PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ATXN1	2	CFL1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBPMS	0	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATXN1L	0	RBFOX2	5	two hybrid	Lim J (2006)	1
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
ATXN1L	0	YY1AP1	0	two hybrid	Lim J (2006)	1
RNF4	1	PML	7	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, protein complementation assay	Bruderer R (2011), Haekli M (2005), Percherancier Y (2009), Tatham MH (2008), Maroui MA (2012), Maroui MA (2012), Li YJ (2012), Kuo CY (2014), Kuo CY (2014), Weisshaar SR (2008), Sahin U (2014)	11
U2AF2	7	CFL1	0	affinity chromatography technology	Whisenant TC (2015)	1
ATXN1	2	TRIM32	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
STUB1	4	UBE2E1	1	pull down, pull down	Soss SE (2011), Parsons JL (2009)	2
UBQLN4	2	TRAF2	1	two hybrid	Lim J (2006)	1
ATXN1	2	ARID5A	4	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
STUB1	4	TRAF2	1	affinity chromatography technology	Jang KW (2011)	1
ATXN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
VCP	6	COIL	1	affinity chromatography technology	Yu CC (2013)	1
ATXN1	2	CPSF7	4	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
CLASRP	1	ATXN1L	0	affinity chromatography technology	Huttlin EL (2017)	1
ATXN1	2	DZIP3	6	two hybrid, affinity chromatography technology, enzymatic study	Lim J (2006), Yoon JH (2013), Yoon JH (2013)	3
UBQLN4	2	C1orf94	1	two hybrid	Lim J (2006)	1
ATXN1	2	USP7	14	two hybrid, affinity chromatography technology	Hong S (2002), Hong S (2002)	2
RBPMS	0	RBFOX2	5	two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Huttlin EL (2015), Huttlin EL (2017)	3
ATXN1L	0	RBPMS	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBPMS	0	ZC3H10	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DZIP3	6	HOTAIR	0	affinity chromatography technology, unspecified method	Yoon JH (2013), Yoon JH (2013)	2
ATXN1	2	KLHL12	4	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
U2AF2	7	VCP	6	affinity chromatography technology	Whisenant TC (2015)	1
RBFOX1	1	ATXN1	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
UBE2E1	1	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
CLASRP	1	ATXN2	3	affinity chromatography technology	Huttlin EL (2017)	1
U2AF2	7	RBFOX2	5	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
ATXN1	2	C1orf94	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
DAZAP2	1	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Venkatesan K (2009), Rolland T (2014)	3
RBFOX2	5	ATXN2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NUDT21	0	CPSF7	4	two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Wan C (2015), Hein MY (2015), Hein MY (2015)	5
ATXN1	2	YY1AP1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
CLASRP	1	RHOXF2	0	two hybrid	Rual JF (2005)	1
GAPDH	0	ATXN1	2	two hybrid, pull down	Koshy B (1996), Koshy B (1996)	2
DAZAP2	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZC3H10	1	DAZAP2	1	two hybrid	Venkatesan K (2009)	1
USP7	14	TRAF2	1	pull down	Zapata JM (2001)	1
ATXN1	2	FAM46A	2	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
DAZAP2	1	C1orf94	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DAZAP2	1	CLASRP	1	two hybrid	Rolland T (2014)	1
VCP	6	ATXN1	2	affinity chromatography technology, pull down	Fujita K (2013), Fujita K (2013)	2
U2AF2	7	CLASRP	1	affinity chromatography technology	Huttlin EL (2017)	1
DAZAP2	1	ARID5A	4	two hybrid	Rolland T (2014)	1
RBFOX1	1	RBFOX2	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
DAZAP2	1	RBFOX2	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
ATXN1L	0	ELP5	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	RBPMS	0	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
ATXN1	2	ATXN1	2	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Guo L (2014), Rolland T (2014)	3
