PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	PCNA	0	affinity chromatography technology	Bennett EJ (2010)	1
RBBP8	1	RBBP8	1	affinity chromatography technology, pull down	Dubin MJ (2004), Dubin MJ (2004)	2
RBBP8	1	KLHL15	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, unspecified method	Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016)	7
BRCA1	7	RB1	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, pull down, pull down, affinity chromatography technology, genetic interference	Aprelikova ON (1999), Fan S (2001), Fan S (2001), Fan S (2001), Yarden RI (1999), Aprelikova ON (1999), Aprelikova ON (1999), Shen JP (2017)	8
POLN	4	RBBP8	1	affinity chromatography technology	Takata K (2015)	1
ATM	9	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wu ZH (2006), Wu ZH (2006), Rosato RR (2010), Wu ZH (2008), Wu ZH (2008), Mohanty S (2014)	6
FXR2	2	BRCA1	7	two hybrid	Hill SJ (2014)	1
RAF1	3	RBBP8	1	two hybrid	Wang J (2011)	1
RBBP8	1	DEFA1	0	affinity chromatography technology	Liu H (2015)	1
CTBP2	7	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Mirnezami AH (2003), Mirnezami AH (2003), Birts CN (2011), Birts CN (2011)	4
PRKDC	12	ATM	9	unspecified method, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Suzuki K (1999), Suzuki K (1999)	3
BRCA1	7	RAD50	3	biochemical, biochemical, two hybrid, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Zhong Q (1999), Zhong Q (1999), Zhong Q (1999), Greenberg RA (2006), Chen L (2008), Hill SJ (2014), Acharya S (2014)	10
TRRAP	31	MED23	3	biochemical	Meyer KD (2008)	1
EEF1A1	0	RBBP8	1	two hybrid	Wang J (2011)	1
CTBP2	7	UBC	7	two hybrid	Paliwal S (2006)	1
BRCA1	7	CTBP1	2	affinity chromatography technology	Li S (1999)	1
BRCA1	7	RPL32	0	affinity chromatography technology	Hill SJ (2014)	1
RB1	2	RAF1	3	pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang S (1998), Wang S (1998), Wang S (1998), Wang S (1999), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Dasgupta P (2004), Singh S (2010), Wang J (2009), Wang J (2009)	11
PLK1	0	IKBKG	0	affinity chromatography technology, affinity chromatography technology	Zhang W (2010), Zhang W (2010)	2
POLN	4	PALB2	3	affinity chromatography technology	Takata K (2015)	1
RBBP8	1	TIPIN	1	genetic interference	Horlbeck MA (2018)	1
EEF1A1	0	IKBKG	0	two hybrid	Ravasi T (2010)	1
ZNF350	1	RBBP8	1	affinity chromatography technology, affinity chromatography technology	Furuta S (2006), Furuta S (2006)	2
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
TIMELESS	8	TIPIN	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Unsal-Kacmaz K (2007), Unsal-Kacmaz K (2007), Yoshizawa-Sugata N (2007), Yoshizawa-Sugata N (2007), Huttlin EL (2015), Huttlin EL (2017), Horlbeck MA (2018)	7
ATM	9	RBBP8	1	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Li S (2000), Li S (2000), Kim ST (1999), Li S (2000)	4
CTBP1	2	RBBP8	1	pull down, affinity chromatography technology, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (1999), Li S (1999), Schaeper U (1998), Schaeper U (1998), Schaeper U (1998), Schaeper U (1998), Schaeper U (1998), Oswald F (2005), Broderick R (2016)	9
CLU	1	RBBP8	1	two hybrid	Wang J (2011)	1
FANCD2	3	BRCA1	7	two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Reuter TY (2003), Vandenberg CJ (2003), Garcia-Higuera I (2001), Garcia-Higuera I (2001), Loke J (2015)	5
RBBP8	1	HID1	5	two hybrid	Rual JF (2005)	1
TRRAP	31	MED14	0	biochemical	Meyer KD (2008)	1
