PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAPK6	1	AMPH	4	two hybrid	Vinayagam A (2011)	1
AP2B1	3	AP2M1	5	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
TRIM25	5	RAI14	4	affinity chromatography technology	Choudhury NR (2017)	1
ITSN1	5	SCOC	3	two hybrid	Wong KA (2012)	1
ITSN2	7	REPS1	2	two hybrid	Wong KA (2012)	1
ITSN1	5	SYNJ1	3	affinity chromatography technology	Tsyba L (2008)	1
SGIP1	5	ITSN1	5	affinity chromatography technology	Dergai O (2010)	1
SCAMP1	3	ITSN1	5	two hybrid, pull down	Fernandez-Chacon R (2000), Fernandez-Chacon R (2000)	2
MAPK6	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
AMPH	4	AP2S1	1	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	TFG	3	affinity chromatography technology, affinity chromatography technology	Schlundt A (2009), Hein MY (2015)	2
UBE2K	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
ITCH	1	PDCD6IP	3	affinity chromatography technology	OConnor HF (2015)	1
TRIM25	5	FNBP4	3	affinity chromatography technology	Choudhury NR (2017)	1
IGBP1	1	ITSN1	5	biochemical	Havugimana PC (2012)	1
TFG	3	ITSN1	5	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	ITSN1	5	affinity chromatography technology	Choudhury NR (2017)	1
EEF1A1	0	PHGDH	4	biochemical	Havugimana PC (2012)	1
ITSN2	7	FNBP4	3	two hybrid	Wong KA (2012)	1
ITSN1	5	ARFIP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Wong KA (2012), Wong KA (2012), Wong KA (2012)	3
AP2M1	5	EPS15L1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	3
EPS15	1	AP2S1	1	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Huttlin EL (2017)	2
ITSN1	5	SETD3	1	biochemical	Havugimana PC (2012)	1
EPS15	1	RAB11FIP2	2	affinity chromatography technology	Cullis DN (2002)	1
DSTN	0	ITSN1	5	biochemical	Havugimana PC (2012)	1
STON2	2	EPS15	1	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology	Martina JA (2001), Martina JA (2001), Martina JA (2001), Brehme M (2009), Rumpf J (2008), Rumpf J (2008), Rumpf J (2008), Rumpf J (2008)	8
ITSN1	5	PACSIN3	2	two hybrid	Wong KA (2012)	1
CLTC	12	REPS1	2	affinity chromatography technology	Hein MY (2015)	1
SKIV2L	1	TTC37	3	biochemical	Wan C (2015)	1
TSG101	1	RAD18	3	two hybrid	Markson G (2009)	1
CLTC	12	EPN2	4	pull down	Rosenthal JA (1999)	1
ITSN2	7	DLGAP1	6	two hybrid	Wong KA (2012)	1
ITSN1	5	CCNO	1	two hybrid	Thalappilly S (2008)	1
AP2M1	5	NECAP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	4
TRIM25	5	KHDRBS1	1	affinity chromatography technology	Choudhury NR (2017)	1
PICALM	0	STON2	2	affinity chromatography technology	Hein MY (2015)	1
PIK3R1	6	WAS	0	affinity chromatography technology, pull down	Banin S (1996), Banin S (1996)	2
AP2S1	1	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	CEP85L	7	two hybrid	Wong KA (2012)	1
FCHSD2	3	MTUS2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
SPRY2	4	CBL	7	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wong ES (2001), Wong ES (2001), Wong ES (2001), Wong ES (2002), Wong ES (2002), Ng C (2008), Ng C (2008), Chandramouli S (2008), Visser GD (2005), Hall AB (2003), Hall AB (2003), Rubin C (2003), Rubin C (2003), Rubin C (2003), Egan JE (2002), Miraoui H (2010), Mayer CE (2010), Sun Q (2010), Severe N (2011), Haglund K (2005), Lao DH (2007), Lao DH (2007), Fong CW (2003), Fong CW (2003), Mason JM (2004), DaSilva J (2006), Lao DH (2006)	27
ITSN1	5	SNAP23	0	pull down	Okamoto M (1999)	1
ITSN1	5	ASAP2	5	two hybrid	Thalappilly S (2008)	1
