PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MRAS	0	RALGDS	4	two hybrid, pull down	Kimmelman A (1997), Ehrhardt GR (1999)	2
HRAS	2	RALGDS	4	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, imaging technique	Mitin NY (2004), Li W (2000), Boettner B (2000), Hofer F (1994), Hofer F (1994), Miller MJ (1997), Spaargaren M (1994), Spaargaren M (1994), Rodriguez-Viciana P (1997), Stang S (1997), Bandyopadhyay S (2010), Nancy V (2002), Chen TC (2014)	13
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
CD68	1	RALGDS	4	two hybrid	Wang J (2011)	1
PDK1	1	RALGDS	4	affinity chromatography technology	Tian X (2002)	1
RAP1A	1	RALGDS	4	two hybrid, pull down, two hybrid	Boettner B (2000), Nancy V (1999), Nancy V (2002)	3
MAPK3	4	ARRB1	2	enzymatic study	Lin FT (1999)	1
ARRB1	2	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Bhattacharya M (2002), Bhattacharya M (2002)	2
RAP1A	1	FADD	1	pull down	Stoletov KV (2004)	1
ARRB2	5	RALGDS	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Bhattacharya M (2002), Bhattacharya M (2002), Bhattacharya M (2002)	3
RIN1	1	KRAS	1	affinity chromatography technology	Huttlin EL (2017)	1
RIN1	1	RRAS	2	affinity chromatography technology	Huttlin EL (2017)	1
RALGDS	4	RAP2A	0	pull down, affinity chromatography technology, two hybrid, pull down	Nancy V (1999), Nancy V (1999), Nancy V (2002), Wang L (2017)	4
RALGDS	4	FADD	1	affinity chromatography technology	Ikner A (2011)	1
ARRB2	5	ARRB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Xiao K (2007), Xiao K (2007), Huttlin EL (2017)	4
SNCA	0	MAPK3	4	affinity chromatography technology	Pan ZZ (2002)	1
SNCA	0	RRAS2	0	affinity chromatography technology	Hein MY (2015)	1
RRAS	2	RALGDS	4	two hybrid, pull down	Spaargaren M (1994), Spaargaren M (1994)	2
LRPAP1	2	RALGDS	4	two hybrid	Li W (2000)	1
RAPGEF2	5	RALGDS	4	two hybrid, pull down	Spaargaren M (1994), Spaargaren M (1994)	2
ARRB2	5	MAPK3	4	affinity chromatography technology, imaging technique	Tohgo A (2003), Chen TC (2014)	2
RRAS2	0	RIN1	1	two hybrid, two hybrid, affinity chromatography technology	Murphy GA (2002), Venkatesan K (2009), Huttlin EL (2017)	3
SNCA	0	RALGDS	4	affinity chromatography technology	Kim KS (2010)	1
TRIM25	5	RAP1A	1	affinity chromatography technology	Choudhury NR (2017)	1
RAP2B	0	RIN1	1	affinity chromatography technology	Boldt K (2016)	1
RALGDS	4	RAP1B	0	two hybrid	Wang J (2011)	1
MAPK3	4	RALGDS	4	imaging technique	Chen TC (2014)	1
RAPGEF2	5	RAP1A	1	enzymatic study, pull down	Rebhun JF (2000), Rebhun JF (2000)	2
SNCA	0	ARRB1	2	affinity chromatography technology	Kim KS (2010)	1
TRIM25	5	RALGDS	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RAP1B	0	affinity chromatography technology	Choudhury NR (2017)	1
RRAS2	0	RALGDS	4	two hybrid, two hybrid	Murphy GA (2002), Wang J (2011)	2
CASP8	1	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Ikner A (2011), Ikner A (2011)	2
CNKSR1	2	RALGDS	4	affinity chromatography technology, affinity chromatography technology	Jaffe AB (2004), Jaffe AB (2004)	2
TRIM25	5	LRPAP1	2	affinity chromatography technology	Choudhury NR (2017)	1
RALGDS	4	RAP2B	0	pull down, two hybrid	Nancy V (1999), Nancy V (2002)	2
KRAS	1	RALGDS	4	two hybrid, two hybrid, pull down, two hybrid	Li W (2000), Spaargaren M (1994), Spaargaren M (1994), Wang J (2011)	4
RIN1	1	RALGDS	4	two hybrid	Shao H (1999)	1
RIT1	1	RALGDS	4	two hybrid	Shao H (1999)	1
RAP2B	0	RAPGEF2	5	pull down	Rebhun JF (2000)	1
HRAS	2	RIN1	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Mitin NY (2004), Han L (1995), Han L (1995), Hu H (2005), Huttlin EL (2017)	5
TRIM25	5	RAPGEF2	5	affinity chromatography technology	Choudhury NR (2017)	1