2013), Chong RA (2014), Herrero-Ruiz J (2014), Zhang L (2012), Coyaud E (2015), Loveless TB (2015), Low TY (2014), Coyaud E (2015), Tseng RC (2015), Wu K (2016), Villalobos V (2010), Pierce NW (2009), Shrestha H (2016), Gu JJ (2016), Vaid M (2011)	46
FBXL7	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koyama-Nasu R (2007), Watanabe N (2004), Liu Y (2015), Kuchay S (2017)	4
YAF2	1	FBXO7	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO31	4	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Jeffery JM (2017)	2
NUAK1	2	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014), Banerjee S (2014), Huttlin EL (2017)	4
UBC	7	FBXO44	0	pull down	Nathan JA (2013)	1
BRCA1	7	CDK9	3	two hybrid	Woods NT (2012)	1
FBXO7	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Kirk R (2008), Hsu JM (2004), Hagens O (2006), Bennett EJ (2010), Hein MY (2015), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Reitsma JM (2017), Reitsma JM (2017)	11
USP37	1	FBXW11	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Kim TY (2014), Low TY (2014), Yeh C (2015), Huttlin EL (2017)	6
SKP1	0	FBXL19	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao J (2012), Kuchay S (2017), Hauri S (2016)	3
FBXO25	1	TTC9C	2	affinity chromatography technology	Teixeira FR (2010)	1
RING1	2	KDM2B	11	affinity chromatography technology	Hauri S (2016)	1
FAF1	1	BTRC	1	affinity chromatography technology, affinity chromatography technology	Zhang L (2012), Zhang L (2012)	2
MYC	2	CDK2	0	genetic interference, genetic interference	Toyoshima M (2012), Zhou Z (2014)	2
CDCA3	0	SKP1	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical	Ayad NG (2003), Ayad NG (2003), Lievens S (2009), Watanabe N (2004), Ayad NG (2003)	5
FBXL12	1	STYX	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan MK (2013), St-Denis N (2016), Li X (2016)	3
FBXO32	2	RBX1	2	affinity chromatography technology	Al-Yacoub N (2016)	1
FBXL14	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
MYC	2	PSMA2	1	affinity chromatography technology	Koch HB (2007)	1
SKP1	0	FBXO2	0	x-ray crystallography, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology	Mizushima T (2007), Lievens S (2009), Nelson RF (2007), Henzl MT (2004), Henzl MT (2004), Glenn KA (2008), Tan A (2008), Erhardt JA (1998), Winston JT (1999), Rolland T (2014), Hauri S (2016)	11
FBXL22	2	SKP1	0	two hybrid, affinity chromatography technology	Spaich S (2012), Spaich S (2012)	2
GHR	1	SKP1	0	affinity chromatography technology, unspecified method	da Silva Almeida AC (2013), Bulatov E (2015)	2
FBXL22	2	CUL1	7	affinity chromatography technology	Spaich S (2012)	1
UBC	7	FBXO7	1	affinity chromatography technology	Matsumoto M (2005)	1
CDC25A	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jin J (2003), Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016)	6
FBXW8	2	FBXW2	0	affinity chromatography technology	Ponyeam W (2012)	1
UBC	7	FBXL15	0	pull down	Zhang X (2017)	1
FBXL3	1	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Yumimoto K (2013), Kuchay S (2017)	5
SLBP	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Dankert JF (2016), Dankert JF (2016)	2
FBXO31	4	CCND1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Santra MK (2009), Santra MK (2009), Santra MK (2009), Yumimoto K (2013), Johansson P (2014)	5
BRCA1	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Lu Y (2012), Lu Y (2012)	2
SKP1	0	FBXL4	1	pull down, affinity chromatography technology	Winston JT (1999), Hauri S (2016)	2
CUL1	7	GHR	1	unspecified method	Bulatov E (2015)	1
FBXO45	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saiga T (2009), Chen X (2014), Chen X (2014), Chen X (2014), Chung FZ (2014), Chung FZ (2014), Hauri S (2016)	7
FBXO31	4	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kumar R (2005), Bennett EJ (2010), Vadhvani M (2013), Jeong YT (2013), Hein MY (2015), Malonia SK (2015), Jeffery JM (2017), Reitsma JM (2017)	8
UBC	7	CENPE	1	pull down	Nathan JA (2013)	1
SKP1	0	FBXO30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Tian X (2015), Hauri S (2016)	3
FBXW8	2	SKP2	2	affinity chromatography technology	Ponyeam W (2012)	1
