PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CDH1	4	TRIM25	5	bioid	Guo Z (2014)	1
CRK	0	FGFR1	2	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Larsson H (1999), Larsson H (1999)	3
SRC	2	EPS8	1	enzymatic study, pull down	Maa MC (1999), Maa MC (1999)	2
SRC	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Burnham MR (1999), Song JJ (2010), Liu W (2010), Chen TC (2014)	4
SHB	4	ABL1	9	affinity chromatography technology, affinity chromatography technology, pull down	Haegerkvist R (2007), Haegerkvist R (2007), Haegerkvist R (2007)	3
SHB	4	LAT	0	affinity chromatography technology, affinity chromatography technology	Lindholm CK (1999), Lindholm CK (2002)	2
CDH1	4	CRK	0	bioid	Guo Z (2014)	1
EPS8	1	GRB2	2	two hybrid	Rolland T (2014)	1
VAV1	2	LCP2	0	affinity chromatography technology, pull down, affinity chromatography technology	Raab M (1997), Onodera H (1996), Shen M (2009)	3
ABL1	9	PLCG1	6	pull down	Koch A (2000)	1
VAV1	2	ABL1	9	pull down, two hybrid, affinity chromatography technology, enzymatic study	Bassermann F (2002), Bassermann F (2002), Bassermann F (2002), Bassermann F (2002)	4
JAK3	3	IL2RG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyazaki T (1994), Russell SM (1994), Warren KJ (2016)	3
SHB	4	EPS8	1	pull down, affinity chromatography technology	Karlsson T (1995), Karlsson T (1995)	2
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
PLCG1	6	LAT	0	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Zhang W (1998), Paz PE (2001), Paz PE (2001), Zhang W (1998), Jiang Y (2007), Braiman A (2006), Braiman A (2006), Matalon O (2016), Matalon O (2016)	9
SHB	4	JAK3	3	pull down	Lindholm CK (2002)	1
SHB	4	ZAP70	5	affinity chromatography technology, pull down	Lindholm CK (2002), Lindholm CK (2002)	2
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
LAT	0	PIK3R1	6	affinity chromatography technology, pull down	Paz PE (2001), Paz PE (2001)	2
FGFR1	2	SRC	2	affinity chromatography technology, affinity chromatography technology	Dudka AA (2010), Vecchione A (2007)	2
LAT	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Paz PE (2001), Zhang W (1998), Perez-Villar JJ (2002), Motto DG (1994), Houtman JC (2006)	5
CDH1	4	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Genda T (2000), Swaminathan G (2011), Shen Y (2008), Guo Z (2014)	4
SHB	4	PLCG1	6	affinity chromatography technology	Lindholm CK (1999)	1
TRIM25	5	SHB	4	affinity chromatography technology	Choudhury NR (2017)	1
VAV1	2	ZAP70	5	pull down, affinity chromatography technology	Katzav S (1994), Huby RD (1995)	2
VAV1	2	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Bertagnolo V (1998), Bertagnolo V (1998), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
SHB	4	PIK3R1	6	pull down, affinity chromatography technology	Karlsson T (1995), Karlsson T (1995)	2
FGFR1	2	NCK2	2	two hybrid	Hu Y (2004)	1
ZAP70	5	ABL1	9	affinity chromatography technology	Neumeister EN (1995)	1
ABL1	9	JAK1	6	pull down	Danial NN (1998)	1
HNRNPL	3	NCK2	2	affinity chromatography technology	Fei T (2017)	1
JAK1	6	GRB2	2	affinity chromatography technology, pull down	Kim H (2001), Giorgetti-Peraldi S (1995)	2
ZAP70	5	LCP2	0	enzymatic study, enzymatic study	Raab M (1997), Kim KS (2002)	2
LAT	0	VAV1	2	pull down, pull down, affinity chromatography technology	Paz PE (2001), Perez-Villar JJ (2002), Perez-Villar JJ (2002)	3
ABL1	9	CRK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, two hybrid, enzymatic study	Brehme M (2009), Brehme M (2009), Brehme M (2009), Peterson ME (2008), Yoshida K (2005), Chen C (2008), Feller SM (1994), Feller SM (1994), Bai RY (1998), Ren J (2002)	10
EGLN3	0	GRB2	2	affinity chromatography technology	Rodriguez J (2016)	1
SHB	4	JAK1	6	pull down	Lindholm CK (2002)	1
CRK	0	GRB2	2	pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Riordan SM (2000), Matsuda M (1996), Okada S (1996), Okada S (1996), Garcia-Guzman M (2000), Brehme M (2009)	6
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
SHB	4	IL2RG	0	pull down	Lindholm CK (2002)	1
IL2RG	0	JAK1	6	affinity chromatography technology	Tanaka N (1994)	1
LCP2	0	NCK2	2	two hybrid	Rolland T (2014)	1
