PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
APC	5	C4A	0	two hybrid	Bandyopadhyay S (2010)	1
BCAR3	5	CCL5	1	two hybrid	Arroyo R (2015)	1
CCR3	1	CCL5	1	pull down, pull down	Daugherty BL (1996), Struyf S (2001)	2
CHEK2	2	CCL5	1	two hybrid	Arroyo R (2015)	1
KRAS	1	PTPN1	2	genetic interference	Luo J (2009)	1
CCL5	1	NTMT1	0	affinity chromatography technology	Huttlin EL (2017)	1
CCL5	1	TRIP6	2	two hybrid	Wang J (2011)	1
CCR3	1	CCL2	0	pull down	Daugherty BL (1996)	1
VCAN	9	CCL5	1	pull down	Hirose J (2001)	1
PALB2	3	CCL5	1	two hybrid	Arroyo R (2015)	1
CCL5	1	SPRYD4	0	affinity chromatography technology	Huttlin EL (2017)	1
TGFB1	2	CCL5	1	two hybrid	Arroyo R (2015)	1
CCL5	1	SDC1	0	affinity chromatography technology	Slimani H (2003)	1
CCL5	1	CCL2	0	genetic interference	Mellado M (2001)	1
PTPN1	2	CCL5	1	two hybrid	Arroyo R (2015)	1
BAG4	2	EDC4	4	affinity chromatography technology	Huttlin EL (2017)	1
CHEK2	2	FZR1	1	genetic interference	Srivas R (2016)	1
CCL5	1	AK4	2	affinity chromatography technology	Huttlin EL (2017)	1
CCL5	1	RELA	1	two hybrid	Wang J (2011)	1
CCL5	1	UBAC1	2	affinity chromatography technology	Huttlin EL (2017)	1
CCL5	1	CCR1	0	pull down, pull down	Struyf S (2001), Proudfoot AE (2001)	2
VCAN	9	CCL2	0	pull down	Hirose J (2001)	1
BAG4	2	CCL5	1	two hybrid	Arroyo R (2015)	1
WT1	1	CCL5	1	two hybrid	Arroyo R (2015)	1
CCR4	0	CCL5	1	pull down	Hoogewerf A (1996)	1
PTPN1	2	PHB	0	affinity chromatography technology	Hein MY (2015)	1
FZR1	1	CCL5	1	two hybrid	Arroyo R (2015)	1
CCL5	1	SPATA20	2	affinity chromatography technology	Huttlin EL (2017)	1
CCL5	1	CXCL8	0	pull down	Marshall LJ (2001)	1
CCL5	1	S100A13	0	affinity chromatography technology	Huttlin EL (2017)	1
CCL5	1	SLC2A5	0	two hybrid	Wang J (2011)	1
KRAS	1	CCL5	1	two hybrid	Arroyo R (2015)	1
CCL5	1	RANGAP1	4	two hybrid	Wang J (2011)	1
CCL5	1	CCR5	1	affinity chromatography technology, pull down, pull down	Slimani H (2003), Struyf S (2001), Proudfoot AE (2001)	3
CCL5	1	SDC4	0	affinity chromatography technology	Slimani H (2003)	1
CCL5	1	EDC4	4	two hybrid	Wang J (2011)	1
KRAS	1	PHB	0	affinity chromatography technology	Rajalingam K (2005)	1
CCL5	1	C4A	0	affinity chromatography technology	Huttlin EL (2017)	1
PHB	0	CCL5	1	two hybrid	Arroyo R (2015)	1
APC	5	CCL5	1	two hybrid	Arroyo R (2015)	1
ACKR2	3	CCL5	1	pull down	Nibbs RJ (1997)	1
CXCL8	0	SDC1	0	pull down	Marshall LJ (2003)	1
CCL5	1	GPD1L	0	affinity chromatography technology	Huttlin EL (2017)	1