PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCAP31	0	RNF5	0	affinity chromatography technology	Wang B (2008)	1
AMFR	2	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Morito D (2008), Ballar P (2007), Ye Y (2005), Zhong Y (2011)	4
RNF5	0	ERLIN2	2	affinity chromatography technology	El Khouri E (2013)	1
ATL3	0	RNF5	0	affinity chromatography technology	Hein MY (2015)	1
RNF5	0	SLC38A7	3	two hybrid	Rolland T (2014)	1
UBE2W	0	RNF185	1	two hybrid	Markson G (2009)	1
RNF5	0	UBE2J1	1	affinity chromatography technology, affinity chromatography technology	Younger JM (2006), Grove DE (2011)	2
XRCC3	1	DERL1	2	affinity chromatography technology	Hein MY (2015)	1
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
UBE2D1	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Wang Y (2014)	3
ABHD16A	2	RNF5	0	two hybrid, two hybrid	Lehner B (2004), Rolland T (2014)	2
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	RNF185	1	two hybrid	Markson G (2009)	1
AMFR	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jo Y (2011), Jo Y (2011), Jo Y (2011), Pearce MM (2007), Huber MD (2013), Christianson JC (2012)	6
CYB561	2	RNF5	0	two hybrid	Rolland T (2014)	1
RNF5	0	FHOD1	3	two hybrid	Lehner B (2004)	1
JKAMP	0	RNF5	0	affinity chromatography technology, enzymatic study	Tcherpakov M (2009), Tcherpakov M (2009)	2
AMFR	2	UBE2K	0	pull down	Flierman D (2006)	1
UBE2E3	0	RNF185	1	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2D1	0	RNF185	1	two hybrid	Markson G (2009)	1
AMFR	2	RNF5	0	affinity chromatography technology	Morito D (2008)	1
UBE2D3	1	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF185	1	UBE2J1	1	affinity chromatography technology	El Khouri E (2013)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
BCAP31	0	CFTR	5	affinity chromatography technology	Wang B (2008)	1
UBE2W	0	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
CFTR	5	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sun F (2006), Sun F (2006), Younger JM (2006), Wang B (2008), Pankow S (2015)	5
ADRB2	0	RNF5	0	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
INSIG2	0	AMFR	2	affinity chromatography technology	Ikeda Y (2009)	1
RNF5	0	YIPF2	1	two hybrid	Rolland T (2014)	1
UBE2Z	0	RNF5	0	two hybrid	Markson G (2009)	1
UBE2E1	1	RNF5	0	two hybrid	Markson G (2009)	1
TNFAIP3	3	UBC	7	x-ray crystallography, enzymatic study, pull down, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, x-ray crystallography, pull down	Bosanac I (2010), Bremm A (2010), Fenner BJ (2009), Tokunaga F (2012), Tokunaga F (2012), Verhelst K (2012), Mevissen TE (2013), Komander D (2009), Evans PC (2004), Skaug B (2011), Bohgaki M (2008), Boone DL (2004), Mevissen TE (2016), Mevissen TE (2016)	14
AMFR	2	MAVS	1	affinity chromatography technology	Jacobs JL (2014)	1
UBE2D3	1	RNF185	1	two hybrid, pull down	Markson G (2009), El Khouri E (2013)	2
MAVS	1	BAG6	2	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
CFTR	5	ERLIN2	2	affinity chromatography technology	Wang X (2006)	1
RNF5	0	DERL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Younger JM (2006), Grove DE (2011), El Khouri E (2013)	3
TNFAIP3	3	UBE2N	1	pull down	Wertz IE (2004)	1
RNF5	0	RNF5	0	enzymatic study, two hybrid, enzymatic study	Sakata E (2010), Rolland T (2014), Matsuda N (2001)	3
DNAJC7	2	RNF5	0	affinity chromatography technology	Hein MY (2015)	1
CFTR	5	JKAMP	0	affinity chromatography technology	Tcherpakov M (2009)	1
UBE2E3	0	RNF5	0	two hybrid, two hybrid, two hybrid	Markson G (2009), Plafker SM (2004), Rolland T (2014)	3
RNF5	0	RNF185	1	two hybrid	Rolland T (2014)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
UBC	7	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Jo Y (2011)	2
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
ADRB2	0	ERLIN2	2	affinity chromatography technology	Roy SJ (2013)	1
RNF185	1	UBC	7	affinity chromatography technology	Iioka H (2007)	1
RNF5	0	SLC1A1	1	two hybrid	Rolland T (2014)	1
TNFAIP3	3	RNF5	0	two hybrid	Hayes SD (2012)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
RNF5	0	MAVS	1	affinity chromatography technology, enzymatic study	Zhong B (2010), Zhong B (2010)	2
UBE2J1	1	DERL1	2	affinity chromatography technology	Claessen JH (2010)	1
UBE2W	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2D3	1	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2U	0	RNF5	0	two hybrid	van Wijk SJ (2009)	1
JKAMP	0	ADRB2	0	affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013)	2
UBE2D2	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Fang S (2001)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
