PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SALL2	2	WDR45	23	affinity chromatography technology	Huttlin EL (2017)	1
NANOG	0	SALL2	2	affinity chromatography technology	Oliviero G (2015)	1
SALL2	2	ATG2B	11	affinity chromatography technology	Huttlin EL (2017)	1
SOX2	4	RBBP7	1	affinity chromatography technology	Engelen E (2011)	1
LHX6	1	SALL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LHX6	1	CARD8	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
SALL2	2	ZMIZ2	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
SALL2	2	GFPT2	3	affinity chromatography technology	Huttlin EL (2017)	1
NCAPH2	4	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
SALL2	2	PTCD2	0	affinity chromatography technology	Huttlin EL (2017)	1
SALL2	2	CEP76	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
EWSR1	2	DDB1	6	bioid	Elzi DJ (2014)	1
CCNJL	3	SALL2	2	affinity chromatography technology	Huttlin EL (2015)	1
SALL2	2	TUBB3	3	affinity chromatography technology	Huttlin EL (2017)	1
POU5F1	0	SALL2	2	affinity chromatography technology	Oliviero G (2015)	1
RCCD1	2	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
SALL2	2	ADAMTSL4	6	two hybrid	Venkatesan K (2009)	1
SOX2	4	SALL2	2	affinity chromatography technology	Engelen E (2011)	1
RBBP7	1	DDB1	6	affinity chromatography technology	Mouysset J (2015)	1
DSN1	0	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
L3MBTL1	1	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL4A	2	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
NANOG	0	DDB1	6	affinity chromatography technology	Oliviero G (2015)	1
HPS1	1	SALL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC16	2	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
SALL2	2	CUL4A	2	pull down	Sung CK (2011)	1
NANOG	0	CUL4A	2	affinity chromatography technology	Oliviero G (2015)	1
POU5F1	0	TUBB3	3	affinity chromatography technology	Oliviero G (2015)	1
POU5F1	0	DDB1	6	affinity chromatography technology	Oliviero G (2015)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
LHX6	1	ATG2B	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IRF3	4	SALL2	2	affinity chromatography technology	Li X (2015)	1
LHX6	1	WDR45	23	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SALL2	2	ZMYM1	2	affinity chromatography technology	Huttlin EL (2017)	1
ASB3	0	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
CUL4B	8	EWSR1	2	affinity chromatography technology	Bennett EJ (2010)	1
POU5F1	0	NR2F2	4	affinity chromatography technology	Rosa A (2011)	1
EWSR1	2	IRF3	4	two hybrid	Ravasi T (2010)	1
PRMT2	3	SALL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
WDR45	23	ATG2B	11	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Huttlin EL (2017)	2
CUL4B	8	RBBP7	1	affinity chromatography technology	Mouysset J (2015)	1
SALL2	2	CUL4B	8	pull down	Sung CK (2011)	1
RFPL4B	0	SALL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL4A	2	RBBP7	1	affinity chromatography technology, affinity chromatography technology	He YJ (2006), Mouysset J (2015)	2
SALL2	2	NR2F2	4	affinity chromatography technology	Huttlin EL (2017)	1
DDB1	6	SALL2	2	affinity chromatography technology, affinity chromatography technology, pull down	Sung CK (2011), Sung CK (2011), Sung CK (2011)	3
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
NANOG	0	SOX2	4	affinity chromatography technology	Oliviero G (2015)	1
EWSR1	2	SALL2	2	two hybrid	Rual JF (2005)	1
PSME3	0	SALL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POU5F1	0	CUL4A	2	affinity chromatography technology	Oliviero G (2015)	1
CARD8	3	SALL2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TSHR	1	SALL2	2	affinity chromatography technology	Huttlin EL (2015)	1
ASB7	1	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
ZC3HC1	1	SALL2	2	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	SALL2	2	enzymatic study	Sung CK (2011)	1
SOX2	4	TUBB3	3	affinity chromatography technology	Cox JL (2013)	1
POU5F1	0	SOX2	4	pull down, affinity chromatography technology, affinity chromatography technology	Remenyi A (2003), Xu C (2013), Oliviero G (2015)	3