PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
STAT1	1	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique	Deberry C (1997), Deberry C (1997), Deberry C (1997), Deberry C (1997), Chen TC (2014)	5
RPTOR	4	2667	0	affinity chromatography technology	Tzatsos A (2006)	1
LYN	2	KIT	4	affinity chromatography technology, affinity chromatography technology, pull down	Liang X (2002), Linnekin D (1997), Linnekin D (1997)	3
VHL	0	HNRNPL	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai Y (2011), Yao P (2013), Yao P (2013)	3
XPO1	8	RPTOR	4	affinity chromatography technology	Kirli K (2015)	1
AKT1	1	TERT	7	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Kawauchi K (2005), Kim MO (2008), Ivanov AA (2017)	3
MAPK8	3	MAPKAP1	0	affinity chromatography technology, pull down	Schroder W (2005), Schroder W (2005)	2
HSP90AA1	7	RPS6KB1	1	affinity chromatography technology	Taipale M (2012)	1
CSNK2A1	15	MDM2	2	enzymatic study, enzymatic study	Goetz C (1999), Hjerrild M (2001)	2
NEDD4	2	RBX1	2	affinity chromatography technology	Liu J (2014)	1
RPS6KB1	1	RHEB	2	enzymatic study	Sun Y (2008)	1
PPP5C	2	HSP90AA1	7	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Zeke T (2005), Silverstein AM (1997), Schuelke JP (2010), Gano JJ (2010), Cliff MJ (2006), Skarra DV (2011), Skarra DV (2011), Horibe T (2011), Taipale M (2014), Taipale M (2014), Hein MY (2015), Woo SH (2009), Woo SH (2009), Woodford MR (2016), St-Denis N (2016), Yadav L (2017), Yadav L (2017)	17
IRS1	7	APP	1	pull down	Olah J (2011)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
FBXO7	1	RPS6KB1	1	enzymatic study	Teixeira FR (2016)	1
HSP90AA1	7	URI1	2	affinity chromatography technology	Gano JJ (2010)	1
RPS6KB1	1	NR1I2	5	enzymatic study	Pondugula SR (2009)	1
HNRNPL	3	EP300	36	affinity chromatography technology	Fei T (2017)	1
RPS6KB1	1	PPP2R2A	0	affinity chromatography technology, affinity chromatography technology	Peterson RT (1999), Bishop JD (2006)	2
RPTOR	4	RPS6	1	affinity chromatography technology	Oh WJ (2010)	1
XPO1	8	MAPKAP1	0	affinity chromatography technology	Kirli K (2015)	1
HSP90AA1	7	BTK	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Huttlin EL (2017)	2
URI1	2	APP	1	pull down	Olah J (2011)	1
MDM2	2	KAT2B	2	pull down, affinity chromatography technology, genetic interference, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study	Jin Y (2002), Jin Y (2002), Jin Y (2002), Jin Y (2004), Jin Y (2004), Jung CR (2010), Morgan JE (2017)	7
NFATC1	12	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Gabriel CH (2016), Gabriel CH (2016)	2
CSNK2A1	15	PIP4K2A	0	biochemical	Wan C (2015)	1
RPS6KB1	1	TERT	7	affinity chromatography technology	Kawauchi K (2005)	1
LYN	2	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
KAT2B	2	VHL	0	affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Ji W (2014)	2
MXD1	2	AKT1	1	affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study	Chou CK (2009), Chou CK (2009), Chou CK (2009), Chou CK (2009), Chou CK (2009), Zhu J (2008)	6
EP300	36	ACTA1	1	affinity chromatography technology	Jung SY (2005)	1
HSP90AA1	7	RRM2	2	affinity chromatography technology	Truman AW (2015)	1
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
ACTA1	1	SRC	2	affinity chromatography technology	Kim JH (2013)	1
DEPTOR	1	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Peterson TR (2009), Peterson TR (2009)	2
EIF3H	3	CSNK2A1	15	affinity chromatography technology, biochemical	Sowa ME (2009), Wan C (2015)	2
COASY	1	RPS6KB1	1	affinity chromatography technology, pull down	Nemazanyy I (2004), Nemazanyy I (2004)	2
TRIB2	2	RPS6KB1	1	affinity chromatography technology, affinity chromatography technology	Wang J (2013), Wang J (2013)	2
TRIM25	5	HSP90AA1	7	affinity chromatography technology	Choudhury NR (2017)	1
RPTOR	4	IRS1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tzatsos A (2006), Tzatsos A (2009), Tzatsos A (2009), Tzatsos A (2009)	4
RPS6KB1	1	2667	0	pull down, enzymatic study	Harrington LS (2004), Shah OJ (2006)	2
