Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
CYP3A43 64816 CHLORZOXAZONE CHEMBL1371 NCI 11736864
CYP3A43 64816 KETOCONAZOLE CHEMBL295698 NCI 15991489
CYP3A43 64816 COBICISTAT CHEMBL2095208 inhibitor ChemblInteractions
CYP3A43 64816 GINKGO CHEMBL2108466 NCI 15901353
CYP3A43 64816 MELATONIN CHEMBL45 NCI 11554431

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
CYP3A43 rs472660 AA olanzapine "dosage","efficacy","toxicity","metabolism/PK" yes Genotype AA is associated with increased clearance of olanzapine in people with Schizophrenia as compared to genotypes AG + GG. 21519338 981479695
CYP3A43 rs472660 A ziprasidone metabolism/PK no Allele A is not associated with increased clearance of ziprasidone in people with Schizophrenia as compared to allele G. 21519338 981479707
CYP3A43 rs472660 A olanzapine metabolism/PK no Allele A is not associated with clearance of olanzapine in people with Schizophrenia as compared to allele G. 21519338 981479851
CYP3A43 rs680055 CG antipsychotics efficacy yes No GG homozygotes were observed. Approximately 50% of patients were receiving clozapine, the rest had other antipsychotics including risperidone (N = 25), olanzapine (N = 16), haloperidol (N = 7), amisulpride (N = 6), aripiprazole (N = 15), ziprasidone (N = 1), fluphenazine (N = 1) and quetiapine (N = 5) Genotype CG is associated with increased response to antipsychotics, aripiprazole, clozapine, haloperidol, olanzapine, quetiapine or risperidone in people with schizoaffective disorder or Schizophrenia as compared to genotype CC. 25150845 1448997283
CYP3A43 rs62471956 G ticagrelor metabolism/PK yes This is a dose effect where GG concentration < AG < AA. Part of a GWAS study with replication cohort. This study did not find changes in primary coronary event outcomes on ticagrelor, but did find differences in AUC of ticagrelor. Allele G is associated with decreased concentrations of ticagrelor in people with Acute coronary syndrome as compared to allele A. 25935875 1447987295