EPS15	1	SGIP1	5	pull down, x-ray crystallography	Shimada A (2016), Shimada A (2016)	2
ITSN1	5	DES	1	two hybrid	Wong KA (2012)	1
FNBP1	0	WASL	2	biochemical, pull down	Havugimana PC (2012), Tsujita K (2006)	2
CSNK2B	5	ITSN1	5	two hybrid	Vinayagam A (2011)	1
LSR	0	STON2	2	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGFG2	2	AGFG1	1	affinity chromatography technology	Huttlin EL (2017)	1
KHDRBS1	1	ITSN1	5	unspecified method	Asbach B (2012)	1
EPS15	1	AGFG1	1	genetic interference, affinity chromatography technology, pull down, biochemical	Doria M (1999), Doria M (1999), de Beer T (2000), Doria M (1999)	4
EPS15	1	NECAP2	0	affinity chromatography technology	Brehme M (2009)	1
ITSN1	5	RAB5A	0	protein complementation assay	Wong KA (2012)	1
ITSN1	5	RAI14	4	two hybrid	Wong KA (2012)	1
SH3GL2	1	CBL	7	affinity chromatography technology	Soubeyran P (2002)	1
SPRY2	4	SH3KBP1	1	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Haglund K (2005), Haglund K (2005), Haglund K (2005), Rolland T (2014)	4
ITSN2	7	EPS15	1	two hybrid, biochemical	Wong KA (2012), Wan C (2015)	2
LSR	0	REPS1	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	EPS15L1	1	affinity chromatography technology	Choudhury NR (2017)	1
RUNDC3A	2	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
DNM1	21	ITSN1	5	pull down, affinity chromatography technology	Solomaha E (2005), Tsyba L (2008)	2
EEF1A1	0	PICALM	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
ARFIP2	0	ARF6	0	two hybrid, two hybrid, pull down, pull down	DSouza-Schorey C (1997), Shin OH (2001), Shin OH (2001), DSouza-Schorey C (1997)	4
PACSIN3	2	WAS	0	affinity chromatography technology	Linkermann A (2009)	1
RUNDC3A	2	AP2B1	3	affinity chromatography technology	Huttlin EL (2017)	1
KHDRBS1	1	SH3KBP1	1	unspecified method, affinity chromatography technology	Asbach B (2012), Havrylov S (2009)	2
LSR	0	EPS15L1	1	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	FCHSD2	3	two hybrid	Wong KA (2012)	1
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
SH3KBP1	1	DNM1	21	affinity chromatography technology	Havrylov S (2009)	1
RPS6KA5	2	MAP3K20	1	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
TRIM25	5	AGFG1	1	affinity chromatography technology	Choudhury NR (2017)	1
SH3KBP1	1	WASL	2	affinity chromatography technology	Havrylov S (2009)	1
ITSN1	5	ITSN2	7	protein complementation assay	Wong KA (2012)	1
ITSN1	5	SPDL1	2	two hybrid	Wong KA (2012)	1
FNBP1	0	WAS	0	affinity chromatography technology, affinity chromatography technology	Linkermann A (2009), Tsujita K (2006)	2
AMPH	4	REPS1	2	affinity chromatography technology	Dergai O (2010)	1
LSR	0	EPS15	1	affinity chromatography technology	Huttlin EL (2017)	1
HIP1	4	CLTC	12	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology	Rao DS (2001), Waelter S (2001), Ybe JA (2009), Hein MY (2015), Chen TC (2014), Legendre-Guillemin V (2002), Ames HM (2013)	7
SOS1	5	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000)	2
AMPH	4	SGIP1	5	affinity chromatography technology	Dergai O (2010)	1
TRIM25	5	CBL	7	affinity chromatography technology	Choudhury NR (2017)	1
ITSN1	5	DLGAP1	6	two hybrid	Wong KA (2012)	1
SYNJ2	2	ITSN2	7	two hybrid, two hybrid	Nakayama M (2002), Wong KA (2012)	2
PDCD6IP	3	TSG101	1	two hybrid, two hybrid, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid	Kim BY (2007), Ichioka F (2007), Ichioka F (2007), von Schwedler UK (2003), Schlundt A (2009), Schlundt A (2009), Schlundt A (2009), Okumura M (2009), Katoh K (2005), Strack B (2003), Strack B (2003), Zhou X (2010), Zhou X (2010), Carlton JG (2008)	14
