PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CREBBP	29	FGFR1	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Fang X (2005), Fang X (2005), Chen TC (2014)	3
FGFR3	7	RPS6KA3	2	enzymatic study	Kang S (2008)	1
NTRK1	1	YBX1	1	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CSE1L	1	affinity chromatography technology	Emdal KB (2015)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
TMPO	0	HSP90AA1	7	affinity chromatography technology	Brady GF (2018)	1
MAPK14	0	MAPK1	1	affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology	Sanz-Moreno V (2003), Tanoue T (2001), Srivastav RK (2011), Chan PM (2008)	4
WDYHV1	0	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
IL17RA	3	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
SRC	2	MAPK3	4	affinity chromatography technology	Lee J (2013)	1
RPS6KA3	2	EIF3C	0	two hybrid	Vinayagam A (2011)	1
FGFR3	7	HSPA8	4	affinity chromatography technology	Laederich MB (2011)	1
FGFR2	6	FGFR1	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	STIP1	1	protein complementation assay	Deribe YL (2009)	1
MAPK14	0	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Tsuchiya Y (2010), Tsuchiya Y (2010)	2
FGFR2	6	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
CDC37	0	RPS6KA3	2	affinity chromatography technology	Li J (2013)	1
SRC	2	RPS6KA3	2	enzymatic study	Kang S (2008)	1
RPS6KA1	3	MAPT	1	enzymatic study	Virdee K (2007)	1
NTRK1	1	RPS6KA1	3	affinity chromatography technology	Emdal KB (2015)	1
GBA	2	HSP90AA1	7	affinity chromatography technology	Lu J (2011)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
FYN	1	RPS6KA3	2	affinity chromatography technology, enzymatic study	Huttlin EL (2017), Kang S (2008)	2
FBXO7	1	ZMYM5	1	enzymatic study	Teixeira FR (2016)	1
PDPK1	0	PEA15	0	two hybrid	Vinayagam A (2011)	1
NDEL1	2	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
MAPK1	1	CREBBP	29	enzymatic study	Janknecht R (1996)	1
CSE1L	1	RPS6KA3	2	biochemical	Kristensen AR (2012)	1
GDA	1	SMS	1	biochemical	Kristensen AR (2012)	1
RPS6KA1	3	NFKBIA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Schouten GJ (1997), Schouten GJ (1997), Schouten GJ (1997), Ghoda L (1997), Ghoda L (1997), Ghoda L (1997), Heilker R (1999)	7
NTRK1	1	TMPO	0	affinity chromatography technology	Emdal KB (2015)	1
NFKBIA	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFX	1	HSP90AA1	7	affinity chromatography technology	Yang X (2010)	1
RPS6KA3	2	MAPK1	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Zhao Y (1996), Smith JA (1999), Wang J (2011), Varjosalo M (2013), Chrestensen CA (2002), Chen TC (2014), Kang S (2008)	7
EGFR	5	ILKAP	2	two hybrid	Yao Z (2017)	1
FYN	1	MAPT	1	affinity chromatography technology, pull down, pull down, enzymatic study	Klein C (2002), Klein C (2002), Bhaskar K (2005), Bhaskar K (2005)	4
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
MAPK1	1	ILKAP	2	biochemical	Wan C (2015)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
CDC37	0	MASP1	3	affinity chromatography technology	Li J (2013)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
NEDD4	2	FGFR2	6	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
EGFR	5	RPS6KA3	2	affinity chromatography technology	Tong J (2014)	1
FGFR1	2	SRC	2	affinity chromatography technology, affinity chromatography technology	Dudka AA (2010), Vecchione A (2007)	2
FYN	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loewenberg M (2006), Taipale M (2012), Taipale M (2012), Huttlin EL (2017)	4
CREBBP	29	HIST1H3A	3	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Senyuk V (2005), Perissi V (1999), Pasheva E (2004), Shen WF (2001), Kouskouti A (2005), Kouskouti A (2005), Yasuda J (2004), Tropberger P (2013), Das C (2009)	9
ESR1	0	CREBBP	29	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Sheppard HM (2001), Fan S (2002), Fan S (2002), Fan S (2002), Jin W (2008), Jaber BM (2004), Jaber BM (2004), Heery DM (1997), Ku TK (2007), Crowe DL (2006)	10
RPS6KA1	3	MAPK3	4	affinity chromatography technology	Roux PP (2003)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
