PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SNU13	0	RFXAP	0	biochemical	Havugimana PC (2012)	1
RFXANK	0	RFXAP	0	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Nekrep N (2001), Nekrep N (2001), Nekrep N (2000), Nekrep N (2000), Nekrep N (2000), Nie J (2015)	6
ANKRA2	0	RFX5	0	unspecified method, affinity chromatography technology, affinity chromatography technology	Xu C (2012), Nie J (2015), Huttlin EL (2017)	3
RFXANK	0	RFX5	0	two hybrid, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Nekrep N (2000), Xu C (2012), Xu C (2012), Nie J (2015), Huttlin EL (2017)	5
EPS8	1	RFXAP	0	two hybrid	Wang J (2011)	1
HDAC4	10	RFXANK	0	pull down, affinity chromatography technology, unspecified method	Wang AH (2005), Wang AH (2005), Xu C (2012)	3
MLLT1	1	RFX5	0	affinity chromatography technology	Park G (2010)	1
RFXAP	0	HDAC4	10	affinity chromatography technology	Wang AH (2005)	1
REV3L	8	RFXAP	0	genetic interference	Kotov IN (2014)	1
HDAC4	10	REV3L	8	two hybrid	Wang AH (2005)	1
RFX5	0	HDAC4	10	affinity chromatography technology	Wang AH (2005)	1
MLLT1	1	RFXAP	0	affinity chromatography technology	Park G (2010)	1
ANKRA2	0	RFXAP	0	affinity chromatography technology	Nie J (2015)	1
HDAC4	10	ANKRA2	0	two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology	Wang AH (2005), Wang AH (2005), Xu C (2012), Rolland T (2014), Nie J (2015)	5
NCL	1	RFXAP	0	biochemical	Havugimana PC (2012)	1
RFXAP	0	RFX5	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Durand B (1997), Hein MY (2015), Huttlin EL (2017)	3