CFTR	5	RNF5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tcherpakov M (2009), Younger JM (2006), Grove DE (2011)	3
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
TMEM173	0	MAVS	1	affinity chromatography technology, affinity chromatography technology	Wang Y (2012), Chen X (2014)	2
PTGDR2	0	JKAMP	0	affinity chromatography technology	Roy SJ (2013)	1
ERLIN2	2	DERL1	2	affinity chromatography technology	Pearce MM (2007)	1
EGLN3	0	TUBA1C	1	affinity chromatography technology	Rodriguez J (2016)	1
CFTR	5	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morito D (2008), Ballar P (2010), Pankow S (2015)	3
EGLN3	0	UBE2G2	0	affinity chromatography technology	Rodriguez J (2016)	1
RNF5	0	UBC	7	enzymatic study	Didier C (2003)	1
TNFAIP3	3	UBE2D1	0	pull down, pull down	Wertz IE (2004), Lee JH (2017)	2
RNF5	0	UBE2G2	0	pull down	Tcherpakov M (2009)	1
UBE2K	0	RNF185	1	two hybrid, affinity chromatography technology	Markson G (2009), Iioka H (2007)	2
UBE2E2	1	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
EGLN3	0	RNF5	0	affinity chromatography technology	Rodriguez J (2016)	1
UBE2E2	1	RNF185	1	two hybrid	Markson G (2009)	1
TOMM40	1	RNF5	0	affinity chromatography technology	Hein MY (2015)	1
RNF5	0	UBE2N	1	pull down	Tcherpakov M (2009)	1
UBE2K	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2V1	0	UBE2K	0	biochemical	Wan C (2015)	1
RNF5	0	CYB561A3	0	two hybrid	Rolland T (2014)	1
RNF5	0	TMEM242	2	two hybrid	Rolland T (2014)	1
UBE2G2	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, affinity chromatography technology, pull down	Ewing RM (2007), Cao J (2007), Chen B (2006), Chen B (2006), Chen B (2006), Li W (2009), Li W (2009), Wang Q (2011), Jo Y (2013), Morito D (2008), Das R (2013), Yan L (2014), Liu W (2014), Li W (2009), Liu W (2014), Christianson JC (2012), Liu Y (2014)	17
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
EGLN3	0	BAG6	2	affinity chromatography technology	Rodriguez J (2016)	1
TUBA1C	1	RNF5	0	affinity chromatography technology	Hein MY (2015)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
RNF5	0	INSIG2	0	two hybrid	Rolland T (2014)	1
RNF5	0	SEC22A	0	two hybrid	Rolland T (2014)	1
BAG6	2	RNF5	0	affinity chromatography technology	Rodrigo-Brenni MC (2014)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
BCAP31	0	DERL1	2	affinity chromatography technology, affinity chromatography technology	Wang B (2008), Wang B (2008)	2
RNF5	0	TMEM173	0	affinity chromatography technology	Zhong B (2009)	1
UBE2E1	1	RNF185	1	two hybrid	Markson G (2009)	1
ADRB2	0	EGLN3	0	affinity chromatography technology, pull down, pull down	Xie L (2009), Xie L (2009), Xie L (2009)	3
DERL1	2	UBE2N	1	affinity chromatography technology	You H (2017)	1
AMFR	2	BAG6	2	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011), Wang Q (2011), Xu Y (2012), Xu Y (2012), Xu Y (2012), Wang Q (2011), Liu Y (2014), Zhang T (2015)	9
UBE2V1	0	RNF185	1	two hybrid	Markson G (2009)	1
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2D1	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2G2	0	UBC	7	x-ray crystallography, pull down, pull down	Bocik WE (2011), Bocik WE (2011), Reyes LF (2006)	3
UBE2D2	0	RNF5	0	two hybrid, pull down	Markson G (2009), Sakata E (2010)	2
UBE2V1	0	RNF5	0	two hybrid	Markson G (2009)	1
INSIG2	0	BAG6	2	affinity chromatography technology	Ikeda Y (2009)	1
ADRB2	0	UBC	7	affinity chromatography technology	Roy SJ (2013)	1
XRCC3	1	RNF5	0	affinity chromatography technology	Hein MY (2015)	1
UBE2D4	0	RNF185	1	two hybrid	Markson G (2009)	1
RNF5	0	PXN	1	affinity chromatography technology, pull down, pull down, enzymatic study	Didier C (2003), Didier C (2003), Didier C (2003), Didier C (2003)	4
YIPF2	1	RNF185	1	two hybrid	Rolland T (2014)	1
ADRB2	0	AMFR	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Roy SJ (2013), Roy SJ (2013), Roy SJ (2013)	3
RNF185	1	BCAP31	0	affinity chromatography technology	Iioka H (2007)	1
UBE2D4	0	RNF5	0	two hybrid, two hybrid	Markson G (2009), Rolland T (2014)	2
UBE2D4	0	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
RNF185	1	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Iioka H (2007), El Khouri E (2013)	2
UBE2N	1	AMFR	2	two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009)	2
EGLN3	0	DNAJC7	2	affinity chromatography technology	Rodriguez J (2016)	1
PTGDR2	0	RNF5	0	affinity chromatography technology	Roy SJ (2013)	1
RNF185	1	DERL1	2	affinity chromatography technology	El Khouri E (2013)	1
RNF185	1	CFTR	5	affinity chromatography technology, affinity chromatography technology	El Khouri E (2013), El Khouri E (2013)	2