PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BIK	0	APP	1	pull down	Olah J (2011)	1
TANK	1	APP	1	pull down	Olah J (2011)	1
BCL2A1	0	BIK	0	unspecified method, two hybrid	Chen L (2005), Rolland T (2014)	2
BCL2L1	0	BIK	0	two hybrid, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method	Rual JF (2005), Chen L (2005), Chen L (2005), Gillissen B (2003), Gillissen B (2003), Jiang A (2001), Kuwana T (2005), Certo M (2006)	8
MCL1	1	BCL2L1	0	affinity chromatography technology	Bae J (2000)	1
BIK	0	NR2F2	4	two hybrid	Wang J (2011)	1
BCL2A1	0	APP	1	pull down	Olah J (2011)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
BIK	0	SOCS3	0	two hybrid	Wang J (2011)	1
BIK	0	CRKL	1	two hybrid	Wang J (2011)	1
MCL1	1	BIK	0	unspecified method, pull down, unspecified method	Chen L (2005), Warr MR (2011), Certo M (2006)	3
BCL2L2	0	BIK	0	affinity chromatography technology, two hybrid, unspecified method	Holmgreen SP (1999), Rolland T (2014), Certo M (2006)	3
BCL2	0	BIK	0	unspecified method, affinity chromatography technology, two hybrid, unspecified method	Chen L (2005), Gillissen B (2003), Li Y (1998), Certo M (2006)	4
CREB3	1	BCL2L1	0	two hybrid	Yu H (2011)	1
RHBDL3	0	BIK	0	affinity chromatography technology	Fleig L (2012)	1
BCL2L2	0	FATE1	0	two hybrid	Rolland T (2014)	1
BIK	0	TANK	1	two hybrid	Wang J (2011)	1
CREB3	1	BIK	0	two hybrid	Yu H (2011)	1
SOCS3	0	APP	1	pull down	Olah J (2011)	1
BIK	0	FATE1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2