FGFR2	6	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA3	2	RASAL1	4	biochemical	Kristensen AR (2012)	1
RPS6KA3	2	BARX1	0	two hybrid	Vinayagam A (2011)	1
CDC37	0	SRC	2	pull down	Rao J (2001)	1
TMEM139	0	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MAPK3	4	CREBBP	29	enzymatic study	Tsai LN (2008)	1
RPS6KA3	2	YBX1	1	enzymatic study	Stratford AL (2008)	1
SLC9A3R1	2	TGM2	2	biochemical	Kristensen AR (2012)	1
RPS6KA3	2	MASP1	3	two hybrid	Vinayagam A (2011)	1
GBA	2	RPS6KA3	2	affinity chromatography technology	Hein MY (2015)	1
ZMYM5	1	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NPEPPS	3	TGM2	2	biochemical	Kristensen AR (2012)	1
FGFR1	2	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, enzymatic study	Nadratowska-Wesolowska B (2013), Nadratowska-Wesolowska B (2013), Nadratowska-Wesolowska B (2013), Nadratowska-Wesolowska B (2013), Nadratowska-Wesolowska B (2013)	5
NFATC1	12	RPS6KA3	2	affinity chromatography technology	Yang TT (2011)	1
MISP	4	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
FGFR2	6	FGFR3	7	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	FBXO7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kuiken HJ (2012), Chen CM (2014), Huttlin EL (2017)	3
CDC37	0	HSPA8	4	affinity chromatography technology	Li J (2013)	1
SPRED2	12	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
CSE1L	1	GDA	1	biochemical	Kristensen AR (2012)	1
RPS6KA3	2	PDPK1	0	affinity chromatography technology, imaging technique	Froedin M (2000), Chen TC (2014)	2
GBA	2	ATP5J	0	affinity chromatography technology	Hein MY (2015)	1
NTRK1	1	GBA	2	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	PPP6R2	3	affinity chromatography technology	Emdal KB (2015)	1
MAPK3	4	ILKAP	2	biochemical	Wan C (2015)	1
IL17RA	3	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA3	2	H2AFX	1	enzymatic study	Zhu F (2011)	1
YBX1	1	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Stratford AL (2008), Stratford AL (2008), Stratford AL (2008)	3
MAPK14	0	EGFR	5	enzymatic study	Raingeaud J (1995)	1
FGFR1	2	NEDD4	2	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Persaud A (2011), Persaud A (2011), Persaud A (2009), Persaud A (2014)	4
GDA	1	SLC9A3R1	2	biochemical	Kristensen AR (2012)	1
NPEPPS	3	RPS6KA1	3	biochemical	Kristensen AR (2012)	1
NTRK1	1	HSPA8	4	affinity chromatography technology	Emdal KB (2015)	1
ILKAP	2	MAPK14	0	enzymatic study	Zhang X (2017)	1
RPS6KA3	2	SLC9A3R1	2	biochemical	Kristensen AR (2012)	1
TMPO	0	RPS6KA3	2	affinity chromatography technology	Brady GF (2018)	1
FYN	1	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	HNRNPH1	3	affinity chromatography technology	Emdal KB (2015)	1
CSE1L	1	NPEPPS	3	biochemical	Kristensen AR (2012)	1
HSP90AA1	7	RPS6KA3	2	affinity chromatography technology	Taipale M (2012)	1
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
KIAA1456	0	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPS6KA3	2	MAPT	1	enzymatic study	Virdee K (2007)	1
HSPA8	4	TGM2	2	two hybrid	Wang J (2011)	1
MAPK3	4	MAPK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Wang J (2009), Wang J (2009), Wan C (2015), Hu B (2006)	6
H2AFX	1	YBX1	1	affinity chromatography technology	Huttlin EL (2017)	1
HSP90AA1	7	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Varjosalo M (2013)	2
TRIM11	1	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
NFATC1	12	CREBBP	29	affinity chromatography technology	Gabriel CH (2016)	1
NTRK1	1	DFFA	0	affinity chromatography technology	Emdal KB (2015)	1
TMPO	0	YBX1	1	affinity chromatography technology	Brady GF (2018)	1
H2AFX	1	MASP1	3	two hybrid	Vinayagam A (2011)	1
NTRK1	1	RPS6KA3	2	affinity chromatography technology	Emdal KB (2015)	1
SMS	1	SLC9A3R1	2	biochemical	Kristensen AR (2012)	1
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
SLC9A3R1	2	MAPK1	1	biochemical	Molina JR (2010)	1
MAPK1	1	YBX1	1	enzymatic study	Coles LS (2005)	1
NTRK1	1	NPEPPS	3	affinity chromatography technology	Emdal KB (2015)	1
NPEPPS	3	RPS6KA3	2	biochemical	Kristensen AR (2012)	1
