PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ALDOA	0	GAPDH	0	biochemical	Wan C (2015)	1
HSPA8	4	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RAD52	5	ACTB	8	affinity chromatography technology	Du Y (2009)	1
YWHAZ	1	HNRNPL	3	affinity chromatography technology	Ewing RM (2007)	1
RPA3	2	RAD51	3	two hybrid	Du Y (2009)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
RPS10	0	RPS19	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
5430	0	ACTB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Hofmann WA (2004), Hofmann WA (2004), Kukalev A (2005), Obrdlik A (2008), Obrdlik A (2008)	5
RAD52	5	PRDX2	1	affinity chromatography technology	Du Y (2009)	1
PRDX1	1	GAPDH	0	two hybrid, biochemical	Stelzl U (2005), Wan C (2015)	2
LDHB	4	YWHAZ	1	biochemical	Kristensen AR (2012)	1
HSPD1	0	HSPA8	4	biochemical	Havugimana PC (2012)	1
EEF1A1	0	HSP90AA1	7	affinity chromatography technology	Aranda-Orgilles B (2008)	1
EEF1A1	0	RPS19	1	biochemical	Havugimana PC (2012)	1
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
RAD52	5	CKB	1	affinity chromatography technology	Du Y (2009)	1
TUBA1A	13	YWHAZ	1	genetic interference	Srivas R (2016)	1
HNRNPL	3	DAZAP1	1	affinity chromatography technology	Fei T (2017)	1
NANOG	0	RAD52	5	affinity chromatography technology	Oliviero G (2015)	1
RAD51	3	UBE2I	0	two hybrid, two hybrid	Kovalenko OV (1996), Shen Z (1996)	2
RPA1	0	GAPDH	0	affinity chromatography technology	Marechal A (2014)	1
RAD52	5	HSP90AA1	7	affinity chromatography technology	Du Y (2009)	1
AURKB	2	TTK	4	affinity chromatography technology	Huttlin EL (2015)	1
RAD52	5	EEF1G	0	affinity chromatography technology	Du Y (2009)	1
RPA1	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
RAD52	5	PPIA	0	affinity chromatography technology	Du Y (2009)	1
TTK	4	5430	0	enzymatic study	Nekhai S (1997)	1
RAD51	3	HSP90AA1	7	two hybrid	Arroyo R (2015)	1
RPA3	2	DAZAP1	1	affinity chromatography technology	Marechal A (2014)	1
ALDOA	0	CKB	1	biochemical	Wan C (2015)	1
TUBA1A	13	WRN	6	genetic interference	Srivas R (2016)	1
HSPD1	0	HSPA4	3	biochemical	Wan C (2015)	1
DAZAP1	1	PRDX1	1	biochemical	Wan C (2015)	1
YWHAZ	1	ENO1	3	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Castello A (2012)	2
ALDOA	0	ENO1	3	biochemical	Wan C (2015)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
LDHB	4	ENO1	3	biochemical	Wan C (2015)	1
RAD52	5	ERCC2	4	affinity chromatography technology, affinity chromatography technology	Liu J (2002), Liu J (2002)	2
RAD52	5	SEC13	0	affinity chromatography technology	Du Y (2009)	1
RPA2	0	RAD52	5	affinity chromatography technology	Jackson D (2002)	1
RAD52	5	RPA3	2	affinity chromatography technology, affinity chromatography technology	Du Y (2009), Du Y (2009)	2
RAD52	5	ALDOA	0	affinity chromatography technology	Du Y (2009)	1
RPA2	0	HSPA8	4	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	ACTB	8	affinity chromatography technology	Marechal A (2014)	1
RPA1	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
RPA3	2	GAPDH	0	affinity chromatography technology	Marechal A (2014)	1
HNRNPL	3	YWHAE	0	biochemical, affinity chromatography technology	Wan C (2015), Fei T (2017)	2
HSP90AA1	7	ALDOA	0	affinity chromatography technology	Falsone SF (2005)	1
EEF1A1	0	GAPDH	0	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
RAD52	5	PFN1	0	affinity chromatography technology	Du Y (2009)	1
