PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCND3	1	CDK4	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Arsenijevic T (2004), Lin J (2001), Zhang Q (1999), Datta NS (1998), Garcia-Morales P (2006), Bockstaele L (2006), Ramachandran N (2004), Wang J (2011), Lodewick J (2013), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Hein MY (2015), Huttlin EL (2017)	15
HDAC1	4	TFDP1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
RBL2	5	LIN54	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2009)	5
E2F4	0	RBL1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CR (2002), Iavarone A (1999), Schmit F (2007), Moberg K (1996), Magae J (1996), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998)	8
CDKN1A	1	HDAC1	4	pull down, affinity chromatography technology, pull down, imaging technique	Li Z (2010), Li Z (2010), Garcia-Wilson E (2005), Chen TC (2014)	4
PHB	0	HDAC1	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi B (2003), Wang S (2002), Gamble SC (2007), He B (2008)	4
PCBD1	0	RBL2	5	two hybrid	Ravasi T (2010)	1
LIN9	3	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
ELAVL1	0	DYRK1A	36	affinity chromatography technology	Abdelmohsen K (2009)	1
CDKN1A	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Ono T (2000), McKenzie PP (2003), McKenzie PP (2003), Law BK (2002), Harper JW (1993), Harper JW (1993), Yam CH (1999), Selma Dagtas A (2010), Naderi S (2005), Varshochi R (2005), Jeong JH (2010), Hsu SP (2008), Scholz A (2003), Peiretti A (2003), Peiretti A (2003), Derjuga A (2001), Kim YB (2000), Park US (2000), Kim WH (2000), Kokontis JM (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bendjennat M (2003), Zheleva DI (2002), Mandal M (1998), Bao GC (2006), Mattock H (2001), Chen Z (2002), Chen J (1996), Chen J (1996), Levkau B (1998), Levkau B (1998), Ramachandran N (2004), Lacy ER (2005), Akagi M (1996), Zhao J (1998), Zhang Y (1999), Poon RY (1998), Gorospe M (1996), Varjosalo M (2013), Varjosalo M (2013), Fogeron ML (2013), Huttlin EL (2015), Hall JR (2014), Hein MY (2015), Hein MY (2015), Chen TC (2014), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	51
RAF1	3	RBBP8	1	two hybrid	Wang J (2011)	1
RAF1	3	CDK4	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CUL1	7	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Michel JJ (1998)	2
PHB	0	E2F1	0	pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi B (2003), Joshi B (2003), Fusaro G (2003), Fusaro G (2003), Wang S (2002), Wang S (2002), Wang S (1999), Wang S (1999), Wang S (2004), Wang S (2004)	10
CDK2	0	LIN37	0	affinity chromatography technology	So J (2015)	1
CCNE1	1	E2F1	0	affinity chromatography technology	Dhillon NK (2002)	1
AATF	0	RBL2	5	affinity chromatography technology	Bruno T (2002)	1
IRF3	4	DCTN1	6	affinity chromatography technology	Li X (2015)	1
CCNA2	1	SKP1	0	affinity chromatography technology	Hein MY (2015)	1
AATF	0	RBL1	1	affinity chromatography technology	Bruno T (2002)	1
BRCA1	7	RAD50	3	biochemical, biochemical, two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Zhong Q (1999), Zhong Q (1999), Zhong Q (1999), Greenberg RA (2006), Chen L (2008), Hill SJ (2014), Acharya S (2014)	10
TXNDC11	1	CCNA2	1	affinity chromatography technology	Huttlin EL (2017)	1
E2F5	0	RBL2	5	biochemical, affinity chromatography technology, two hybrid	Hijmans EM (1995), Litovchick L (2007), Kong LJ (2006)	3
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
CUL1	7	EZH2	4	affinity chromatography technology	Sahasrabuddhe AA (2014)	1
CDK4	2	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Varjosalo M (2013), Ivanov AA (2017)	2
FOXK1	5	RBL1	1	affinity chromatography technology	Li X (2015)	1
RBL1	1	CCNA2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dyson N (1993), Joaquin M (2002), Gibbs E (1996), Schulman BA (1998), Schulman BA (1998), Huttlin EL (2015), Huttlin EL (2017)	7
CDK4	2	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Kehn K (2004), Kehn K (2004), Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017), Denicourt C (2008), Ivanov AA (2017)	8