HSP90AA1	7	LYN	2	affinity chromatography technology	Taipale M (2012)	1
MTOR	14	RPS6	1	affinity chromatography technology	Oh WJ (2010)	1
ELAVL1	0	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Abdelmohsen K (2009), Datta K (2005), Datta K (2005), Yuen JS (2007)	4
TERT	7	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down	Oh W (2010), Oh W (2010), Oh W (2010), Oh W (2010), Hu C (2015), Hu C (2015)	6
MTOR	14	TERT	7	affinity chromatography technology	Kawauchi K (2005)	1
EIF4E	1	RPS6KB1	1	affinity chromatography technology	Ma XM (2008)	1
XPO1	8	FBXO7	1	pull down	Nelson DE (2011)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
KAT2B	2	AKT1	1	enzymatic study, affinity chromatography technology	Sundaresan NR (2011), Sundaresan NR (2011)	2
ABL1	9	RPS6KB1	1	genetic interference	Shen JP (2017)	1
CSNK2B	5	LYN	2	two hybrid	Lehner B (2004)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
RPS6KB1	1	EEF2K	3	pull down	Wang X (2001)	1
VHL	0	APP	1	pull down	Olah J (2011)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CLEC3B	0	APP	1	pull down	Olah J (2011)	1
TERT	7	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PPP5C	2	XPO1	8	biochemical	Kristensen AR (2012)	1
UBL4A	0	APP	1	pull down	Olah J (2011)	1
HSP90AA1	7	NR1I2	5	affinity chromatography technology	Taipale M (2012)	1
EIF3C	0	MTOR	14	affinity chromatography technology	Holz MK (2005)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
MXD1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	CSNK2A1	15	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
RPTOR	4	RPS6KB1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Ali SM (2005), Ha SH (2006), Hara K (2002), Nojima H (2003), Kwak D (2012), Carriere A (2011), Ha SH (2006), Li L (2013), Garcia-Martinez JM (2009)	9
MTOR	14	DEPTOR	1	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Duan S (2011), Duan S (2011), Gao D (2011), Gao D (2011), Gao D (2011), Peterson TR (2009), Peterson TR (2009)	7
VHL	0	PLD2	1	affinity chromatography technology, pull down, pull down	Park MH (2015), Park MH (2015), Park MH (2015)	3
MTOR	14	2667	0	affinity chromatography technology	Ozes ON (2001)	1
RPS6KB1	1	MXD1	2	enzymatic study	Zhu J (2008)	1
EIF3B	3	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Holz MK (2005), Oh WJ (2010), Ma XM (2008)	3
CSNK2A1	15	AKT1	1	enzymatic study	Di Maira G (2005)	1
EIF3H	3	EIF3C	0	affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, genetic interference	Sowa ME (2009), Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Horlbeck MA (2018)	7
ABL1	9	PRKCZ	5	affinity chromatography technology	Lasfer M (2006)	1
HSP90AA1	7	XPO1	8	affinity chromatography technology	Falsone SF (2005)	1
XPO1	8	CSNK2B	5	affinity chromatography technology	Kirli K (2015)	1
STK11	2	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	RPS6	1	affinity chromatography technology	Bursac S (2012)	1
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
SRC	2	SYK	3	enzymatic study, affinity chromatography technology, enzymatic study	Kurosaki T (1994), Asazuma N (1997), Hirose M (2004)	3
PRKCZ	5	RPS6KB1	1	affinity chromatography technology	Inoue T (2006)	1
VHL	0	SQSTM1	0	affinity chromatography technology, affinity chromatography technology	Chen K (2016), Chen K (2016)	2
XPO1	8	URI1	2	affinity chromatography technology	Kirli K (2015)	1
HNRNPL	3	PPP2R2A	0	affinity chromatography technology	Fei T (2017)	1
EIF3F	1	APP	1	pull down	Olah J (2011)	1
XPO1	8	STAT1	1	unspecified method, affinity chromatography technology	Xu D (2012), Kirli K (2015)	2
SYK	3	MAPT	1	enzymatic study, affinity chromatography technology	Lebouvier T (2008), Lebouvier T (2008)	2
UBL4A	0	RPS6KB1	1	affinity chromatography technology	Huttlin EL (2017)	1
AKT1	1	SRC	2	imaging technique, affinity chromatography technology	Chen TC (2014), Lee J (2013)	2
MAPK8	3	MAPT	1	enzymatic study	Goedert M (1997)	1
RPS6KB1	1	RPS6	1	enzymatic study, enzymatic study	Dunlop EA (2011), Lee DF (2007)	2