TIMELESS	8	TRRAP	31	genetic interference	Horlbeck MA (2018)	1
KIF7	3	RBBP8	1	affinity chromatography technology	Hein MY (2015)	1
LIMS1	0	RBBP8	1	two hybrid	Rual JF (2005)	1
ATM	9	MRE11	3	unspecified method, biochemical, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Falck J (2005)	3
PRKDC	12	MRE11	3	unspecified method	Kim ST (1999)	1
THOC2	4	RBBP8	1	affinity chromatography technology	Hein MY (2015)	1
FANCD2	3	CTBP1	2	affinity chromatography technology, affinity chromatography technology	Huard CC (2013), Huard CC (2013)	2
UIMC1	4	UBC	7	pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, unspecified method, x-ray crystallography, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Sobhian B (2007), Sobhian B (2007), Wang B (2009), Hu X (2012), Sekiyama N (2012), Cho HJ (2009), Markin CJ (2010), Sekiyama N (2012), Sekiyama N (2012), Sato Y (2009), Sato Y (2009), Nikkilae J (2009), Nikkilae J (2009), Wu J (2009), Guzzo CM (2012), Nathan JA (2013), Anamika A (2014), Kensche T (2012), Yan J (2007), Castaneda CA (2013), Nakasone MA (2013), Thach TT (2015), Zhang X (2017), Li Y (2017), Kristariyanto YA (2017)	25
PCNA	0	EXO1	3	imaging technique, far western blotting	Nielsen FC (2004), Dzantiev L (2004)	2
RBL2	5	RAF1	3	pull down, two hybrid, affinity chromatography technology	Wang S (1998), Wang S (1998), Wang S (1998)	3
RBBP8	1	FANCD2	3	affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, genetic interference, imaging technique, affinity chromatography technology	Yeo JE (2014), Murina O (2014), Murina O (2014), Murina O (2014), Murina O (2014), Murina O (2014), Unno J (2014), Unno J (2014), Unno J (2014), Unno J (2014), Unno J (2014), Unno J (2014)	12
SIAH1	2	RBBP8	1	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Germani A (2003), Germani A (2003), Germani A (2003), Liu H (2015)	4
FANCD2	3	NBN	1	affinity chromatography technology	Nakanishi K (2002)	1
ERP44	1	RBBP8	1	affinity chromatography technology	Huttlin EL (2017)	1
MDM2	2	CTBP1	2	far western blotting, affinity chromatography technology	Mirnezami AH (2003), Mirnezami AH (2003)	2
PIN1	0	PLK1	0	affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Shen M (1998), Shen M (1998), Shen M (1998), Lu PJ (1999), Eckerdt F (2005), Eckerdt F (2005)	6
FANCD2	3	POLN	4	imaging technique, affinity chromatography technology	Park HK (2010), Moldovan GL (2010)	2
PRKDC	12	FANCD2	3	genetic interference	Aggarwal M (2013)	1
PALB2	3	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang F (2009), Sy SM (2009), Zhang F (2009), Zhang F (2009), Zhang F (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Sy SM (2009), Zhang F (2012), Johnson N (2013), Anantha RW (2013), Hill SJ (2014), Bleuyard JY (2012), Orthwein A (2015), Orthwein A (2015), Loke J (2015), Simhadri S (2014), Ma J (2012), Ma J (2012), Foo TK (2017)	22
MED14	0	RBBP8	1	genetic interference	Horlbeck MA (2018)	1
PLK1	0	RBBP8	1	affinity chromatography technology	Hein MY (2015)	1
UBC	7	MAP2K4	3	pull down	Zhang X (2017)	1
MDM2	2	MRE11	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
BRCA1	7	PCNA	0	affinity chromatography technology, affinity chromatography technology	Hill SJ (2014), Ertych N (2016)	2
MDM2	2	CLU	1	pull down	Miyamoto-Sato E (2010)	1
POLN	4	BARD1	4	affinity chromatography technology	Takata K (2015)	1
MED23	3	CTBP1	2	affinity chromatography technology	Lambert JP (2015)	1
