PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NFKBIZ	5	NFKB1	2	affinity chromatography technology, two hybrid	Yamazaki S (2001), Wang J (2011)	2
STAT3	0	NFKB2	3	affinity chromatography technology, imaging technique	Nadiminty N (2006), Yu LJ (2015)	2
NFKB1	2	NFKB2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bouwmeester T (2004), Bouwmeester T (2004), Wang J (2011), Li X (2015)	4
RBM3	1	NFKBIZ	5	affinity chromatography technology	Zhu X (2016)	1
STAT3	0	NFKBIZ	5	two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid	Wu Z (2009), Wu Z (2009), Wu Z (2009), Wu Z (2009), Wang J (2011)	5
STAT3	0	NFKB1	2	affinity chromatography technology, pull down, imaging technique	Yu Z (2002), Yu Z (2002), Chen TC (2014)	3
NFKB2	3	NFKBIZ	5	two hybrid	Ravasi T (2010)	1