TRIM25	5	FBXO7	1	affinity chromatography technology	Choudhury NR (2017)	1
EP300	36	KAT2B	2	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kiernan R (2003), Kim JH (2011), Lee M (2010), Santos-Rosa H (2003), Yang XJ (1996), Yang XJ (1996), Yang XJ (1996), Mizuguchi Y (2012)	8
SQSTM1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Linares JF (2015), Linares JF (2015)	3
CSNK2A1	15	VHL	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Lolkema MP (2005), Lolkema MP (2005), Yang H (2007)	3
XPO1	8	ABL1	9	unspecified method, unspecified method	Xu D (2012), Hantschel O (2005)	2
RPS6KB1	1	RRM2	2	genetic interference	Shen JP (2017)	1
EIF3H	3	EIF3F	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	6
RPS6KB1	1	VHL	0	genetic interference	Shen JP (2017)	1
HSP90AA1	7	EIF3H	3	affinity chromatography technology	Falsone SF (2005)	1
PPP5C	2	MAPT	1	enzymatic study	Liu F (2002)	1
AKT1	1	ACTA1	1	affinity chromatography technology, affinity chromatography technology	Foster KS (2006), Kim JH (2013)	2
EIF3F	1	EIF3C	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Havugimana PC (2012), Huttlin EL (2015), Martineau Y (2014), Wan C (2015), Huttlin EL (2017)	6
RPTOR	4	EP300	36	affinity chromatography technology	Wan W (2017)	1
MAPK8	3	EP300	36	enzymatic study	See RH (2001)	1
PDK1	1	RPS6KB1	1	pull down	Minami T (2001)	1
NEDD4	2	URI1	2	pull down	Ingham RJ (2005)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
EIF3B	3	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Holz MK (2005), Oh WJ (2010), Oh WJ (2010)	3
NEDD4	2	ABL1	9	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
HSP90AA1	7	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Sato S (2000), Basso AD (2002), Su CH (2011), Klein JB (2005), Sun L (2012)	7
EP300	36	SRC	2	affinity chromatography technology, affinity chromatography technology	Paladino D (2016), Paladino D (2016)	2
MAPK8	3	RPTOR	4	affinity chromatography technology, affinity chromatography technology	Kwak D (2012), Kwak D (2012)	2
ELAVL1	0	XPO1	8	affinity chromatography technology	Abdelmohsen K (2009)	1
MAPKAP1	0	AKT1	1	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, two hybrid, pull down	Jacinto E (2006), Murata H (2011), Facchinetti V (2008), Facchinetti V (2008), Tatebe H (2017), Tatebe H (2017)	6
SRC	2	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Olayioye MA (1999), Cirri P (1997), Chang YJ (2004), Chang YJ (2004)	4
CSNK2A1	15	MAPT	1	enzymatic study	Raftery M (2005)	1
RICTOR	4	MAPKAP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Jacinto E (2006), Yang Q (2006), Jacinto E (2006), Pearce LR (2007), Pearce LR (2007), Gao D (2010), Gao D (2010), Oh WJ (2010), Oh WJ (2010), Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Ikenoue T (2008), Murata H (2011), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Martin J (2008), Thedieck K (2007), Hong F (2008), Facchinetti V (2008), Chen CH (2011), Glidden EJ (2012), Thedieck K (2007)	24
XPO1	8	EEF2K	3	affinity chromatography technology	Kirli K (2015)	1
MDM2	2	NEDD4	2	unspecified method, enzymatic study, affinity chromatography technology	Burch LR (2004), Xu C (2014), Xu C (2014)	3
CSNK2A1	15	STK11	2	genetic interference	Srivas R (2016)	1
RPS6KB1	1	APP	1	pull down	Olah J (2011)	1
EIF3F	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, two hybrid	Harris TE (2006), Harris TE (2006), Harris TE (2006)	3
RPS6KB1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fenton TR (2010), Fenton TR (2010), Fenton TR (2010)	3
CSNK2A1	15	EIF3C	0	affinity chromatography technology	So J (2015)	1
AKT1	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology	Zhang J (2014), Zhang J (2014)	2
PIP4K2A	0	STK11	2	affinity chromatography technology	Huttlin EL (2017)	1
KAT2B	2	NFATC1	12	enzymatic study	Kim JH (2011)	1
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
EIF3B	3	RPS6KB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Holz MK (2005), Holz MK (2005), Ma XM (2008), Martineau Y (2014)	4