RBL2	5	CCND1	1	two hybrid	Kong LJ (2006)	1
RBL2	5	LIN52	1	affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007)	2
BRCA1	7	SKP2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lu Y (2012), Lu Y (2012), Parameswaran B (2015)	3
CDKN1A	1	CCNA1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, imaging technique	Zheleva DI (2002), Ramachandran N (2004), Rohaly G (2005), Heron-Milhavet L (2006), Chen TC (2014)	5
EZH2	4	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	van der Vlag J (1999), van der Vlag J (1999), Caretti G (2004), Tong ZT (2012), Tong ZT (2012), Su L (2012), Su L (2012), Wan C (2015)	8
RBL1	1	E2F5	0	two hybrid	Hijmans EM (1995)	1
CCNE1	1	SKP2	2	pull down, enzymatic study	Yeh KH (2001), Enchev RI (2012)	2
LIN9	3	LIN52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Huttlin EL (2017)	5
CDK4	2	RBL1	1	enzymatic study	Anders L (2011)	1
CCNA1	3	CDK2	0	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, imaging technique	Sweeney C (1996), Yang R (1997), Yang R (1997), Mueller-Tidow C (2001), Brown NR (1999), Niida H (2005), Yam CH (2000), Wang H (2009), Narayanan R (2005), Harwell RM (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Peiretti A (2003), Pan ZQ (1993), Kim KS (2002), Lyapina SA (1998), Desai D (1995), Thomas DM (2004), Johnson LN (2002), Rohaly G (2005), Chen TC (2014)	22
RBL2	5	SMARCA4	19	two hybrid	Dunaief JL (2002)	1
CCNA2	1	BRCA1	7	affinity chromatography technology, pull down	Ruffner H (1999), Wang H (1997)	2
CDKN1A	1	CDK4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Selma Dagtas A (2010), Guidoboni M (2005), Santiago FS (2007), Santiago FS (2007), Hsu SP (2008), Kehn K (2004), Kokontis JM (1998), Orend G (1998), Zheleva DI (2002), Mandal M (1998), Chen J (1996), Chen J (1996), Ramachandran N (2004), Gorospe M (1996), Fogeron ML (2013), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Roessig L (2001)	20
SKP2	2	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, imaging technique	Amador V (2007), Hwang CY (2007), Calvisi DF (2009), Bendjennat M (2003), Wu L (2012), Wu L (2012), Abbas T (2008), Ungermannova D (2005), Chen TC (2014)	9
CCND2	2	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Huttlin EL (2015), Huttlin EL (2017)	3
LIN54	1	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
ID2	0	RBL1	1	affinity chromatography technology	Lasorella A (2000)	1
CCND1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006), Wei S (2008), Yu ZK (1998)	4
CCNE1	1	RBL1	1	affinity chromatography technology	Shanahan F (1999)	1
PHB	0	RBL2	5	two hybrid, pull down, affinity chromatography technology	Wang S (1999), Wang S (1999), Wang S (1999)	3
RBL1	1	CCNA1	3	pull down	Yang R (1999)	1
BRCA1	7	DYRK1A	36	affinity chromatography technology	Ertych N (2016)	1
SNW1	0	RAD50	3	affinity chromatography technology	Lleres D (2010)	1
FOXK1	5	RBL2	5	affinity chromatography technology	Li X (2015)	1
CDK6	0	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology	Sugimoto M (1999), Lin J (2001), Sweeney KJ (1997), Ruas M (2007), Shu F (2007), Ramachandran N (2004), Ghiani C (2001)	7
PML	7	EZH2	4	affinity chromatography technology	Villa R (2007)	1
ID2	0	DYRK1A	36	affinity chromatography technology, enzymatic study	Lee SB (2016), Lee SB (2016)	2
RBL2	5	RAF1	3	pull down, two hybrid, affinity chromatography technology	Wang S (1998), Wang S (1998), Wang S (1998)	3
E2F1	0	CCNA1	3	pull down, affinity chromatography technology, pull down	Yang R (1999), Yang R (1999), Ji P (2006)	3
TAF1	9	RBL1	1	affinity chromatography technology	Shao Z (1997)	1
SKP2	2	RAD50	3	affinity chromatography technology	Wu J (2012)	1
RBL2	5	PPP2CA	7	pull down	Vuocolo S (2003)	1
TXNDC11	1	RBL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOP1	1	ELAVL1	0	affinity chromatography technology	Czubaty A (2005)	1
LIN9	3	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
PCBD1	0	DYRK1B	1	two hybrid, affinity chromatography technology	Lim S (2002), Lim S (2002)	2
