PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RHEB	2	RABAC1	0	two hybrid	Li Y (2007)	1
BNIP3	2	BNIP3L	1	two hybrid, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Venkatesan K (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	6
RPS6KB1	1	RHEB	2	enzymatic study	Sun Y (2008)	1
CREB3	1	BNIP3	2	two hybrid	Yu H (2011)	1
ENPP7	1	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
NCAM1	1	RHEB	2	two hybrid	Wang J (2011)	1
IL20RA	2	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
RAP1A	1	TSC2	17	affinity chromatography technology, biochemical	Castro AF (2003), Yamamoto Y (2002)	2
ITGB8	0	RHEB	2	affinity chromatography technology	Huttlin EL (2015)	1
APOE	1	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
SPATA19	0	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
LGALS7	0	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
RHEB	2	RAP1A	1	affinity chromatography technology	Long X (2005)	1
PSEN2	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
PDE6D	0	HRAS	2	two hybrid, two hybrid	Hanzal-Bayer M (2002), Nancy V (2002)	2
RHEB	2	HRAS	2	affinity chromatography technology	Long X (2005)	1
NEDD9	3	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
MTOR	14	FKBP8	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Bai X (2007), Bai X (2007), Bai X (2007), Blaskovich MA (2013)	4
ECSIT	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
MTOR	14	RPTOR	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jacinto E (2004), Jacinto E (2004), Sarbassov DD (2004), Sarbassov DD (2004), Sarbassov DD (2004), Schalm SS (2003), Hara K (2002), Ha SH (2006), Wang L (2006), Frias MA (2006), Frias MA (2006), Buerger C (2006), Jacinto E (2006), McMahon LP (2005), Oshiro N (2004), Kawai S (2003), Choi KM (2003), Hara K (2002), Hara K (2002), Kim DH (2002), Kim DH (2002), Schieke SM (2006), Ha SH (2006), Wang L (2006), Frias MA (2006), Buerger C (2006), Sarbassov DD (2006), Tzatsos A (2006), Sarbassov DD (2005), Yang Q (2006), Kaizuka T (2010), Pearce LR (2007), Oh WJ (2010), Oh WJ (2010), Agrawal P (2012), Kwak D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Wu D (2012), Gwinn DM (2010), Sancak Y (2007), Sancak Y (2007), Yang Q (2006), Carriere A (2011), Jacinto E (2006), Rosner M (2010), Kim DH (2003), Kim DH (2003), Carriere A (2008), Murata H (2011), Koike-Kumagai M (2009), Koike-Kumagai M (2009), Hussain S (2013), Hussain S (2013), Peterson TR (2009), Peterson TR (2009), Su WC (2009), Hernandez-Negrete I (2007), Yan X (2012), Ramirez-Rangel I (2011), Ramirez-Rangel I (2011), Martin J (2008), Martin J (2008), Linares JF (2013), Coffman K (2014), Oshiro N (2014), Thedieck K (2007), Thedieck K (2007), Thedieck K (2007), Dan HC (2008), Dan HC (2008), Dan HC (2008), Hong F (2008), Hong F (2008), Choo AY (2008), Toschi A (2009), Loewith R (2002), Xu Y (2013), Sancak Y (2010), Sancak Y (2010), Vander Haar E (2007), Vander Haar E (2007), Kaadige MR (2015), Misra UK (2014), Misra UK (2014), Thedieck K (2007), Thomas JD (2014), Park D (2014), Alayev A (2016), Alayev A (2016)	91
RPTOR	4	RPS6KB1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Ali SM (2005), Ha SH (2006), Hara K (2002), Nojima H (2003), Kwak D (2012), Carriere A (2011), Ha SH (2006), Li L (2013), Garcia-Martinez JM (2009)	9
RHEB	2	TRAF2	1	affinity chromatography technology	Pilot-Storck F (2010)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
RAC1	7	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
RHEB	2	RAF1	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down	Long X (2005), Karbowniczek M (2004), Long X (2005), Karbowniczek M (2004), Yee WM (1997), Yee WM (1997)	6
RHEB	2	ATR	6	pull down, affinity chromatography technology	Long X (2005), Long X (2005)	2
NFATC2IP	2	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
HRAS	2	RAF1	3	two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Stang S (1997), Germani A (2003), Mitin NY (2004), Vargiu P (2004), Yuryev A (2003), Li W (2000), Li W (2000), Kiyono M (2000), Janoueix-Lerosey I (1998), Boettner B (2000), Karbowniczek M (2006), Han L (1995), Jelinek T (1994), Romero F (1999), Morcos P (1996), Hu CD (1995), Hu CD (1995), Rodriguez-Viciana P (1997), Huang YZ (2003), Stang S (1997), Dougherty MK (2005), Ji H (2016), Fridman M (2000), Ivanov AA (2017)	24
RAP1A	1	RAB7A	0	biochemical	Wan C (2015)	1
RHEB	2	LAMP2	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF2	1	NFATC2IP	2	affinity chromatography technology	Lieberson R (2001)	1
PDE6D	0	RHEB	2	two hybrid	Hanzal-Bayer M (2002)	1
DUSP19	0	RHEB	2	affinity chromatography technology	Li X (2016)	1
TRIM25	5	RAB7A	0	affinity chromatography technology	Choudhury NR (2017)	1
TNF	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Micheau O (2003), Kuai J (2004), Kuai J (2004), Haas TL (2009), Ea CK (2006), Fritsch J (2014), Yamaguchi N (2015)	7
TRIM25	5	RAF1	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	MTOR	14	affinity chromatography technology	Choudhury NR (2017)	1
