PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NR4A2	6	RXRB	0	two hybrid	Albers M (2005)	1
NCOA1	6	RARB	2	pull down, two hybrid, pull down	Takeshita A (1996), Albers M (2005), Flajollet S (2007)	3
NR3C1	2	NRIP1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid, pull down	Tazawa H (2003), Tazawa H (2003), Zilliacus J (2001), Zilliacus J (2001), Subramaniam N (1999), Windahl SH (1999), Windahl SH (1999)	7
CDC5L	2	RXRB	0	affinity chromatography technology	Lleres D (2010)	1
RXRB	0	GRK2	4	affinity chromatography technology	Hein MY (2015)	1
RXRB	0	MCAT	0	affinity chromatography technology	Hein MY (2015)	1
RARB	2	RXRB	0	two hybrid, two hybrid	Albers M (2005), Rolland T (2014)	2
PPARG	0	VDR	2	pull down, affinity chromatography technology	Alimirah F (2012), Alimirah F (2012)	2
NR1H3	1	NR3C1	2	two hybrid	Nader N (2012)	1
RXRB	0	CDC42BPB	16	affinity chromatography technology	Hein MY (2015)	1
NR1H2	2	NCOA1	6	two hybrid	Albers M (2005)	1
RXRB	0	MRPS10	1	affinity chromatography technology	Hein MY (2015)	1
PPARD	4	NCOA1	6	two hybrid, pull down, pull down, pull down	Albers M (2005), Molnar F (2005), Cho MC (2006), Lim HJ (2004)	4
RARG	2	NCOA1	6	two hybrid, pull down	Albers M (2005), Flajollet S (2007)	2
NR1I2	5	RXRB	0	two hybrid, affinity chromatography technology	Albers M (2005), Elias A (2013)	2
NR1H3	1	NRIP1	4	two hybrid	Albers M (2005)	1
PPARA	1	NCOA1	6	two hybrid, pull down, two hybrid, pull down, fluorescent resonance energy transfe	Dowell P (1997), Treuter E (1998), Needham M (2000), Molnar F (2005), Mukherjee R (2002)	5
PPARG	0	FLYWCH2	0	affinity chromatography technology	Huttlin EL (2017)	1
NCOA1	6	NR4A2	6	affinity chromatography technology	Holla VR (2011)	1
NRIP1	4	NR1H2	2	two hybrid	Albers M (2005)	1
RARG	2	RARA	5	affinity chromatography technology	Huttlin EL (2017)	1
AKAP13	11	PPARA	1	pull down	Rubino D (1998)	1
NR2C2	0	RXRB	0	two hybrid	Albers M (2005)	1
VDR	2	NR1H2	2	two hybrid	Albers M (2005)	1
RXRB	0	NR1H2	2	pull down, two hybrid, two hybrid	Feltkamp D (1999), Albers M (2005), Albers M (2005)	3
PPARG	0	NR4A2	6	unspecified method	Lee G (2002)	1
RXRB	0	PPARG	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Albers M (2005), Nickkho-Amiry M (2012), Li X (2015)	3
PPARA	1	RXRB	0	affinity chromatography technology	Nickkho-Amiry M (2012)	1
NR1H4	0	RXRB	0	affinity chromatography technology	Huttlin EL (2017)	1
RARG	2	RXRB	0	two hybrid, affinity chromatography technology	Albers M (2005), Huttlin EL (2017)	2
NR1H4	0	NCOA1	6	two hybrid, pull down	Bramlett KS (2000), Cai SY (2010)	2
THRB	1	NCOA1	6	pull down, genetic interference, pull down, unspecified method, two hybrid, two hybrid, pull down, pull down	Liu Y (1998), Jeyakumar M (1997), Jeyakumar M (1997), Jeyakumar M (1997), Albers M (2005), Chan CM (2013), Kim HJ (1999), DiRenzo J (1997)	8
RXRB	0	TXLNA	3	affinity chromatography technology	Hein MY (2015)	1
RXRB	0	GTF2H1	0	pull down, two hybrid	Liu Y (2005), Liu Y (2005)	2
RXRB	0	PTMS	2	pull down	Miyamoto-Sato E (2010)	1
RXRB	0	WRAP53	1	affinity chromatography technology	Hein MY (2015)	1
PPARA	1	NR1H3	1	pull down	Miyata KS (1996)	1
NR3C1	2	NCOA1	6	pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, bioid	Zilliacus J (2001), Kucera T (2002), Windahl SH (1999), Fryer CJ (1998), Needham M (2000), Li G (2006), Lempiaeinen JK (2017)	7
RXRB	0	ZDHHC12	0	two hybrid	Wang J (2011)	1