FBXL17	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan MK (2013), Raducu M (2016), Raducu M (2016), Hauri S (2016)	4
CCND1	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Higashi H (1996), Higashi H (1996), Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	6
CUL1	7	FBXL15	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Cui Y (2011), Huttlin EL (2015), Huttlin EL (2017), Reitsma JM (2017)	5
FBXO17	1	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
SKP1	0	UBE2D1	0	pull down, pull down	Kamura T (2000), Lin DI (2006)	2
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
COPS6	0	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Angers S (2006), He YJ (2006), McCall CM (2008), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009), Olma MH (2009), Huttlin EL (2015), Huttlin EL (2017)	12
FBXW7	2	CUL1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu G (2001), Tron AE (2012), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Bennett EJ (2010), Strohmaier H (2001), Davis MA (2013), JunGang Z (2012), Busino L (2003), Pierce NW (2013), Chung FZ (2014), Yumimoto K (2012), Low TY (2014), Kourtis N (2015), Gorelik M (2016), Gorelik M (2016), Huttlin EL (2017), Reiterer V (2017), Reiterer V (2017), Ye M (2017), Reitsma JM (2017)	23
SLBP	0	CCNF	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dankert JF (2017), Dankert JF (2016), Dankert JF (2016), Dankert JF (2016)	4
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
COPS6	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXO21	2	RBX1	2	affinity chromatography technology	Watanabe K (2015)	1
FBXL12	1	RBX1	2	affinity chromatography technology	Kim M (2008)	1
CDK9	3	SKP1	0	pull down, affinity chromatography technology	Kiernan RE (2001), Kiernan RE (2001)	2
MYC	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Koch HB (2007), von der Lehr N (2003), Wang J (2011)	3
MYC	2	BTRC	1	affinity chromatography technology, enzymatic study	Popov N (2010), Popov N (2010)	2
FBXO4	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Cenciarelli C (1999), Hagens O (2006), Choo YY (2011), Liu B (2012), Jeong YT (2013), Huttlin EL (2017), Reitsma JM (2017)	8
CDK2	0	CKS1B	0	x-ray crystallography, affinity chromatography technology, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Bourne Y (1996), Xu S (2007), Yao ZP (2006), Seeliger MA (2005), Varjosalo M (2013), Radulovic M (2010), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	12
KDM2B	11	UBE2D1	0	enzymatic study	Janzer A (2012)	1
STYX	1	FBXL14	2	affinity chromatography technology	St-Denis N (2016)	1
CDKN1B	1	MYC	2	affinity chromatography technology, protein complementation assay	Bahram F (2016), Bahram F (2016)	2
MED21	1	FBXL19	5	affinity chromatography technology	Huttlin EL (2017)	1
PSMA2	1	RBX1	2	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
FBXW2	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Xu J (2017), Xu J (2017), Xu J (2017)	3
ZC3HC1	1	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bassermann F (2007), Bassermann F (2005), Bassermann F (2005), Bassermann F (2005), von Klitzing C (2011), Liu YQ (2015), Liu YQ (2015)	7
GHR	1	FBXW11	2	biochemical	Sedek M (2014)	1
STYX	1	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down	St-Denis N (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017)	7
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
PTCH1	8	CUL1	7	affinity chromatography technology	Yamaki Y (2016)	1
BTRC	1	MCL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Dehan E (2009), Ding Q (2007), Ding Q (2007), Ding Q (2007), Ding Q (2007)	5
BTRC	1	CDC25A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Ray D (2005), Jin J (2003), Jin J (2003), Honaker Y (2010), Honaker Y (2010), Gao D (2009), Donzelli M (2004), Donzelli M (2004), Jin J (2005), Busino L (2003), Busino L (2003), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Loveless TB (2015), Coyaud E (2015), He N (2005), He N (2005), St-Denis N (2016), Huttlin EL (2017)	23