EIF3C	0	RPS6KB1	1	affinity chromatography technology	Holz MK (2005)	1
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
RPS6KB1	1	DEPTOR	1	enzymatic study	Zhao Y (2011)	1
NCBP1	7	MTOR	14	affinity chromatography technology	Ma XM (2008)	1
HNRNPL	3	URI1	2	affinity chromatography technology	Fei T (2017)	1
STK11	2	RPS6KB1	1	imaging technique	Chen TC (2014)	1
EIF3H	3	CSNK2B	5	affinity chromatography technology	Sowa ME (2009)	1
ELAVL1	0	RPS6KB1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
SRC	2	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
RICTOR	4	RPS6KB1	1	pull down, imaging technique	Ali SM (2005), Chen TC (2014)	2
SQSTM1	0	RPS6KB1	1	affinity chromatography technology	Duran A (2011)	1
ELAVL1	0	RRM2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
PDK1	1	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hara K (2002), Misra UK (2014), Misra UK (2014)	3
NEDD4	2	IRS2	6	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down	Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015), Fukushima T (2015)	5
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
BTK	1	SYK	3	affinity chromatography technology	Morrogh LM (1999)	1
UBL4A	0	TRAF4	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM25	5	MTOR	14	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	PPP2R2A	0	affinity chromatography technology	Kirli K (2015)	1
SRC	2	MDM2	2	unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015), Batuello CN (2015)	5
VHL	0	HSP90AA1	7	affinity chromatography technology, genetic interference	Yang C (2013), Shen JP (2017)	2
RPS6KB1	1	KAT2B	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fenton TR (2010), Fenton TR (2010), Fenton TR (2010)	3
TRIM25	5	MDM2	2	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	LYN	2	affinity chromatography technology	Abdelmohsen K (2009)	1
EIF4E	1	APP	1	pull down	Olah J (2011)	1
XPO1	8	EIF3C	0	affinity chromatography technology, genetic interference	Kirli K (2015), Horlbeck MA (2018)	2
RPS6KB1	1	RPS6KB1	1	enzymatic study	Martineau Y (2014)	1
TRIM25	5	RPTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
MAPK8	3	AKT1	1	enzymatic study	Xiao L (2010)	1
MDM2	2	EIF3B	3	affinity chromatography technology	Jacob AG (2014)	1
RBX1	2	RPS6KB1	1	pull down, affinity chromatography technology	Panasyuk G (2008), Panasyuk G (2008)	2
SQSTM1	0	PRKCZ	5	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, imaging technique, affinity chromatography technology	Sanz L (2000), Hirano Y (2004), Chang S (2002), Wilson MI (2003), Feng Y (2005), Kim GY (2012), Urbanczyk A (2011), Linares JF (2011), So J (2015), Tsai LC (2015), Huttlin EL (2017), Tobias IS (2016), Tobias IS (2016)	13
AKT1	1	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Lin WN (2008), Lee IT (2010), Sundaresan NR (2011), Howie HL (2011), Chen J (2004), Chen J (2004)	6
MAPK8	3	IRS1	7	two hybrid, affinity chromatography technology, pull down	Aguirre V (2002), Aguirre V (2000), Aguirre V (2000)	3
KAT2B	2	PDK1	1	enzymatic study	Sundaresan NR (2011)	1
PPP5C	2	APP	1	pull down	Olah J (2011)	1
TRIM25	5	SQSTM1	0	affinity chromatography technology	Choudhury NR (2017)	1
RPS6KB1	1	CSNK2B	5	pull down, pull down, affinity chromatography technology	Panasyuk G (2006), Panasyuk G (2006), Panasyuk G (2006)	3
SYK	3	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
TRIM25	5	RPS6	1	affinity chromatography technology	Choudhury NR (2017)	1
RHEB	2	RPTOR	4	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Long X (2005), Long X (2005), Oshiro N (2014), Thomas JD (2014)	4
BTK	1	RPS6KB1	1	enzymatic study	Rebholz H (2006)	1
SRC	2	KIT	4	unspecified method	Wollberg P (2003)	1
VHL	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kohroki J (2005), Kamura T (2002), Kuznetsova AV (2003), Norman JA (2006), Knauth K (2006), Kamura T (2004), Heir P (2013), Essers PB (2014), Lee SB (2016)	10
UBL4A	0	HSP90AA1	7	affinity chromatography technology	Xu Y (2012)	1
TRIM25	5	ABL1	9	affinity chromatography technology	Choudhury NR (2017)	1
