PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NR1H4	0	RXRA	1	two hybrid, pull down, pull down, affinity chromatography technology	Seol W (1995), Seol W (1995), Kemper JK (2009), Kemper JK (2009)	4
AJUBA	2	RARA	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Hou Z (2010), Hou Z (2010), Hou Z (2010), Hou Z (2010)	4
RXRG	1	CAMK2B	9	two hybrid	Albers M (2005)	1
THRB	1	RXRG	1	two hybrid	Albers M (2005)	1
MPPED2	4	RXRG	1	two hybrid	Rolland T (2014)	1
RARG	2	NR2F6	1	two hybrid	Avram D (1999)	1
NR0B2	1	NR1H3	1	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Brendel C (2002), Brendel C (2002), Brendel C (2002), Brendel C (2002), Lee JH (2016), Lee JH (2016), Lee JH (2016)	7
NR4A1	4	RXRG	1	pull down	Wansa KD (2002)	1
PPARG	0	VDR	2	pull down, affinity chromatography technology	Alimirah F (2012), Alimirah F (2012)	2
MPPED2	4	NR2F6	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
VDR	2	RXRG	1	two hybrid, two hybrid	Ellison TI (2005), Albers M (2005)	2
NR1I2	5	RXRA	1	two hybrid, two hybrid, pull down	Albers M (2005), Rana R (2013), Doricakova A (2013)	3
ITGB3BP	0	RXRG	1	two hybrid, two hybrid	Li D (2001), Li D (2001)	2
AJUBA	2	RARG	2	affinity chromatography technology	Hou Z (2010)	1
RARG	2	NR0B2	1	two hybrid	Albers M (2005)	1
RXRG	1	RXRA	1	affinity chromatography technology	Huttlin EL (2017)	1
RXRG	1	PPARA	1	two hybrid, affinity chromatography technology	Stelzl U (2005), Nickkho-Amiry M (2012)	2
RXRG	1	NR2F6	1	affinity chromatography technology	Huttlin EL (2017)	1
PPARD	4	NR0B2	1	two hybrid	Albers M (2005)	1
PPARA	1	RXRA	1	pull down, pull down, pull down, affinity chromatography technology, pull down	Gorla-Bajszczak A (1999), Tang C (2003), Tachibana K (2013), Nickkho-Amiry M (2012), Molnar F (2005)	5
PPARG	0	NCOR2	12	imaging technique, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, two hybrid, pull down, unspecified method	Guan HP (2005), Guan HP (2005), Albers M (2005), Lefebvre B (2010), Song K (2013), Lee G (2002), Carmona MC (2007), Tagami T (2009), Jeninga EH (2007), Koppen A (2009)	10
RARA	5	RXRG	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Albers M (2005), Wang J (2011), Rolland T (2014), Yu H (2011)	5
RARG	2	RARA	5	affinity chromatography technology	Huttlin EL (2017)	1
VDR	2	NR1H2	2	two hybrid	Albers M (2005)	1
VDR	2	RXRA	1	pull down, two hybrid, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique, imaging technique, pull down, pull down, pull down, pull down, pull down, two hybrid, pull down, two hybrid, pull down, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, imaging technique, two hybrid, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Baudino TA (1998), Baudino TA (1998), Zhang C (2001), Song CS (2006), Dunlop TW (2005), Ting HJ (2005), Kim S (2005), Kim S (2005), Solomon C (2001), Liu YY (2000), Liu YY (2000), Rachez C (2000), Jimenez-Lara AM (1999), Yanagisawa J (1999), Yanagisawa J (1999), Yanagisawa J (1999), Ismail A (2004), Carvallo L (2008), Peleg S (2010), Albers M (2005), Herdick M (2000), Pedigo NG (2005), Hsieh JC (2003), Sorg BL (2006), Seuter S (2007), Seuter S (2007), Wang J (2011), Bartik L (2010), Rochel N (2011), Molnar F (2005), Ahmad K (2015), Ahmad K (2015)	32