RBL2	5	ID2	0	affinity chromatography technology, affinity chromatography technology	Rodriguez JL (2006), Lasorella A (2000)	2
SERPINB2	0	RBL2	5	affinity chromatography technology, affinity chromatography technology	Macaluso M (2006), Macaluso M (2006)	2
RBL2	5	CCNA2	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Li Y (1993), Farkas T (2002), Huttlin EL (2015), Huttlin EL (2017)	4
RBL2	5	SKP2	2	affinity chromatography technology, enzymatic study	Bhattacharya S (2003), Tedesco D (2002)	2
LIN52	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Hauri S (2016)	2
SUV39H1	0	RBL2	5	affinity chromatography technology	Nicolas E (2003)	1
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
CDK4	2	SKP1	0	two hybrid	Wang J (2011)	1
HDAC1	4	PML	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Khan MM (2001), Khan MM (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Wu WS (2001), Morey L (2008), Kuo HY (2013), Kim YE (2015)	10
E2F1	0	CCNA2	1	affinity chromatography technology, pull down, affinity chromatography technology	Xu M (1994), Xu M (1994), Schulman BA (1998)	3
PML	7	CUL1	7	affinity chromatography technology	Shima Y (2008)	1
ELAVL1	0	RBL2	5	affinity chromatography technology	Abdelmohsen K (2009)	1
PML	7	TP63	0	affinity chromatography technology, pull down	Bernassola F (2005), Bernassola F (2005)	2
TOP1	1	SNW1	0	unspecified method	Trzcinska AM (2002)	1
RBL2	5	XBP1	2	two hybrid	Ravasi T (2010)	1
DYRK1B	1	FOXK1	5	affinity chromatography technology	Varjosalo M (2013)	1
SKP2	2	CCNA2	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Bashir T (2010), Rosner M (2009), Rosner M (2004), Zhang H (1995), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
RBL2	5	GRAMD4	4	two hybrid	Kong LJ (2006)	1
DYRK1A	36	CCNA2	1	affinity chromatography technology	Varjosalo M (2013)	1
DYRK1A	36	LIN52	1	enzymatic study	Tschoep K (2011)	1
ID2	0	SUV39H1	0	two hybrid	Weimann M (2013)	1
RBL1	1	E2F1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dyson N (1993), Dyson N (1993), Moberg K (1996), Dhillon NK (2002), Su S (2013), Trimarchi JM (1998)	6
RAF1	3	CCND2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
USP4	3	RBL2	5	pull down	Blanchette P (2001)	1
ELAVL1	0	TFDP1	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK6	0	RBL2	5	enzymatic study	Anders L (2011)	1
RINT1	1	RBL1	1	pull down	Kong LJ (2006)	1
CUL1	7	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Lyapina SA (1998), Huttlin EL (2015), Huttlin EL (2017)	4
LIN9	3	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
LIN54	1	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
CDK2	0	ID2	0	enzymatic study, enzymatic study	Deed RW (1997), Hara E (1997)	2
SKP2	2	CDK2	0	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Yam CH (1999), Calvisi DF (2009), Gao D (2009), Bashir T (2010), Yao ZP (2006), Rosner M (2009), Lyapina SA (1998), Zhang H (1995), Zhang H (1995), Inuzuka H (2012), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	17
SKP2	2	SKP1	0	affinity chromatography technology, pull down, pull down, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Strack P (2000), Ng RW (1998), Ng RW (1998), Schulman BA (2000), Cenciarelli C (1999), Marti A (1999), Sabile A (2006), Ji P (2004), Wang W (2004), Tokarz S (2004), Watanabe N (2004), Lin HK (2009), Lin HK (2009), Lin HK (2009), Price CT (2009), Huang Z (2004), Wu J (2012), Bashir T (2010), Saiga T (2009), Li T (2005), Carrano AC (1999), Wu J (2012), Wu L (2012), Rodier G (2008), Swarnalatha M (2013), Yumimoto K (2013), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Tian X (2015), Liu YQ (2015), Kuchay S (2017), Chan CH (2013), Chan CH (2013), Hauri S (2016), Ma X (2017)	37
PML	7	RBL2	5	affinity chromatography technology, affinity chromatography technology, imaging technique	Martin N (2012), Martin N (2012), Martin N (2012)	3
CDKN1A	1	CCNE1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	McKenzie PP (2003), McKenzie PP (2003), Jeon Y (2007), Derjuga A (2001), Datta NS (1998), Orend G (1998), Wu G (1997), Liu J (1997), Bresnahan WA (1996), Bendjennat M (2003), Bao GC (2006), Chen J (1996), Chen J (1996), Chen J (1996), Levkau B (1998), Poon RY (1996), Zhao J (1998), Wang J (2011), Fogeron ML (2013), Chen TC (2014)	20