AURKB	2	TUBA1A	13	affinity chromatography technology	Fogeron ML (2013)	1
EEF1A1	0	HNRNPL	3	biochemical	Havugimana PC (2012)	1
RPA3	2	HSPA8	4	affinity chromatography technology	Marechal A (2014)	1
RAD51	3	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, pull down, far western blotting	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Otterlei M (2006)	5
RAD51	3	SUMO1	0	two hybrid	Shen Z (1996)	1
RPA2	0	GAPDH	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005), Marechal A (2014)	3
PRDX1	1	PRDX2	1	biochemical, biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	3
RAD52	5	RPS19	1	affinity chromatography technology	Du Y (2009)	1
5430	0	RPA1	0	affinity chromatography technology	Fousteri M (2006)	1
TTK	4	HSP90AA1	7	enzymatic study, affinity chromatography technology	Woodford MR (2016), Woodford MR (2016)	2
RPA3	2	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Boldt K (2016)	2
RAD52	5	DAZAP1	1	affinity chromatography technology	Du Y (2009)	1
RAD52	5	HSPA8	4	affinity chromatography technology	Du Y (2009)	1
YWHAE	0	TUBA1A	13	affinity chromatography technology	Gloeckner CJ (2007)	1
WRN	6	RAD52	5	pull down, pull down, far western blotting, two hybrid, far western blotting, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Otterlei M (2006), Otterlei M (2006), Otterlei M (2006), Baynton K (2003), Baynton K (2003), Baynton K (2003), Baynton K (2003), Baynton K (2003)	8
RPA1	0	PRDX1	1	affinity chromatography technology	Marechal A (2014)	1
RAD52	5	SUMO1	0	two hybrid	Shen Z (1996)	1
HSPD1	0	GAPDH	0	biochemical	Havugimana PC (2012)	1
RAD52	5	GAPDH	0	affinity chromatography technology	Du Y (2009)	1
ERCC3	3	ERCC2	4	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Giglia-Mari G (2004), Marinoni JC (1997), Drapkin R (1994), Iyer N (1996), Iyer N (1996), Havugimana PC (2012), Stehling O (2012), Luo J (2015), Luo J (2015)	9
AURKB	2	HSPD1	0	affinity chromatography technology	Fogeron ML (2013)	1
RPA1	0	DAZAP1	1	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	ACTB	8	affinity chromatography technology	Marechal A (2014)	1
GAPDH	0	YWHAE	0	two hybrid	Vinayagam A (2011)	1
RAD52	5	RAD51	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Chen G (1999), Chen G (1999), Otterlei M (2006), Otterlei M (2006), Du Y (2009)	5
RAD52	5	5430	0	affinity chromatography technology	Liu J (2002)	1
TTK	4	RAD52	5	enzymatic study	Lim G (2017)	1
DAZAP1	1	PRDX2	1	biochemical	Wan C (2015)	1
PFN1	0	RAD51	3	two hybrid	Du Y (2009)	1
YWHAE	0	HSPA8	4	affinity chromatography technology	Gloeckner CJ (2007)	1
RPA3	2	EEF1A1	0	affinity chromatography technology	Marechal A (2014)	1
RPA3	2	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
RPA2	0	DAZAP1	1	affinity chromatography technology	Marechal A (2014)	1
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
HSPA8	4	GAPDH	0	biochemical	Wan C (2015)	1
NANOG	0	TUBA1A	13	affinity chromatography technology	Oliviero G (2015)	1
EEF1D	3	EEF1G	0	two hybrid, two hybrid, two hybrid, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Stelzl U (2005), Stelzl U (2005), Kristensen AR (2012), Rolland T (2014), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	8
ENO1	3	PPIA	0	biochemical	Havugimana PC (2012)	1
RAD52	5	UBE2I	0	two hybrid	Shen Z (1996)	1
HSP90AA1	7	GAPDH	0	affinity chromatography technology, biochemical	Falsone SF (2005), Wan C (2015)	2
YWHAE	0	EEF1G	0	affinity chromatography technology	Zuo S (2010)	1