RHEB	2	BNIP3L	1	two hybrid	Li Y (2007)	1
CREB3	1	RABAC1	0	two hybrid	Wang J (2011)	1
TRIM25	5	RPTOR	4	affinity chromatography technology	Choudhury NR (2017)	1
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RHEB	2	BNIP3	2	two hybrid, fluorescent resonance energy transfe	Li Y (2007), Li Y (2007)	2
RHEB	2	ATM	9	pull down, affinity chromatography technology	Long X (2005), Long X (2005)	2
RHEB	2	RAB9A	0	imaging technique	Saito K (2005)	1
VPS4A	4	RHEB	2	affinity chromatography technology	Huttlin EL (2015)	1
RHEB	2	RPTOR	4	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Long X (2005), Long X (2005), Oshiro N (2014), Thomas JD (2014)	4
TRIM25	5	RAP1A	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	VPS4A	4	affinity chromatography technology	Choudhury NR (2017)	1
IL20RA	2	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
TMEM52B	0	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
PSEN1	11	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
ARIH2	4	RHEB	2	two hybrid	Wang J (2011)	1
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
RPS6KB1	1	MTOR	14	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chiang GG (2005), Holz MK (2005), Holz MK (2005), Hara K (2002), Isotani S (1999), Long X (2005), Toral-Barza L (2005), Ali SM (2005), Saitoh M (2002), Kim DH (2002), Edinger AL (2003), Leone M (2006), Takahashi T (2000), Burnett PE (1998), Sarbassov DD (2005), Agrawal P (2012), Sancak Y (2007), Oshiro N (2004), Sarbassov DD (2005), Kim DH (2003), Kim DH (2003), Nojima H (2003), Martin J (2008), Wing LY (2005), Ren HY (2015)	25
RHEB	2	HTT	14	pull down, affinity chromatography technology	Pryor WM (2014), Pryor WM (2014)	2
A2M	8	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
TSC1	4	RHEB	2	enzymatic study	Garami A (2003)	1
FKBP8	1	RHEB	2	affinity chromatography technology, pull down, two hybrid	Bai X (2007), Bai X (2007), Bai X (2007)	3
FKBP8	1	RPTOR	4	affinity chromatography technology	Bai X (2007)	1
SLC15A1	0	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
A2M	8	APOE	1	affinity chromatography technology, pull down, two hybrid	Krimbou L (1998), Krimbou L (1998), Soler-Lopez M (2011)	3
RHEB	2	TSC2	17	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Castro AF (2003), Inoki K (2003), Garami A (2003), Zhang Y (2003), Cao Y (2006), Castro AF (2003), Long X (2005), Long X (2005)	8
HTT	14	MTOR	14	affinity chromatography technology	Pryor WM (2014)	1
RHEB	2	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
RAP1A	1	RAF1	3	two hybrid, x-ray crystallography, pull down, pull down	Han L (1995), Nassar N (1995), Hu CD (1999), Okada T (1999)	4
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
LDHB	4	RHEB	2	biochemical	Wan C (2015)	1
HTT	14	RPS6KB1	1	unspecified method	Krauss S (2013)	1
PDE6D	0	RAP1A	1	two hybrid, two hybrid	Nancy V (2002), Hanzal-Bayer M (2002)	2
TNF	0	RHEB	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRAF2	1	MTOR	14	imaging technique	Chen TC (2014)	1
A2M	8	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
RHEB	2	MTOR	14	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Long X (2005), Long X (2005), Long X (2005), Smith EM (2005), Bernardi R (2006), Long X (2005), Long X (2005), Sun Y (2008), Tee AR (2005), Pryor WM (2014)	10
TSC2	17	TSC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dan HC (2002), Hodges AK (2001), Aicher LD (2001), van Slegtenhorst M (1998), Nellist M (2002), Li Y (2004), Mak BC (2003), van Slegtenhorst M (1998), van Slegtenhorst M (1998), Ma L (2005), Cai SL (2006), Cao Y (2006), Ma L (2005), Inoki K (2003), Nellist M (2005), Goncharova EA (2006), Astrinidis A (2006), Cao Y (2006), Astrinidis A (2003), Hodges AK (2001), Hodges AK (2001), Nellist M (2001), Aicher LD (2001), Murthy V (2000), van Slegtenhorst M (1998), Dan HC (2002), Miloloza A (2000), Nakashima A (2007), Nakashima A (2007), Benvenuto G (2000), Chong-Kopera H (2006), York B (2005), Vega-Rubin-de-Celis S (2010), Vega-Rubin-de-Celis S (2010), Lin Y (2011), Cloutier P (2017), Cloutier P (2017)	37
CREB3	1	RHEB	2	two hybrid	Yu H (2011)	1
TRIM25	5	LDHB	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
ATR	6	ATM	9	unspecified method, enzymatic study	Kim ST (1999), Stiff T (2006)	2
TRIM25	5	RPS6KB1	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RHEB	2	affinity chromatography technology	Choudhury NR (2017)	1
DUSP19	0	RAP1A	1	affinity chromatography technology	Li X (2016)	1
RHEB	2	RAB7A	0	imaging technique, biochemical	Saito K (2005), Wan C (2015)	2
MTOR	14	RAP1A	1	affinity chromatography technology	Long X (2005)	1
RHEB	2	PLD1	5	affinity chromatography technology, pull down, enzymatic study	Sun Y (2008), Sun Y (2008), Sun Y (2008)	3
TNF	0	RAC1	7	genetic interference	Ahmad M (2002)	1
RHEB	2	SRPRB	0	affinity chromatography technology	Huttlin EL (2017)	1
RELL2	0	RHEB	2	affinity chromatography technology	Huttlin EL (2017)	1
TNF	0	LAMP2	0	affinity chromatography technology	Fritsch J (2014)	1