PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CRYAB	0	ALB	1	affinity chromatography technology	Rothbard JB (2011)	1
SCN5A	9	CALM1	0	two hybrid, unspecified method, x-ray crystallography, two hybrid	Tan HL (2002), Tan HL (2002), Chagot B (2011), Young KA (2005)	4
SCN5A	9	NEDD4	2	pull down, enzymatic study	van Bemmelen MX (2004), van Bemmelen MX (2004)	2
SCN5A	9	NEDD4L	3	affinity chromatography technology	Luo L (2017)	1
SCN5A	9	CRYAB	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Huang Y (2016), Huang Y (2016), Huang Y (2016), Huang Y (2016)	4
SCN5A	9	SNTB1	1	affinity chromatography technology	Gee SH (1998)	1
SCN5A	9	SNTA1	1	affinity chromatography technology, unspecified method	Gee SH (1998), Gee SH (1998)	2
SCN5A	9	WWP2	7	pull down	Rougier JS (2005)	1
NEDD4L	3	CRYAB	0	affinity chromatography technology, affinity chromatography technology	Huang Y (2016), Huang Y (2016)	2
CAV3	0	SCN5A	9	affinity chromatography technology	Vatta M (2006)	1
CAV3	0	NEDD4L	3	affinity chromatography technology, affinity chromatography technology	Guo J (2012), Guo J (2012)	2
CDK2	0	SCN5A	9	enzymatic study	Zhao R (2013)	1
SCN5A	9	SNTB2	4	affinity chromatography technology	Gee SH (1998)	1
GAN	4	SCN5A	9	affinity chromatography technology	Johnson-Kerner BL (2015)	1
ALB	1	SCN5A	9	affinity chromatography technology	Zhou M (2004)	1