NEDD4	2	RPS6KA3	2	enzymatic study	Persaud A (2009)	1
RPS6KA3	2	HIST1H3A	3	enzymatic study	Sassone-Corsi P (1999)	1
TRAF2	1	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Peng C (2012), Peng C (2012)	2
MAPT	1	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elliott E (2007), Shimura H (2004), Huttlin EL (2017)	3
RPS6KA3	2	ATP5J	0	two hybrid	Vinayagam A (2011)	1
TMPO	0	HNRNPH1	3	affinity chromatography technology	Brady GF (2018)	1
NTRK1	1	EIF3C	0	affinity chromatography technology	Emdal KB (2015)	1
IRGC	1	RPS6KA1	3	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	SRC	2	affinity chromatography technology, pull down, enzymatic study	Persaud A (2014), Persaud A (2014), Persaud A (2014)	3
SRC	2	ESR1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, imaging technique, imaging technique, imaging technique, pull down, imaging technique, imaging technique, affinity chromatography technology, two hybrid	Migliaccio A (2000), Teo AK (2001), Slentz-Kesler K (2000), Bourdoncle A (2005), Jaber BM (2004), Jaber BM (2004), Ku TK (2007), Cabodi S (2004), Monroe DG (2003), Hitosugi T (2007), Zwart W (2007), Zwart W (2007), Zwart W (2007), Yoshimaru T (2013), Yoshimaru T (2013), Zhang H (2006), Zhang H (2006), Zhang H (2006), Endler A (2012), Endler A (2012)	20
IRGC	1	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA3	2	SMS	1	two hybrid	Vinayagam A (2011)	1
EGFR	5	TRAF2	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2008), Puliyappadamba VT (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
NTRK1	1	STIP1	1	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
EGFR	5	YBX1	1	affinity chromatography technology	Yao Z (2017)	1
PEA15	0	MAPK1	1	two hybrid, pull down, affinity chromatography technology	Formstecher E (2001), Formstecher E (2001), Casar B (2007)	3
NTRK1	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rao R (2010), Taipale M (2012), Emdal KB (2015)	3
CREBBP	29	RPS6KA3	2	affinity chromatography technology, affinity chromatography technology	Merienne K (2001), Merienne K (2001)	2
NAPRT	4	RASAL1	4	biochemical	Kristensen AR (2012)	1
HSPA8	4	CREBBP	29	affinity chromatography technology	Du C (2017)	1
FYN	1	FGFR2	6	affinity chromatography technology	Kaabeche K (2004)	1
ESR1	0	HSPA8	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Fan M (2005), Tateishi Y (2004), Ambrosino C (2010), Tarallo R (2011), Gebauer M (1998), Dhamad AE (2016), Dhamad AE (2016)	7
NEDD4	2	NTRK1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Arevalo JC (2006), Arevalo JC (2006), Arevalo JC (2006), Georgieva MV (2011), Georgieva MV (2011), Persaud A (2009), Persaud A (2009), Emdal KB (2015)	8
NEDD4	2	FYN	1	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
FBXO7	1	FGFR2	6	enzymatic study	Teixeira FR (2016)	1
MAPK14	0	RPS6KA3	2	affinity chromatography technology	Tanoue T (2001)	1
CSE1L	1	SMS	1	biochemical	Kristensen AR (2012)	1
CDC37	0	RPS6KA1	3	affinity chromatography technology	Li J (2013)	1
HSP90AA1	7	FGFR1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Vecchione A (2007)	2
FGFR1	2	RPS6KA1	3	two hybrid, affinity chromatography technology, affinity chromatography technology	Hu Y (2004), Hu Y (2004), Hu Y (2004)	3
NTRK1	1	SLC9A3R1	2	affinity chromatography technology	Emdal KB (2015)	1
WDYHV1	0	TRAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
FBXO7	1	ILKAP	2	enzymatic study	Teixeira FR (2016)	1
PEA15	0	MAPK3	4	two hybrid, two hybrid	Formstecher E (2001), Vinayagam A (2011)	2
HNRNPH1	3	RPS6KA3	2	biochemical	Wan C (2015)	1
EGFR	5	CSE1L	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Yao Z (2017)	2
SRC	2	TMPO	0	enzymatic study	Tifft KE (2009)	1
NTRK1	1	SMS	1	affinity chromatography technology	Emdal KB (2015)	1
TGM2	2	RPS6KA3	2	biochemical	Kristensen AR (2012)	1
NPEPPS	3	SLC9A3R1	2	biochemical	Kristensen AR (2012)	1
EGFR	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hitosugi T (2007), Hitosugi T (2007), Yao Z (2017)	3
NEDD4	2	GBA	2	enzymatic study	Persaud A (2009)	1