PRKDC	12	7515	0	affinity chromatography technology, affinity chromatography technology	Toulany M (2008), Toulany M (2008)	2
RBBP8	1	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
FANCD2	3	FZR1	1	affinity chromatography technology, affinity chromatography technology	Lai F (2012), Lai F (2012)	2
USP4	3	RBL2	5	pull down	Blanchette P (2001)	1
PRKDC	12	RBBP8	1	unspecified method	Kim ST (1999)	1
CTBP2	7	IKZF1	2	two hybrid, two hybrid, affinity chromatography technology	Rolland T (2014), Yu H (2011), Huttlin EL (2017)	3
MDM2	2	EEF1A1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Frum R (2007), Frum R (2007), Frum R (2007), Tsai NP (2012), Tsai NP (2012)	5
UBC	7	UBA2	0	pull down	Gong L (1999)	1
RBBP8	1	UBA2	0	genetic interference	Horlbeck MA (2018)	1
FZR1	1	PLK1	0	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Sedgwick GG (2012), Lee SB (2015), Williamson A (2011)	5
PRKDC	12	BRCA1	7	unspecified method	Kim ST (1999)	1
BRCA1	7	MRE11	3	biochemical, pull down, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Paull TT (2001), Chiba N (2001), Chiba N (2001), Zhong Q (1999), Greenberg RA (2006), Zhao GY (2007), Hill SJ (2014), Suhasini AN (2013)	9
RB1	2	FZR1	1	affinity chromatography technology, biochemical	Binne UK (2007), Binne UK (2007)	2
MED23	3	TIMELESS	8	genetic interference	Horlbeck MA (2018)	1
CTBP2	7	CTBP1	2	two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sewalt RG (1999), Wang J (2011), Corominas R (2014), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	8
BARD1	4	UIMC1	4	affinity chromatography technology, affinity chromatography technology	Sobhian B (2007), Sowa ME (2009)	2
RBBP8	1	LMO4	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Sum EY (2002), Sum EY (2002), Sum EY (2002), Sutherland KD (2003), Rolland T (2014), Liu H (2015)	6
CUL3	17	EEF1A1	0	affinity chromatography technology	Bennett EJ (2010)	1
ZNF598	6	RPL32	0	biochemical	Garzia A (2017)	1
PLK1	0	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Zou J (2013), Zou J (2014)	2
USP4	3	RBL1	1	pull down	Blanchette P (2001)	1
MED23	3	TIPIN	1	genetic interference	Horlbeck MA (2018)	1
CTBP1	2	RB1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EXO1	3	ATM	9	affinity chromatography technology, pull down	Bolderson E (2010), Bolderson E (2010)	2
UBC	7	MRE11	3	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CTBP1	2	IKZF1	2	pull down, affinity chromatography technology, two hybrid, two hybrid, two hybrid	Koipally J (2000), Koipally J (2000), Vinayagam A (2011), Corominas R (2014), Rolland T (2014)	5
MDM2	2	RBBP8	1	affinity chromatography technology	Okoro DR (2013)	1
RBBP8	1	RBL1	1	two hybrid, two hybrid	Fusco C (1998), Rual JF (2005)	2
ATM	9	FANCD2	3	pull down, affinity chromatography technology, two hybrid, enzymatic study	Taniguchi T (2002), Taniguchi T (2002), Reuter TY (2003), Taniguchi T (2002)	4
NBN	1	PRKDC	12	pull down, affinity chromatography technology	Falck J (2005), Falck J (2005)	2
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
PIN1	0	RBBP8	1	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
USP4	3	PCNA	0	enzymatic study	Clerici M (2014)	1
BARD1	4	RAD50	3	biochemical, affinity chromatography technology	Greenberg RA (2006), Greenberg RA (2006)	2
DNA2	3	RBBP8	1	affinity chromatography technology, pull down	Hoa NN (2015), Hoa NN (2015)	2
RBBP8	1	MRE11	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lafranchi L (2014), Broderick R (2016), Liu H (2015), Ferretti LP (2016), Ferretti LP (2016)	5
