PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EHMT2	4	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Bantscheff M (2011)	2
PRDM1	5	EHMT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gyory I (2004), Su ST (2009), Morgan MA (2012), Gyory I (2004)	4
HDAC1	4	PRDM1	5	affinity chromatography technology, affinity chromatography technology	Su ST (2009), Morgan MA (2012)	2
BMX	0	SRC	2	affinity chromatography technology	Tsai YT (2000)	1
IRF1	0	IRF2	7	pull down	Tooze RM (2006)	1
TLE1	6	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn JW (2009), Ahn JW (2009), Su L (2012), Su L (2012)	4
HDAC1	4	SENP1	0	affinity chromatography technology	Cheng J (2004)	1
PRDM1	5	HSPD1	0	affinity chromatography technology	Hung KH (2016)	1
PRDM1	5	HIST1H1A	0	enzymatic study	Gyory I (2004)	1
MS4A1	1	PRDM1	5	imaging technique	Wilkinson ST (2012)	1
IRF1	0	HSP90AA1	7	affinity chromatography technology	Gao B (2013)	1
PRDM1	5	UBE4A	2	affinity chromatography technology	Huttlin EL (2017)	1
KDM1A	2	GTF2I	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003)	3
PRMT5	3	PRDM1	5	affinity chromatography technology, affinity chromatography technology	Eckert D (2008), Morgan MA (2012)	2
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
PRDM1	5	IRF1	0	imaging technique	Barnes NA (2009)	1
PRDM1	5	IRF2	7	imaging technique, genetic interference	Barnes NA (2009), Ma Y (2017)	2
KDM1A	2	PRMT5	3	genetic interference	Wong AS (2016)	1
PRDM1	5	IKZF3	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hung KH (2016), Hung KH (2016), Hung KH (2016), Hung KH (2016)	4
HDAC1	4	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2002), Hakimi MA (2003), You A (2001), You A (2001), Shi YJ (2005), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Godmann M (2007), Terhune SS (2010), Godmann M (2010), Godmann M (2010), Wang Y (2009), Nicholson TB (2011), Li Q (2011), Cui S (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Wang Q (2016), Huttlin EL (2017)	26
PRDM1	5	DLG1	2	affinity chromatography technology	Huttlin EL (2017)	1
HSPD1	0	HSPA5	0	biochemical	Havugimana PC (2012)	1
SENP1	0	PRDM1	5	affinity chromatography technology	Shimshon L (2011)	1
ELAVL1	0	PRDM1	5	affinity chromatography technology	Abdelmohsen K (2009)	1
PRDM1	5	RRAS	2	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	HSPA5	0	affinity chromatography technology	Gano JJ (2010)	1
ZBTB32	0	PRDM1	5	affinity chromatography technology	Yoon HS (2012)	1
PRDM1	5	BMX	0	affinity chromatography technology	Huttlin EL (2017)	1
PRDM1	5	GTF2I	1	affinity chromatography technology	Hung KH (2016)	1
EHMT2	4	HIST2H3A	0	enzymatic study	Gyory I (2004)	1
PRDM1	5	PIAS1	4	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ying HY (2012), Ying HY (2012), Ying HY (2012)	3
HSP90AA1	7	PRDM1	5	affinity chromatography technology	Taipale M (2012)	1
HDAC1	4	GTF2I	1	affinity chromatography technology	Wen YD (2003)	1
ELAVL1	0	HDAC2	1	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	UBE4A	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PRDM1	5	DPYSL3	1	affinity chromatography technology	Huttlin EL (2017)	1
PRDM1	5	HSPA5	0	affinity chromatography technology	Hung KH (2016)	1
HSP90AA1	7	PRMT5	3	affinity chromatography technology	Maloney A (2007)	1
ATXN1	2	PRDM1	5	two hybrid	Lim J (2006)	1
HDAC2	1	KDM1A	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, genetic interference	Hakimi MA (2002), Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Tong JK (1998), Lee MG (2005), Humphrey GW (2001), Humphrey GW (2001), Zibetti C (2010), Wang Y (2009), Li Q (2011), Cui S (2011), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Wong AS (2016)	17
ELAVL1	0	SENP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC1	4	EHMT2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
IKZF3	1	HDAC2	1	affinity chromatography technology	Koipally J (2002)	1
PRDM1	5	PRDM1	5	affinity chromatography technology	Yoon HS (2012)	1
PRDM1	5	TLE1	6	pull down	Ren B (1999)	1
KDM1A	2	PRDM1	5	affinity chromatography technology, affinity chromatography technology, pull down	Su ST (2009), Su ST (2009), Su ST (2009)	3
ATXN1	2	ZBTB32	0	two hybrid	Lim J (2006)	1
HSP90AA1	7	IRF2	7	affinity chromatography technology	Taipale M (2012)	1
HDAC2	1	GTF2I	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hakimi MA (2003), Hakimi MA (2003), Hakimi MA (2003), Wen YD (2003)	4
PRDM1	5	HDAC2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu J (2000), Yu J (2000), Gyoery I (2003), Su ST (2009), Ying HY (2012), Morgan MA (2012)	6
TLE1	6	TLE2	4	pull down, pull down, two hybrid	Grbavec D (1998), Grbavec D (1998), Grbavec D (1998)	3
EHMT2	4	HIST1H1A	0	enzymatic study	Gyory I (2004)	1
HSP90AA1	7	BMX	0	affinity chromatography technology	Taipale M (2012)	1
PRDM1	5	SRC	2	affinity chromatography technology	Huttlin EL (2017)	1
HSPD1	0	HSPA9	2	biochemical	Havugimana PC (2012)	1
PRDM1	5	TLE2	4	pull down	Ren B (1999)	1
PRDM1	5	HSPA9	2	affinity chromatography technology	Hung KH (2016)	1
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
ATXN1	2	PIAS1	4	two hybrid	Suter B (2013)	1
PRMT7	0	PRDM1	5	affinity chromatography technology	Eckert D (2008)	1
HSP90AA1	7	HSPA9	2	affinity chromatography technology	Gano JJ (2010)	1
HDAC1	4	HSPD1	0	affinity chromatography technology, affinity chromatography technology	Johnson CA (2002), Hein MY (2015)	2
HDAC2	1	SENP1	0	affinity chromatography technology	Brandl A (2012)	1
PRDM1	5	HIST2H3A	0	enzymatic study	Gyory I (2004)	1
PRMT5	3	HDAC1	4	genetic interference	Wong AS (2016)	1