RPS6KB1	1	AKT1	1	biochemical, imaging technique	Berven LA (2004), Chen TC (2014)	2
KIR3DL1	1	RPS6KB1	1	two hybrid	Wang J (2011)	1
MDM2	2	RPS6KB1	1	affinity chromatography technology, affinity chromatography technology	Lai KP (2010), Lai KP (2010)	2
PPP5C	2	RPS6KB1	1	affinity chromatography technology	Hein MY (2015)	1
UBL4A	0	ACTA1	1	affinity chromatography technology	Xu Y (2012)	1
RPS6KB1	1	PIP4K2A	0	enzymatic study	Tang X (2003)	1
HNRNPL	3	DEPTOR	1	affinity chromatography technology	Fei T (2017)	1
MTOR	14	PPP2R2A	0	pull down	Peterson RT (1999)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
ACTA1	1	ABL1	9	pull down	Hantschel O (2005)	1
MAPK8	3	APP	1	pull down, enzymatic study, pull down	Olah J (2011), Scheinfeld MH (2003), Scheinfeld MH (2003)	3
AKT1	1	RPTOR	4	affinity chromatography technology	Kim EK (2011)	1
POLDIP3	0	RPS6KB1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Richardson CJ (2004), Richardson CJ (2004), Richardson CJ (2004), Richardson CJ (2004)	4
EIF3B	3	EIF4E	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Harris TE (2006), Ma XM (2008), Ma XM (2008)	3
ELAVL1	0	EEF2K	3	affinity chromatography technology	Abdelmohsen K (2009)	1
ACTA1	1	RPS6KB1	1	pull down	Berven LA (2004)	1
TRIM25	5	PPP5C	2	affinity chromatography technology	Choudhury NR (2017)	1
PRKCZ	5	HSP90AA1	7	two hybrid, affinity chromatography technology, affinity chromatography technology	Bandyopadhyay S (2010), Taipale M (2012), Taipale M (2012)	3
RPTOR	4	EIF4E	1	affinity chromatography technology	Wang L (2006)	1
TRIB2	2	RPTOR	4	affinity chromatography technology	Huttlin EL (2017)	1
MTOR	14	PDK1	1	genetic interference, affinity chromatography technology, affinity chromatography technology	Isotani S (1999), Misra UK (2014), Misra UK (2014)	3
PRKCZ	5	SRC	2	affinity chromatography technology, affinity chromatography technology	Seibenhener ML (1999), Seibenhener ML (1999)	2
NEDD4	2	SYK	3	pull down	Persaud A (2009)	1
RPS6KB1	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chiang GG (2005), Holz MK (2005), Holz MK (2005), Hara K (2002), Isotani S (1999), Long X (2005), Toral-Barza L (2005), Ali SM (2005), Saitoh M (2002), Kim DH (2002), Edinger AL (2003), Leone M (2006), Takahashi T (2000), Burnett PE (1998), Sarbassov DD (2005), Agrawal P (2012), Sancak Y (2007), Oshiro N (2004), Sarbassov DD (2005), Kim DH (2003), Kim DH (2003), Nojima H (2003), Martin J (2008), Wing LY (2005), Ren HY (2015)	25
HTT	14	KAT2B	2	pull down	Steffan JS (2001)	1
IRS1	7	IRS2	6	biochemical	Sun H (2003)	1
EIF3H	3	EIF3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Zhou M (2008), Zhou M (2008), Havugimana PC (2012), Lee CS (2008), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
RHEB	2	HTT	14	pull down, affinity chromatography technology	Pryor WM (2014), Pryor WM (2014)	2
ELAVL1	0	PPP2R2A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RPS6KB1	1	IRS1	7	enzymatic study, pull down, enzymatic study	Xu X (2012), Xu X (2012), Xu X (2008)	3
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
UBL4A	0	RPS6	1	affinity chromatography technology	Xu Y (2012)	1
EIF4E	1	MTOR	14	affinity chromatography technology	Ma XM (2008)	1
XPO1	8	NCBP1	7	affinity chromatography technology	Kirli K (2015)	1
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
RICTOR	4	RPS6	1	affinity chromatography technology	Oh WJ (2010)	1
NCBP1	7	POLDIP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma XM (2008), Ma XM (2008), Kroczynska B (2014)	3
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
STK11	2	TRIM25	5	two hybrid	Arroyo R (2015)	1
RPS6KB1	1	CLEC3B	0	two hybrid	Vinayagam A (2011)	1
RPS6	1	VHL	0	affinity chromatography technology, affinity chromatography technology, biochemical	Zhao WT (2013), Zhao WT (2013), Zhao WT (2013)	3
SRC	2	PLD2	1	enzymatic study, affinity chromatography technology, pull down	Ahn BH (2003), Ahn BH (2003), Ahn BH (2003)	3
MAPK8	3	HSP90AA1	7	affinity chromatography technology	Nieto-Miguel T (2008)	1
