PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP28	3	MYC	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Popov N (2007), Popov N (2007), Popov N (2007), Han H (2013), Diefenbacher ME (2015), Diefenbacher ME (2015)	6
LMNA	2	SENP2	3	two hybrid	Dittmer TA (2014)	1
NUP153	1	RANGAP1	4	affinity chromatography technology	Hein MY (2015)	1
KPNB1	3	NUP153	1	pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakielny S (1999), Nakielny S (1999), Kehlenbach RH (2000), Ben-Efraim I (2001), Walther TC (2003), Ciciarello M (2010), Hein MY (2015), Hein MY (2015)	8
ELAVL1	0	ARL6IP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
SUMO1	0	HIPK2	0	two hybrid, imaging technique, pull down	Lee BH (2003), de la Vega L (2011), de la Vega L (2011)	3
SUMO2	0	SENP2	3	two hybrid, pull down	Rolland T (2014), Ouyang J (2009)	2
LMNA	2	AGTRAP	1	two hybrid	Dittmer TA (2014)	1
TRIM63	0	SUMO2	0	two hybrid, pull down	Dai KS (2001), Dai KS (2001)	2
SUMO1	0	USP25	0	pull down, pull down, pull down	Meulmeester E (2008), Meulmeester E (2008), Yang Y (2017)	3
SENP2	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
DAXX	5	SUMO1	0	two hybrid, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, x-ray crystallography, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, two hybrid, x-ray crystallography, two hybrid	Lin DY (2002), Ryu SW (2000), Ryu SW (2000), Ryu SW (2000), Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Naik MT (2011), Chang CC (2011), Chang CC (2011), Chen A (2006), Chen A (2006), Saul VV (2014), Ullmann R (2012), Lin DY (2006), Lin DY (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Naik MT (2011), Li C (2017)	20
TRIM63	0	SENP2	3	enzymatic study	Loch CM (2012)	1
SENP2	3	KPNA1	5	pull down	Hirano H (2017)	1
SENP2	3	SUMO3	0	enzymatic study, two hybrid, enzymatic study, enzymatic study	Zhang H (2002), Rolland T (2014), Zhang H (2002), Zhao Y (2015)	4
NUP107	1	NUP133	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, biochemical, bioid, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Belgareh N (2001), Kaur S (2010), Zuccolo M (2007), Glavy JS (2007), Glavy JS (2007), Havugimana PC (2012), Whittle JR (2009), Wan C (2015), Kim DI (2014), Kim DI (2014), Kim DI (2014), Hein MY (2015), Boldt K (2016)	18
SENP2	3	CCDC155	2	two hybrid	Rolland T (2014)	1
KPNB1	3	RANGAP1	4	affinity chromatography technology	Hein MY (2015)	1
SENP2	3	FUNDC1	0	two hybrid	Rolland T (2014)	1
LMNA	2	HNRNPK	4	affinity chromatography technology	Depreux FF (2015)	1
TMEM17	0	SENP2	3	bioid	Gupta GD (2015)	1
LMNA	2	ARL6IP1	0	two hybrid	Dittmer TA (2014)	1
LMNA	2	RANGAP1	4	bioid	Roux KJ (2012)	1
DAXX	5	SUMO3	0	pull down	Chang CC (2011)	1
SENP2	3	RANGAP1	4	enzymatic study	Zhang H (2002)	1
KPNB1	3	SUMO1	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	KPNB1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
NUP107	1	SUMO1	0	affinity chromatography technology	Hein MY (2015)	1
SUMO1	0	RANGAP1	4	pull down	Tatham MH (2003)	1
AGTRAP	1	SENP2	3	two hybrid	Rolland T (2014)	1
NUP153	1	KPNA1	5	affinity chromatography technology	Hein MY (2015)	1
SENP2	3	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lu H (2014), Lu H (2014), Lu H (2014)	3
FZR1	1	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
KPNA1	5	KPNB1	3	pull down, pull down, pull down, biochemical, affinity chromatography technology, pull down	Koehler M (1999), Percipalle P (1997), Plafker SM (2000), Havugimana PC (2012), Hein MY (2015), Tsujii A (2015)	6
HIPK2	0	DAXX	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hofmann TG (2003), Hofmann TG (2003), McDonough H (2009), Kumar N (2013)	4
NUP153	1	SUMO1	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	SENP2	3	affinity chromatography technology	Abdelmohsen K (2009)	1
SUMO3	0	USP25	0	pull down, pull down	Meulmeester E (2008), Meulmeester E (2008)	2
MYC	2	NUP153	1	affinity chromatography technology	Koch HB (2007)	1
LMNA	2	CCDC155	2	two hybrid	Dittmer TA (2014)	1
NEDD4L	3	SENP2	3	pull down	Persaud A (2009)	1
APP	1	MYC	2	pull down	Virok DP (2011)	1
USP25	0	SUMO2	0	pull down, two hybrid, pull down	Meulmeester E (2008), Rolland T (2014), Yang Y (2017)	3
LMNA	2	KPNA1	5	two hybrid	Dittmer TA (2014)	1
MYC	2	KPNB1	3	affinity chromatography technology	Koch HB (2007)	1
SENP2	3	MYC	2	enzymatic study	Gonzalez-Prieto R (2015)	1
ELAVL1	0	NEDD4L	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK5RAP2	3	SENP2	3	two hybrid	Stelzl U (2005)	1