BRCA1	7	RBL1	1	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
PCNA	0	FANCD2	3	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Howlett NG (2009), Howlett NG (2009), Howlett NG (2009), Chen X (2016)	4
MED23	3	RB1	2	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
UBC	7	FANCD2	3	pull down, affinity chromatography technology	Rego MA (2012), Yamamoto KN (2011)	2
PRKDC	12	FZR1	1	affinity chromatography technology, affinity chromatography technology	Shang ZF (2015), Shang ZF (2015)	2
NBN	1	RAD50	3	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Desai-Mehta A (2001), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Greenberg RA (2006), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wan C (2015), Suhasini AN (2013), Suhasini AN (2013), Lee KY (2015)	17
UIMC1	4	MDM2	2	affinity chromatography technology	Yan J (2009)	1
BARD1	4	NBN	1	biochemical, affinity chromatography technology	Greenberg RA (2006), Greenberg RA (2006)	2
PALB2	3	RBBP8	1	affinity chromatography technology	Sy SM (2009)	1
BRCA1	7	RBL2	5	imaging technique, pull down	Fan S (2001), Fan S (2001)	2
PCNA	0	PRKDC	12	affinity chromatography technology	Ohta S (2002)	1
RBBP8	1	FXR2	2	two hybrid	Rual JF (2005)	1
MED23	3	RBBP8	1	genetic interference	Horlbeck MA (2018)	1
RBL2	5	RBL1	1	affinity chromatography technology	Litovchick L (2007)	1
PRRG4	1	RBBP8	1	two hybrid	Wang J (2011)	1
TIMELESS	8	7515	0	biochemical	Havugimana PC (2012)	1
PALB2	3	CUL3	17	affinity chromatography technology	Orthwein A (2015)	1
BARD1	4	MRE11	3	affinity chromatography technology	Greenberg RA (2006)	1
PCNA	0	EEF1A1	0	affinity chromatography technology	Naryzhny SN (2010)	1
SCOC	3	RBBP8	1	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	UIMC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Kim H (2007), Kim H (2007), Sobhian B (2007), Sobhian B (2007), Sowa ME (2009), Strauss C (2011), Strauss C (2011), Feng L (2009), Feng L (2009), Yan J (2007), Wang B (2007), Wang B (2007), Wang B (2007), Nikkilae J (2009), Nikkilae J (2009), Mok MT (2010), Johnson N (2013), Hill SJ (2014), Hu Y (2014), Hu Y (2014), Hu Y (2014), Renaud E (2016), Li Y (2017)	23
BRIX1	0	UBA2	0	two hybrid	Stelzl U (2005)	1
BRCA1	7	RBBP8	1	unspecified method, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Rodriguez M (2003), Li S (1999), Li S (1999), Li S (1999), Wong AK (1998), Wong AK (1998), Li S (2000), Wu-Baer F (2001), Yu X (1998), Yu X (1998), Yu X (2000), Yu X (2000), Yu X (2000), Kim H (2007), Yu X (2006), Yu X (2006), Wu-Baer F (2010), Volcic M (2012), Wang B (2007), Wang B (2007), Furuta S (2006), Furuta S (2006), Drikos I (2009), Tischkowitz M (2008), Li S (2000), Wu-Baer F (2001), Chen L (2008), Sevcik J (2013), Johnson N (2013), Hill SJ (2014), Cruz-Garcia A (2014), Hu Y (2014), Parameswaran B (2015), Liu H (2015), Renaud E (2016)	35
SPEN	22	CTBP1	2	affinity chromatography technology, pull down	Oswald F (2005), Oswald F (2005)	2
RB1	2	RBBP8	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fusco C (1998), Fusco C (1998), Liu F (2006)	4
NBN	1	RBBP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Chen L (2008), Chen L (2008), Liu H (2015), Liu H (2015), Liu H (2015), Ferretti LP (2016), Ferretti LP (2016)	7
CUL3	17	PRKDC	12	affinity chromatography technology	Bennett EJ (2010)	1
RBBP8	1	PCNA	0	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Gu B (2009), Gu B (2009), Gu B (2009), Gu B (2009)	4