DAB2	1	AP2B1	3	affinity chromatography technology	Mulkearns EE (2012)	1
AMPH	4	ITSN1	5	affinity chromatography technology	Dergai M (2011)	1
CBL	7	TRIM8	6	two hybrid	Woodsmith J (2012)	1
AP2M1	5	AP2S1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
ITSN1	5	CLTC	12	two hybrid	Wong KA (2012)	1
ITCH	1	SMARCC2	9	pull down	Ingham RJ (2005)	1
ITSN1	5	RAB11FIP2	2	two hybrid	Wong KA (2012)	1
FNBP4	3	KHDRBS1	1	unspecified method	Goldstrohm AC (2001)	1
EPS15	1	AP2B1	3	affinity chromatography technology	Brehme M (2009)	1
EPS15	1	AP2M1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	5
SCAMP1	3	EPS15	1	two hybrid	Fernandez-Chacon R (2000)	1
ITSN1	5	MRPL20	3	two hybrid	Stelzl U (2005)	1
PACSIN3	2	DNM2	2	affinity chromatography technology	Linkermann A (2009)	1
SH3GL2	1	ITCH	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, far western blotting, pull down, unspecified method	Angers A (2004), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	7
SH3KBP1	1	CBLB	3	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down	Szymkiewicz I (2002), Szymkiewicz I (2002), Szymkiewicz I (2002), Havrylov S (2009), Moncalian G (2006), Jozic D (2005), Jozic D (2005), Kowanetz K (2003), Ceregido MA (2013), Ceregido MA (2013), Ceregido MA (2013)	11
ITSN1	5	FNBP4	3	two hybrid	Wong KA (2012)	1
TFG	3	TRIM25	5	affinity chromatography technology	Lee NR (2013)	1
ITSN1	5	PPFIA2	8	two hybrid	Wong KA (2012)	1
AP2B1	3	AP2S1	1	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
ITSN1	5	SKIV2L	1	biochemical	Havugimana PC (2012)	1
AP2M1	5	EEF1A1	0	affinity chromatography technology	Brehme M (2009)	1
ITSN1	5	SYNJ2	2	two hybrid	Wong KA (2012)	1
LSR	0	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	ITSN1	5	two hybrid, protein complementation assay, affinity chromatography technology	Wong KA (2012), Wong KA (2012), Dergai M (2011)	3
MAP3K20	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
MAPK6	1	HIP1	4	two hybrid	Vinayagam A (2011)	1
STON2	2	ITSN1	5	two hybrid, affinity chromatography technology, pull down	Martina JA (2001), Martina JA (2001), Martina JA (2001)	3
CDC42	3	PAK3	2	two hybrid, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Wang JB (2005), Govind S (2001)	3
SOS1	5	ITSN1	5	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Tong XK (2000), Tong XK (2000), Bandyopadhyay S (2010), Tsyba L (2008), Wang JB (2005)	5
ITSN1	5	UNC119	4	two hybrid	Stelzl U (2005)	1
DNM2	2	ITSN1	5	two hybrid, pull down, pull down	Vinayagam A (2011), Solomaha E (2005), Elhamdani A (2006)	3
TK1	0	KIF5A	2	two hybrid	Vinayagam A (2011)	1
ITSN2	7	FCHSD2	3	two hybrid	Wong KA (2012)	1
ITSN1	5	PIK3R1	6	two hybrid	Wong KA (2012)	1
RABEP1	4	GOLGA5	5	affinity chromatography technology	Boldt K (2016)	1
ITSN1	5	PREX1	5	two hybrid	Wong KA (2012)	1
ITSN1	5	SF3B4	2	two hybrid	Thalappilly S (2008)	1
MAPK6	1	PDCD6IP	3	two hybrid	Vinayagam A (2011)	1
ITSN1	5	CDC42	3	affinity chromatography technology, pull down, x-ray crystallography	Hussain NK (2001), Hussain NK (2001), Snyder JT (2002)	3
SPRY2	4	PACSIN3	2	two hybrid	Rolland T (2014)	1
WAS	0	CBLB	3	affinity chromatography technology	Watanabe Y (2013)	1
ITSN2	7	GAREM2	1	two hybrid	Wong KA (2012)	1
ITSN1	5	EPS15	1	two hybrid, affinity chromatography technology, biochemical	Wong KA (2012), Sengar AS (1999), Wan C (2015)	3
ITSN2	7	SH3KBP1	1	two hybrid	Wong KA (2012)	1
