PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RGS2	2	ZBTB48	3	two hybrid	Vinayagam A (2011)	1
RGS2	2	LRFN1	4	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	DDR1	5	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	IBTK	3	affinity chromatography technology	Ewing RM (2007)	1
RGS2	2	METAP2	3	affinity chromatography technology	Huttlin EL (2017)	1
RGS2	2	DUSP21	0	two hybrid	Vinayagam A (2011)	1
RGS2	2	METTL18	4	two hybrid	Vinayagam A (2011)	1
RGS2	2	BBS10	2	two hybrid	Vinayagam A (2011)	1
UBC	7	CHD3	19	pull down	Nathan JA (2013)	1
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
RGS2	2	MON1A	0	two hybrid	Vinayagam A (2011)	1
PRKCB	4	EGFR	5	enzymatic study	Khaled Z (1995)	1
RGS2	2	EIF3E	1	affinity chromatography technology	Ewing RM (2007)	1
LIG1	4	DDB1	6	affinity chromatography technology, affinity chromatography technology	Peng Z (2016), Peng Z (2016)	2
IBTK	3	WDR74	0	affinity chromatography technology	Hein MY (2015)	1
RGS2	2	GNAQ	1	pull down	Day PW (2003)	1
EIF3L	4	EIF3E	1	biochemical, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Morris-Desbois C (2001), Luke-Glaser S (2007), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	6
RGS2	2	RIN3	2	two hybrid	Vinayagam A (2011)	1
RGS2	2	GNA15	1	pull down	Day PW (2003)	1
ADRB2	0	RGS2	2	protein complementation assay	Kittanakom S (2014)	1
PRKCG	3	IBTK	3	affinity chromatography technology	Janda E (2011)	1
RGS2	2	PRKG1	3	pull down, affinity chromatography technology	Tang KM (2003), Tang KM (2003)	2
RAP1B	0	RGS2	2	two hybrid	Wang J (2011)	1
RGS2	2	CHD3	19	two hybrid	Vinayagam A (2011)	1
RGS2	2	UBC	7	two hybrid	Vinayagam A (2011)	1
RGS2	2	SERPINA10	0	affinity chromatography technology	Huttlin EL (2017)	1
PRKCB	4	IBTK	3	enzymatic study, affinity chromatography technology	Janda E (2011), Janda E (2011)	2
CHD3	19	METAP2	3	biochemical	Wan C (2015)	1
PRKCB	4	RGS2	2	enzymatic study	Cunningham ML (2001)	1
PRKCA	7	PRKCG	3	affinity chromatography technology	Huttlin EL (2017)	1
PRKN	1	NIPSNAP1	3	affinity chromatography technology	Zanon A (2013)	1
RGS2	2	ZNF579	2	two hybrid	Vinayagam A (2011)	1
RGS2	2	LIG1	4	two hybrid	Vinayagam A (2011)	1
ADCY5	6	RGS2	2	affinity chromatography technology, pull down	Salim S (2003), Salim S (2003)	2
STK26	0	DYNLL1	0	affinity chromatography technology	Varjosalo M (2013)	1
ARFGAP1	3	CRMP1	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	GNAS	9	affinity chromatography technology	Tong J (2014)	1
ADRB2	0	GNAS	9	fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Gales C (2005), Roy SJ (2013), Feldman DS (2002)	3
ADRB2	0	GNAI3	0	affinity chromatography technology	Roy SJ (2013)	1
FZD5	2	RGS2	2	two hybrid	Wang J (2011)	1
NINL	1	PTPN13	6	bioid	Gupta GD (2015)	1
RGS2	2	ZYX	2	two hybrid	Vinayagam A (2011)	1
RGS2	2	MIPOL1	1	affinity chromatography technology	Huttlin EL (2017)	1
GDE1	1	REEP5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RGS2	2	RABAC1	0	two hybrid	Vinayagam A (2011)	1
RGS2	2	TAF2	1	affinity chromatography technology	Huttlin EL (2017)	1
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
NINL	1	HAUS5	0	bioid	Gupta GD (2015)	1
DDB1	6	STRIP1	3	biochemical	Havugimana PC (2012)	1
KLK8	2	RGS2	2	two hybrid	Wang J (2011)	1
RGS2	2	HAUS5	0	two hybrid	Vinayagam A (2011)	1
RGS2	2	COMT	2	two hybrid	Vinayagam A (2011)	1
IBTK	3	UBC	7	affinity chromatography technology	Pisano A (2015)	1
RGS2	2	STXBP4	0	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	BBS10	2	affinity chromatography technology	Yao Z (2017)	1
PRKCA	7	IBTK	3	affinity chromatography technology	Janda E (2011)	1
PRKCA	7	PRKCB	4	affinity chromatography technology	Huttlin EL (2017)	1
RABAC1	0	RIN3	2	two hybrid	Vinayagam A (2011)	1
PRKCG	3	RGS2	2	enzymatic study	Cunningham ML (2001)	1