MED14	0	MED23	3	affinity chromatography technology, biochemical, bioid, affinity chromatography technology	Ryu S (1999), Wan C (2015), Lambert JP (2015), Lambert JP (2015)	4
BRCA1	7	NBN	1	biochemical, biochemical, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Zhong Q (1999), Shimada M (2009), Chen L (2008), Hill SJ (2014), Goldstein M (2015), Goldstein M (2015), Parameswaran B (2015)	9
FZR1	1	RBBP8	1	affinity chromatography technology, pull down	Lafranchi L (2014), Lafranchi L (2014)	2
MRE11	3	RAD50	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Chiba N (2001), Chiba N (2001), Chiba N (2001), Dolganov GM (1996), Dolganov GM (1996), Trujillo KM (1998), Goedecke W (1999), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Cho YW (2007), Greenberg RA (2006), Alt JR (2005), Alt JR (2005), Havugimana PC (2012), Wan C (2015), Wijnhoven P (2015), Boldt K (2016), Suhasini AN (2013), Suhasini AN (2013), Lee KY (2015), Nicholson J (2017)	25
MAP2K4	3	RBBP8	1	two hybrid	Wang J (2011)	1
ZNF598	6	PRKDC	12	affinity chromatography technology	Garzia A (2017)	1
RBBP8	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, unspecified method	Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016), Ferretti LP (2016)	4
CTBP1	2	RBL1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	RAD50	3	affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005)	2
RBBP8	1	ZNF598	6	genetic interference	Horlbeck MA (2018)	1
PCNA	0	7515	0	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, fluorescent resonance energy transfe, affinity chromatography technology	Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Fan J (2004), Ogi T (2010)	6
RB1	2	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Hsieh JK (1999), Nguyen DX (2004), Zheng Z (2012), Sdek P (2005), Delston RB (2011), Delston RB (2011), Sdek P (2004), Sdek P (2004), Xiao ZX (1995), Xiao ZX (1995), Xiao ZX (1995), Uchida C (2006), Markham D (2006), Chan HM (2001), Chan HM (2001), Zhang H (2015), Zhang H (2015), Jaenicke RU (1996)	18
SPEN	22	RBBP8	1	pull down, affinity chromatography technology	Oswald F (2005), Oswald F (2005)	2
CUL3	17	BRIX1	0	affinity chromatography technology	Bennett EJ (2010)	1
PLK1	0	CLU	1	affinity chromatography technology	Huttlin EL (2015)	1
RBBP8	1	RGS17	1	two hybrid	Wang J (2011)	1
RBBP8	1	EXD2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Broderick R (2016), Broderick R (2016), Broderick R (2016)	3
NBN	1	MRE11	3	biochemical, affinity chromatography technology, biochemical, two hybrid, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang Y (2000), Cerosaletti KM (2003), Trujillo KM (1998), Matsuzaki K (2008), Desai-Mehta A (2001), Desai-Mehta A (2001), Desai-Mehta A (2001), Zheng L (2009), Goldberg M (2003), Goldberg M (2003), Goldberg M (2003), Cho YW (2007), Nakanishi K (2002), Shimada M (2009), Shimada M (2009), Yanagihara H (2011), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Alt JR (2005), Havugimana PC (2012), Wijnhoven P (2015), Suhasini AN (2013), Suhasini AN (2013), Nicholson J (2017)	26
SIAH1	2	WDYHV1	0	two hybrid	Rolland T (2014)	1
EXD2	1	MRE11	3	affinity chromatography technology	Broderick R (2016)	1
RBBP8	1	TRRAP	31	genetic interference	Horlbeck MA (2018)	1
TIMELESS	8	PCNA	0	affinity chromatography technology	Yang XH (2008)	1
RBBP8	1	BRIX1	0	affinity chromatography technology	Liu H (2015)	1
USP4	3	RB1	2	pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Blanchette P (2001), Blanchette P (2001), DeSalle LM (2001), DeSalle LM (2001), DeSalle LM (2001)	5