ATXN1	2	NUDT21	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	DAZAP2	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	C1orf94	1	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
UBQLN4	2	TRIM32	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1L	0	HIVEP1	13	two hybrid	Lim J (2006)	1
ATXN1	2	FAM46B	2	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
VCP	6	RBFOX2	5	affinity chromatography technology	Yu CC (2013)	1
ATXN1	2	IST1	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	RBFOX2	5	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013), Rolland T (2014)	4
ATXN1	2	STUB1	4	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Al-Ramahi I (2006), Al-Ramahi I (2006), Choi JY (2007), Choi JY (2007)	4
STUB1	4	VCP	6	affinity chromatography technology, pull down	Vij N (2006), Liu S (2013)	2
PML	7	ATXN1	2	imaging technique, enzymatic study	Guo L (2014), Guo L (2014)	2
RBFOX1	1	RHOXF2	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Corominas R (2014)	3
ATXN1	2	HIVEP1	13	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	UBE2E1	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Kang AR (2015)	6
ATXN1	2	USP54	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	ATXN2	3	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
FAM46B	2	DAZAP2	1	two hybrid	Venkatesan K (2009)	1
RBFOX2	5	C1orf94	1	two hybrid	Rolland T (2014)	1
ARID5A	4	RHOXF2	0	two hybrid	Rolland T (2014)	1
ARID5A	4	RBPMS	0	two hybrid	Rolland T (2014)	1
ATXN1	2	CCNK	1	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
RBFOX1	1	ATXN2	3	two hybrid	Lim J (2006)	1
ATXN1L	0	COIL	1	two hybrid	Lim J (2006)	1
RHOXF2	0	FAM46B	2	two hybrid	Rual JF (2005)	1
ATXN1	2	CRK	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Suter B (2013)	3
ATXN1	2	ZC3H10	1	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
ATXN1L	0	ATXN1	2	two hybrid, affinity chromatography technology, two hybrid	Mizutani A (2005), Mizutani A (2005), Lim J (2006)	3
ATXN1	2	SIX5	2	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	CIC	9	two hybrid, two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006), Huttlin EL (2017)	3
ATXN1L	0	DAZAP2	1	two hybrid	Lim J (2006)	1
ATXN1	2	CLASRP	1	two hybrid, affinity chromatography technology	Lim J (2006), Huttlin EL (2017)	2
RBFOX2	5	RHOXF2	0	two hybrid	Rual JF (2005)	1
TRIM32	2	UBE2E1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Locke M (2009), Albor A (2006)	5
ATXN1	2	TRAF2	1	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
ATXN1	2	OTX2	3	two hybrid, two hybrid	Lim J (2006), Suter B (2013)	2
ATXN1	2	ELP5	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
UBE2E1	1	DZIP3	6	two hybrid	Markson G (2009)	1
CCNK	1	RBPMS	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ATXN1	2	U2AF2	7	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ATXN1	2	HOTAIR	0	affinity chromatography technology, unspecified method	Yoon JH (2013), Yoon JH (2013)	2
CFL1	0	GAPDH	0	biochemical	Wan C (2015)	1
ATXN1	2	UBQLN4	2	two hybrid, two hybrid	Davidson JD (2000), Lim J (2006)	2
RNF4	1	ATXN1	2	imaging technique, enzymatic study	Guo L (2014), Guo L (2014)	2
RBFOX1	1	DAZAP2	1	two hybrid	Corominas R (2014)	1
ATXN1	2	TBC1D5	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
USP7	14	PML	7	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Sivachandran N (2010), Sarkari F (2011), Sarkari F (2011), Hein MY (2015)	4
ZHX1	1	ATXN1	2	two hybrid, two hybrid, affinity chromatography technology	Yamada K (2003), Lim J (2006), Lim J (2006)	3
ATXN1	2	COIL	1	two hybrid, pull down, pull down, affinity chromatography technology, pull down, two hybrid	Hong S (2003), Hong S (2003), Hong S (2003), Hong S (2003), Hong S (2008), Lim J (2006)	6
ATXN1L	0	USP54	5	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
CCNK	1	RHOXF2	0	two hybrid	Rual JF (2005)	1
UBQLN4	2	DAZAP2	1	two hybrid	Lim J (2006)	1
USP7	14	UBE2E1	1	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Wheaton K (2017)	6