ESR1	0	YBX1	1	affinity chromatography technology	Tarallo R (2011)	1
PPP6R2	3	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
CSE1L	1	SLC9A3R1	2	biochemical	Kristensen AR (2012)	1
FBXO7	1	HNRNPH1	3	affinity chromatography technology	Teixeira FR (2016)	1
RPS6KA3	2	HSPA8	4	biochemical	Kristensen AR (2012)	1
SRC	2	MAPK1	1	affinity chromatography technology	Lee J (2013)	1
HSP90AA1	7	SRC	2	affinity chromatography technology, affinity chromatography technology	Hutchison KA (1992), Tsutsumi S (2012)	2
NAPRT	4	HSPA8	4	biochemical	Kristensen AR (2012)	1
EGFR	5	MAPT	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
FYN	1	CDC37	0	affinity chromatography technology	Huttlin EL (2017)	1
FGFR3	7	ILKAP	2	biochemical	Wan C (2015)	1
H2AFX	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Dittmann K (2011), Yao Z (2017)	2
CSE1L	1	TGM2	2	biochemical	Kristensen AR (2012)	1
RPS6KA1	3	ILKAP	2	biochemical	Wan C (2015)	1
SRC	2	CREBBP	29	pull down, affinity chromatography technology, imaging technique	Whiting RJ (2012), Ruas JL (2005), Ruas JL (2005)	3
PEA15	0	RPS6KA3	2	affinity chromatography technology, pull down, affinity chromatography technology	Vaidyanathan H (2003), Vaidyanathan H (2003), Vaidyanathan H (2003)	3
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
FBXO7	1	FGFR1	2	enzymatic study	Teixeira FR (2016)	1
RPS6KA3	2	NFKBIA	0	enzymatic study	Peng C (2012)	1
RPS6KA3	2	MAPK3	4	affinity chromatography technology, imaging technique	Zhao Y (1996), Chen TC (2014)	2
FGFR1	2	CDC37	0	affinity chromatography technology, affinity chromatography technology	Vecchione A (2007), Vecchione A (2007)	2
HSPA8	4	STIP1	1	biochemical, far western blotting, pull down, pull down, pull down, biochemical	Havugimana PC (2012), Gebauer M (1998), Gebauer M (1998), Liu FH (1999), Tsukahara F (2000), Wan C (2015)	6
RPS6KA1	3	MAPK1	1	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Roux PP (2003), Eblen ST (2003), Smith JA (1999), Ding Q (2005), Varjosalo M (2013), Jahrling JB (2014), Smith JA (2000)	7
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
FGFR3	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Laederich MB (2011), Taipale M (2012)	2
ESR1	0	MAPK1	1	pull down, enzymatic study	Metivier R (2002), Tremblay A (2001)	2
FBXO7	1	RPS6KA3	2	enzymatic study	Teixeira FR (2016)	1
MAPK14	0	MAPK3	4	affinity chromatography technology, protein complementation assay	Sanz-Moreno V (2003), Srivastav RK (2011)	2
STIP1	1	RPS6KA3	2	biochemical	Wan C (2015)	1
CREBBP	29	RPS6KA1	3	affinity chromatography technology, affinity chromatography technology	Fang X (2005), Wang Z (2003)	2
RPS6KA1	3	ESR1	0	enzymatic study	Joel PB (1998)	1
ILKAP	2	RPS6KA3	2	enzymatic study	Zhang X (2017)	1
FGFR3	7	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Laederich MB (2011), Laederich MB (2011), Laederich MB (2011)	3
NTRK1	1	CDC37	0	affinity chromatography technology, affinity chromatography technology	Rao R (2010), Emdal KB (2015)	2
NFKBIA	0	TGM2	2	affinity chromatography technology	Kumar S (2012)	1
SRC	2	MAPT	1	enzymatic study	Bhaskar K (2005)	1
NTRK1	1	MAPK1	1	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	HNRNPH1	3	affinity chromatography technology, affinity chromatography technology	Tong J (2008), Li J (2013)	2
MISP	4	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
PDPK1	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
NEDD4	2	EGFR	5	enzymatic study, pull down	Persaud A (2009), Persaud A (2009)	2
RPS6KA1	3	RPS6KA3	2	affinity chromatography technology	Varjosalo M (2013)	1
RPS6KA3	2	ESR1	0	affinity chromatography technology	Clark DE (2001)	1
RPS6KA3	2	HMGN1	0	enzymatic study	Prymakowska-Bosak M (2001)	1
FGFR2	6	SRC	2	affinity chromatography technology	Schueller AC (2008)	1
GDA	1	RPS6KA3	2	biochemical	Kristensen AR (2012)	1
RPS6KA3	2	NAPRT	4	biochemical	Kristensen AR (2012)	1
ESR1	0	H2AFX	1	affinity chromatography technology	Tarallo R (2011)	1
STRADB	1	RPS6KA3	2	affinity chromatography technology	Huttlin EL (2017)	1
RPS6KA3	2	DFFA	0	biochemical	Kristensen AR (2012)	1