PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RFX3	7	TRAF2	1	two hybrid	Rual JF (2005)	1
RTCB	1	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
FOXJ1	0	RFX1	3	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
XYLT2	3	FOXJ1	0	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	DDX1	6	affinity chromatography technology	Boldt K (2016)	1
CREB1	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Kim HC (2010)	2
MBD2	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brackertz M (2002), Ng HH (1999), Ng HH (1999), Ng HH (1999), Zhang Y (1999), Zhang Y (1999), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Bantscheff M (2011), Joshi P (2013), Fujita H (2003), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	16
FHL3	0	RFX6	3	two hybrid	Rual JF (2005)	1
RFX3	7	HDAC2	1	affinity chromatography technology	Boldt K (2016)	1
RFX1	3	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
FHL2	0	FHL3	0	two hybrid, two hybrid, fluorescent resonance energy transfe	Fimia GM (2000), Li HY (2001), Li HY (2001)	3
FHL3	0	TRIP6	2	two hybrid	Rual JF (2005)	1
CFAP20	0	CDK20	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
MBD2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Brackertz M (2002), Ng HH (1999), Zhang Y (1999), Angrisano T (2006), Feng Q (2001), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	8
RFX3	7	VPS45	0	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	HDAC2	1	affinity chromatography technology	Engelen E (2011)	1
CDK20	0	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
DDX1	6	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
FHL2	0	BIN1	2	two hybrid	Wixler V (2000)	1
RFX3	7	CFAP20	0	affinity chromatography technology	Boldt K (2016)	1
HDAC1	4	HDAC2	1	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology	Hakimi MA (2002), Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Fischle W (2002), Johnson CA (2002), Fischle W (2001), Fischer DD (2002), Fischer DD (2002), Ashburner BP (2001), Zhang Y (1999), Tong JK (1998), Tong JK (1998), Hassig CA (1998), Hassig CA (1998), Zhang Y (1997), van der Vlag J (1999), van der Vlag J (1999), Noh EJ (2009), Noh EJ (2009), Galasinski SC (2002), Galasinski SC (2002), Galasinski SC (2002), He S (2005), Humphrey GW (2001), Park JH (2004), Park JH (2004), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Adenuga D (2010), Xue Y (1998), Xue Y (1998), Martinez FP (2012), Martinez FP (2012), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Joshi P (2013), Schnur N (2007), Schnur N (2007), Oh YM (2009), Wan C (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	48
RFX3	7	PLK1	0	affinity chromatography technology	Boldt K (2016)	1
FOXJ1	0	RFX3	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017), Boldt K (2016)	3
CFAP20	0	TBC1D32	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Boldt K (2016)	2
FHL2	0	RFX3	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PTOV1	3	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	RFX6	3	two hybrid	Rual JF (2005)	1
TBC1D32	3	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	TAF6L	3	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	RFX1	3	affinity chromatography technology	Cox JL (2013)	1
EWSR1	2	HDAC2	1	biochemical	Havugimana PC (2012)	1
PLK1	0	HDAC2	1	affinity chromatography technology	Boldt K (2016)	1
CDK20	0	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
FOXN3	2	RFX3	7	affinity chromatography technology	Huttlin EL (2017)	1
RFX3	7	CDK20	0	affinity chromatography technology	Boldt K (2016)	1
RFX4	4	RFX3	7	affinity chromatography technology	Morotomi-Yano K (2002)	1
IRF6	2	RFX3	7	two hybrid	Ravasi T (2010)	1
EWSR1	2	RFX3	7	two hybrid	Ravasi T (2010)	1
TBC1D32	3	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
XYLT2	3	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	MBD2	1	affinity chromatography technology	Cox JL (2013)	1
MBD2	1	MTA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Zhang Y (1999), Feng Q (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Wan C (2015)	6