FBXO7	1	SKP1	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Cenciarelli C (1999), Cenciarelli C (1999), Hsu JM (2004), Nelson DE (2011), Hagens O (2006), Kang J (2014), Winston JT (1999), Hein MY (2015), Hein MY (2015), Vingill S (2016), Vingill S (2016), Huttlin EL (2017), Teixeira FR (2016), Teixeira FR (2016), Hauri S (2016)	16
ZC3HC1	1	RBX1	2	affinity chromatography technology	Bassermann F (2005)	1
FBXW8	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Okabe H (2007), Xu X (2008)	3
FBXO46	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Jeong YT (2013), Reitsma JM (2017)	2
23429	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hauri S (2016)	2
CTNNB1	30	CUL1	7	affinity chromatography technology	Read MA (2000)	1
CDK2	0	USP37	1	enzymatic study, bioid	Huang X (2011), Yeh C (2015)	2
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
CDK9	3	SKP2	2	affinity chromatography technology	Kiernan RE (2001)	1
SKP2	2	BTRC	1	affinity chromatography technology, pull down, affinity chromatography technology	Wei S (2012), Wei S (2012), Wei S (2012)	3
CDKN1B	1	SKP1	0	unspecified method, unspecified method	Carrano AC (1999), Ooi LC (2013)	2
BRCA1	7	FBXO44	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu Y (2012), Lu Y (2012), Lu Y (2012)	3
FBXW11	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Suzuki H (2000), Sowa ME (2009), Watanabe N (2004), Fuchs SY (1999), Tan P (1999), Herter JR (2002), Lievens S (2009), Lievens S (2009), DAnnibale S (2014), Kim TY (2014), Kim TY (2014), Coyaud E (2015), Low TY (2014), Hein MY (2015), Liu X (2017), Hauri S (2016)	16
YAF2	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Hauri S (2016)	2
PSMA2	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bloom J (2006), Bousquet-Dubouch MP (2009), Bennett EJ (2010)	3
FBXW7	2	FBXO45	1	affinity chromatography technology, affinity chromatography technology	Kourtis N (2015), Huttlin EL (2017)	2
FBXO8	1	CUL1	7	affinity chromatography technology, affinity chromatography technology	Yano H (2008), Yano H (2008)	2
FBXW11	2	CDC25A	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Ray D (2005), Ray D (2005), Jin J (2003), Jin J (2005), Gao D (2011), Busino L (2003), Busino L (2003), Kim TY (2014), Jin J (2003), Coyaud E (2015), Low TY (2014), St-Denis N (2016), Li X (2016), Huttlin EL (2017), Liu X (2017), Liu X (2017), Yadav L (2017), Yadav L (2017)	18
SLBP	0	CUL1	7	affinity chromatography technology	Dankert JF (2016)	1
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
CAND1	2	FBXL3	1	affinity chromatography technology	Pierce NW (2013)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
RBX1	2	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Shima Y (2008)	2
FBXO34	0	SKP1	0	two hybrid, two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Tian X (2015)	3
CAND1	2	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Kim AY (2008), Zheng J (2002), Zheng J (2002), Liu J (2002), Liu J (2002)	7
PCGF1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Oliviero G (2015), Oliviero G (2015), Hauri S (2016), Hauri S (2016)	6
NUAK1	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Banerjee S (2014), Banerjee S (2014), Banerjee S (2014), Huttlin EL (2017)	4
FBXO22	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Busino L (2007), Hein MY (2015), Tian X (2015), Hauri S (2016)	4
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
VCP	6	CDC37	0	affinity chromatography technology	Yu CC (2013)	1
FBXO17	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
STYX	1	CUL1	7	affinity chromatography technology	Li X (2016)	1
NFKBIA	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kawakami T (2001), Read MA (2000), Suzuki H (1999), Surjit M (2012), Furukawa M (2000), Furukawa M (2000)	6
PSMA2	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bousquet-Dubouch MP (2009), Hauri S (2016)	2
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
FBXO28	2	CUL1	7	affinity chromatography technology, affinity chromatography technology	Kratz AS (2016), Reitsma JM (2017)	2
