PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNAPIN	1	RGS7	4	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Hunt RA (2003), Hunt RA (2003), Hunt RA (2003), Hunt RA (2003)	4
RGS7	4	GNAQ	1	fluorescent resonance energy transfe	Witherow DS (2003)	1
HSP90AA1	7	RGS7	4	affinity chromatography technology	Taipale M (2012)	1
CCT5	1	GNB5	2	affinity chromatography technology	Howlett AC (2009)	1
PKD1	18	RGS7	4	two hybrid, affinity chromatography technology, pull down	Kim E (1999), Kim E (1999), Kim E (1999)	3
RGS7	4	GNAZ	1	affinity chromatography technology	Saitoh O (1999)	1
RGS7	4	GNAI3	0	affinity chromatography technology	Saitoh O (1999)	1
GNB5	2	RGS7	4	pull down, biochemical, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levay K (1999), Levay K (1999), Posner BA (1999), Snow BE (1999), Snow BE (1998), Howlett AC (2009), Huttlin EL (2015), Huttlin EL (2017)	8
CCT5	1	RGS7	4	affinity chromatography technology	Howlett AC (2009)	1