Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
SCN9A 6335 PHENACEMIDE CHEMBL918 blocker ChemblInteractions
SCN9A 6335 LIDOCAINE CHEMBL79 blocker TdgClinicalTrial, ChemblInteractions, TEND
SCN9A 6335 MERETHOXYLLINE PROCAINE CHEMBL1200443 blocker ChemblInteractions
SCN9A 6335 ZONISAMIDE CHEMBL750 inhibitor, blocker TdgClinicalTrial, ChemblInteractions, DrugBank 19557119, 20025128, 20001433, 18433351, 14704463, 15511691, 19948168
SCN9A 6335 TETRODOTOXIN CHEMBL507974 channel blocker TdgClinicalTrial, GuideToPharmacologyInteractions
SCN9A 6335 ETHOTOIN CHEMBL1095 blocker ChemblInteractions
SCN9A 6335 DISOPYRAMIDE PHOSPHATE CHEMBL1201020 blocker ChemblInteractions
SCN9A 6335 DYCLONINE HYDROCHLORIDE CHEMBL1200478 blocker ChemblInteractions
SCN9A 6335 TOPIRAMATE CHEMBL220492 blocker ChemblInteractions
SCN9A 6335 PROCAINE HYDROCHLORIDE CHEMBL1200841 blocker ChemblInteractions
SCN9A 6335 FOSPHENYTOIN SODIUM CHEMBL919 blocker ChemblInteractions
SCN9A 6335 NW-3509 CHEMBL3545207 blocker ChemblInteractions
SCN9A 6335 PF-05089771 CHEMBL3545171 blocker ChemblInteractions
SCN9A 6335 TETRACAINE HYDROCHLORIDE CHEMBL1255654 blocker ChemblInteractions
SCN9A 6335 MEPIVACAINE HYDROCHLORIDE CHEMBL1200440 blocker ChemblInteractions
SCN9A 6335 SAFINAMIDE CHEMBL396778 TdgClinicalTrial
SCN9A 6335 PROPARACAINE HYDROCHLORIDE CHEMBL1200464 blocker ChemblInteractions
SCN9A 6335 QUINIDINE GLUCONATE CHEMBL1200437 blocker ChemblInteractions
SCN9A 6335 PRILOCAINE HYDROCHLORIDE CHEMBL1200586 blocker ChemblInteractions
SCN9A 6335 BENOXINATE HYDROCHLORIDE CHEMBL1200654 blocker ChemblInteractions
SCN9A 6335 ARTICAINE HYDROCHLORIDE CHEMBL1200819 blocker ChemblInteractions
SCN9A 6335 CHLOROPROCAINE HYDROCHLORIDE CHEMBL944 blocker ChemblInteractions
SCN9A 6335 LACOSAMIDE CHEMBL58323 blocker, channel blocker GuideToPharmacologyInteractions, ChemblInteractions, DrugBank
SCN9A 6335 VERATRIDINE CHEMBL439496 activator GuideToPharmacologyInteractions
SCN9A 6335 DRONEDARONE HYDROCHLORIDE CHEMBL1201729 blocker ChemblInteractions
SCN9A 6335 PRILOCAINE CHEMBL1194 blocker ChemblInteractions
SCN9A 6335 MORICIZINE HYDROCHLORIDE CHEMBL1200334 blocker ChemblInteractions
SCN9A 6335 PROPOXYCAINE HYDROCHLORIDE CHEMBL1769 blocker ChemblInteractions
SCN9A 6335 LAMOTRIGINE CHEMBL741 blocker ChemblInteractions
SCN9A 6335 LIDOCAINE HYDROCHLORIDE HYDRATE CHEMBL1200409 blocker ChemblInteractions
SCN9A 6335 TOCAINIDE HYDROCHLORIDE CHEMBL1200773 blocker ChemblInteractions
SCN9A 6335 XEN403 CHEMBL3545091 blocker ChemblInteractions
SCN9A 6335 NKTR-171 CHEMBL3545209 blocker ChemblInteractions
SCN9A 6335 RAXATRIGINE CHEMBL3544913 blocker ChemblInteractions
SCN9A 6335 NERISPIRDINE CHEMBL2107762 blocker ChemblInteractions
SCN9A 6335 ESLICARBAZEPINE CHEMBL315985 blocker ChemblInteractions
SCN9A 6335 PROCAINAMIDE HYDROCHLORIDE CHEMBL605 blocker ChemblInteractions
SCN9A 6335 FUNAPIDE CHEMBL3707218 TdgClinicalTrial
