Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
RXRA 6256 ACITRETIN CHEMBL1131 agonist ChemblInteractions, DrugBank 9074840, 9153406
RXRA 6256 CHEMBL1204498 CHEMBL1204498 DrugBank 10592235
RXRA 6256 CHEMBL332486 CHEMBL332486 antagonist GuideToPharmacologyInteractions
RXRA 6256 SDX-101 CHEMBL1716091 modulator TdgClinicalTrial, ChemblInteractions
RXRA 6256 IRX-4204 CHEMBL75133 agonist ChemblInteractions
RXRA 6256 BEXAROTENE CHEMBL1023 agonist, activator TALC, TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 18765556, 11702369, 17483357, 15056048, 14700480, 15632250, 16495926, 17008586, 15897247
RXRA 6256 ALITRETINOIN CHEMBL705 agonist GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 16946489, 16819260, 19678713, 16751185, 16428452, 16782282, 18321241
RXRA 6256 CHEMBL486954 CHEMBL486954 DrugBank 10592235
RXRA 6256 TRIBUTYLSTANNANYL CHEMBL1236208 DrugBank 10592235
RXRA 6256 CHEMBL288436 CHEMBL288436 agonist GuideToPharmacologyInteractions
RXRA 6256 MOFAROTENE CHEMBL146506 modulator ChemblInteractions
RXRA 6256 CLOTIAZEPAM CHEMBL1697737 agonist GuideToPharmacologyInteractions
RXRA 6256 ETRETINATE CHEMBL464 agonist ChemblInteractions, DrugBank 9074840, 8301142, 9298126
RXRA 6256 CHEMBL375270 CHEMBL375270 DrugBank 10592235
RXRA 6256 CHEMBL189938 CHEMBL189938 DrugBank 10592235
RXRA 6256 ADAPALENE CHEMBL1265 TdgClinicalTrial, TEND, DrugBank 8142113, 10651997
RXRA 6256 ETODOLAC CHEMBL622 other DrugBank 15699354

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
RXRA rs1805343 A rosuvastatin metabolism/PK yes Table 2 lists this is C reference allele (lower exposure) and A variant allele (higher exposure). Allele A is associated with increased exposure to rosuvastatin in healthy individuals. 30100615 1449733142
RXRA rs3132291 A docetaxel metabolism/PK yes as part of haplotype "AG" comprising 4458G>A(rs3132291) and 4988A>G(rs4842198). The AG haplotype was associated with decreased Cmax, AUC(0-infinity), and increased clearance as compared to the GA haplotype. Patients carrying the AG/AG diplotype also had a 20% lower Cmax and AUC 0-infinity and a 21% increased clearance as compared to those who carried one or no copies. Allele A is associated with increased metabolism of docetaxel in people with Nasopharyngeal Neoplasms as compared to allele G. 24193570 1451097080