PCGF1	1	KDM2B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Gearhart MD (2006), Gao Z (2012), Gao Z (2012), Wu X (2013), Inagaki T (2015), Oliviero G (2015), Oliviero G (2015), Hauri S (2016)	8
SKP1	0	TTC9C	2	two hybrid, affinity chromatography technology	Rolland T (2014), Hein MY (2015)	2
FBXO25	1	FBXO32	2	affinity chromatography technology	Teixeira FR (2010)	1
CUL1	7	FBXL5	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vashisht AA (2009), Salahudeen AA (2009), Liu B (2012), Vinas-Castells R (2013), Moroishi T (2014), Moroishi T (2014), Chen ZW (2015), Wu WD (2016), Huttlin EL (2017)	9
SKP1	0	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Wu G (2001), Wu G (2001), Wu G (2001), Hao B (2007), Schuelein C (2011), Busino L (2012), Busino L (2012), Busino L (2012), Matsumoto A (2011), Watanabe N (2004), Strohmaier H (2001), Choi BH (2014), Yumimoto K (2012), Kourtis N (2015), Kourtis N (2015), Hao J (2015), Tian X (2015), Liu YQ (2015), Gorelik M (2016), Gorelik M (2016), Gorelik M (2016), Yeh CH (2016), Reiterer V (2017), Reiterer V (2017), Reiterer V (2017), Kuchay S (2017), Ye M (2017)	28
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
RBX1	2	CUL7	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Dias DC (2002), Dias DC (2002), Andrews P (2006), Andrews P (2006), Huber C (2005), Huber C (2005), Xu X (2012), Nie J (2015)	9
BTRC	1	CAND1	2	affinity chromatography technology	Coyaud E (2015)	1
RBX1	2	GHR	1	unspecified method	Bulatov E (2015)	1
FBXO6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yoshida Y (2007), Yoshida Y (2007), Nelson RF (2007), Glenn KA (2008), Yoshida Y (2011), Liu B (2012), Liu B (2012), Tian X (2015), Hauri S (2016)	9
COPS6	0	FBXO11	14	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010)	2
CDC25A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Donzelli M (2004), Busino L (2003), Donzelli M (2002), He N (2005), Li X (2016), Yadav L (2017), Yadav L (2017)	7
FBXO2	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
FBXO7	1	CACYBP	0	enzymatic study	Teixeira FR (2016)	1
PSMA2	1	CAND1	2	affinity chromatography technology	Bousquet-Dubouch MP (2009)	1
COPS6	0	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Huttlin EL (2017)	3
MCL1	1	FBXO4	0	affinity chromatography technology	Feng C (2017)	1
CDCA3	0	CUL1	7	affinity chromatography technology, pull down	Ayad NG (2003), Ayad NG (2003)	2
FBXO2	0	CUL7	4	affinity chromatography technology	Wen H (2010)	1
TRIM21	0	SKP1	0	affinity chromatography technology, biochemical	Sabile A (2006), Sabile A (2006)	2
BTRC	1	GHR	1	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	van Kerkhof P (2007), da Silva Almeida AC (2012), da Silva Almeida AC (2013), da Silva Almeida AC (2013)	4
SUGT1	1	SKP2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Huttlin EL (2017)	3
FBXW8	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Ponyeam W (2012), Litterman N (2011), Bennett EJ (2010), Liu B (2012), Low TY (2014), Reitsma JM (2017)	7
CUL1	7	FBXO22	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Liu B (2012), Reitsma JM (2017)	3
FBXL5	3	COPS6	0	affinity chromatography technology	Huttlin EL (2017)	1
FBXO6	0	RBX1	2	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
FBXL3	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Liu B (2012), Yumimoto K (2013), Reitsma JM (2017)	4
FBXL14	2	TTC9C	2	affinity chromatography technology	Huttlin EL (2017)	1
KDM2B	11	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koyama-Nasu R (2007), Han XR (2016), Han XR (2016)	3
FBXO6	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Yoshida Y (2005), Yoshida Y (2005)	2
UBC	7	PSMA2	1	affinity chromatography technology	Matsumoto M (2005)	1
CUL7	4	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Tsutsumi T (2008), Xu X (2012), Hauri S (2016)	4
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
CTNNB1	30	SKP1	0	affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique	Matsuzawa SI (2001), Winston JT (1999), Wang D (2011), Chen TC (2014)	4
RBX1	2	CDKN1B	1	enzymatic study	Duda DM (2008)	1
CKS1B	0	CDKN1B	1	enzymatic study, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Wang W (2003), Sitry D (2002), Zhou W (2009), Ooi LC (2013), Huttlin EL (2017)	5