BTK	1	APP	1	pull down	Olah J (2011)	1
IRS2	6	RPTOR	4	pull down	Tzatsos A (2009)	1
RPS6KB1	1	EIF3F	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Holz MK (2005), Martineau Y (2014), Martineau Y (2014)	3
HSP90AA1	7	RPS6	1	affinity chromatography technology, affinity chromatography technology	Kim TS (2006), Falsone SF (2005)	2
ELAVL1	0	IRS2	6	affinity chromatography technology	Abdelmohsen K (2009)	1
HNRNPL	3	RPS6KB1	1	affinity chromatography technology	Fei T (2017)	1
EIF3F	1	CSNK2A1	15	affinity chromatography technology	Sowa ME (2009)	1
STK11	2	APP	1	pull down	Olah J (2011)	1
CSNK2A1	15	HNRNPL	3	enzymatic study	Zhang M (2011)	1
MAPK8	3	RPS6KB1	1	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology	Wang J (2011), Zhang J (2013), Zhang J (2013), Zhang J (2013)	4
HSP90AA1	7	TERT	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Haendeler J (2003), Kawauchi K (2005), Holt SE (1999), Lee JH (2010), Lee JH (2010), Forsythe HL (2001)	6
EP300	36	STAT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Paulson M (1999), Hiroi M (2003), Ray S (2002), Strassheim D (2009), Liu X (2008), Ghosh AK (2001), Yang WS (2005), Zhang Y (2015), Kotla S (2015), Kotla S (2015)	10
ELAVL1	0	HNRNPL	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CSNK2A1	15	APP	1	pull down	Olah J (2011)	1
RBX1	2	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Gao D (2010), Gao D (2010)	2
AKT1	1	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016)	5
IRS1	7	MTOR	14	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ozes ON (2001), Tzatsos A (2006), Tzatsos A (2006)	3
MAPKAP1	0	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Pearce LR (2007), Oh WJ (2010), Yang Q (2006), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Martin J (2008), Thedieck K (2007), Thedieck K (2007), Hong F (2008), Facchinetti V (2008), Facchinetti V (2008), Glidden EJ (2012), Vander Haar E (2007)	17
XPO1	8	PLD2	1	affinity chromatography technology	Kirli K (2015)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
EIF3B	3	NCBP1	7	affinity chromatography technology, affinity chromatography technology	Ma XM (2008), Ma XM (2008)	2
MTOR	14	PLD2	1	affinity chromatography technology	Ha SH (2006)	1
MTOR	14	RICTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Frias MA (2006), Jacinto E (2006), Yang Q (2006), Frias MA (2006), Sarbassov DD (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Guo Z (2012), Sarbassov DD (2006), Sancak Y (2007), Yang Q (2006), Jacinto E (2006), Jacinto E (2006), Rosner M (2010), Ikenoue T (2008), Ikenoue T (2008), Murata H (2011), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Woods NT (2012), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Martin J (2008), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), McDonald PC (2008), McDonald PC (2008), Hong F (2008), Hong F (2008), Facchinetti V (2008), Toschi A (2009), Zhang F (2010), Chen CH (2011), Chen CH (2011), Xu Y (2013), Xu Y (2013), Glidden EJ (2012), Glidden EJ (2012), Vander Haar E (2007), Koo J (2015), Thedieck K (2007)	59
HNRNPL	3	MAPT	1	affinity chromatography technology	Fei T (2017)	1
IRS2	6	RPS6KB1	1	affinity chromatography technology	Warren KJ (2016)	1
CSNK2A1	15	RPS6KB1	1	pull down	Panasyuk G (2006)	1
XPO1	8	RPS6	1	affinity chromatography technology	Kirli K (2015)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
NEDD4	2	RPS6KB1	1	enzymatic study	Persaud A (2009)	1
CSNK2B	5	MDM2	2	enzymatic study	Goetz C (1999)	1
HNRNPL	3	NFATC1	12	affinity chromatography technology	Fei T (2017)	1
RPS6KB1	1	EIF3H	3	affinity chromatography technology	Holz MK (2005)	1
HTT	14	MTOR	14	affinity chromatography technology	Pryor WM (2014)	1
HNRNPL	3	PRKCZ	5	affinity chromatography technology	Fei T (2017)	1
RICTOR	4	AKT1	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, imaging technique, enzymatic study	Sarbassov DD (2006), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Woods NT (2012), Kim EK (2011), Chen CH (2011), Garcia-Martinez JM (2009), Chen TC (2014), Pitre A (2012)	10