ARF6	0	CLTC	12	affinity chromatography technology	Krauss M (2006)	1
SH3KBP1	1	DAB2	1	affinity chromatography technology, two hybrid, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2003), Kowanetz K (2003)	3
TRIM25	5	PLK1	0	affinity chromatography technology	Choudhury NR (2017)	1
CLTC	12	STON2	2	affinity chromatography technology	Hein MY (2015)	1
PIK3R1	6	SH3KBP1	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Gout I (2000), Tossidou I (2010), Borthwick EB (2004), Borthwick EB (2004)	4
ITSN2	7	DNM2	2	two hybrid	Wong KA (2012)	1
CDC42	3	MAP3K20	1	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	FNBP1	0	affinity chromatography technology	Choudhury NR (2017)	1
PICALM	0	CLTC	12	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tebar F (1999), Tebar F (1999), Hein MY (2015), Hein MY (2015)	4
DNM1	21	AMPH	4	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997), Wigge P (1997), McMahon HT (1997), Chen-Hwang MC (2002), Grabs D (1997), Solomaha E (2005), Stamenova SD (2007)	9
RUNDC3A	2	EPS15	1	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	GOLGA5	5	two hybrid	Wong KA (2012)	1
CDC42	3	CBL	7	affinity chromatography technology, pull down, affinity chromatography technology	Wu WJ (2003), Wu WJ (2003), Simmons A (2005)	3
SH3GL2	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
PICALM	0	TRIM25	5	biochemical	Wan C (2015)	1
PICALM	0	EPS15	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RNASEH2A	0	SETD3	1	biochemical	Wan C (2015)	1
TSG101	1	KIF5A	2	two hybrid	Amit I (2004)	1
ITSN1	5	PPL	6	two hybrid	Wong KA (2012)	1
NCKIPSD	2	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
ITSN2	7	RABEP1	4	two hybrid	Wong KA (2012)	1
PICALM	0	AP2B1	3	affinity chromatography technology	Hein MY (2015)	1
DNM2	2	PICALM	0	biochemical	Havugimana PC (2012)	1
CBL	7	CBLB	3	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Rorsman C (2016)	2
KHDRBS1	1	NCKIPSD	2	unspecified method	Asbach B (2012)	1
CDC42	3	GOLGA5	5	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
RUNDC3A	2	NECAP2	0	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	SNX5	3	two hybrid	Stelzl U (2005)	1
TRIM25	5	PDE4D	4	affinity chromatography technology	Choudhury NR (2017)	1
ITSN1	5	TTC37	3	biochemical	Havugimana PC (2012)	1
ITSN1	5	WASL	2	pull down	Hussain NK (2001)	1
EPS15	1	AGFG2	2	genetic interference, biochemical	Doria M (1999), Doria M (1999)	2
TRIM25	5	AGFG2	2	affinity chromatography technology	Choudhury NR (2017)	1
ITSN1	5	PIK3AP1	5	two hybrid	Thalappilly S (2008)	1
WASL	2	CDC42	3	pull down, pull down, two hybrid, pull down	Carlier MF (2000), Miki H (1998), Bandyopadhyay S (2010), Martinez-Quiles N (2001)	4
CLTC	12	AP2B1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Slepnev VI (2000), Knuehl C (2006), Knuehl C (2006), Hein MY (2015)	4
ITSN1	5	RNF40	11	two hybrid	Wong KA (2012)	1
ASAP2	5	SH3KBP1	1	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
CDC42	3	UNC119	4	two hybrid	Stelzl U (2005)	1
DNM2	2	SH3GL2	1	pull down	Solomaha E (2005)	1
ITSN1	5	SMARCC2	9	two hybrid	Stelzl U (2005)	1
FCHSD2	3	WASL	2	two hybrid	Wang J (2011)	1
SH3KBP1	1	CLTC	12	affinity chromatography technology	Kowanetz K (2003)	1
DTX3	4	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITSN1	5	EEF1A1	0	two hybrid	Stelzl U (2005)	1
CBLB	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavagna-Sevenier C (1998), Elly C (1999), Elly C (1999), Alcazar I (2009), Fang D (2001)	5