LIN54	1	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
LIN37	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	5
CCNA2	1	CDK6	0	affinity chromatography technology	Datta NS (1998)	1
RBL2	5	LDHC	2	two hybrid	Kong LJ (2006)	1
SKP2	2	PHB	0	affinity chromatography technology	Chander H (2010)	1
CDK2	0	CDK6	0	biochemical, imaging technique	Cheng A (2000), Chen TC (2014)	2
USP4	3	RBL1	1	pull down	Blanchette P (2001)	1
CCND2	2	RBL2	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBL2	5	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferreira R (1998), Bouzahzah B (2000), Bouzahzah B (2000), Iavarone A (1999)	4
CDKN1A	1	USP4	3	two hybrid	Vinayagam A (2011)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
EZH2	4	RBL2	5	affinity chromatography technology, affinity chromatography technology, pull down	Tonini T (2004), Tonini T (2004), Tonini T (2004)	3
PML	7	E2F4	0	affinity chromatography technology, affinity chromatography technology	Martin N (2012), Martin N (2012)	2
RBL2	5	CCND3	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Kong LJ (2006), Huttlin EL (2015), Huttlin EL (2017)	3
TOP1	1	RBL2	5	unspecified method	Trzcinska AM (2002)	1
TP63	0	FOXK1	5	affinity chromatography technology	Huttlin EL (2017)	1
CCNA2	1	CCNA1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	HDAC1	4	pull down	Yarden RI (1999)	1
CCND1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology	Okabe H (2007), Lin DI (2006)	2
CCNE1	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Wong AK (2000), Shanahan F (1999)	2
LIN9	3	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	4
LIN54	1	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2017)	7
LIN37	0	E2F4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	3
RBBP8	1	RBL1	1	two hybrid, two hybrid	Fusco C (1998), Rual JF (2005)	2
CDKN1A	1	TP63	0	genetic interference	McDade SS (2011)	1
DYRK1B	1	RBL1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
CDK6	0	PML	7	enzymatic study	Yuan WC (2011)	1
ELAVL1	0	SKP1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
HDAC1	4	HBP1	1	affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Lampert F (2018)	2
ELAVL1	0	CDK6	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	EZH2	4	enzymatic study	Chen S (2010)	1
IRF3	4	RBL1	1	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
E2F4	0	ID2	0	affinity chromatography technology	Rodriguez JL (2006)	1
PHB	0	RAF1	3	affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down	Wang S (1999), Wang S (1999), Wang S (1999), Rajalingam K (2005), Rajalingam K (2005)	5
CDK6	0	RBL1	1	enzymatic study	Anders L (2011)	1
BRCA1	7	RBL1	1	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
CUL1	7	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
SNW1	0	DCTN1	6	affinity chromatography technology	Lleres D (2010)	1
RBL1	1	TFDP1	3	affinity chromatography technology	Wu CL (1995)	1
LIN54	1	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Schmit F (2007), Hauri S (2016)	3
ELAVL1	0	LIN54	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TOP1	1	RBL1	1	unspecified method	Trzcinska AM (2002)	1
CCND3	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Bockstaele L (2006), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	5
RBL2	5	CCNA1	3	pull down	Yang R (1999)	1
MCM7	5	RBBP4	3	biochemical	Havugimana PC (2012)	1
CCNA2	1	CDKN1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joaquin M (2003), Amador V (2007), Wu G (1997), Lin ML (2011), Chen J (1996), Levkau B (1998), Poon RY (1996), Fogeron ML (2013), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
RAF1	3	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RBL2	5	BRF1	6	pull down, affinity chromatography technology	Sutcliffe JE (1999), Sutcliffe JE (1999)	2
SNW1	0	RBL2	5	pull down	Prathapam T (2002)	1
E2F4	0	TFDP2	1	x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng N (1999), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017)	4
