Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
RRM2 6241 FLUDARABINE PHOSPHATE CHEMBL1096882 inhibitor ChemblInteractions
RRM2 6241 IMEXON CHEMBL146428 DrugBank
RRM2 6241 FLUDARABINE CHEMBL1568 inhibitor GuideToPharmacologyInteractions
RRM2 6241 HYDROXYUREA CHEMBL467 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
RRM2 6241 TEZACITABINE CHEMBL2105467 inhibitor ChemblInteractions
RRM2 6241 GEMCITABINE HYDROCHLORIDE CHEMBL1637 inhibitor ChemblInteractions
RRM2 6241 TRIAPINE CHEMBL231616 TdgClinicalTrial
RRM2 6241 CLOFARABINE CHEMBL1750 inhibitor GuideToPharmacologyInteractions, ChemblInteractions
RRM2 6241 GEMCITABINE CHEMBL888 inhibitor ClearityFoundationClinicalTrial, GuideToPharmacologyInteractions
RRM2 6241 GALLIUM NITRATE CHEMBL1200983 inhibitor ChemblInteractions, DrugBank 12776257, 15651176, 1335254
RRM2 6241 CLADRIBINE CHEMBL1619 inhibitor DrugBank 16316309, 9923554, 19576186, 17852710, 19715446
RRM2 6241 MOTEXAFIN GADOLINIUM CHEMBL3544910 inhibitor TdgClinicalTrial, DrugBank, TTD

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
RRM2 rs1130609 GT + TT cladribine efficacy yes As measured by a poorer overall survival. Genotypes GT + TT is associated with decreased response to cladribine and cytarabine in children with Leukemia, Myeloid, Acute as compared to genotype GG. 24024897 1183700217
RRM2 rs5030743 CG + GG cladribine efficacy yes As measured by a poorer overall survival. Note this is a G/C SNP, therefore the risk allele could potentially get mixed up. Genotypes CG + GG is associated with decreased response to cladribine and cytarabine in children with Leukemia, Myeloid, Acute as compared to genotype CC. 24024897 1183700223