EPS15L1	1	AGFG1	1	genetic interference	Doria M (1999)	1
ITSN1	5	KIF16B	4	two hybrid	Wong KA (2012)	1
ITCH	1	CBL	7	affinity chromatography technology	Azakir BA (2009)	1
DAB2	1	AP2M1	5	affinity chromatography technology	Mulkearns EE (2012)	1
SNX5	3	ARFIP2	0	biochemical	Kristensen AR (2012)	1
UBE2K	0	DTX3	4	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
TFG	3	MTUS2	4	affinity chromatography technology	Hein MY (2015)	1
ITSN1	5	DAB2	1	two hybrid	Wong KA (2012)	1
TK1	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
AP2M1	5	ITSN2	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KHDRBS1	1	WBP11	0	biochemical	Wan C (2015)	1
PACSIN3	2	WASL	2	pull down	Modregger J (2000)	1
MAPK8IP2	5	ITSN1	5	two hybrid	Vinayagam A (2011)	1
TSG101	1	TRIM25	5	biochemical	Wan C (2015)	1
WAS	0	ITSN2	7	two hybrid, affinity chromatography technology, pull down, two hybrid	McGavin MK (2001), McGavin MK (2001), McGavin MK (2001), Wong KA (2012)	4
CLTC	12	EPS15	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Chi S (2008)	2
ITSN1	5	TRIM8	6	two hybrid	Wong KA (2012)	1
SOS1	5	ITSN2	7	two hybrid, two hybrid	Bandyopadhyay S (2010), Wong KA (2012)	2
ITSN1	5	PDE4D	4	protein complementation assay, affinity chromatography technology	Wong KA (2012), Wong KA (2012)	2
TSG101	1	CBL	7	affinity chromatography technology, imaging technique	Kumar B (2016), Kumar B (2016)	2
ITSN1	5	WAS	0	affinity chromatography technology, affinity chromatography technology	Tsyba L (2008), Wang JB (2005)	2
MAP3K20	1	ITSN1	5	two hybrid	Vinayagam A (2011)	1
PACSIN3	2	SYNJ1	3	pull down	Modregger J (2000)	1
TRIM25	5	AP2B1	3	affinity chromatography technology	Choudhury NR (2017)	1
PAK3	2	ITSN1	5	affinity chromatography technology	Wang JB (2005)	1
SH3KBP1	1	SH3GL2	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Soubeyran P (2002), Soubeyran P (2002), Soubeyran P (2002), Schmidt MH (2004), Schmidt MH (2004), Vinayagam A (2011)	6
REPS1	2	RAB11FIP2	2	affinity chromatography technology	Cullis DN (2002)	1
CLTC	12	SNX5	3	two hybrid	Towler MC (2004)	1
LMO4	1	ITSN1	5	two hybrid	Colland F (2004)	1
SH3KBP1	1	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Watanabe S (2000), Watanabe S (2000), Petrelli A (2002), Soubeyran P (2002), Soubeyran P (2002), Szymkiewicz I (2002), Borinstein SC (2000), Schmidt MH (2006), Schmidt MH (2004), Schmidt MH (2004), Verdier F (2002), Verdier F (2002), Feshchenko EA (2004), Chandra V (2010), Niiro H (2012), Feng L (2011), Havrylov S (2009), Zhang J (2009), Zhang J (2009), Ababou A (2009), Le Bras S (2007), Jozic D (2005), Kowanetz K (2004), Kowanetz K (2003), Kowanetz K (2003), Tibaldi EV (2003), Tibaldi EV (2003), Take H (2000), Take H (2000), Schroeder B (2012), Schroeder B (2012), Peruzzi G (2007), Selbach M (2006), Sato S (2013), Taipale M (2014), Taipale M (2014), Diesenberg K (2015), Petrelli A (2002), Huttlin EL (2017)	39
SCOC	3	GCC1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	RABEP1	4	affinity chromatography technology	Choudhury NR (2017)	1
ITSN1	5	GCC1	1	two hybrid	Wong KA (2012)	1
TRIM25	5	HIP1	4	affinity chromatography technology	Choudhury NR (2017)	1
SNAP23	0	SCAMP1	3	affinity chromatography technology	Guo Z (2002)	1
ITSN1	5	ARF6	0	protein complementation assay	Wong KA (2012)	1
TRIM25	5	SF3B4	2	affinity chromatography technology	Choudhury NR (2017)	1
TFG	3	PDCD6IP	3	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	SETD3	1	affinity chromatography technology	Choudhury NR (2017)	1