BRCA1	7	RBL2	5	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
CDK2	0	TFDP1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology	Dynlacht BD (1997), Dynlacht BD (1997), So J (2015)	3
RBL1	1	BRF1	6	pull down, affinity chromatography technology	Sutcliffe JE (1999), Sutcliffe JE (1999)	2
RBL1	1	TFDP2	1	affinity chromatography technology	Wu CL (1995)	1
RBBP4	3	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Schmit F (2007), Huttlin EL (2017), Hauri S (2016)	4
TAF1	9	RBL2	5	affinity chromatography technology	Shao Z (1997)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
CDK2	0	PHB	0	affinity chromatography technology	Neganova I (2011)	1
RBL2	5	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
RBL2	5	DCTN1	6	two hybrid	Kong LJ (2006)	1
SNW1	0	ELAVL1	0	affinity chromatography technology	Lleres D (2010)	1
BRCA1	7	CDK4	2	pull down, enzymatic study, enzymatic study	Wang H (1997), Kehn K (2007), Miralem T (2003)	3
PPP2CA	7	CDK6	0	biochemical, enzymatic study	Cheng A (2000), Cheng A (2000)	2
CUL1	7	TOP1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL1	7	CDKN1A	1	affinity chromatography technology	Yu ZK (1998)	1
E2F5	0	TFDP1	3	biochemical, two hybrid, affinity chromatography technology	Hijmans EM (1995), Sardet C (1995), Hauri S (2016)	3
DYRK1A	36	RBL1	1	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), Varjosalo M (2013)	3
LIN37	0	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
BRCA1	7	RBBP8	1	unspecified method, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rodriguez M (2003), Li S (1999), Li S (1999), Li S (1999), Wong AK (1998), Wong AK (1998), Li S (2000), Wu-Baer F (2001), Yu X (1998), Yu X (1998), Yu X (2000), Yu X (2000), Yu X (2000), Kim H (2007), Yu X (2006), Yu X (2006), Wu-Baer F (2010), Volcic M (2012), Wang B (2007), Wang B (2007), Furuta S (2006), Furuta S (2006), Drikos I (2009), Tischkowitz M (2008), Li S (2000), Wu-Baer F (2001), Chen L (2008), Sevcik J (2013), Johnson N (2013), Hill SJ (2014), Cruz-Garcia A (2014), Hu Y (2014), Parameswaran B (2015), Liu H (2015), Renaud E (2016)	35
ELAVL1	0	SKP2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CCND1	1	MCM7	5	two hybrid, pull down, affinity chromatography technology, biochemical	Gladden AB (2003), Gladden AB (2003), Gladden AB (2003), Gladden AB (2003)	4
RBL2	5	E2F1	0	affinity chromatography technology	Dhillon NK (2002)	1
IRF3	4	RBL2	5	affinity chromatography technology	Li S (2011)	1
RBL2	5	LIN9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Osterloh L (2007)	5
BRCA1	7	CCNE1	1	affinity chromatography technology	Matsuoka S (2007)	1
RBL2	5	RBBP9	0	affinity chromatography technology	Woitach JT (1998)	1
CDK4	2	HDAC1	4	genetic interference	Shen JP (2017)	1
CUL1	7	PPP2CA	7	affinity chromatography technology	Bennett EJ (2010)	1
RBL2	5	TFDP2	1	affinity chromatography technology	Litovchick L (2007)	1
DGKZ	6	RBL1	1	affinity chromatography technology	Los AP (2006)	1
CCNA1	3	SKP2	2	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ji P (2006), Ji P (2006), Ji P (2006), Yam CH (2000), Gao D (2009), Ji P (2007)	6
CCND1	1	CDKN1A	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lin J (1996), Guidoboni M (2005), Garcia-Wilson E (2005), Santiago FS (2007), Santiago FS (2007), Zheleva DI (2002), Ruas M (2007), Chen J (1996), Chen J (1996), Poon RY (1996), Ramachandran N (2004), Wang J (2011), Fogeron ML (2013), Rolland T (2014), Yu H (2011), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Hukkelhoven E (2012), Huttlin EL (2017), Welcker M (1998)	21
SMARCA4	19	RBBP4	3	biochemical	Sif S (2001)	1
LIN37	0	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
BRCA1	7	E2F1	0	affinity chromatography technology	Gorski JJ (2011)	1
CDK6	0	CCND2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Lin J (2001), Sweeney KJ (1997), Varjosalo M (2013), Ivanov AA (2017)	4
SNW1	0	CUL1	7	affinity chromatography technology	Lleres D (2010)	1
ELAVL1	0	RBBP4	3	affinity chromatography technology	Abdelmohsen K (2009)	1