NR1H4	0	NCOR2	12	pull down	Johnson DR (2006)	1
NR0B2	1	RXRA	1	two hybrid, pull down, two hybrid	Lee YK (2000), Brendel C (2002), Wang J (2011)	3
NR1H4	0	RXRG	1	two hybrid	Albers M (2005)	1
NR4A1	4	RXRA	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, genetic interference, two hybrid, pull down	Lin B (2004), Lin B (2004), Zhao WX (2007), Zhao WX (2007), Zhao WX (2007), Perlmann T (1995), Perlmann T (1995)	7
THRB	1	RXRA	1	pull down, pull down, two hybrid, far western blotting, two hybrid, pull down, pull down, pull down, imaging technique	Monden T (1997), Jeyakumar M (1997), Tagami T (2009), Li H (1997), Albers M (2005), White DM (1997), Garcia-Fernandez LF (1998), Liao CS (2009), Liao CS (2009)	9
NCOR2	12	RXRA	1	two hybrid, pull down, two hybrid, two hybrid	Tagami T (1998), Mouchon A (1999), Li H (1997), Albers M (2005)	4
NCOR2	12	NR1H2	2	two hybrid, two hybrid, pull down	Albers M (2005), Albers M (2005), Johnson DR (2006)	3
HOXD4	2	RXRG	1	two hybrid	Ravasi T (2010)	1
SRF	1	NCOR2	12	two hybrid, two hybrid, pull down, pull down	Lee SK (2000), Lee SK (2000), Lee SK (2000), Lee SK (2000)	4
RARG	2	RXRA	1	two hybrid	Albers M (2005)	1
VDR	2	NR0B2	1	two hybrid	Albers M (2005)	1
PPARG	0	NR0B2	1	affinity chromatography technology, pull down, unspecified method	Nishizawa H (2002), Nishizawa H (2002), Koppen A (2009)	3
PPARA	1	NR1H3	1	pull down	Miyata KS (1996)	1
NR0B2	1	NR1I2	5	two hybrid, pull down	Li T (2006), Li T (2006)	2
RXRA	1	NR1H3	1	pull down, two hybrid	Miyata KS (1996), Albers M (2005)	2
PPARA	1	NCOR2	12	x-ray crystallography, affinity chromatography technology	Xu HE (2002), Pourcet B (2010)	2
NR1H2	2	RXRA	1	two hybrid, pull down, two hybrid	Seol W (1995), Seol W (1995), Albers M (2005)	3
NR0B2	1	NR1H2	2	pull down, affinity chromatography technology	Brendel C (2002), Lee JH (2016)	2
NR1I2	5	RXRG	1	two hybrid	Albers M (2005)	1
PPARD	4	RXRG	1	two hybrid, affinity chromatography technology	Albers M (2005), Nickkho-Amiry M (2012)	2
RXRG	1	MAP4	8	two hybrid	Albers M (2005)	1
NCOR2	12	NR1I2	5	pull down, pull down, two hybrid, two hybrid	Mani S (2005), Johnson DR (2006), Johnson DR (2006), Takeshita A (2002)	4
RXRA	1	NR2F6	1	two hybrid	Avram D (1999)	1
NCOR2	12	VDR	2	pull down, two hybrid	Puccetti E (2002), Tagami T (1998)	2
CUL1	7	RXRG	1	affinity chromatography technology	Bennett EJ (2010)	1
PPARG	0	RXRG	1	affinity chromatography technology	Nickkho-Amiry M (2012)	1
PPARD	4	RXRA	1	two hybrid, affinity chromatography technology, pull down, two hybrid	Albers M (2005), Nickkho-Amiry M (2012), Molnar F (2005), Gustafsson MC (2009)	4
NR1H3	1	RXRG	1	two hybrid, two hybrid, two hybrid	Albers M (2005), Rolland T (2014), Yu H (2011)	3
RARB	2	RXRA	1	x-ray crystallography	Pogenberg V (2005)	1