CTBP1	2	PLK1	0	affinity chromatography technology	Spyer M (2006)	1
PLK1	0	MDM2	2	enzymatic study, affinity chromatography technology, pull down	Dias SS (2009), Dias SS (2009), Dias SS (2009)	3
MBTPS2	1	RBBP8	1	genetic interference	Horlbeck MA (2018)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
UIMC1	4	RBBP8	1	affinity chromatography technology	Wang B (2007)	1
TRRAP	31	MRE11	3	affinity chromatography technology	Ichim G (2013)	1
USP4	3	MRE11	3	affinity chromatography technology, affinity chromatography technology	Wijnhoven P (2015), Wijnhoven P (2015)	2
BRCA1	7	ZNF350	1	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng L (2000), Zheng L (2000), Zheng L (2000), Furuta S (2006), Furuta S (2006), Lin LF (2013)	6
RAD50	3	RBBP8	1	affinity chromatography technology	Greenberg RA (2006)	1
PIN1	0	IKZF1	2	two hybrid	Rolland T (2014)	1
ATM	9	MDM2	2	enzymatic study, enzymatic study	Wang Z (2012), Luo H (2016)	2
RBBP8	1	UBC	7	far western blotting, affinity chromatography technology	Murina O (2014), Unno J (2014)	2
PIN1	0	RAF1	3	affinity chromatography technology, affinity chromatography technology	Dougherty MK (2005), Dougherty MK (2005)	2
RBBP8	1	WDYHV1	0	two hybrid	Rual JF (2005)	1
MED23	3	CTBP2	7	affinity chromatography technology	Lambert JP (2015)	1
USP4	3	RBBP8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wijnhoven P (2015), Wijnhoven P (2015), Liu H (2015), Liu H (2015), Liu H (2015), Liu H (2015)	6
MED23	3	RAD50	3	affinity chromatography technology	Lambert JP (2015)	1
PLK1	0	LMO4	1	two hybrid	Vinayagam A (2011)	1
BARD1	4	RBBP8	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yu X (2000), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Wu-Baer F (2010), Coleman KA (2011), Hu Y (2014)	7
RBBP8	1	RPL32	0	genetic interference	Horlbeck MA (2018)	1
UIMC1	4	ERP44	1	affinity chromatography technology	Sowa ME (2009)	1
SIAH1	2	SIAH2	0	affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Depaux A (2006), Depaux A (2006), Depaux A (2006), Huttlin EL (2017)	5
CUL3	17	FXR2	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	KLHL15	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Oberg EA (2012), Huttlin EL (2017), Ferretti LP (2016)	4
ATM	9	NBN	1	unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim ST (1999), Wang Y (2000), Cariveau MJ (2007), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Falck J (2005), Wu J (2012), Wu J (2012), Wei F (2015)	12
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
EXD2	1	BRCA1	7	affinity chromatography technology	Broderick R (2016)	1
UBC	7	USP4	3	affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down	Matsumoto M (2005), Faesen AC (2011), Song EJ (2010), Clerici M (2014), Kwasna D (2018)	5
RBBP8	1	RBL2	5	affinity chromatography technology, two hybrid, two hybrid, two hybrid	Meloni AR (1999), Meloni AR (1999), Fusco C (1998), Kong LJ (2006)	4
IKBKG	0	RBBP8	1	two hybrid	Wang J (2011)	1
RAD50	3	ATM	9	biochemical	Wang Y (2000)	1
RBBP8	1	EXO1	3	affinity chromatography technology	Broderick R (2016)	1
LMO1	0	RBBP8	1	two hybrid	Rolland T (2014)	1
SIAH2	0	RBBP8	1	pull down	Germani A (2003)	1
RBBP8	1	IKZF1	2	affinity chromatography technology	Koipally J (2002)	1
RBBP8	1	7515	0	affinity chromatography technology	Liu H (2015)	1
MDM2	2	NBN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alt JR (2005), Alt JR (2005), Bouska A (2008)	3
