Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
HRH4 59340 AMOXAPINE CHEMBL1113 binder DrugBank 15947036
HRH4 59340 CHEMBL46296 CHEMBL46296 agonist GuideToPharmacologyInteractions
HRH4 59340 CHEMBL12704 CHEMBL12704 agonist GuideToPharmacologyInteractions
HRH4 59340 CHEMBL1275655 CHEMBL1275655 agonist GuideToPharmacologyInteractions
HRH4 59340 CONESSINE CHEMBL191703 antagonist GuideToPharmacologyInteractions
HRH4 59340 NAFCILLIN CHEMBL1443 antagonist GuideToPharmacologyInteractions
HRH4 59340 IODOPHENPROPIT CHEMBL498770 antagonist GuideToPharmacologyInteractions
HRH4 59340 THIOPERAMIDE CHEMBL260374 antagonist GuideToPharmacologyInteractions
HRH4 59340 HISTAMINE CHEMBL90 agonist GuideToPharmacologyInteractions, DrugBank 20618322, 20573261, 20632959
HRH4 59340 MIANSERIN CHEMBL6437 binder DrugBank
HRH4 59340 CHEMBL26116 CHEMBL26116 agonist GuideToPharmacologyInteractions
HRH4 59340 2-METHYLHISTAMINE CHEMBL12620 agonist GuideToPharmacologyInteractions
HRH4 59340 IMMEPIP CHEMBL18661 agonist GuideToPharmacologyInteractions
HRH4 59340 N-METHYLHISTAMINE CHEMBL507 agonist GuideToPharmacologyInteractions
HRH4 59340 IMPROMIDINE CHEMBL12608 agonist GuideToPharmacologyInteractions
HRH4 59340 BURIMAMIDE CHEMBL12160 antagonist GuideToPharmacologyInteractions
HRH4 59340 CHEMBL185951 CHEMBL185951 antagonist GuideToPharmacologyInteractions
HRH4 59340 MK-0249 CHEMBL476323 antagonist GuideToPharmacologyInteractions
HRH4 59340 LOXAPINE CHEMBL831 binder DrugBank
HRH4 59340 4-METHYLHISTAMINE CHEMBL275443 agonist GuideToPharmacologyInteractions
HRH4 59340 DIMAPRIT CHEMBL12344 agonist GuideToPharmacologyInteractions
HRH4 59340 IMETIT CHEMBL19439 agonist GuideToPharmacologyInteractions
HRH4 59340 METHIMEPIP CHEMBL175782 agonist GuideToPharmacologyInteractions
HRH4 59340 CIPROXIFAN CHEMBL14638 antagonist GuideToPharmacologyInteractions
HRH4 59340 TIPROLISANT CHEMBL462605 antagonist GuideToPharmacologyInteractions
HRH4 59340 TOREFORANT CHEMBL3301609 antagonist GuideToPharmacologyInteractions, ChemblInteractions
HRH4 59340 PF-03893787 CHEMBL1915540 antagonist GuideToPharmacologyInteractions, ChemblInteractions
HRH4 59340 CLOZAPINE CHEMBL42 antagonist TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 16860312, 11752352, 17346280, 16854056
HRH4 59340 CHEMBL67601 CHEMBL67601 agonist GuideToPharmacologyInteractions
HRH4 59340 IMPROGAN CHEMBL2261340 agonist GuideToPharmacologyInteractions
HRH4 59340 CHEMBL1196470 CHEMBL1196470 agonist GuideToPharmacologyInteractions
HRH4 59340 CLOBENPROPIT CHEMBL14690 agonist GuideToPharmacologyInteractions
HRH4 59340 JNJ-7777120 CHEMBL129198 antagonist GuideToPharmacologyInteractions
HRH4 59340 UR-63325 CHEMBL3545345 antagonist ChemblInteractions
HRH4 59340 OLANZAPINE CHEMBL715 antagonist DrugBank 18308814

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
HRH4 rs4483927 G risperidone efficacy no Allele G is not associated with response to risperidone in people with Schizophrenia as compared to allele T. 28696411 1450928272
HRH4 rs4483927 TT risperidone efficacy yes Patients with the TT genotype had a smaller reduction in positive, negative, general and total PANSS (Positive and Negative Syndrome Scale) scores after 4 and 8 weeks of treatment as compared to those with the GG or GT genotype. At 4 weeks, the TT genotype showed a significantly smaller reduction for all scores; at 8 weeks, it only showed a significantly smaller reduction for the positive and total scores. Please note that either ANOVA or Kruskal-Wallis tests were used, so all genotypes were compared against each other, and no post-hoc test information was provided. Genotype TT is associated with decreased response to risperidone in people with Schizophrenia as compared to genotypes GG + GT. 23422377 1183492275