RXRG	1	SRF	1	pull down, two hybrid	Kim SW (2001), Kim SW (2001)	2
NCOR2	12	RARB	2	two hybrid	Albers M (2005)	1
NR0B2	1	RARA	5	pull down, two hybrid, pull down	Seol W (1996), Seol W (1998), Seol W (1998)	3
NCOR2	12	RXRG	1	two hybrid	Albers M (2005)	1
PPARG	0	NR4A1	4	unspecified method	Lee G (2002)	1
RPAP2	3	RXRG	1	affinity chromatography technology	Jeronimo C (2007)	1
AJUBA	2	RXRG	1	affinity chromatography technology	Hou Z (2010)	1
THRB	1	CAMK2B	9	two hybrid	Albers M (2005)	1
NCOR2	12	RARA	5	affinity chromatography technology, pull down, pull down, far western blotting, two hybrid, pull down, two hybrid, pull down, pull down	Dong S (2002), Hong SH (1997), Mouchon A (1999), Li H (1997), Li H (1997), Reineke EL (2007), Albers M (2005), Dhordain P (1997), Johnson DR (2006)	9
THRB	1	NCOR2	12	pull down, two hybrid, two hybrid, two hybrid, far western blotting, affinity chromatography technology	Liu Y (1998), Tagami T (1998), Ando S (2001), Tagami T (2009), Li H (1997), Jeyakumar M (2007)	6
RARA	5	SRF	1	two hybrid, pull down	Kim SW (2001), Kim SW (2001)	2
NCOR2	12	NR4A1	4	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sohn YC (2001), Sohn YC (2001), Sohn YC (2001), Kelly SN (2005)	4
ITGB3BP	0	RXRA	1	pull down, two hybrid	Li D (1999), Li D (1999)	2
RARA	5	RARB	2	affinity chromatography technology	Huttlin EL (2017)	1
RXRG	1	CEBPZ	4	two hybrid	Ravasi T (2010)	1
NR1H2	2	RXRG	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Albers M (2005), Vinayagam A (2011), Rolland T (2014), Huttlin EL (2017)	4
DCK	0	RXRG	1	two hybrid	Vinayagam A (2011)	1
NR2F6	1	THRB	1	pull down, two hybrid, affinity chromatography technology	Zhu XG (2000), Zhu XG (2000), Zhu XG (2000)	3
NCOR2	12	RARG	2	two hybrid	Albers M (2005)	1
RXRA	1	PPARG	0	biochemical, pull down, x-ray crystallography, pull down, pull down, pull down, imaging technique, pull down, pull down, pull down, pull down, x-ray crystallography, affinity chromatography technology, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tontonoz P (1994), Berger J (2000), Gampe RT (2000), Tontonoz P (1998), Billiet L (2008), Tachibana K (2013), Song K (2013), Mukherjee R (1997), Lee G (2002), Li S (2013), Bernardes A (2012), Bernardes A (2012), Nickkho-Amiry M (2012), Jurkowski W (2011), Gupta RA (2003), Rochel N (2011), Rochel N (2011), Malerod L (2003), Chen F (2003), Chen F (2003), Tagami T (2009), Chandra V (2008), Lu J (2008), Molnar F (2005), Jeninga EH (2007), Ray DM (2008), Ray DM (2008), DiRenzo J (1997), Li X (2015), Park S (2015)	30
NR0B2	1	RXRG	1	pull down	Seol W (1996)	1
RARB	2	RXRG	1	two hybrid, two hybrid, two hybrid	Ravasi T (2010), Albers M (2005), Rolland T (2014)	3
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
PPARD	4	NCOR2	12	two hybrid, affinity chromatography technology, pull down	Shi Y (2002), Shi Y (2002), Lim HJ (2004)	3
RARA	5	NR1H2	2	two hybrid	Albers M (2005)	1
RXRA	1	SRF	1	two hybrid	Kim SW (2001)	1
RARG	2	RXRG	1	two hybrid	Albers M (2005)	1