PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	TP53	0	affinity chromatography technology	Galban S (2003)	1
TP53	0	BAK1	0	affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Leu JI (2004), Leu JI (2004), Leu JI (2004), Gogada R (2011), Holloway A (2014), Zhang X (2016)	6
BCL2L2	0	BCL2L11	4	two hybrid, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology	Hsu SY (1998), OConnor L (1998), Hsu SY (1998), Certo M (2006), Huttlin EL (2017)	5
BCL2L2	0	BAX	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Holmgreen SP (1999), Huttlin EL (2017), Kim EM (2014), Kim EM (2014)	4
BCL2L2	0	BAK1	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Holmgreen SP (1999), Rolland T (2014), Kim EM (2014)	3
TP53	0	BAX	3	imaging technique, affinity chromatography technology, pull down	Chen TC (2014), Kim EM (2014), Kim EM (2014)	3
BAD	1	BAX	3	affinity chromatography technology	Flores-Delgado G (2007)	1
BCL2L2	0	BBC3	1	affinity chromatography technology	Huttlin EL (2017)	1
BID	1	BAK1	0	unspecified method	Holloway A (2014)	1
THOC7	0	BCL2L2	0	affinity chromatography technology	Hein MY (2015)	1
BCL2L2	0	CCDC155	2	two hybrid	Rolland T (2014)	1
BID	1	BAX	3	imaging technique	Chen TC (2014)	1
THOC2	4	BCL2L2	0	affinity chromatography technology	Hein MY (2015)	1
BAK1	0	BAX	3	affinity chromatography technology, affinity chromatography technology	Sundararajan R (2001), Gogada R (2011)	2
BCL2L2	0	HRK	0	unspecified method	Chen L (2005)	1
PRKN	1	TCF4	26	two hybrid	Corominas R (2014)	1
NKAPD1	0	BCL2L2	0	affinity chromatography technology	Huttlin EL (2017)	1
LMNA	2	BCL2L2	0	two hybrid	Dittmer TA (2014)	1
BAD	1	PPP1CA	3	affinity chromatography technology	Flores-Delgado G (2007)	1
FATE1	0	CCDC155	2	two hybrid	Rolland T (2014)	1
LMNA	2	CCDC155	2	two hybrid	Dittmer TA (2014)	1
BCL2L2	0	BIK	0	affinity chromatography technology, two hybrid, unspecified method	Holmgreen SP (1999), Rolland T (2014), Certo M (2006)	3
CDH1	4	BCL2L2	0	bioid	Guo Z (2014)	1
TP53	0	LMNA	2	affinity chromatography technology	Horikawa I (2014)	1
BCL2L2	0	BAD	1	unspecified method, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology	Chen L (2005), Ayllon V (2002), Bae J (2001), Bae J (2001), Holmgreen SP (1999), Certo M (2006), Craik AC (2010)	7
BCL2L2	0	PRKN	1	affinity chromatography technology	Hollville E (2014)	1
PPP1CA	3	CDH1	4	affinity chromatography technology, bioid	Flores-Delgado G (2007), Guo Z (2014)	2
BCL2L2	0	PINK1	2	affinity chromatography technology	Hollville E (2014)	1
LMNA	2	ELAVL1	0	affinity chromatography technology	Depreux FF (2015)	1
PRKN	1	TP53	0	pull down, enzymatic study	Jung YY (2017), Jung YY (2017)	2
TP53	0	TCF4	26	pull down, affinity chromatography technology	Kotlyar M (2015), Li X (2015)	2
BCL2L2	0	FATE1	0	two hybrid	Rolland T (2014)	1
LMNA	2	FATE1	0	two hybrid	Dittmer TA (2014)	1
PRKN	1	LMNA	2	affinity chromatography technology	Zanon A (2013)	1
ELAVL1	0	NKAPD1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BCL2L2	0	TP53	0	unspecified method, affinity chromatography technology, pull down	Lee MS (2014), Kim EM (2014), Kim EM (2014)	3
BCL2L2	0	SLC27A2	2	affinity chromatography technology	Huttlin EL (2017)	1
BCL2L2	0	BID	1	unspecified method, unspecified method, affinity chromatography technology	Chen L (2005), Certo M (2006), Huttlin EL (2017)	3
BCL2L2	0	PPP1CA	3	affinity chromatography technology, pull down	Ayllon V (2002), Ayllon V (2002)	2
ELAVL1	0	BCL2L2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
BMF	0	BCL2L2	0	affinity chromatography technology, two hybrid	Puthalakath H (2001), Rolland T (2014)	2
THOC2	4	THOC7	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Masuda S (2005), Havugimana PC (2012), Chi B (2013), Wan C (2015), Hein MY (2015), Hein MY (2015)	6
PPP1CA	3	TP53	0	two hybrid	Colland F (2004)	1
BCL2L2	0	TCF4	26	two hybrid	Rolland T (2014)	1
PINK1	2	PRKN	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, genetic interference, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Shiba K (2009), Shiba K (2009), Geisler S (2010), Um JW (2009), Um JW (2009), Xiong H (2009), Xiong H (2009), Xiong H (2009), Kondapalli C (2012), Kondapalli C (2012), Sha D (2010), Sha D (2010), Sha D (2010), Sha D (2010), Lazarou M (2013), Zheng X (2013), Fedorowicz MA (2014), Vives-Bauza C (2010), Shiba-Fukushima K (2014), Bertolin G (2015), Fiesel FC (2015), Kazlauskaite A (2015), Moore DJ (2006), Moore DJ (2006), Zhang T (2016), Klosowiak JL (2016), Gersch M (2017)	27
BIK	0	FATE1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
BCL2L11	4	BAX	3	affinity chromatography technology	Huttlin EL (2015)	1
CDH1	4	LMNA	2	affinity chromatography technology	Catimel B (2005)	1
ELAVL1	0	HRK	0	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKN	1	ELAVL1	0	affinity chromatography technology	Zanon A (2013)	1