PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DCTN1	6	PAFAH1B1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Tai CY (2002), Faulkner NE (2000), Faulkner NE (2000), Gupta GD (2015), Boldt K (2016)	5
TUBA1A	13	TUBB	3	biochemical, biochemical, pull down	Havugimana PC (2012), Kristensen AR (2012), Wang W (2014)	3
BRCA1	7	TUBB	3	affinity chromatography technology, affinity chromatography technology	Lotti LV (2002), Ertych N (2016)	2
NANOG	0	CLIP1	2	affinity chromatography technology	Oliviero G (2015)	1
PCGF1	1	DPPA4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015), Oliviero G (2015)	5
DYNC1H1	41	CLIP1	2	affinity chromatography technology	Hein MY (2015)	1
MAPRE1	0	DYNC1H1	41	affinity chromatography technology	Hein MY (2015)	1
CLIP1	2	RAC1	7	affinity chromatography technology	Fukata M (2002)	1
TUBA1A	13	MAPRE1	0	pull down	Ligon LA (2006)	1
TUBA1A	13	CLIP1	2	pull down	Ligon LA (2006)	1
PSMC2	2	CLIP1	2	biochemical	Kristensen AR (2012)	1
POU5F1	0	PCGF1	1	affinity chromatography technology	Oliviero G (2015)	1
CLIP1	2	GPS1	1	biochemical	Wan C (2015)	1
ZNF598	6	TUBB	3	affinity chromatography technology	Garzia A (2017)	1
MAEA	3	CLIP1	2	biochemical	Kristensen AR (2012)	1
MAPRE1	0	PAFAH1B1	3	biochemical, affinity chromatography technology	Kristensen AR (2012), Boldt K (2016)	2
ZNF598	6	CHD4	22	affinity chromatography technology	Garzia A (2017)	1
BUB3	0	CLIP1	2	biochemical	Kristensen AR (2012)	1
POU5F1	0	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hawkins PG (2010), Oliviero G (2015)	2
PCGF1	1	CLIP1	2	affinity chromatography technology	Oliviero G (2015)	1
CLIP1	2	CDC42	3	affinity chromatography technology	Fukata M (2002)	1
HDAC6	0	BIN1	2	affinity chromatography technology	Watson GW (2016)	1
CADPS	3	CLIP1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC6	0	CLIP1	2	affinity chromatography technology, affinity chromatography technology	Li D (2014), Li D (2014)	2
POU5F1	0	DPPA4	0	affinity chromatography technology	Oliviero G (2015)	1
DPPA4	0	CLIP1	2	affinity chromatography technology	Oliviero G (2015)	1
TUBB	3	CLIP1	2	pull down	Ligon LA (2006)	1
BIN1	2	CLIP1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Meunier B (2009), Meunier B (2009), Meunier B (2009), DAlessandro M (2015), DAlessandro M (2015), DAlessandro M (2015)	6
IQGAP1	1	CLIP1	2	affinity chromatography technology, pull down	Fukata M (2002), Fukata M (2002)	2
BMP1	5	MAEA	3	affinity chromatography technology	Huttlin EL (2017)	1
ZNF598	6	CLIP1	2	affinity chromatography technology	Garzia A (2017)	1
DCTN1	6	MAPRE1	0	bioid, affinity chromatography technology, affinity chromatography technology	Gupta GD (2015), Hein MY (2015), Boldt K (2016)	3
HDAC6	0	DYNC1H1	41	affinity chromatography technology	Banerjee I (2014)	1
DCTN1	6	DYNC1H1	41	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, bioid, affinity chromatography technology	Payne C (2003), Havugimana PC (2012), Splinter D (2012), Wan C (2015), Gupta GD (2015), Hein MY (2015)	6
BRCA1	7	IQGAP1	1	affinity chromatography technology	Ertych N (2016)	1
PAFAH1B1	3	CLIP1	2	two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Coquelle FM (2002), Coquelle FM (2002), Coquelle FM (2002), Caspi M (2003), Caspi M (2003), Caspi M (2003)	6
CALM1	0	BIN1	2	affinity chromatography technology	Myers MD (2016)	1
