PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
C17orf105	0	S100A2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FKBP4	0	S100A2	0	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
S100A1	1	S100B	0	two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Rual JF (2005), Deloulme JC (2000), Deloulme JC (2000), Yang Q (1999), Rolland T (2014), Yu H (2011)	6
S100A2	0	S100B	0	two hybrid	Rolland T (2014)	1
FOXP2	13	S100A2	0	affinity chromatography technology	Huttlin EL (2017)	1
STUB1	4	S100A2	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Shimamoto S (2013), Shimamoto S (2013), Shimamoto S (2013)	3
MDM2	2	S100B	0	pull down	van Dieck J (2010)	1
ATF2	1	S100A2	0	affinity chromatography technology	Lau E (2012)	1
S100A2	0	HOPX	0	affinity chromatography technology	Buckley NE (2014)	1
FKBP4	0	S100A1	1	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
PPID	0	S100A1	1	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
S100A1	1	S100A2	0	two hybrid	Rolland T (2014)	1
MDM2	2	S100A2	0	pull down	van Dieck J (2010)	1
MDM2	2	S100A1	1	pull down	van Dieck J (2010)	1
GMCL1	0	S100A2	0	affinity chromatography technology	Huttlin EL (2017)	1
PPID	0	S100A2	0	pull down, affinity chromatography technology	Shimamoto S (2010), Shimamoto S (2010)	2
SINHCAF	0	S100A2	0	affinity chromatography technology	Huttlin EL (2017)	1
S100A2	0	S100A2	0	two hybrid, affinity chromatography technology, two hybrid, two hybrid	Rual JF (2005), Deshpande R (2000), Deshpande R (2000), Rolland T (2014)	4