CDK2	0	PML	7	enzymatic study	Yuan WC (2011)	1
SKP1	0	CDKN1A	1	imaging technique	Chen TC (2014)	1
SNW1	0	RBL1	1	pull down	Prathapam T (2002)	1
BRCA1	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Lu Y (2012), Lu Y (2012)	2
RBL2	5	RBBP4	3	affinity chromatography technology	Litovchick L (2007)	1
CDK2	0	TOP1	1	affinity chromatography technology	Neganova I (2011)	1
EZH2	4	RBBP4	3	affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li G (2010), Kaneko S (2010), Kaneko S (2010), Cao Q (2014), Hein MY (2015), Hauri S (2016), Hauri S (2016)	7
RBL1	1	SMARCA4	19	two hybrid	Dunaief JL (2002)	1
CCNE1	1	E2F4	0	affinity chromatography technology	Shanahan F (1999)	1
PHB	0	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (2002), Wang S (2002), Wang S (2004), Wang S (2004)	4
TFDP1	3	E2F1	0	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sardet C (1995), Suzuki M (1998), Wu CL (1995), Helin K (1993), Helin K (1993), Docquier A (2012), Dynlacht BD (1997), Vidal M (1996), Vidal M (1996), Cartwright P (1998), Magae J (1996), Nath S (2014), Trimarchi JM (1998), Logan N (2004), Hauri S (2016)	15
LIN54	1	TFDP1	3	affinity chromatography technology	Litovchick L (2007)	1
DYRK1B	1	RBL2	5	affinity chromatography technology	Varjosalo M (2013)	1
CCND1	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Higashi H (1996), Higashi H (1996), Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	6
CCNE1	1	RBL2	5	affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Li Y (1993)	2
RARG	2	RBL2	5	affinity chromatography technology	Huttlin EL (2017)	1
RBL2	5	TP63	0	genetic interference	McDade SS (2011)	1
CUL1	7	PCBD1	0	affinity chromatography technology	Bennett EJ (2010)	1
LIN37	0	LIN52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	6
CCNE1	1	CDK6	0	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
SUV39H1	0	RBBP4	3	pull down	Vaute O (2002)	1
RBL2	5	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	4
BRCA1	7	TOP1	1	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Shen JP (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017), Ando K (2017)	7
DYRK1B	1	ID2	0	enzymatic study, affinity chromatography technology	Lee SB (2016), Lee SB (2016)	2
LIN54	1	LIN52	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007)	4
ELAVL1	0	CCND1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CUL1	7	CCNA2	1	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Hein MY (2015)	2
E2F1	0	CDK2	0	pull down, enzymatic study, affinity chromatography technology, enzymatic study	Xu M (1994), Dynlacht BD (1997), Dynlacht BD (1997), Ohta T (2001)	4
TXNDC11	1	RBL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EZH2	4	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
CDK6	0	TFDP1	3	enzymatic study	Anders L (2011)	1
CCND2	2	PPP2CA	7	affinity chromatography technology	Russo LC (2017)	1
CDK2	0	MCM7	5	affinity chromatography technology	Neganova I (2011)	1
RAD50	3	RBBP8	1	affinity chromatography technology	Greenberg RA (2006)	1
CUL1	7	CDK4	2	affinity chromatography technology	Bennett EJ (2010)	1
RBL2	5	LBX1	1	two hybrid	Kong LJ (2006)	1
CDK2	0	SKP1	0	x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao ZP (2006), Lyapina SA (1998), Zhang H (1995), Varjosalo M (2013), So J (2015), Hein MY (2015)	6
SUV39H1	0	HDAC1	4	affinity chromatography technology, pull down	Vaute O (2002), Vaute O (2002)	2
HDAC1	4	SMARCA4	19	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Qiu Z (2008), Battaglioli E (2002), Hang CT (2010), DiRenzo J (2000)	4
CCND1	1	TAF1	9	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Adnane J (1999), Adnane J (1999), Adnane J (1999), Siegert JL (2000)	4
SUV39H1	0	RBL1	1	affinity chromatography technology	Nicolas E (2003)	1
RBL2	5	MCM7	5	pull down	Sterner JM (1998)	1
LIN54	1	RBL1	1	affinity chromatography technology	Schmit F (2007)	1
CUL1	7	IRF3	4	affinity chromatography technology	Bibeau-Poirier A (2006)	1
CDKN1A	1	RBBP4	3	two hybrid	Vinayagam A (2011)	1
