PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCOA1	6	RARB	2	pull down, two hybrid, pull down	Takeshita A (1996), Albers M (2005), Flajollet S (2007)	3
ARID1A	16	RARA	5	pull down	Flajollet S (2007)	1
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
RARB	2	PSMC5	4	two hybrid	Albers M (2005)	1
HACE1	2	RARB	2	affinity chromatography technology	Zhao J (2009)	1
HACE1	2	RARA	5	affinity chromatography technology	Zhao J (2009)	1
RARA	5	PSMC5	4	pull down, pull down, affinity chromatography technology, two hybrid	Zechel C (2002), vom Baur E (1996), Ferry C (2009), Choi HS (1996)	4
RARB	2	RXRB	0	two hybrid, two hybrid	Albers M (2005), Rolland T (2014)	2
RARA	5	HR	2	two hybrid	Ravasi T (2010)	1
ARID1A	16	SMARCD3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
RXRG	1	RXRA	1	affinity chromatography technology	Huttlin EL (2017)	1
RXRA	1	PSMC5	4	pull down, two hybrid	vom Baur E (1996), Choi HS (1996)	2
CEBPB	2	RARB	2	pull down	Boruk M (1998)	1
SMARCE1	1	ARID1A	16	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Hu K (2006), Ryme J (2009), Kaeser MD (2008), Kaeser MD (2008), Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	9
RARA	5	ITGB1BP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Albers M (2005), Taipale M (2014), Taipale M (2014)	3
RARA	5	RXRG	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Albers M (2005), Wang J (2011), Rolland T (2014), Yu H (2011)	5
SMAD2	5	ARID1A	16	affinity chromatography technology	Xi Q (2008)	1
PRKD2	3	RARB	2	two hybrid	Colland F (2004)	1
SMARCD3	0	RARB	2	pull down	Flajollet S (2007)	1
SMARCE1	1	SMARCD3	0	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Mak AB (2010), Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	5
CEBPA	0	RARB	2	pull down	Boruk M (1998)	1
NCOR2	12	RXRA	1	two hybrid, pull down, two hybrid, two hybrid	Tagami T (1998), Mouchon A (1999), Li H (1997), Albers M (2005)	4
SMARCD3	0	RXRA	1	pull down	Flajollet S (2007)	1
ARID1A	16	RARB	2	pull down	Flajollet S (2007)	1
MEOX2	2	RARB	2	two hybrid	Rolland T (2014)	1
ARID1A	16	NCOA1	6	pull down	Flajollet S (2007)	1
CEBPA	0	RARA	5	pull down, affinity chromatography technology	Girard N (2013), Girard N (2013)	2
PRKD2	3	RXRA	1	two hybrid	Colland F (2004)	1
SMARCE1	1	RARB	2	pull down	Flajollet S (2007)	1
NCOR2	12	CEBPB	2	affinity chromatography technology, affinity chromatography technology, pull down	Ki SH (2005), Ki SH (2005), Ki SH (2005)	3
RARA	5	NCOA1	6	pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Llopis J (2000), Llopis J (2000), Llopis J (2000), Mouchon A (1999), Torchia J (1997), Reineke EL (2007), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Cai SY (2010), DiRenzo J (1997)	11
RARA	5	RXRB	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Albers M (2005), Wang J (2011), Huttlin EL (2017)	4
RARB	2	HR	2	two hybrid	Ravasi T (2010)	1
RARB	2	RXRA	1	x-ray crystallography	Pogenberg V (2005)	1
SMARCD3	0	RARA	5	pull down, pull down	Flajollet S (2007), Flajollet S (2007)	2
MEOX2	2	SMARCE1	1	two hybrid	Rolland T (2014)	1
NCOR2	12	RARB	2	two hybrid	Albers M (2005)	1
SMAD2	5	RARB	2	two hybrid	Colland F (2004)	1
SMAD2	5	RXRA	1	two hybrid	Colland F (2004)	1
RXRB	0	NCOA1	6	two hybrid	Albers M (2005)	1
CEBPB	2	CEBPA	0	pull down, pull down	Cao Z (1991), Lin L (2005)	2
RARB	2	MAP6	3	two hybrid	Albers M (2005)	1
NCOR2	12	RXRG	1	two hybrid	Albers M (2005)	1
GATA3	2	RARB	2	two hybrid	Ravasi T (2010)	1
NCOR2	12	RARA	5	affinity chromatography technology, pull down, pull down, far western blotting, two hybrid, pull down, two hybrid, pull down, pull down	Dong S (2002), Hong SH (1997), Mouchon A (1999), Li H (1997), Li H (1997), Reineke EL (2007), Albers M (2005), Dhordain P (1997), Johnson DR (2006)	9
RARA	5	RARB	2	affinity chromatography technology	Huttlin EL (2017)	1
NCOA1	6	SMARCE1	1	pull down, pull down, pull down	Belandia B (2002), Kiskinis E (2006), Flajollet S (2007)	3
ITGB1BP2	0	RARB	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RARB	2	RXRG	1	two hybrid, two hybrid, two hybrid	Ravasi T (2010), Albers M (2005), Rolland T (2014)	3
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
CCNH	3	RARB	2	two hybrid	Wang J (2011)	1
RARB	2	PNRC1	0	two hybrid	Albers M (2005)	1