FBXO7	1	ABL1	9	enzymatic study	Teixeira FR (2016)	1
MAPT	1	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Babu JR (2005), Babu JR (2005), Rui YN (2015)	3
CSNK2A1	15	SQSTM1	0	enzymatic study, enzymatic study	Matsumoto G (2011), Watanabe Y (2017)	2
NCBP1	7	RPS6KB1	1	affinity chromatography technology	Ma XM (2008)	1
BTK	1	LYN	2	pull down	Cheng G (1994)	1
MDM2	2	XPO1	8	affinity chromatography technology	Jacob AG (2014)	1
RPS6KB1	1	PLD2	1	affinity chromatography technology	Ha SH (2006)	1
HTT	14	RPS6KB1	1	unspecified method	Krauss S (2013)	1
TRIM25	5	RRM2	2	affinity chromatography technology	Choudhury NR (2017)	1
CSNK2B	5	PIP4K2A	0	biochemical	Wan C (2015)	1
EP300	36	MAPT	1	enzymatic study	Min SW (2010)	1
SYK	3	LYN	2	affinity chromatography technology, pull down	Sidorenko SP (1995), Sidorenko SP (1995)	2
RPS6KB1	1	DPPA4	0	two hybrid	Vinayagam A (2011)	1
STAT1	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Kristof AS (2003), Kristof AS (2003), Fielhaber JA (2009), Fielhaber JA (2009), Fielhaber JA (2009), Chen TC (2014)	6
MTOR	14	ABL1	9	affinity chromatography technology, affinity chromatography technology	Kumar V (2000), Kumar V (2000)	2
AKT1	1	MTOR	14	pull down, unspecified method, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique, enzymatic study, imaging technique	Sekulic A (2000), Cheng SW (2004), Oh WJ (2010), Sarbassov DD (2005), Ikenoue T (2008), Murata H (2011), Martin J (2008), Facchinetti V (2008), Facchinetti V (2008), Chen CH (2011), Xu Y (2013), Glidden EJ (2012), Chen TC (2014), Pitre A (2012), Moon HE (2015)	15
IRS2	6	MTOR	14	affinity chromatography technology	Warren KJ (2016)	1
EIF3B	3	EIF3C	0	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Miyamoto S (2005), Shi J (2009), Havugimana PC (2012), Lee CS (2008), Wan C (2015)	5
RHEB	2	MTOR	14	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Long X (2005), Long X (2005), Long X (2005), Smith EM (2005), Bernardi R (2006), Long X (2005), Long X (2005), Sun Y (2008), Tee AR (2005), Pryor WM (2014)	10
SYK	3	APP	1	pull down	Olah J (2011)	1
HTT	14	HSP90AA1	7	pull down, unspecified method	He WT (2017), He WT (2017)	2
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
TRIB2	2	APP	1	pull down	Olah J (2011)	1
AKT1	1	MAPT	1	enzymatic study	Sadik G (2009)	1
ELAVL1	0	RICTOR	4	affinity chromatography technology	Abdelmohsen K (2009)	1
XPO1	8	EIF3H	3	affinity chromatography technology	Kirli K (2015)	1
EIF3F	1	CSNK2B	5	affinity chromatography technology	Sowa ME (2009)	1
UBL4A	0	HNRNPL	3	affinity chromatography technology	Xu Y (2012)	1
RPS6KB1	1	MAPT	1	enzymatic study	Virdee K (2007)	1
PRKCZ	5	CSNK2B	5	affinity chromatography technology	Bren GD (2000)	1
HTT	14	DPPA4	0	two hybrid	Suter B (2013)	1
RPTOR	4	DEPTOR	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gwinn DM (2010), Peterson TR (2009), Peterson TR (2009)	3
TRIM25	5	RPS6KB1	1	affinity chromatography technology	Choudhury NR (2017)	1
XPO1	8	RICTOR	4	affinity chromatography technology	Kirli K (2015)	1
SRC	2	CSNK2A1	15	affinity chromatography technology	Liang K (2010)	1
IRS1	7	AKT1	1	affinity chromatography technology, enzymatic study	Paz K (1999), Luo M (2007)	2
TRIM25	5	RHEB	2	affinity chromatography technology	Choudhury NR (2017)	1
SQSTM1	0	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Duran A (2011), Duran A (2011), Linares JF (2015)	3
XPO1	8	IRS2	6	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	DEPTOR	1	affinity chromatography technology	Kirli K (2015)	1
NFATC1	12	RPS6KB1	1	affinity chromatography technology	Yang TT (2011)	1
EP300	36	VHL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roe JS (2006), Roe JS (2011), Roe JS (2011), Ji W (2014), Chen K (2015)	5
XPO1	8	MTOR	14	affinity chromatography technology	Kirli K (2015)	1
MTOR	14	EP300	36	enzymatic study	Wan W (2017)	1