SOX2	4	RFX3	7	affinity chromatography technology	Engelen E (2011)	1
RFX3	7	SEC63	3	affinity chromatography technology	Huttlin EL (2015)	1
CFAP20	0	PLK1	0	affinity chromatography technology	Boldt K (2016)	1
PKNOX1	1	RFX3	7	two hybrid	Ravasi T (2010)	1
RTCB	1	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	RTCB	1	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	MBD2	1	affinity chromatography technology	Boldt K (2016)	1
RFX3	7	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
CREB1	1	FHL2	0	two hybrid, affinity chromatography technology	Fimia GM (2000), Fimia GM (2000)	2
RFX3	7	TBC1D32	3	affinity chromatography technology	Boldt K (2016)	1
FOXJ1	0	TBC1D32	3	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
RFX1	3	RFX3	7	affinity chromatography technology	Boldt K (2016)	1
PLK1	0	FOXJ1	0	affinity chromatography technology	Boldt K (2016)	1
SOX2	4	HDAC1	4	affinity chromatography technology	Engelen E (2011)	1
RFX3	7	ACAD9	1	affinity chromatography technology	Boldt K (2016)	1
EWSR1	2	TRAF2	1	two hybrid	Rolland T (2014)	1
RFX3	7	PABPC5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RFX3	7	PTOV1	3	affinity chromatography technology	Boldt K (2016)	1
HDAC1	4	FOXJ1	0	affinity chromatography technology	Boldt K (2016)	1
FHL3	0	RFX3	7	two hybrid	Rolland T (2014)	1
RFX3	7	TMED4	0	affinity chromatography technology	Boldt K (2016)	1
PTOV1	3	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
BIN1	2	RFX3	7	two hybrid	Ravasi T (2010)	1
XYLT2	3	TAF6L	3	affinity chromatography technology	Boldt K (2016)	1
DDX1	6	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
FOXJ1	0	CFAP20	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Boldt K (2016)	2
CREB1	1	HDAC1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Canettieri G (2003), Canettieri G (2003), Canettieri G (2003), Kim HC (2010)	4
SOX2	4	MTA2	1	affinity chromatography technology, affinity chromatography technology	Engelen E (2011), Engelen E (2011)	2
FOXN3	2	RFX1	3	affinity chromatography technology	Huttlin EL (2017)	1
FOXJ2	3	RFX1	3	affinity chromatography technology	Li X (2015)	1
RFX3	7	TRIP6	2	two hybrid	Rolland T (2014)	1
SOX2	4	TAF6L	3	affinity chromatography technology	Cox JL (2013)	1
RTCB	1	DDX1	6	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	4
RFX3	7	IGSF8	1	affinity chromatography technology	Huttlin EL (2017)	1
CREB1	1	FHL3	0	two hybrid, affinity chromatography technology	Fimia GM (2000), Fimia GM (2000)	2
RFX3	7	MINDY3	3	affinity chromatography technology	Huttlin EL (2017)	1
PTOV1	3	RTCB	1	affinity chromatography technology	Boldt K (2016)	1
PTOV1	3	XYLT2	3	affinity chromatography technology	Boldt K (2016)	1
RTCB	1	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
MTA2	1	HDAC2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Yao YL (2003), Yao YL (2003), Hakimi MA (2003), Zhang Y (1999), Banach-Orlowska M (2009), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Wang Y (2009), Fu J (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015)	14
RFX1	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu Y (2006), Wang KR (2007), Boldt K (2016)	3
HDAC1	4	MTA2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), You A (2001), Zhang Y (1999), Zhang Y (1999), Yasui D (2002), Banach-Orlowska M (2009), Banach-Orlowska M (2009), Cui Y (2006), Pflum MK (2001), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Humphrey GW (2001), Zhang Y (1998), Terhune SS (2010), Opsahl JA (2010), Wang Y (2009), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	27
XYLT2	3	MTA2	1	affinity chromatography technology	Boldt K (2016)	1
FOXJ2	3	HDAC2	1	affinity chromatography technology	Li X (2015)	1
FOXJ1	0	CDK20	0	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
FOXJ2	3	RFX3	7	affinity chromatography technology	Li X (2015)	1
RFX3	7	HDAC1	4	affinity chromatography technology	Boldt K (2016)	1
CREB1	1	RFX3	7	two hybrid	Ravasi T (2010)	1
HDAC1	4	TAF6L	3	affinity chromatography technology	Boldt K (2016)	1