RGS2	2	PRKN	1	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	PTPN13	6	affinity chromatography technology	Huttlin EL (2017)	1
RABAC1	0	REEP5	1	two hybrid, affinity chromatography technology	Vinayagam A (2011), Huttlin EL (2017)	2
RGS2	2	DDB1	6	affinity chromatography technology	Sjoegren B (2015)	1
RGS2	2	STRIP1	3	affinity chromatography technology	Huttlin EL (2017)	1
RGS2	2	CTSB	5	two hybrid	Vinayagam A (2011)	1
RGS2	2	TSPAN15	0	two hybrid	Vinayagam A (2011)	1
EGFR	5	STK26	0	affinity chromatography technology	Tong J (2014)	1
PRKN	1	XRCC6	3	affinity chromatography technology	Zanon A (2013)	1
EGFR	5	RGS2	2	enzymatic study	Derrien A (2001)	1
RGS2	2	REEP5	1	two hybrid	Vinayagam A (2011)	1
RGS2	2	WDR74	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	GDE1	1	two hybrid, pull down	Zheng B (2000), Zheng B (2000)	2
UBC	7	FBXO44	0	pull down	Nathan JA (2013)	1
RGS2	2	XRCC6	3	two hybrid	Vinayagam A (2011)	1
PTPN13	6	LRFN1	4	affinity chromatography technology	Boldt K (2016)	1
ARFGAP1	3	REEP5	1	two hybrid	Wang J (2011)	1
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
RGS2	2	KBTBD7	3	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
RGS2	2	MTUS2	4	two hybrid	Rolland T (2014)	1
STRIP1	3	STK26	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Goudreault M (2009), Goudreault M (2009), Goudreault M (2009)	3
FBXO44	0	DDB1	6	affinity chromatography technology	Sjoegren B (2015)	1
EGFR	5	KBTBD7	3	affinity chromatography technology	Yao Z (2017)	1
COPB2	3	RGS2	2	biochemical	Sullivan BM (2000)	1
RGS2	2	GNAS	9	pull down	Tseng CC (1998)	1
PRKN	1	PRKCSH	2	affinity chromatography technology	Zanon A (2013)	1
RGS2	2	CEP126	0	two hybrid	Vinayagam A (2011)	1
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
PTPN13	6	STXBP4	0	affinity chromatography technology	St-Denis N (2016)	1
PRKCA	7	EGFR	5	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Gauthier ML (2003), Gauthier ML (2003), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
RGS2	2	STK26	0	affinity chromatography technology	Huttlin EL (2017)	1
CHD3	19	GIT1	10	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
RGS2	2	GNAI3	0	pull down	Chen C (1997)	1
PRKN	1	HSPA8	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2003), Zanon A (2013)	4
RGS2	2	DYNLL1	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	FBXO44	0	affinity chromatography technology, affinity chromatography technology	Sjoegren B (2015), Sjoegren B (2015)	2
EGFR	5	CLTA	1	affinity chromatography technology, affinity chromatography technology	Wu SL (2006), Wu SL (2006)	2
GNAS	9	METAP2	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKCA	7	RGS2	2	enzymatic study	Cunningham ML (2001)	1
RGS2	2	GIT1	10	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	NINL	1	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
ADRB2	0	UBC	7	affinity chromatography technology	Roy SJ (2013)	1
RGS2	2	TUBB2B	2	two hybrid	Vinayagam A (2011)	1
GNA15	1	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
RGS2	2	IER3IP1	0	two hybrid	Vinayagam A (2011)	1
GNAQ	1	GNAS	9	biochemical	Havugimana PC (2012)	1
CLTA	1	RGS2	2	two hybrid	Wang J (2011)	1
RGS2	2	HSPA8	4	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	PRKCSH	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RAB2A	4	COMT	2	affinity chromatography technology	Boldt K (2016)	1
RGS2	2	ARFGAP1	3	two hybrid	Stelzl U (2005)	1
RGS2	2	EIF3L	4	two hybrid	Vinayagam A (2011)	1
RGS2	2	RAB2A	4	two hybrid	Vinayagam A (2011)	1
RGS2	2	NIPSNAP1	3	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
RGS2	2	VPS29	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CLTA	1	HSPA8	4	unspecified method	DeLuca-Flaherty C (1990)	1
RGS2	2	CRMP1	0	two hybrid	Vinayagam A (2011)	1