DAXX	5	SUMO2	0	x-ray crystallography, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid	Escobar-Cabrera E (2011), Escobar-Cabrera E (2011), Chen A (2006), Chen A (2006), Ullmann R (2012), Ullmann R (2012), Lin DY (2006), Ouyang J (2009), Li C (2017)	9
USP25	0	APP	1	affinity chromatography technology	Jung ES (2015)	1
NUP43	0	SENP2	3	bioid	Kim DI (2014)	1
ARL6IP1	0	SENP2	3	two hybrid	Rolland T (2014)	1
DAXX	5	FZR1	1	affinity chromatography technology	Kwan PS (2013)	1
SUMO3	0	HIPK2	0	pull down	de la Vega L (2011)	1
MYC	2	NUP133	4	affinity chromatography technology	Koch HB (2007)	1
SENP2	3	SYNE4	1	two hybrid	Rolland T (2014)	1
SENP2	3	SUMO1	0	enzymatic study, pull down	Zhang H (2002), Hemelaar J (2004)	2
NUP133	4	NUP153	1	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
USP25	0	USP28	3	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2017)	2
ELAVL1	0	HNRNPK	4	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
SENP2	3	NACC1	9	enzymatic study	Tatemichi Y (2015)	1
TMEM216	0	APP	1	bioid	Gupta GD (2015)	1
LMNA	2	ELAVL1	0	affinity chromatography technology	Depreux FF (2015)	1
SENP2	3	TMEM239	0	two hybrid	Rolland T (2014)	1
KPNB1	3	NUP43	0	affinity chromatography technology	Hein MY (2015)	1
NUP107	1	RANGAP1	4	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
NACC1	9	BCOR	2	affinity chromatography technology, two hybrid	Korutla L (2009), Korutla L (2009)	2
BCOR	2	SENP2	3	affinity chromatography technology	Oliviero G (2015)	1
IKBKG	0	SENP2	3	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Fenner BJ (2010), Fenner BJ (2010), Fenner BJ (2010), Lee MH (2011), Lee MH (2011)	5
HNRNPK	4	SENP2	3	affinity chromatography technology, affinity chromatography technology	Lee SW (2012), Lee SW (2012)	2
IKBKG	0	MYC	2	affinity chromatography technology	Kim BY (2010)	1
ELAVL1	0	SUMO2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NUP107	1	KPNB1	3	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Walther TC (2003), Kim DI (2014), Hein MY (2015), Hein MY (2015)	4
MYC	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Agrawal P (2010)	2
CDCA5	0	SENP2	3	two hybrid	Wang J (2011)	1
SENP2	3	KPNB1	3	pull down	Hirano H (2017)	1
TMEM216	0	SENP2	3	bioid	Gupta GD (2015)	1
SUMO1	0	HNRNPK	4	pull down	Lee SW (2012)	1
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM63	0	USP28	3	enzymatic study	Loch CM (2012)	1
CTDNEP1	1	SENP2	3	bioid	St-Denis N (2016)	1
NUP43	0	NUP153	1	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
SENP2	3	PGK2	2	affinity chromatography technology	Huttlin EL (2017)	1
SUMO2	0	HNRNPK	4	pull down	Ouyang J (2009)	1
HIPK2	0	SENP2	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Hofmann TG (2005), Hofmann TG (2005), Hofmann TG (2005)	3
NUP107	1	SENP2	3	bioid, affinity chromatography technology	Kim DI (2014), Hein MY (2015)	2
SENP2	3	TPD52	0	two hybrid	Wang J (2011)	1
NUP133	4	SENP2	3	bioid	Kim DI (2014)	1
IKBKG	0	KPNA1	5	affinity chromatography technology	Hwang B (2015)	1
ELAVL1	0	USP28	3	affinity chromatography technology	Abdelmohsen K (2009)	1
MYC	2	HNRNPK	4	affinity chromatography technology	Koch HB (2007)	1
SENP2	3	USP28	3	affinity chromatography technology	Huttlin EL (2017)	1
SUMO2	0	HIPK2	0	pull down	de la Vega L (2011)	1
USP25	0	SENP2	3	affinity chromatography technology	Xu D (2017)	1
KPNB1	3	NUP133	4	affinity chromatography technology	Hein MY (2015)	1
TRIM63	0	APP	1	pull down	Olah J (2011)	1
LMNA	2	NUP133	4	bioid, bioid	Roux KJ (2012), Kim DI (2014)	2
NUP43	0	NUP133	4	affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Loiodice I (2004), Huttlin EL (2015), Kim DI (2014), Huttlin EL (2017)	4
LMNA	2	NUP153	1	bioid, bioid	Roux KJ (2012), Kim DI (2014)	2
SENP2	3	DAXX	5	enzymatic study	Lin DY (2006)	1
NUP153	1	SUMO2	0	affinity chromatography technology	Hein MY (2015)	1
NUP107	1	NUP153	1	biochemical, biochemical, bioid, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Kim DI (2014), Hein MY (2015), Hein MY (2015)	5
ELAVL1	0	TMEM216	0	affinity chromatography technology	Abdelmohsen K (2009)	1
NUP43	0	NUP107	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Loiodice I (2004), Kaur S (2010), Glavy JS (2007), Huttlin EL (2015), Kim DI (2014), Hein MY (2015), Huttlin EL (2017)	7
SENP2	3	NUP153	1	pull down, pull down, affinity chromatography technology	Hang J (2002), Zhang H (2002), Hein MY (2015)	3
USP28	3	SUMO2	0	affinity chromatography technology, x-ray crystallography, pull down	Sowa ME (2009), Wen Y (2015), Wen Y (2015)	3