RARA	5	NCOA1	6	pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Llopis J (2000), Llopis J (2000), Llopis J (2000), Mouchon A (1999), Torchia J (1997), Reineke EL (2007), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Cai SY (2010), DiRenzo J (1997)	11
PPARG	0	NCOA1	6	fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid, pull down, x-ray crystallography, unspecified method, pull down, two hybrid, pull down, two hybrid, pull down, two hybrid, pull down, unspecified method	Iannone MA (2001), Yang W (2000), Feige JN (2007), DiRenzo J (1997), Needham M (2000), Heinlein CA (1999), Qin C (2004), Chan CM (2013), Chou WL (2007), Nolte RT (1998), Lee G (2002), Agostini M (2006), Waku T (2010), Waku T (2010), Carmona MC (2007), Molnar F (2005), Chintharlapalli S (2007), Jeninga EH (2007), Koppen A (2009)	19
RARA	5	RXRB	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Albers M (2005), Wang J (2011), Huttlin EL (2017)	4
FLYWCH2	0	RXRB	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
THRB	1	NRIP1	4	two hybrid	Albers M (2005)	1
RXRB	0	AFF4	2	affinity chromatography technology	Hein MY (2015)	1
RXRB	0	CACNA1B	8	pull down	Miyamoto-Sato E (2010)	1
PPARA	1	NRIP1	4	pull down	Treuter E (1998)	1
RXRB	0	CCNK	1	affinity chromatography technology	Hein MY (2015)	1
NR3C1	2	RXRB	0	two hybrid	Ravasi T (2010)	1
PTMS	2	NR3C1	2	affinity chromatography technology, affinity chromatography technology	Okamoto K (2005), Okamoto K (2005)	2
RXRB	0	NCOA1	6	two hybrid	Albers M (2005)	1
PPARD	4	RXRB	0	two hybrid, affinity chromatography technology	Albers M (2005), Nickkho-Amiry M (2012)	2
AKAP13	11	RXRB	0	pull down	Rubino D (1998)	1
THRB	1	RXRB	0	two hybrid	Albers M (2005)	1
PPARG	0	NRIP1	4	pull down, fluorescent resonance energy transfe, unspecified method, unspecified method	Treuter E (1998), Iannone MA (2001), Lee G (2002), Koppen A (2009)	4
VDR	2	RXRB	0	two hybrid, two hybrid	Albers M (2005), Wang J (2011)	2
RXRB	0	POLR3F	1	affinity chromatography technology	Hein MY (2015)	1
NR1H3	1	NCOA1	6	two hybrid	Albers M (2005)	1
RARA	5	RARB	2	affinity chromatography technology	Huttlin EL (2017)	1
NR3C1	2	PPARG	0	affinity chromatography technology	Nie M (2005)	1
RXRB	0	C2CD5	0	affinity chromatography technology	Hein MY (2015)	1
RXRB	0	MAP4	8	two hybrid	Albers M (2005)	1
RXRB	0	NRIP1	4	pull down	Treuter E (1998)	1
VDR	2	NRIP1	4	two hybrid	Albers M (2005)	1
NR1I2	5	NCOA1	6	x-ray crystallography, two hybrid, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Watkins RE (2003), Rana R (2013), Takeshita A (2002), Pondugula SR (2009), Albers M (2005), Lim YP (2007), Lim YP (2007), Wang H (2008), Li T (2006), Li T (2006), Li T (2005)	11
RARA	5	NR1H2	2	two hybrid	Albers M (2005)	1
VDR	2	NCOA1	6	pull down, pull down, pull down, pull down, pull down, two hybrid, two hybrid, pull down, two hybrid, pull down	Solomon C (2001), Liu YY (2000), Jimenez-Lara AM (1999), Carvallo L (2008), Herdick M (2000), Chan CM (2013), Albers M (2005), Yamamoto H (2003), Yamamoto H (2003), DiRenzo J (1997)	10
RARA	5	NRIP1	4	affinity chromatography technology, pull down, pull down, pull down, pull down, two hybrid	Hu X (2004), Farooqui M (2003), LHorset F (1996), Zechel C (2002), Mouchon A (1999), Rolland T (2014)	6
NR1H3	1	RXRB	0	two hybrid, two hybrid, two hybrid	Albers M (2005), Albers M (2005), Rolland T (2014)	3
RXRB	0	SPOP	1	two hybrid, two hybrid	Rual JF (2005), Wang J (2011)	2