POLN	4	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, imaging technique	Moldovan GL (2010), Bi X (2006), Barkley LR (2012), Park JM (2014), Park JM (2014)	5
PCNA	0	MDM2	2	affinity chromatography technology, affinity chromatography technology	Groehler AL (2010), Banks D (2006)	2
FANCD2	3	DNA2	3	affinity chromatography technology, affinity chromatography technology	Karanja KK (2012), Karanja KK (2012)	2
RBBP8	1	TMEM54	1	two hybrid	Wang J (2011)	1
POLN	4	BRCA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Takata K (2015), Takata K (2015), Takata K (2015)	3
RBL2	5	RAD50	3	affinity chromatography technology, affinity chromatography technology	Kong LJ (2006), Kong LJ (2006)	2
BRCA1	7	BARD1	4	two hybrid, two hybrid, pull down, pull down, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, two hybrid, pull down, pull down, fluorescent resonance energy transfe, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, two hybrid, x-ray crystallography, imaging technique, imaging technique, two hybrid, affinity chromatography technology, protein complementation assay, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Wu LC (1996), Wang Q (2001), Wang Q (2001), Mallery DL (2002), Wu-Baer F (2003), Hashizume R (2001), Fabbro M (2002), Rodriguez JA (2004), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Dong Y (2003), Chiba N (2001), Kleiman FE (2001), Kleiman FE (2001), Kleiman FE (2001), Wu LC (1996), Morris JR (2002), Brzovic PS (2001), Xia Y (2003), Meza JE (1999), Kentsis A (2002), Hashizume R (2001), Fabbro M (2004), Brzovic PS (2001), Yu X (1998), Jin Y (1997), Scully R (1999), Fabbro M (2004), Kleiman FE (1999), Kleiman FE (1999), Tascou S (2003), Brzovic PS (2003), Benezra M (2003), Meza JE (1999), Cantor SB (2001), Wang Q (1998), Ryser S (2009), Ryser S (2009), Nishikawa H (2009), Nishikawa H (2009), Sobhian B (2007), Harte MT (2010), Simons AM (2006), Wei L (2008), Kumaraswamy E (2007), Kumaraswamy E (2007), Dizin E (2010), Dizin E (2010), Greenberg RA (2006), Greenberg RA (2006), Greenberg RA (2006), Zhu Q (2011), Chen A (2002), Chen A (2002), Sy SM (2009), Sy SM (2009), Nelson AC (2010), Nelson AC (2010), Morris JR (2006), Brzovic PS (2001), Mok MT (2010), Au WW (2005), Ayi TC (1998), Choudhury AD (2005), Sarkar M (2008), Sarkar M (2008), Thakar A (2010), Lu Y (2012), Kentsis A (2002), Christou CM (2014), Christou CM (2014), Sevcik J (2013), Johnson N (2013), Matsuzawa A (2014), Matsuzawa A (2014), Hill SJ (2014), Hill SJ (2014), Hill SJ (2014), Starita LM (2015), Hu Y (2014), Wu W (2015), Loke J (2015), Densham RM (2016), Boukerroucha M (2015), Huttlin EL (2017), Liang Y (2017), Liang Y (2017), Liang Y (2017), Ertych N (2016), Ertych N (2016)	91
LMO4	1	BRCA1	7	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology	Sum EY (2002), Sum EY (2002), Sum EY (2002), Sum EY (2002), Sum EY (2002), Sutherland KD (2003)	6
UBC	7	CLU	1	pull down	Zoubeidi A (2010)	1
MED23	3	SPEN	22	bioid, affinity chromatography technology	Lambert JP (2015), Lambert JP (2015)	2
EEF1A1	0	RAF1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Lamberti A (2007), Lamberti A (2007), Lamberti A (2007)	3
USP4	3	RAD50	3	affinity chromatography technology	Wijnhoven P (2015)	1
CTBP2	7	RBBP8	1	two hybrid, affinity chromatography technology	Wang J (2011), Broderick R (2016)	2
DNA2	3	EXO1	3	genetic interference	Karanja KK (2012)	1
IGFBP7	1	RBBP8	1	two hybrid	Wang J (2011)	1