MAPK6	1	CDC42	3	affinity chromatography technology	Rodriguez J (2016)	1
AP2M1	5	REPS1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Li J (2013), Huttlin EL (2015), Huttlin EL (2017)	4
ITSN1	5	EPN2	4	two hybrid	Wong KA (2012)	1
ITSN1	5	EPS15L1	1	two hybrid, biochemical	Wong KA (2012), Wan C (2015)	2
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
KHDRBS1	1	ITSN2	7	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Asbach B (2012), Asbach B (2012), Asbach B (2012)	3
SCAMP1	3	SNAP25	8	pull down	Fernandez-Chacon R (2000)	1
SH3GL2	1	DNM1	21	pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Solomaha E (2005)	3
SH3KBP1	1	SYNJ1	3	affinity chromatography technology, far western blotting, affinity chromatography technology	Kurakin AV (2003), Kurakin AV (2003), Havrylov S (2009)	3
ALOX5	1	KIF16B	4	affinity chromatography technology	Huttlin EL (2017)	1
PLK1	0	ITSN1	5	two hybrid	Vinayagam A (2011)	1
ITSN1	5	AGFG1	1	two hybrid	Wong KA (2012)	1
AP2S1	1	ITSN2	7	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	ITSN1	5	two hybrid	Amit I (2004)	1
TK1	0	EEF1A1	0	two hybrid	Vinayagam A (2011)	1
ITSN1	5	ZFPM2	4	two hybrid	Wong KA (2012)	1
AP2M1	5	RUNDC3A	2	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
PDCD6IP	3	SH3GL2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Schmidt MH (2004), Schmidt MH (2004), Ichioka F (2007), Ichioka F (2007)	4
RPS6KA5	2	ITSN1	5	two hybrid	Vinayagam A (2011)	1
KHDRBS1	1	AMPH	4	unspecified method	Asbach B (2012)	1
MAPK6	1	PHGDH	4	two hybrid	Vinayagam A (2011)	1
ITSN1	5	SH3KBP1	1	affinity chromatography technology	Nikolaienko O (2009)	1
MAPK6	1	PLK1	0	two hybrid, affinity chromatography technology	Vinayagam A (2011), Rodriguez J (2016)	2
ITSN1	5	SNAP25	8	pull down, two hybrid	Okamoto M (1999), Okamoto M (1999)	2
PIK3R1	6	SOS1	5	imaging technique	Chen TC (2014)	1
DISC1	6	ITSN1	5	two hybrid, affinity chromatography technology	Morris JA (2003), Wong KA (2012)	2
RUNDC3A	2	AP2S1	1	affinity chromatography technology	Huttlin EL (2017)	1
TSG101	1	SH3KBP1	1	biochemical	Wan C (2015)	1
ITSN1	5	RNASEH2A	0	biochemical	Havugimana PC (2012)	1
SYNJ1	3	AMPH	4	pull down, affinity chromatography technology, unspecified method	Micheva KD (1997), Micheva KD (1997), Cestra G (1999)	3
CBL	7	ITSN1	5	far western blotting, two hybrid, affinity chromatography technology, affinity chromatography technology	Martin NP (2006), Thalappilly S (2008), Dergai M (2011), Tsyba L (2008)	4
TSG101	1	RAB5A	0	imaging technique	Kumar B (2016)	1
ITSN1	5	PICALM	0	two hybrid	Wong KA (2012)	1
NCKIPSD	2	ITSN2	7	affinity chromatography technology	Huttlin EL (2017)	1
TK1	0	UNC119	4	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
SPRY2	4	DNM2	2	two hybrid	Vinayagam A (2011)	1
ITSN1	5	CBLB	3	affinity chromatography technology	Tsyba L (2008)	1
DNM2	2	SH3KBP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Schroeder B (2010), Schroeder B (2010), Havrylov S (2009), Wan C (2015)	4
AMPH	4	CLTC	12	pull down, affinity chromatography technology	Ramjaun AR (1998), Slepnev VI (2000)	2
TRIM25	5	PHGDH	4	affinity chromatography technology	Choudhury NR (2017)	1
PIK3R1	6	KHDRBS1	1	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Shen Z (1999), Shen Z (1999), Asbach B (2012), Asbach B (2012), Asbach B (2012), Sung CK (1994), Sung CK (1994)	8
ITSN1	5	REPS1	2	affinity chromatography technology	Dergai O (2010)	1
ITCH	1	UBE2K	0	pull down	Sheng Y (2012)	1