ZNF598	6	DCTN1	6	affinity chromatography technology	Garzia A (2017)	1
PCGF1	1	NANOG	0	biochemical, affinity chromatography technology	Oliviero G (2015), Oliviero G (2015)	2
RAC1	7	CALM1	0	affinity chromatography technology	Boldt K (2016)	1
NANOG	0	TUBB	3	affinity chromatography technology	Oliviero G (2015)	1
MAPRE1	0	TUBB	3	pull down, pull down	Kanaba T (2012), Ligon LA (2006)	2
NANOG	0	TUBA1A	13	affinity chromatography technology	Oliviero G (2015)	1
HDAC6	0	TUBB	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhao Z (2010), Zhao Z (2010), New M (2013), Watson GW (2016)	4
PSMC2	2	TUBB	3	biochemical	Havugimana PC (2012)	1
BRCA1	7	DYNC1H1	41	two hybrid	Woods NT (2012)	1
TSC22D2	2	CLIP1	2	two hybrid	Li Q (2016)	1
GORASP1	1	CLIP1	2	affinity chromatography technology	Huttlin EL (2017)	1
PAFAH1B1	3	DYNC1H1	41	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Tai CY (2002), Tai CY (2002), Tai CY (2002), Ding C (2009), Yamada M (2008), Caspi M (2003), Wan C (2015), Hein MY (2015), Boldt K (2016)	9
BMP1	5	CLIP1	2	affinity chromatography technology	Huttlin EL (2017)	1
POU5F1	0	CLIP1	2	affinity chromatography technology	Oliviero G (2015)	1
AMOT	6	CLIP1	2	bioid	Couzens AL (2013)	1
POU5F1	0	TUBB	3	affinity chromatography technology	Oliviero G (2015)	1
CALM1	0	IQGAP1	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li Z (2003), Briggs MW (2002), Ren JG (2008), Hein MY (2015), Boldt K (2016)	5
BRCA1	7	PSMC2	2	affinity chromatography technology	Ertych N (2016)	1
TUBA1A	13	PAFAH1B1	3	pull down, pull down	Sapir T (1997), Sapir T (1997)	2
BRCA1	7	MTOR	14	affinity chromatography technology	Woods NT (2012)	1
CLIP1	2	MAPRE1	0	pull down, affinity chromatography technology, affinity chromatography technology	Ligon LA (2006), Hein MY (2015), Boldt K (2016)	3
TUBA1A	13	MTOR	14	genetic interference	Srivas R (2016)	1
DCTN1	6	CLIP1	2	bioid	Gupta GD (2015)	1
CALM1	0	CLIP1	2	pull down	Shen X (2005)	1
BRCA1	7	CLIP1	2	affinity chromatography technology	Ertych N (2016)	1
RUNDC3A	2	CLIP1	2	affinity chromatography technology	Huttlin EL (2017)	1
CLIP1	2	CHD4	22	biochemical	Wan C (2015)	1
BRCA1	7	BUB3	0	affinity chromatography technology	Ertych N (2016)	1
MAPRE1	0	CALM1	0	affinity chromatography technology	Hein MY (2015)	1
BRCA1	7	DCTN1	6	affinity chromatography technology	Ertych N (2016)	1
HDAC6	0	TUBA1A	13	enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Matsuyama A (2002), Hubbert C (2002), Zhao Z (2010), Zhao Z (2010), New M (2013)	6
HDAC6	0	MAPRE1	0	affinity chromatography technology	Zilberman Y (2009)	1
RAC1	7	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kuroda S (1996), Fukata M (2002), Hart MJ (1996), Zhang B (1998), Sandrock K (2010), Boldt K (2016)	6
PSMC2	2	ZNF598	6	genetic interference, affinity chromatography technology	Horlbeck MA (2018), Garzia A (2017)	2
CDC42	3	IQGAP1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuroda S (1996), Kuroda S (1996), Fukata M (2002), Hart MJ (1996), Hart MJ (1996), Joyal JL (1997), Zhang B (1998), Bourguignon LY (2005), Hein MY (2015), Hein MY (2015)	10
CLIP1	2	MTOR	14	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Choi JH (2002), Choi JH (2002), Choi JH (2002), Choi JH (2002)	4
DAB2IP	3	CLIP1	2	affinity chromatography technology	Huttlin EL (2017)	1