PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FKBPL	1	PLS1	1	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	CSNK1E	0	affinity chromatography technology	Kirli K (2015)	1
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
RBCK1	0	ESR1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Gustafsson Sheppard N (2012), Donley C (2013), Donley C (2013)	6
CSNK1D	3	ANKRD49	0	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	EDRF1	6	affinity chromatography technology	Gano JJ (2010)	1
HSP90AA1	7	USP19	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Gano JJ (2010), Lee JG (2014), Lee JG (2014), Lee JG (2014), He WT (2016), He WT (2016), He WT (2016)	7
FKBPL	1	BRAF	12	affinity chromatography technology	Huttlin EL (2017)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
RNF31	3	RBCK1	0	affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down	Haas TL (2009), Yagi H (2012), Yagi H (2012), Yagi H (2012), Nakamura M (2006), Tokunaga F (2012), Kirisako T (2006), Kirisako T (2006), Rivkin E (2013), Schaeffer V (2014), Tokunaga F (2011), Tokunaga F (2011), Chen Y (2015), Draber P (2015), Draber P (2015), Klein T (2015), Klein T (2015), Stieglitz B (2012), Huttlin EL (2017), Liu J (2017), Liu J (2017)	21
FKBPL	1	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CSNK1D	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
HSP90AA1	7	BRAF	12	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Eisenhardt AE (2016)	2
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
BRAF	12	CDC37	0	affinity chromatography technology, affinity chromatography technology	Gloeckner CJ (2007), Eisenhardt AE (2016)	2
ESR1	0	FKBPL	1	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
RNF31	3	ESR1	0	affinity chromatography technology, affinity chromatography technology	Zhu J (2014), Zhu J (2014)	2
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
FKBPL	1	UBC	7	affinity chromatography technology	Donley C (2013)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
XPO1	8	TUBA1B	0	affinity chromatography technology	Kirli K (2015)	1
ESR1	0	HSP90AB1	2	affinity chromatography technology	Dhamad AE (2016)	1
HSP90AB1	2	AHSA1	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Zurawska A (2010), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Wan C (2015), Wolfgeher D (2015), Synoradzki K (2015)	8
RBCK1	0	APP	1	pull down	Olah J (2011)	1
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
FKBPL	1	UNC119	4	two hybrid	Stelzl U (2005)	1
CDC37	0	USP19	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDKN1A	1	FKBPL	1	pull down, affinity chromatography technology, affinity chromatography technology	Jascur T (2005), Jascur T (2005), Jascur T (2005)	3
FKBPL	1	APP	1	pull down	Olah J (2011)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
HSP90AA1	7	AHSA1	0	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Panaretou B (2002), Panaretou B (2002), Panaretou B (2002), Mollapour M (2010), Tsutsumi S (2012), Tsutsumi S (2012), Gano JJ (2010), Zurawska A (2010), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Wan C (2015), Wolfgeher D (2015), Sun L (2012), Sun L (2012), Woodford MR (2016), Woodford MR (2016), Woodford MR (2016), Synoradzki K (2015)	19
FKBPL	1	TARS2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FKBPL	1	NADSYN1	3	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	ESR1	0	affinity chromatography technology	Castoria G (2012)	1
FKBPL	1	EDRF1	6	affinity chromatography technology	Huttlin EL (2017)	1
FKBPL	1	TUBA1B	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37	0	AHSA1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
XPO1	8	CSNK1D	3	affinity chromatography technology	Kirli K (2015)	1
FKBPL	1	CSNK1E	0	affinity chromatography technology	Huttlin EL (2017)	1
FKBPL	1	HSP90AB1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
FKBPL	1	RNF31	3	affinity chromatography technology	Huttlin EL (2017)	1
FKBPL	1	AHSA1	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
UBC	7	HSP90AB1	2	affinity chromatography technology	Bish RA (2007)	1
AHSA1	0	TARS2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDKN1A	1	UNC119	4	two hybrid	Vinayagam A (2011)	1
FKBPL	1	CTU1	1	affinity chromatography technology	Huttlin EL (2017)	1
CDKN1A	1	APP	1	pull down	Olah J (2011)	1
ANKRD49	0	CSNK1E	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK1E	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FKBPL	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jascur T (2005), Jascur T (2005), Donley C (2013), Donley C (2013), Taipale M (2014), Taipale M (2014)	6
HSP90AB1	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Cheng MB (2010), Gano JJ (2010), Skarra DV (2011), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Wan C (2015), Hein MY (2015)	8
FKBPL	1	ANKRD49	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Hart T (2015), Huttlin EL (2017)	4
XPO1	8	FKBPL	1	affinity chromatography technology	Kirli K (2015)	1
HSP90AB1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Erazo T (2013), Erazo T (2013), Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014), Hein MY (2015), Li J (2013), Karras GI (2017), Synoradzki K (2015)	10
CSNK1D	3	FKBPL	1	affinity chromatography technology	Huttlin EL (2017)	1
CDC37	0	FKBPL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
FKBPL	1	RBCK1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013), Donley C (2013), Huttlin EL (2017)	4
USP19	1	UBC	7	enzymatic study, pull down, pull down	Lee JG (2014), Zhang X (2017), Kwasna D (2018)	3
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
CSNK1E	0	CSNK1D	3	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2017)	2
BRAF	12	HSP90AB1	2	affinity chromatography technology	Gloeckner CJ (2007)	1
CALCOCO2	0	FKBPL	1	two hybrid	Rolland T (2014)	1
HSP90AA1	7	CDKN1A	1	affinity chromatography technology	Jascur T (2005)	1
ESR1	0	CDKN1A	1	pull down, pull down, pull down, affinity chromatography technology	Fritah A (2005), Maynadier M (2008), Maynadier M (2008), Kinyamu HK (2003)	4
AHSA1	0	APP	1	pull down	Olah J (2011)	1
CDC37	0	TUBA1B	0	affinity chromatography technology	Li J (2013)	1
RBCK1	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Donley C (2013), Donley C (2013)	2
CDC37	0	TARS2	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AB1	2	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1