NANOG	0	HSPA8	4	affinity chromatography technology	Oliviero G (2015)	1
RAD51	3	RPA1	0	pull down, two hybrid	Sugiyama T (2002), Du Y (2009)	2
RAD52	5	YWHAE	0	affinity chromatography technology	Du Y (2009)	1
RPA2	0	PRDX1	1	affinity chromatography technology	Marechal A (2014)	1
RAD52	5	PRDX1	1	affinity chromatography technology	Du Y (2009)	1
AURKB	2	RAD52	5	enzymatic study	Lim G (2017)	1
HNRNPL	3	RAD52	5	affinity chromatography technology	Fei T (2017)	1
RPA2	0	WRN	6	affinity chromatography technology	Marechal A (2014)	1
LDHB	4	CKB	1	biochemical	Kristensen AR (2012)	1
RAD52	5	EEF1D	3	affinity chromatography technology	Du Y (2009)	1
5430	0	ERCC3	3	affinity chromatography technology	Fousteri M (2006)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
LDHB	4	PPIA	0	biochemical	Wan C (2015)	1
RAD52	5	RPS10	0	affinity chromatography technology	Du Y (2009)	1
UBE2I	0	AURKB	2	enzymatic study	Ban R (2011)	1
RAD52	5	RAD52	5	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Baynton K (2003), Baynton K (2003), Du Y (2009), Miyoshi A (2003)	4
PRDX2	1	YWHAZ	1	two hybrid	Wang J (2011)	1
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
RAD52	5	ARFGAP1	3	affinity chromatography technology	Du Y (2009)	1
ALDOA	0	HSPD1	0	biochemical	Havugimana PC (2012)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
RAD52	5	HSPD1	0	affinity chromatography technology	Du Y (2009)	1
EEF1D	3	EEF1A1	0	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
RAD52	5	EEF1A1	0	affinity chromatography technology	Du Y (2009)	1
RAD52	5	ERCC3	3	affinity chromatography technology, affinity chromatography technology	Liu J (2002), Liu J (2002)	2
GAPDH	0	PRDX2	1	biochemical	Wan C (2015)	1
RPA2	0	EEF1A1	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Marechal A (2014)	2
PFN1	0	ACTB	8	pull down, two hybrid	Nunoi H (1999), Du Y (2009)	2
SUMO1	0	WRN	6	two hybrid	Hecker CM (2006)	1
RPA3	2	PRDX1	1	affinity chromatography technology	Marechal A (2014)	1
EEF1A1	0	HSPA8	4	affinity chromatography technology	Aranda-Orgilles B (2008)	1
RPA1	0	RAD52	5	pull down	Sugiyama T (2002)	1
RAD52	5	GNAI1	10	affinity chromatography technology	Du Y (2009)	1
HSP90AA1	7	AURKB	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012), Fogeron ML (2013), Huttlin EL (2015), Huttlin EL (2017)	5
PPIA	0	RPA2	0	biochemical	Havugimana PC (2012)	1
TUBA1A	13	GAPDH	0	biochemical	Kristensen AR (2012)	1
RAD52	5	HSPA4	3	affinity chromatography technology, affinity chromatography technology	Du Y (2009), Du Y (2009)	2
RAD52	5	LDHB	4	affinity chromatography technology	Du Y (2009)	1
DAZAP1	1	PFN1	0	biochemical	Wan C (2015)	1
RPA2	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
EEF1A1	0	EEF1G	0	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	4
RAD51	3	TUBA1A	13	biochemical	Skvarova Kramarzova K (2017)	1
RAD52	5	YWHAZ	1	affinity chromatography technology	Du Y (2009)	1
RAD52	5	TUBA1A	13	affinity chromatography technology	Du Y (2009)	1
RPA1	0	EEF1A1	0	affinity chromatography technology	Marechal A (2014)	1
RAD52	5	ENO1	3	affinity chromatography technology	Du Y (2009)	1
RPA3	2	ACTB	8	affinity chromatography technology	Marechal A (2014)	1
ENO1	3	GAPDH	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
RPA1	0	HSPA8	4	affinity chromatography technology	Marechal A (2014)	1
ACTB	8	EEF1A1	0	biochemical	Wan C (2015)	1
EEF1A1	0	5430	0	biochemical	Wan C (2015)	1