TRIM25	5	ABL1	9	affinity chromatography technology	Choudhury NR (2017)	1
NCK2	2	SHB	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
FGFR1	2	PLCG1	6	two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007)	11
SHB	4	KDR	4	affinity chromatography technology	Holmqvist K (2004)	1
SHB	4	VAV1	2	affinity chromatography technology, pull down	Lindholm CK (2002), Lindholm CK (2002)	2
SHB	4	SRC	2	pull down, affinity chromatography technology	Karlsson T (1995), Karlsson T (1995)	2
TRIM25	5	EGLN3	0	affinity chromatography technology	Choudhury NR (2017)	1
CRK	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique	Gelkop S (2001), Gelkop S (2001), Garcia-Guzman M (2000), Brehme M (2009), Grossmann A (2015), Chen TC (2014)	6
GRB2	2	LCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid	Lewitzky M (2001), Robinson A (1996), Erdreich-Epstein A (1999), Hendricks-Taylor LR (1997), Asada H (1999), Bandyopadhyay S (2010), Chu J (1998), Berry DM (2002), Brehme M (2009), Rolland T (2014)	10
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
ZAP70	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down	Nel AE (1995), Braiman A (2006), Hubert P (1996)	3
CDH1	4	SHB	4	bioid	Guo Z (2014)	1
ZAP70	5	LAT	0	enzymatic study, enzymatic study, imaging technique, affinity chromatography technology	Paz PE (2001), Perez-Villar JJ (2002), Houtman JC (2006), Xie JJ (2013)	4
JAK1	6	IL2RB	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Miyazaki T (1994), Russell SM (1994), Usacheva A (2002), Zhu MH (1998), Migone TS (1998), Tanaka N (1994)	6
JAK3	3	JAK1	6	affinity chromatography technology	Doucet C (2002)	1
KDR	4	GRB2	2	affinity chromatography technology	DAngelo G (1999)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
JAK1	6	PLCG1	6	affinity chromatography technology	Chang YJ (2004)	1
TRIM25	5	GRB2	2	affinity chromatography technology	Choudhury NR (2017)	1
KDR	4	PLCG1	6	pull down	Cunningham SA (1997)	1
HNRNPL	3	SHB	4	affinity chromatography technology	Fei T (2017)	1
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
FGFR1	2	VAV1	2	unspecified method	Liu BA (2012)	1
VAV1	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Bertagnolo V (1998), Bertagnolo V (1998), Bertagnolo V (1998), Shigematsu H (1997), Shigematsu H (1997), Shigematsu H (1997)	6
SHB	4	IL2RB	1	pull down	Lindholm CK (2002)	1
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
FGFR1	2	CDH1	4	imaging technique	Chen TC (2014)	1
CRK	0	SHB	4	affinity chromatography technology	Lu L (2000)	1
SHB	4	GRB2	2	affinity chromatography technology	Welsh M (1998)	1
ABL1	9	PIK3R1	6	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kapeller R (1994), Ren SY (2005), Ren SY (2005), Ren SY (2005), Brehme M (2009)	5
LCP2	0	PLCG1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Yablonski D (2001), Yablonski D (2001), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
SHB	4	LCP2	0	affinity chromatography technology, pull down	Lindholm CK (2002), Lindholm CK (2002)	2
IL2RB	1	GRB2	2	pull down	Delespine-Carmagnat M (2000)	1
EGLN3	0	SHB	4	affinity chromatography technology	Rodriguez J (2016)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
LCP2	0	PIK3R1	6	two hybrid, affinity chromatography technology	Shim EK (2004), Shim EK (2004)	2
FGFR1	2	PIK3R1	6	imaging technique, two hybrid, pull down	Chen TC (2014), Hu Y (2004), Shi E (1993)	3
SHB	4	FGFR1	2	pull down, affinity chromatography technology	Karlsson T (1995), Karlsson T (1995)	2
WDYHV1	0	SHB	4	affinity chromatography technology	Huttlin EL (2017)	1
ZAP70	5	GRB2	2	affinity chromatography technology, affinity chromatography technology	Nel AE (1995), Jin HS (2013)	2
HNRNPL	3	PLCG1	6	affinity chromatography technology	Fei T (2017)	1
LAT	0	LCP2	0	affinity chromatography technology	Xie JJ (2013)	1
CDH1	4	NCK2	2	bioid	Guo Z (2014)	1
CRK	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Hsia DA (2003), Garcia-Guzman M (2000)	2
CRK	0	ZAP70	5	pull down	Gelkop S (1999)	1
PIK3R1	6	ZAP70	5	affinity chromatography technology	Moon KD (2005)	1
SRC	2	KDR	4	affinity chromatography technology, affinity chromatography technology, unspecified method	Meyer RD (2008), Gavard J (2008), Sun Z (2012)	3