RUNDC3A	2	EPS15L1	1	affinity chromatography technology	Huttlin EL (2017)	1
ITCH	1	ITSN1	5	fluorescent resonance energy transfe, affinity chromatography technology	Desrochers G (2015), Desrochers G (2015)	2
AP2M1	5	CLTC	12	affinity chromatography technology, affinity chromatography technology	Brehme M (2009), Hein MY (2015)	2
SYNJ1	3	CLTC	12	pull down	Brett TJ (2002)	1
EPS15L1	1	AGFG2	2	genetic interference	Doria M (1999)	1
CDC42	3	WAS	0	pull down, pull down, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down	Tian L (2000), Kim AS (2000), Kolluri R (1996), Symons M (1996), Bandyopadhyay S (2010), Mott HR (1999), Owen D (2000), Edlund S (2004), Tetley GJN (2017)	9
ITSN1	5	KIF5A	2	two hybrid	Stelzl U (2005)	1
ITSN1	5	PFDN5	0	two hybrid	Thalappilly S (2008)	1
ITSN1	5	GAREM2	1	two hybrid	Wong KA (2012)	1
STON2	2	AP2M1	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Walther K (2001), Brehme M (2009), Huttlin EL (2015), Huttlin EL (2017)	4
ITSN1	5	CLIP2	10	two hybrid	Wong KA (2012)	1
PIK3R1	6	PDE4D	4	far western blotting	Beard MB (1999)	1
DNM1	21	FNBP1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Kamioka Y (2004), Kamioka Y (2004), Kamioka Y (2004)	3
ITSN2	7	PIK3C2B	5	two hybrid	Wong KA (2012)	1
DNM2	2	PIK3R1	6	affinity chromatography technology	Feng H (2012)	1
CBL	7	EEF1A1	0	affinity chromatography technology	Feshchenko EA (2004)	1
PACSIN3	2	DNM1	21	pull down	Modregger J (2000)	1
AP2S1	1	REPS1	2	affinity chromatography technology	Huttlin EL (2017)	1
ITSN1	5	WBP11	0	two hybrid	Thalappilly S (2008)	1
PLK1	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
ITSN1	5	HIP1	4	two hybrid	Wong KA (2012)	1
AMPH	4	SH3GL2	1	pull down	Micheva KD (1997)	1
ITSN1	5	FNBP1	0	two hybrid	Wong KA (2012)	1
ITSN2	7	CBL	7	two hybrid	Wong KA (2012)	1
RAB5A	0	MAP3K20	1	affinity chromatography technology	Hein MY (2015)	1
ITSN1	5	AGFG2	2	two hybrid	Wong KA (2012)	1
EPS15	1	DNM2	2	affinity chromatography technology	Salcini AE (2001)	1
PACSIN3	2	KHDRBS1	1	affinity chromatography technology, biochemical	Linkermann A (2009), Wan C (2015)	2
RAB5A	0	SH3KBP1	1	affinity chromatography technology	Schroeder B (2012)	1
TRIM25	5	TRIM8	6	two hybrid	Woodsmith J (2012)	1
TRIM25	5	AP2M1	5	affinity chromatography technology	Choudhury NR (2017)	1
AP2S1	1	STON2	2	affinity chromatography technology	Huttlin EL (2017)	1
RAB5A	0	PIK3R1	6	affinity chromatography technology	Chamberlain MD (2004)	1
CSNK2B	5	LMO4	1	two hybrid	Vinayagam A (2011)	1
TRIM25	5	PIK3C2B	5	affinity chromatography technology	Choudhury NR (2017)	1
PHGDH	4	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
PLK1	0	EPS15L1	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
ITSN2	7	PIK3AP1	5	two hybrid	Wong KA (2012)	1
ITSN1	5	PIK3C2B	5	two hybrid	Wong KA (2012)	1
MAPK8IP2	5	UNC119	4	two hybrid	Vinayagam A (2011)	1
ITSN2	7	WASL	2	two hybrid	Wong KA (2012)	1
ITSN1	5	RABEP1	4	two hybrid	Wong KA (2012)	1
PLK1	0	DNM2	2	affinity chromatography technology	Hein MY (2015)	1
NECAP2	0	ITSN1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ITSN1	5	PDCD6IP	3	two hybrid	Wong KA (2012)	1
RUNDC3A	2	REPS1	2	affinity chromatography technology	Huttlin EL (2017)	1
AP2B1	3	NECAP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
PICALM	0	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
ITSN1	5	AP2B1	3	two hybrid, two hybrid	Thalappilly S (2008), Wong KA (2012)	2
AMPH	4	AP2M1	5	affinity chromatography technology	Huttlin EL (2017)	1