RNF2	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Cao Q (2014), Hauri S (2016), Hauri S (2016)	4
BRCA1	7	FBXO5	2	affinity chromatography technology, affinity chromatography technology	Lu Y (2012), Lu Y (2012)	2
BRCA1	7	CCND1	1	pull down, enzymatic study	Wang H (1997), Kehn K (2007)	2
CUL1	7	FBXO21	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Watanabe K (2015), Zhang C (2015), Zhang C (2015), Reitsma JM (2017)	5
CUL1	7	CAND1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Min KW (2003), Min KW (2003), Menon S (2008), Chew EH (2007), Min KW (2005), Min KW (2005), Min KW (2005), Hwang JW (2003), Hwang JW (2003), Mao X (2011), Chua YS (2011), Chua YS (2011), Tron AE (2012), Zheng J (2002), Zheng J (2002), Bornstein G (2006), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), He YJ (2006), Emberley ED (2012), Choo YY (2011), Jonason JH (2007), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Liu J (2002), Liu J (2002), Liu J (2002), Liu J (2002), Korzeniewski N (2012), Pierce NW (2013), Kim AY (2008), Zhang S (2016), Tikhmyanova N (2017), Tikhmyanova N (2017), Reitsma JM (2017), Reitsma JM (2017)	41
FBXW2	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cenciarelli C (1999), Saiga T (2009), Bennett EJ (2010), Busino L (2003), Liu B (2012), Low TY (2014), Xu J (2017), Reitsma JM (2017)	8
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
COPS6	0	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009)	2
NUAK1	2	CUL1	7	affinity chromatography technology	Banerjee S (2014)	1
SUGT1	1	CACYBP	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CCNF	2	RBX1	2	affinity chromatography technology	Yoshida Y (2011)	1
23429	0	KDM2B	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Wu X (2013), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
FBXO18	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim J (2002), Kim J (2002), Kim JH (2004), Bennett EJ (2010), Jeong YT (2013), Jeong YT (2013), Reitsma JM (2017)	7
VCP	6	TRIM21	0	affinity chromatography technology	Yu CC (2013)	1
FBXO27	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Glenn KA (2008), Yoshida Y (2011)	2
UBE2D1	0	RING1	2	two hybrid, pull down	Markson G (2009), Alchanati I (2009)	2
FBXO34	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2017), Reitsma JM (2017)	3
SKP1	0	FBXO28	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Rolland T (2014), Hauri S (2016), Kratz AS (2016)	3
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
CUL1	7	FBXW9	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017)	2
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
CCND1	1	FBXO4	0	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Lin DI (2006), Lin DI (2006), Barbash O (2011), Lin DI (2006), Lin DI (2006), Lee EK (2013), Barbash O (2009), Qie S (2017), Qie S (2017), Gong Y (2014)	10
CCND1	1	CUL7	4	affinity chromatography technology	Okabe H (2007)	1
FBXL14	2	SUGT1	1	affinity chromatography technology	Huttlin EL (2017)	1
CUL1	7	FBXW5	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Busino L (2003), Jeong YT (2013), Chung FZ (2014), Low TY (2014), Reitsma JM (2017)	6
FBXL2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Li LQ (2016), Kuchay S (2017), Reitsma JM (2017)	4
FBXO2	0	RBX1	2	affinity chromatography technology	Glenn KA (2008)	1
KDM2B	11	SKP1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gearhart MD (2006), Koyama-Nasu R (2007), Inagaki T (2015), Inagaki T (2015), Busino L (2007), Han XR (2016), Kuchay S (2017), Hauri S (2016)	8
CUL1	7	FBXO9	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Reitsma JM (2017), Reitsma JM (2017)	3
FBXO7	1	STYX	1	enzymatic study	Teixeira FR (2016)	1
COPS6	0	FBXO42	0	affinity chromatography technology	Bennett EJ (2010)	1
CDC25A	2	VCP	6	affinity chromatography technology	Riemer A (2014)	1
FBXO4	0	NEDD8	0	affinity chromatography technology	Ewing RM (2007)	1
CDKN1B	1	CUL1	7	unspecified method, pull down	Carrano AC (1999), Enchev RI (2012)	2
UBE2D1	0	CAND1	2	biochemical	You J (2001)	1