EIF3F	1	EIF3B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sowa ME (2009), Zhou M (2008), Zhou M (2008), Shi J (2009), Havugimana PC (2012), Lee CS (2008), Huttlin EL (2015), Martineau Y (2014), Wan C (2015), Huttlin EL (2017)	10
MAPK8	3	MTOR	14	affinity chromatography technology	Kwak D (2012)	1
BTK	1	ACTA1	1	affinity chromatography technology	Li Y (2011)	1
HTT	14	SQSTM1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Filimonenko M (2010), Zhou L (2014), Rui YN (2015), Rui YN (2015)	4
ABL1	9	MAPT	1	enzymatic study, enzymatic study, affinity chromatography technology	Lebouvier T (2008), Derkinderen P (2005), Derkinderen P (2005)	3
NEDD4	2	AKT1	1	enzymatic study, enzymatic study, affinity chromatography technology	Persaud A (2009), Fan CD (2013), Fan CD (2013)	3
DEPTOR	1	APP	1	pull down	Olah J (2011)	1
RRM2	2	VHL	0	genetic interference	Shen JP (2017)	1
STK11	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nony P (2003), Brajenovic M (2004), Gaude H (2012), Taipale M (2012), Huttlin EL (2017)	5
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
RPTOR	4	RICTOR	4	affinity chromatography technology, affinity chromatography technology	Rosner M (2010), Rosner M (2010)	2
HSP90AA1	7	CSNK2A1	15	pull down, enzymatic study, enzymatic study, affinity chromatography technology	Miyata Y (1995), Muller P (2012), Zhang M (2011), Woo SH (2009)	4
SRC	2	MAPT	1	enzymatic study	Bhaskar K (2005)	1
NEDD4	2	IRS1	7	pull down	Persaud A (2009)	1
ABL1	9	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bali P (2005), Sun H (2011), Tsukahara F (2010), Taipale M (2012), Wu LX (2006)	5
MAPKAP1	0	RPS6	1	affinity chromatography technology	Oh WJ (2010)	1
TRAF4	1	RPS6KB1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fleckenstein DS (2003), Ren HY (2015), Ren HY (2015)	3
XPO1	8	CSNK2A1	15	affinity chromatography technology	Kirli K (2015)	1
EIF3B	3	RPS6	1	affinity chromatography technology, affinity chromatography technology	Holz MK (2005), Kedersha N (2016)	2
RPS6KB1	1	XPO1	8	affinity chromatography technology	Panasyuk G (2006)	1
NCBP1	7	UBL4A	0	affinity chromatography technology	Hein MY (2015)	1
VHL	0	PRKCZ	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okuda H (1999), Okuda H (1999), Schermer B (2006)	3
PRKCZ	5	AKT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Doornbos RP (1999), Wang J (2008), Wang J (2008), Joshi J (2008), Joshi J (2008)	5
MAPKAP1	0	RPS6KB1	1	biochemical	Yang Q (2006)	1
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
KIT	4	RPS6KB1	1	genetic interference	Shen JP (2017)	1
FBXO7	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016), Teixeira FR (2016)	3
EP300	36	MDM2	2	pull down, affinity chromatography technology, biochemical, pull down, pull down, enzymatic study, affinity chromatography technology, biochemical, enzymatic study	Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Grossman SR (1998), Matt T (2004), Wang X (2004), Gillotin S (2010), Kobet E (2000), Nihira NT (2017)	9
RPS6KB1	1	URI1	2	enzymatic study	Theurillat JP (2011)	1
COASY	1	APP	1	pull down	Olah J (2011)	1
ABL1	9	MDM2	2	affinity chromatography technology, pull down, enzymatic study, unspecified method, enzymatic study	Goldberg Z (2002), Goldberg Z (2002), Goldberg Z (2002), Batuello CN (2015), Batuello CN (2015)	5
HNRNPL	3	RPTOR	4	affinity chromatography technology	Fei T (2017)	1
EIF3F	1	EIF4E	1	affinity chromatography technology	Sowa ME (2009)	1
RPTOR	4	PLD2	1	affinity chromatography technology	Ha SH (2006)	1
EIF3C	0	RPTOR	4	affinity chromatography technology	Holz MK (2005)	1
MDM2	2	STK11	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
TRIM25	5	RICTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
STAT1	1	RPS6KB1	1	biochemical	Fielhaber JA (2009)	1
EP300	36	NFATC1	12	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim JH (2011), Kawamura T (2004), Kawamura T (2004), Gabriel CH (2016), Gabriel CH (2016)	5
NEDD4	2	HNRNPL	3	pull down	Ingham RJ (2005)	1
TRIM25	5	LYN	2	affinity chromatography technology	Choudhury NR (2017)	1