AP2S1	1	EPS15L1	1	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	RPS6KA5	2	two hybrid	Wang J (2011)	1
RPS6KA5	2	UNC119	4	two hybrid	Vinayagam A (2011)	1
ARHGAP31	2	ITSN1	5	affinity chromatography technology	Tsyba L (2008)	1
AMPH	4	AP2B1	3	affinity chromatography technology, affinity chromatography technology	Slepnev VI (2000), Huttlin EL (2017)	2
FCHSD2	3	WAS	0	two hybrid	Wang J (2011)	1
PACSIN3	2	RAI14	4	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	CSNK2B	5	two hybrid	Wang J (2011)	1
ITSN2	7	EPS15L1	1	two hybrid, affinity chromatography technology, biochemical	Wong KA (2012), Titz B (2010), Wan C (2015)	3
ITSN2	7	PDCD6IP	3	two hybrid	Wong KA (2012)	1
FNBP1	0	DNM2	2	pull down, imaging technique	Tsujita K (2006), Kamioka Y (2004)	2
TRIM25	5	EEF1A1	0	biochemical	Wan C (2015)	1
PICALM	0	DAB2	1	affinity chromatography technology	Hein MY (2015)	1
PIK3R1	6	ALOX5	1	affinity chromatography technology, affinity chromatography technology	Ha YJ (2011), Ha YJ (2011)	2
ITSN1	5	SPRY2	4	two hybrid	Wong KA (2012)	1
ITSN1	5	EPHB2	10	affinity chromatography technology	Irie F (2002)	1
WAS	0	CBL	7	affinity chromatography technology	Watanabe Y (2013)	1
MAPK6	1	AP2S1	1	affinity chromatography technology	Rodriguez J (2016)	1
DNM2	2	AMPH	4	pull down, pull down	Solomaha E (2005), Elhamdani A (2006)	2
NECAP2	0	AP2S1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SYNJ1	3	AP2M1	5	pull down, affinity chromatography technology, affinity chromatography technology	Brett TJ (2002), Huttlin EL (2015), Huttlin EL (2017)	3
RAD18	3	TRIM8	6	two hybrid	Woodsmith J (2012)	1
SGIP1	5	REPS1	2	affinity chromatography technology	Dergai O (2010)	1
DAB2	1	CLTC	12	affinity chromatography technology, affinity chromatography technology	Mulkearns EE (2012), Hein MY (2015)	2
ITSN2	7	AMPH	4	two hybrid	Wong KA (2012)	1
ITSN1	5	MTUS2	4	two hybrid	Wong KA (2012)	1
SH3KBP1	1	PDCD6IP	3	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down	Schmidt MH (2004), Rauch S (2011), Havrylov S (2009), Usami Y (2007), Ichioka F (2007), Ichioka F (2007), Schmidt MH (2005), Carlton JG (2008), Chen B (2000)	9
TRIM25	5	DNM2	2	affinity chromatography technology	Choudhury NR (2017)	1
GATD1	1	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	RNASEH2A	0	affinity chromatography technology	Choudhury NR (2017)	1
STON2	2	EPS15L1	1	two hybrid	Martina JA (2001)	1
CYTH1	1	ARF6	0	pull down	Laroche G (2007)	1
PLK1	0	RAI14	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAD18	3	ITSN1	5	affinity chromatography technology	Hein MY (2015)	1
NCKIPSD	2	EPS15L1	1	affinity chromatography technology	Huttlin EL (2017)	1
SH3KBP1	1	SYNJ2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havrylov S (2009), Kowanetz K (2004), Kowanetz K (2004), Huttlin EL (2017)	4
SYNJ1	3	SH3GL2	1	pull down, pull down, affinity chromatography technology	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997)	3
ITSN1	5	CYTH1	1	two hybrid	Wong KA (2012)	1
ALOX5	1	ITSN1	5	affinity chromatography technology	Huttlin EL (2017)	1
RABEP1	4	RAB5A	0	two hybrid, two hybrid, two hybrid, biochemical, pull down, pull down, pull down, affinity chromatography technology, pull down	Xiao GH (1997), Vitale G (1998), Vitale G (1998), Vitale G (1998), Stenmark H (1995), Valsdottir R (2001), Christoforidis S (2000), Schnatwinkel C (2004), Kaelin S (2015)	9
TRIM25	5	SNX5	3	affinity chromatography technology	Choudhury NR (2017)	1