PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BABAM2	2	BRCC3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Dong Y (2003), Dong Y (2003), Dong Y (2003), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009)	17
ABRAXAS2	1	IFNAR1	4	imaging technique	Zheng H (2013)	1
BABAM2	2	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Sowa ME (2009), Hu X (2011), Hu X (2011), Kristensen AR (2012), Zhang J (2014), Yan K (2015), Zheng H (2013)	8
BRCC3	0	IFNAR1	4	enzymatic study	Zheng H (2013)	1
BABAM2	2	SHMT2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
SHMT1	1	SHMT2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2017)	2
SHMT2	3	CREB3	1	affinity chromatography technology, two hybrid	Castello A (2012), Yu H (2011)	2
BABAM1	1	SHMT2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
IFNAR1	4	SHMT2	3	affinity chromatography technology, imaging technique, affinity chromatography technology	Zheng H (2013), Zheng H (2013), Zheng H (2013)	3
JMJD6	1	SHMT2	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Castello A (2012)	2
BRCC3	0	ABRAXAS2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2010), Kristensen AR (2012), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	12
ABRAXAS2	1	SHMT2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Huttlin EL (2017), Zheng H (2013), Zheng H (2013), Zheng H (2013), Zheng H (2013)	5
ABRAXAS2	1	SHMT1	1	affinity chromatography technology, affinity chromatography technology	Zheng H (2013), Zheng H (2013)	2
BABAM1	1	ABRAXAS2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Hu X (2011), Hu X (2011), Zhang J (2014), Huttlin EL (2015), Yan K (2015), Huttlin EL (2017), Zheng H (2013), Zheng H (2013)	9
BRCC3	0	BABAM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Cooper EM (2010), Hu X (2011), Hu X (2011), Feng L (2009), Feng L (2009), Feng L (2009), Huttlin EL (2015), Huttlin EL (2017)	14
BABAM2	2	BABAM1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Sowa ME (2009), Sowa ME (2009), Wang B (2009), Wang B (2009), Shao G (2009), Shao G (2009), Hu X (2011), Hu X (2011), Hu X (2011), Patterson-Fortin J (2010), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Feng L (2009), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	21
SHMT2	3	TMOD2	3	affinity chromatography technology, biochemical	Castello A (2012), Wan C (2015)	2
IFNAR1	4	SHMT1	1	affinity chromatography technology	Zheng H (2013)	1
BRCC3	0	SHMT2	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2