USP4	3	RBBP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wijnhoven P (2015), Wijnhoven P (2015), Liu H (2015), Liu H (2015), Liu H (2015), Liu H (2015)	6
BRCA1	7	E2F4	0	pull down	Wang H (1997)	1
PML	7	SKP1	0	affinity chromatography technology	Shima Y (2008)	1
TFDP1	3	E2F4	0	two hybrid, pull down, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology	Sardet C (1995), Dynlacht BD (1997), Beijersbergen RL (1994), Ginsberg D (1994), Trimarchi JM (1998), Hauri S (2016)	6
HBP1	1	RBL2	5	two hybrid	Lavender P (1997)	1
SMARCA4	19	PML	7	imaging technique	Chuang YS (2011)	1
CDKN1A	1	TXNDC11	1	two hybrid	Wang J (2011)	1
E2F1	0	RBBP4	3	affinity chromatography technology	Nicolas E (2000)	1
E2F4	0	RBL2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Iavarone A (1999), Litovchick L (2007), Schmit F (2007), Kong LJ (2006), Farkas T (2002), Osterloh L (2007), Yakovlev VA (2013), Martin N (2012), Martin N (2012)	9
RBL1	1	MCM7	5	pull down	Sterner JM (1998)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
E2F1	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nicolas E (2000), Zhou F (2008), Peche LY (2015), Peche LY (2015)	4
RBL2	5	SKP1	0	affinity chromatography technology	Bhattacharya S (2003)	1
DYRK1B	1	CCNA2	1	affinity chromatography technology	Varjosalo M (2013)	1
LIN9	3	LIN37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Litovchick L (2007), Schmit F (2007), Schmit F (2007), Schmit F (2007), Huttlin EL (2015), Huttlin EL (2017)	9
CDK2	0	BRCA1	7	affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study	Ruffner H (1999), Ruffner H (1999), Ruffner H (1999), Wang H (1997), Chen Y (1996)	5
CDK4	2	RBL2	5	enzymatic study	Anders L (2011)	1
E2F4	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ferreira R (1998), Iavarone A (1999), Chen L (2012)	3
RBBP8	1	RBL2	5	affinity chromatography technology, two hybrid, two hybrid, two hybrid	Meloni AR (1999), Meloni AR (1999), Fusco C (1998), Kong LJ (2006)	4
SNW1	0	RINT1	1	two hybrid	Rolland T (2014)	1
CDK2	0	RBL2	5	enzymatic study, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Lacy S (1997), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Howard CM (2000), Huttlin EL (2017)	9
RBL1	1	PHB	0	pull down, affinity chromatography technology	Wang S (1999), Wang S (1999)	2
CCND3	1	CDKN1A	1	two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Rual JF (2005), Datta NS (1998), Chen J (1996), Ramachandran N (2004), Wang J (2011), Fogeron ML (2013), Lodewick J (2013), Rolland T (2014), Huttlin EL (2015), Hein MY (2015), Chen TC (2014), Huttlin EL (2017)	12
RAD50	3	RINT1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xiao J (2001), Xiao J (2001), Xiao J (2001), Xiao J (2001), Kong LJ (2006)	5
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
BRCA1	7	DCTN1	6	affinity chromatography technology	Ertych N (2016)	1
CCND2	2	CDKN1A	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Kehn K (2004), Bao GC (2006), Chen J (1996), Fogeron ML (2013), Rolland T (2014), Huttlin EL (2015), Chen TC (2014), Huttlin EL (2017), Welcker M (1998)	10
RBBP4	3	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology	Yarden RI (1999), Yarden RI (1999), Ertych N (2016)	3
RBL2	5	CUL1	7	affinity chromatography technology	Bhattacharya S (2003)	1
HDAC1	4	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
CDKN1A	1	CDK6	0	affinity chromatography technology, pull down, affinity chromatography technology	Selma Dagtas A (2010), Ramachandran N (2004), Huttlin EL (2017)	3
HDAC1	4	RBL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lai A (1999), Ferreira R (1998), Ferreira R (1998)	3
CDK4	2	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugimoto M (1999), Sugimoto M (1999), Serrano M (1993), Lin J (2001), Taules M (1998), Cariou S (2000), Coleman KG (1997), Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Diehl JA (1997), Okabe H (2007), Bustany S (2011), Gladden AB (2003), Sweeney KJ (1997), Musgrove EA (1996), Vlach J (1996), Garcia-Morales P (2006), Bindra RS (2002), Ruas M (2007), Poon RY (1996), Ramachandran N (2004), Larrea MD (2009), Waaijers S (2013), Mallampalli RK (2013), Rolland T (2014), Chen TC (2014), Barbash O (2009), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Ghiani C (2001), Ito H (2016), Huttlin EL (2017), Roessig L (2001), Qie S (2017)	35