SCN9A 6335 PROPAFENONE HYDROCHLORIDE CHEMBL1201063 blocker ChemblInteractions
SCN9A 6335 PHENYTOIN CHEMBL16 blocker ChemblInteractions
SCN9A 6335 RG7893 CHEMBL3707353 blocker ChemblInteractions
SCN9A 6335 ORPHENADRINE CITRATE CHEMBL1200395 blocker ChemblInteractions
SCN9A 6335 RANOLAZINE CHEMBL1404 inhibitor, blocker TdgClinicalTrial, DrugBank, TTD 19077543, 11752352
SCN9A 6335 CHEMBL120768 CHEMBL120768 channel blocker GuideToPharmacologyInteractions
SCN9A 6335 PYRIMETHAMINE CHEMBL36 channel blocker GuideToPharmacologyInteractions
SCN9A 6335 MEXILETINE HYDROCHLORIDE CHEMBL1200606 blocker ChemblInteractions
SCN9A 6335 QUINIDINE SULFATE CHEMBL3707183 blocker ChemblInteractions
SCN9A 6335 OXCARBAZEPINE CHEMBL1068 blocker ChemblInteractions
SCN9A 6335 RG6029 CHEMBL3707380 blocker ChemblInteractions
SCN9A 6335 RALFINAMIDE CHEMBL2107771 blocker ChemblInteractions
SCN9A 6335 INDECAINIDE HYDROCHLORIDE CHEMBL1200341 blocker ChemblInteractions
SCN9A 6335 PHENAZOPYRIDINE HYDROCHLORIDE CHEMBL1201022 blocker ChemblInteractions
SCN9A 6335 ORPHENADRINE (CHLORIDE) CHEMBL1201023 blocker ChemblInteractions
SCN9A 6335 IRAMPANEL CHEMBL29741 blocker ChemblInteractions
SCN9A 6335 TETRACAINE CHEMBL698 blocker ChemblInteractions
SCN9A 6335 CARBAMAZEPINE CHEMBL108 blocker ChemblInteractions
SCN9A 6335 PHENYTOIN SODIUM CHEMBL1611 blocker ChemblInteractions
SCN9A 6335 ETIDOCAINE HYDROCHLORIDE CHEMBL1200597 blocker ChemblInteractions
SCN9A 6335 SAXITOXIN CHEMBL501134 channel blocker GuideToPharmacologyInteractions
SCN9A 6335 ESLICARBAZEPINE ACETATE CHEMBL87992 blocker ChemblInteractions
SCN9A 6335 QUINIDINE POLYGALACTURONATE CHEMBL1201486 blocker ChemblInteractions
SCN9A 6335 RILUZOLE CHEMBL744 blocker ChemblInteractions
SCN9A 6335 HEXYLCAINE HYDROCHLORIDE CHEMBL1200715 blocker ChemblInteractions
SCN9A 6335 PRIMIDONE CHEMBL856 blocker ChemblInteractions
SCN9A 6335 AZD3161 CHEMBL3545208 blocker ChemblInteractions
SCN9A 6335 DSP-2230 CHEMBL3545012 blocker ChemblInteractions
SCN9A 6335 MEPHENYTOIN CHEMBL861 blocker ChemblInteractions
SCN9A 6335 ROPIVACAINE HYDROCHLORIDE CHEMBL1889140 blocker ChemblInteractions
SCN9A 6335 RUFINAMIDE CHEMBL1201754 modulator, blocker ChemblInteractions, DrugBank 23221868

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
SCN9A rs6746030 AA + AG propofol other yes The AA and AG genotypes were associated with lower BIS values, indicating increased susceptibility to propofol compared to the GG genotypes (51.13±15.37 vs. 61.30±10.39). Please note: the authors examined 58 SNPs but did not do multiple testing corrections. Genotypes AA + AG are associated with increased response to propofol as compared to genotype GG. 28611364 1448639517
SCN9A rs6746030 A botulinum toxin type a efficacy no No significant difference in allele frequency between responders and non-responders. Allele A is not associated with response to botulinum toxin type a in women with Migraine NOS as compared to allele G. 31014225 1451104887