PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
RBMX	2	KHDRBS2	1	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Rual JF (2005), Rual JF (2005), Jeronimo C (2007), Rolland T (2014)	4
GOLT1B	0	ASTE1	1	affinity chromatography technology	Hein MY (2015)	1
INTS3	2	INTS5	3	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010)	2
INTS5	3	INTS6	4	affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010)	2
ELAVL1	0	GOLT1B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
INTS6	4	INTS11	1	affinity chromatography technology	Malovannaya A (2010)	1
NABP1	0	INIP	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Hein MY (2015)	5
XPO1	8	5430	0	affinity chromatography technology	Kirli K (2015)	1
NABP1	0	INTS11	1	affinity chromatography technology	Hein MY (2015)	1
INTS5	3	5430	0	affinity chromatography technology	Malovannaya A (2010)	1
INTS5	3	XPO1	8	genetic interference	Horlbeck MA (2018)	1
ELAVL1	0	NABP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NABP1	0	GOLT1B	0	affinity chromatography technology	Hein MY (2015)	1
RBMX	2	NABP1	0	two hybrid	Rolland T (2014)	1
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
INTS6	4	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Malovannaya A (2010), Hein MY (2015), Yadav L (2017), Yadav L (2017)	4
PPP2R1A	8	INTS11	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Yadav L (2017)	2
RBMX	2	QKI	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NABP1	0	INTS6	4	affinity chromatography technology	Hein MY (2015)	1
INTS3	2	PPP2R1A	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Malovannaya A (2010), Hein MY (2015), Yadav L (2017), Yadav L (2017)	4
ELAVL1	0	5430	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	QKI	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	PPP2R1A	8	imaging technique, affinity chromatography technology	Chen TC (2014), Kikuchi J (2003)	2
XPO1	8	TFCP2	1	affinity chromatography technology	Kirli K (2015)	1
INTS3	2	5430	0	affinity chromatography technology	Malovannaya A (2010)	1
NABP1	0	ASTE1	1	affinity chromatography technology	Hein MY (2015)	1
NABP1	0	5430	0	affinity chromatography technology	Hein MY (2015)	1
INTS11	1	5430	0	affinity chromatography technology	Baillat D (2005)	1
QKI	1	NABP1	0	two hybrid	Rolland T (2014)	1
NABP1	0	KHDRBS2	1	two hybrid	Rolland T (2014)	1
NABP1	0	PPP2R1A	8	affinity chromatography technology	Hein MY (2015)	1
PPP2R1A	8	RBMX	2	affinity chromatography technology	Fogeron ML (2013)	1
INTS6	4	5430	0	affinity chromatography technology	Malovannaya A (2010)	1
INTS3	2	INTS11	1	affinity chromatography technology	Malovannaya A (2010)	1
NABP1	0	AGGF1	2	affinity chromatography technology	Hein MY (2015)	1
MKRN3	2	NABP1	0	two hybrid	Rolland T (2014)	1
QKI	1	5430	0	affinity chromatography technology	Malovannaya A (2010)	1
GOLT1B	0	PPP2R1A	8	genetic interference	Horlbeck MA (2018)	1
INTS5	3	INTS11	1	affinity chromatography technology	Malovannaya A (2010)	1
INTS3	2	INIP	1	pull down, affinity chromatography technology, biochemical, biochemical	Huang J (2009), Huang J (2009), Havugimana PC (2012), Wan C (2015)	4
ELAVL1	0	INTS3	2	affinity chromatography technology	Abdelmohsen K (2009)	1
INTS5	3	PPP2R1A	8	affinity chromatography technology, genetic interference, affinity chromatography technology, bioid	Malovannaya A (2010), Horlbeck MA (2018), Yadav L (2017), Yadav L (2017)	4
INTS5	3	NABP1	0	affinity chromatography technology	Malovannaya A (2010)	1
INTS3	2	NABP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Malovannaya A (2010), Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Huang J (2009), Hein MY (2015)	7
NABP1	0	XPO1	8	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	PPP2R1A	8	affinity chromatography technology	Abdelmohsen K (2009)	1
TP53	0	NABP1	0	pull down	Kotlyar M (2015)	1
TFCP2	1	NABP1	0	two hybrid	Rolland T (2014)	1
INTS3	2	INTS6	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Malovannaya A (2010), Malovannaya A (2010), Huttlin EL (2017)	3