PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RIT1	1	RIT2	1	affinity chromatography technology	Huttlin EL (2017)	1
ALB	1	RLF	5	affinity chromatography technology	Zhou M (2004)	1
CNKSR2	5	RLF	5	affinity chromatography technology	Lanigan TM (2003)	1
CBX3	1	RLF	5	affinity chromatography technology	Hauri S (2016)	1
HIST1H3A	3	CBX3	1	affinity chromatography technology, pull down, pull down, x-ray crystallography, unspecified method	Kutney SN (2004), Lavigne M (2009), Lavigne M (2009), Allen HF (2014), Allen HF (2014)	5
CLK1	1	RLF	5	enzymatic study	Lipp JJ (2015)	1
KRAS	1	RLF	5	genetic interference	Luo J (2009)	1
HIST1H3A	3	RLF	5	bioid	Lambert JP (2015)	1
TRIM14	1	CBX3	1	bioid	Tan P (2017)	1
RIT2	1	RLF	5	pull down	Shao H (1999)	1
8339	0	RLF	5	bioid	Lambert JP (2015)	1
TRIM11	1	RLF	5	affinity chromatography technology	Huttlin EL (2017)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
RIT1	1	RLF	5	pull down	Shao H (1999)	1
GCH1	0	RLF	5	two hybrid	Swick L (2006)	1
TRIM14	1	RLF	5	two hybrid	Tan P (2017)	1
CBX5	3	HIST1H3A	3	affinity chromatography technology, pull down, pull down, unspecified method, imaging technique, bioid, affinity chromatography technology	Terada Y (2006), Lavigne M (2009), Lavigne M (2009), Dawson MA (2009), Dawson MA (2009), Lambert JP (2015), Huttlin EL (2017)	7
CBX5	3	RLF	5	affinity chromatography technology	Hauri S (2016)	1
PRPF40A	5	RLF	5	two hybrid	Colland F (2004)	1
HNRNPL	3	RLF	5	affinity chromatography technology	Fei T (2017)	1