Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
RGS4	5999	PERPHENAZINE	CHEMBL567		PharmGKB
RGS4	5999	OLANZAPINE	CHEMBL715		PharmGKB
RGS4	5999	RISPERIDONE	CHEMBL85		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
RGS4	rs2661319	C	risperidone	efficacy	yes		Allele C is associated with decreased response to risperidone in people with Schizophrenia as compared to allele T.	18204343	613979204
RGS4	rs951436	C	antipsychotics	efficacy	no		Allele C is not associated with response to antipsychotics in people with Schizophrenia as compared to allele A.	16604300	655387115
RGS4	rs2842030	TT	olanzapine	efficacy	not stated	compared to quetiapine, risperidone or ziprasidone based on Positive and Negative Syndrome Scale (PANSS) positive scores	Genotype TT is associated with increased response to olanzapine and perphenazine in people with Schizophrenia as compared to genotypes GG + GT.	17588543	608431246
RGS4	rs2842030	GG	risperidone	efficacy	not stated	compared to perphenazine, quetiapine, and ziprasidone treatment	Genotype GG is associated with increased response to risperidone in people with Schizophrenia as compared to genotypes GT + TT.	17588543	608431255
RGS4	rs951439	TT	quetiapine	efficacy	not stated		Genotype TT is associated with increased response to quetiapine and ziprasidone in people with Schizophrenia as compared to genotype CC.	17588543	655387138
RGS4	rs10917670	TT	risperidone	efficacy	no	did not significantly influence end-point scores of any scale after Bonferroni correction for multiple comparisons	Genotype TT is associated with increased response to risperidone in people with Schizophrenia as compared to genotype CC.	18204343	655387136