CDK6	0	CCND3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Lin J (2001), Meyerson M (1994), Datta NS (1998), Bockstaele L (2006), Shu F (2007), Ramachandran N (2004), Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	11
IRF3	4	PPP2CA	7	affinity chromatography technology	Peng D (2017)	1
BRCA1	7	PPP2CA	7	affinity chromatography technology	Woods NT (2012)	1
BRCA1	7	CCND1	1	pull down, enzymatic study	Wang H (1997), Kehn K (2007)	2
SKP2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li X (2003), Min KW (2003), Lisztwan J (1998), Lisztwan J (1998), Marti A (1999), Zheng N (2002), Menon S (2008), Chew EH (2007), Chew EH (2007), Ji P (2006), Sabile A (2006), Tan P (1999), Lin HK (2009), Nie L (2011), Chua YS (2011), Huang Z (2004), Wu J (2012), Koyama-Nasu R (2007), Bashir T (2010), Saiga T (2009), Choo YY (2011), Jonason JH (2007), Jonason JH (2007), Bennett EJ (2010), Michel JJ (1998), Carrano AC (1999), Lyapina SA (1998), Lyapina SA (1998), Wu J (2012), Yu ZK (1998), Yu ZK (1998), Rodier G (2008), Swarnalatha M (2013), Cordero-Espinoza L (2013), Yumimoto K (2013), Chung FZ (2014), Zhou W (2014), Zhou W (2014), Yumimoto K (2012), Zhang S (2016), Zhang S (2016), Huttlin EL (2017), Kuchay S (2017), Reitsma JM (2017), Reitsma JM (2017), Ma X (2017)	46
SKP2	2	E2F1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marti A (1999), Marti A (1999), Zhang Z (2005), Farhana L (2002), Salon C (2007), Swarnalatha M (2013)	6
E2F1	0	TFDP2	1	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wu CL (1995), Cartwright P (1998), Huttlin EL (2015), Trimarchi JM (1998), Huttlin EL (2017)	5
HDAC1	4	CCND1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Fu M (2005), Fu M (2005), Batra S (2010)	3
BRCA1	7	LDHC	2	two hybrid	Woods NT (2012)	1
RBL2	5	RAD50	3	affinity chromatography technology, affinity chromatography technology	Kong LJ (2006), Kong LJ (2006)	2
E2F4	0	CDK4	2	affinity chromatography technology	Boldt K (2016)	1
CDK6	0	EZH2	4	enzymatic study	Anders L (2011)	1
CDKN1A	1	RBL2	5	affinity chromatography technology	Fogeron ML (2013)	1
DGKZ	6	RBL2	5	affinity chromatography technology	Los AP (2006)	1
TFDP2	1	E2F5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCND2	2	CCNE1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
DYRK1A	36	RBL2	5	affinity chromatography technology	Varjosalo M (2013)	1
RBL2	5	RINT1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Kong LJ (2006), Kong LJ (2006), Kong LJ (2006), Kong LJ (2006)	4
CDK2	0	E2F4	0	affinity chromatography technology	So J (2015)	1
EZH2	4	BRCA1	7	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Wang L (2013), Wang L (2013), Wang L (2013), Wang L (2013), Gong C (2015)	5
RBL1	1	RBBP9	0	affinity chromatography technology	Woitach JT (1998)	1
LIN37	0	RBL1	1	affinity chromatography technology, affinity chromatography technology	Schmit F (2007), Schmit F (2007)	2
USP4	3	RAD50	3	affinity chromatography technology	Wijnhoven P (2015)	1
EZH2	4	ELAVL1	0	affinity chromatography technology	Cao Q (2014)	1
RAF1	3	PPP2CA	7	affinity chromatography technology	Rajalingam K (2005)	1
CDK4	2	TOP1	1	genetic interference	Shen JP (2017)	1
E2F1	0	CDKN1A	1	imaging technique	Devgan V (2005)	1
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
CUL1	7	E2F1	0	affinity chromatography technology, pull down	Marti A (1999), Marti A (1999)	2
BRCA1	7	TP63	0	affinity chromatography technology, imaging technique	Buckley NE (2011), Buckley NE (2014)	2
BRCA1	7	SMARCA4	19	affinity chromatography technology, pull down, biochemical, pull down, affinity chromatography technology, affinity chromatography technology	Hill DA (2004), Bochar DA (2000), Bochar DA (2000), Bochar DA (2000), Tu Z (2013), Ertych N (2016)	6
PPP2CA	7	CDK2	0	biochemical, enzymatic study, enzymatic study	Cheng A (2000), Cheng A (2000), Cheng A (2005)	3