PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HOOK2	0	VPS16	6	affinity chromatography technology	Xu L (2008)	1
AKTIP	3	TRIM32	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	HOOK2	0	affinity chromatography technology	Foerster S (2013)	1
EGFR	5	PDS5A	5	affinity chromatography technology	Tong J (2014)	1
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
AKTIP	3	GTF3C1	11	two hybrid	Stelzl U (2005)	1
AKTIP	3	TWNK	2	two hybrid	Stelzl U (2005)	1
SSX2IP	0	AKTIP	3	bioid	Gupta GD (2015)	1
AKTIP	3	VPS41	3	affinity chromatography technology	Xu L (2008)	1
HOOK1	0	HOOK2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008)	4
TNFSF13B	0	HOOK3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SSX2IP	0	HOOK3	2	bioid	Gupta GD (2015)	1
AKTIP	3	TIMM50	4	affinity chromatography technology	Ewing RM (2007)	1
RPA1	0	PDS5A	5	affinity chromatography technology	Marechal A (2014)	1
AKTIP	3	HDLBP	9	affinity chromatography technology	Ewing RM (2007)	1
HOOK3	2	FAM160A1	4	affinity chromatography technology	Huttlin EL (2017)	1
TNFSF13B	0	HOOK2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKTIP	3	PRKDC	12	affinity chromatography technology	Subramanian PD (2016)	1
TERF2	2	ASS1	0	two hybrid	Lee OH (2011)	1
AKTIP	3	HOOK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	9
AKTIP	3	FAM160A2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu L (2008), Xu L (2008), Huttlin EL (2015), Huttlin EL (2017)	4
RPA1	0	EGFR	5	affinity chromatography technology	Marechal A (2014)	1
HOOK3	2	FAM160A2	3	affinity chromatography technology, affinity chromatography technology	Xu L (2008), Huttlin EL (2017)	2
TNFSF13B	0	AKTIP	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TERF1	1	UTP14A	0	two hybrid	Stelzl U (2005)	1
TSC1	4	AKT1	1	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Roux PP (2004), Dan HC (2002), Ivanov AA (2017)	3
AKTIP	3	TRIM23	3	two hybrid	Markson G (2009)	1
AKTIP	3	ASS1	0	two hybrid	Stelzl U (2005)	1
HOOK3	2	HOOK2	0	affinity chromatography technology, two hybrid, two hybrid	Xu L (2008), Xu L (2008), Xu L (2008)	3
AKTIP	3	NAB1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKTIP	3	DZIP3	6	two hybrid	Markson G (2009)	1
HOOK1	0	VPS16	6	affinity chromatography technology	Xu L (2008)	1
EGFR	5	IMMT	0	affinity chromatography technology	Tong J (2014)	1
AKTIP	3	MARCH5	0	two hybrid	Markson G (2009)	1
HDLBP	9	PRKDC	12	affinity chromatography technology	Wang Q (2005)	1
HOOK2	0	VPS41	3	affinity chromatography technology	Xu L (2008)	1
RPA1	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
AKTIP	3	FAM160A1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKTIP	3	TRIM41	6	two hybrid	Markson G (2009)	1
HOOK3	2	VPS41	3	affinity chromatography technology	Xu L (2008)	1
AKTIP	3	CEP126	0	two hybrid	Stelzl U (2005)	1
AKTIP	3	PDS5A	5	affinity chromatography technology	Ewing RM (2007)	1
AKTIP	3	PGGT1B	0	affinity chromatography technology	Huttlin EL (2015)	1
HOOK1	0	VPS41	3	affinity chromatography technology	Xu L (2008)	1
AKTIP	3	POLA2	2	two hybrid	Stelzl U (2005)	1
FAM160A2	3	HOOK1	0	affinity chromatography technology	Xu L (2008)	1
VPS18	4	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wartosch L (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017), Hunter MR (2017), Hunter MR (2017), Hunter MR (2017), Hunter MR (2017)	11
PRKDC	12	AKT1	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference	Feng J (2004), Feng J (2004), Feng J (2004), Dragoi AM (2005), Dragoi AM (2005), Dragoi AM (2005), Shen JP (2017)	7
AKT1	1	DCTN1	6	two hybrid	Vinayagam A (2011)	1
AKTIP	3	RPA1	0	two hybrid	Stelzl U (2005)	1
CTBP2	7	AKTIP	3	two hybrid	Rual JF (2005)	1
AKTIP	3	EGFR	5	affinity chromatography technology, affinity chromatography technology	Muthusami S (2015), Subramanian PD (2016)	2
AKTIP	3	IARS	5	affinity chromatography technology	Ewing RM (2007)	1
AKTIP	3	IMMT	0	two hybrid	Stelzl U (2005)	1
EGFR	5	TIMM50	4	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
HOOK1	0	HOOK3	2	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Huttlin EL (2017)	6
AKTIP	3	VPS18	4	affinity chromatography technology	Xu L (2008)	1
AKTIP	3	EXOC7	3	two hybrid	Stelzl U (2005)	1
TRIM35	1	AKTIP	3	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	AKTIP	3	affinity chromatography technology, pull down, pull down	Remy I (2004), Remy I (2004), Remy I (2004)	3
EGFR	5	IARS	5	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
AKTIP	3	TSC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AKTIP	3	HOOK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Huttlin EL (2015), Huttlin EL (2017)	8
AKTIP	3	DCTN1	6	affinity chromatography technology	Ewing RM (2007)	1
TERF1	1	ASS1	0	two hybrid	Lee OH (2011)	1
AKTIP	3	VPS16	6	affinity chromatography technology	Xu L (2008)	1
EGFR	5	TRIM23	3	affinity chromatography technology	Yao Z (2017)	1
HOOK2	0	AKTIP	3	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Xu L (2008), Huttlin EL (2015), Huttlin EL (2017)	8
AKTIP	3	TERF1	1	pull down, affinity chromatography technology	Burla R (2015), Burla R (2015)	2
TERF2	2	TERF1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Giannone RJ (2010), Ye JZ (2004), Ye JZ (2004)	3
VPS16	6	VPS41	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Hein MY (2015), van der Kant R (2015), van der Kant R (2015), Huttlin EL (2017)	6
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
PRKDC	12	RPA1	0	pull down, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Gong Z (2011), Marechal A (2014)	3
AKTIP	3	UTP14A	0	two hybrid	Stelzl U (2005)	1
EGFR	5	CTBP2	7	affinity chromatography technology	Tong J (2014)	1
EGFR	5	EXOC7	3	affinity chromatography technology	Foerster S (2013)	1
AKTIP	3	TERF2	2	pull down, affinity chromatography technology	Burla R (2015), Burla R (2015)	2
TNFSF13B	0	HOOK1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HOOK3	2	VPS16	6	affinity chromatography technology	Xu L (2008)	1
EGFR	5	PRKDC	12	affinity chromatography technology	Foerster S (2013)	1
HOOK1	0	VPS18	4	affinity chromatography technology	Xu L (2008)	1
VPS16	6	VPS18	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kim BY (2001), Kim BY (2001), Havugimana PC (2012), Wartosch L (2015), Wartosch L (2015), Wartosch L (2015), Hein MY (2015), Hein MY (2015), Graham SC (2013), van der Kant R (2015), van der Kant R (2015)	11
TERF1	1	PRKDC	12	affinity chromatography technology	Takai H (2007)	1
UTP14A	0	HOOK2	0	two hybrid	Rual JF (2005)	1
TNFSF13B	0	FAM160A2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2