PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
AES	2	TLE1	6	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dastidar SG (2012)	2
SIX3	3	MTA1	3	affinity chromatography technology	Kumar R (2010)	1
SIX3	3	TLE1	6	two hybrid, pull down	Lopez-Rios J (2003), Lopez-Rios J (2003)	2
SIX3	3	AES	2	two hybrid, pull down	Lopez-Rios J (2003), Lopez-Rios J (2003)	2
PAX6	3	SIX3	3	pull down	Mikkola I (2001)	1
SIX3	3	NR4A3	3	pull down, affinity chromatography technology, two hybrid, pull down, pull down, two hybrid	Laflamme C (2003), Laflamme C (2003), Ohkura N (2001), Ohkura N (2001), Laflamme C (2004), Laflamme C (2004)	6